INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
·
IF 4.326
Chao Jiang,Yao Yang,Binbo Jiang,Jingyuan Sun,Zhengliang Huang,Zuwei Liao,Jingdai Wang,Yongrong Yang
Multiphase polypropylene is an important engineering plastic. Stickiness concerns in multiphase polypropylene particles with a high rubber content are well known, and they are not favorable to industrial production stability. However, there has been a scarcity of green and effective surface stickiness reduction techniques. In this work, a Damp mode was employed to construct multiple concentration zones at the particle scale, allowing the synthesis of polypropylene with a high rubber content, reduced particle surface stickiness, and dramatically increased copolymerization activity. The rubber content limit of the conventional gas-phase technique (designated as the Dry mode) was found to be approximately 30 wt % before the particles became sticky, whereas the rubber content limit of the Damp mode was found to be 45 wt %. More notably, early in the procedure, the gas-phase copolymerization activity was boosted by 86.7%. Furthermore, given the same rubber content, the impact strength and flexural modulus of the polymers synthesized in both modes and commercial resins were found to be essentially the same. Lastly, the polymer particles synthesized in Damp mode had a multizone structure with an EPR-rich core and an EPR-poor shell. This work establishes a new method for reducing the surface stickiness of multiphase polypropylene particles, paving the way for the manufacturing of high-performance polypropylene resins using ordinary polypropylene plants.
研究领域:
材料科学
·
化学工程
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高影响因子
Cell Reports Medicine
·
2025
·
IF 10.6
Cheng Gao,Ruifeng Luo,Cheryl H.T. Kwong,Jinwei Liu,Mian Tang,Beibei Xie,Tianshun Duan,Ruibing Wang
The effectiveness of whole tumor cell vaccines prepared by traditional inactivation methodology is often hindered by insufficient immunogenicity. Here, we report development of a cancer vaccine through the intracellular gelation of tumor cells, combined with CD47 blockade and damage-associated molecular pattern (DAMP) exposure, for effective tumor prevention and treatment. Intracellular hydrogelation preserves the morphology and antigenicity of tumor cells. CD47 blockade and DAMP exposure synergistically enhance the “eat me” signals and inhibit the “don’t eat me” signals on tumor cells, significantly improving their immunogenicity. In the context of tumor prevention and treatment of pre-existing tumors, this vaccine polarizes CD4 + T cells toward a T H 1 phenotype, reduces regulatory T cells and T cell exhaustion, and elicits a robust tumor-antigen-specific T cell response. When combined with an immune checkpoint inhibitor, this vaccine demonstrates enhanced efficacy in eradicating established tumors. The successful application of this vaccine using ascites and subcutaneous tumor cells supports the feasibility of developing personalized whole tumor cell vaccines for diverse tumor types.
研究领域:
肿瘤学
·
免疫学
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DOI
PubMed
高影响因子
Cell Reports
·
2025
·
IF 6.9
Rong Wu,Yunong Zeng,Jiaochan Han,Lei Li,Qing-Ming Xiong,Shuyu Li,Shanshan Fu,Ping Qin,Ze Wang,Yi He,Zhengzheng Yan,Weidong Xiao,Zhenhua Zeng,Zhe-Xiong Lian,Zhi-Bin Zhao,Wei Xiao,Yong Jiang,Shenhai Gong
Damage-associated molecular patterns (DAMPs) often cause an exaggerated immune response. Fatty acid-binding protein 5 (FABP5) is traditionally considered a cytosolic protein responsible for the transport of fatty acids. However, little is known about the role of FABP5 in sepsis. Herein, we found that circulating FABP5 levels were higher in patients with sepsis and were associated with adverse outcomes. The circulating FABP5 originated mainly from macrophage pyroptosis in the later stages of sepsis despite a decrease in cytoplasm-resident FABP5 expression. Functionally, circulating FABP5 penetrated the living macrophage membrane and bound to the intracellular domain of TLR4, ultimately inducing secondary inflammation through the NF-κB and MAPK pathways. Unlike circulating oxidized FABP5, cytoplasm-resident FABP5 was present in its reduced form and suppressed macrophage pyroptosis. Clearance of circulating DAMP FABP5 by preventing the passive release from dying macrophages or using a specific blocking antibody can improve survival in mice with sepsis.
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高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Wang Tong,Yang Jiabao,Cao Qi,Pu Xingyu,Li Yuke,Chen Hui,Zhao Junsong,Zhang Yixin,Chen Xingyuan,Li Xuanhua
Encapsulation engineering is an effective strategy to improve the stability of perovskite solar cells. However, current encapsulation materials are not suitable for lead-based devices because of their complex encapsulation processes, poor thermal management, and inefficient lead leakage suppression. In this work, we design a self-crosslinked fluorosilicone polymer gel, achieving nondestructive encapsulation at room temperature. Moreover, the proposed encapsulation strategy effectively promotes heat transfer and mitigates the potential impact of heat accumulation. As a result, the encapsulated devices maintain 98% of the normalized power conversion efficiency after 1000 h in the damp heat test and retain 95% of the normalized efficiency after 220 cycles in the thermal cycling test, satisfying the requirements of the International Electrotechnical Commission 61215 standard. The encapsulated devices also exhibit excellent lead leakage inhibition rates, 99% in the rain test and 98% in the immersion test, owing to excellent glass protection and strong coordination interaction. Our strategy provides a universal and integrated solution for achieving efficient, stable, and sustainable perovskite photovoltaics.
研究领域:
材料科学
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能源技术
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光伏技术
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PubMed
高影响因子
Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 20
·10556-10564
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IF 11.9
Shengwen Zou,Jun Kang,Yuzheng Zhang,Mingjing Qi,Xiaojun Yan,Xiaoliang Zhang,Jianmei Huang
CsPbI3 as a newly emerging semiconductor material has displayed tremendous prospects for optoelectronic applications. However, the poor photoactive black-phase stability limits its further application. In this work, we introduce transition metal nickel ion (Ni2+) as a B-site substitute into CsPbI3 nanocrystals (NCs) to stabilize their black phase. The optimized CsPbI3 NCs film presents a record photoactive black-phase stability time of 54 hours under the conditions of 85 °C and 85% relative humidity, over 108 times that of the undoped film. Furthermore, the Ni2+-doped CsPbI3 NCs solutions maintain bright red emission after vigorous stirring with an equal volume of water for 200 hours (the undoped solution is almost completely quenched), and also show bright red emission after being stored in the air for 200 days (the undoped solution is completely quenched within 43 days). Meanwhile, the photoluminescence quantum yield increased from 31.48% for undoped CsPbI3 NCs to 87.69% for doped Ni-3.65% CsPbI3 NCs. We suggest that these outstanding stabilities and excellent optical properties can mainly be attributed to the increased defect formation energy after rational Ni doping and lattice adjustment by partial replacement of Pb2+ with small-sized Ni2+. Our work provides guidance for the synthesis of phase-stabilized CsPbI3 NCs and an insight into the effect of B-site doping in a perovskite lattice, providing a promising pathway to construct stable and efficient photoelectronic devices.
研究领域:
材料科学
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光电材料
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半导体物理
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高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2026
·
IF 3.1
Yanmei He,Xiao Lin,Wanwan Zhong,Xingyan Liu,Xiuyan Yang,Youlian Yao,Meimei Li,Jianyong Zhang
Shuganning injection (SGNI) is derived from Yinchenhao decoction and has the functions of promoting diuresis, reducing jaundice and protecting the liver. It is primarily utilized in the treatment of liver diseases, particularly damp-heat jaundice. However, the pharmacodynamic material basis and specific mechanisms remain unclear. Therefore, this study aims to elucidate the pharmacodynamic material basis and mechanism of SGNI in the treatment of damp-heat jaundice syndrome (DHJS). High-throughput metabolomics was employed to identify biomarkers associated with DHJS. The migratory prototype components and metabolites present in the blood of SGNI were characterized through serum pharmacochemistry. Correlation analysis was conducted to associate the biomarkers of DHJS with the migrating components in the blood of SGNI, clarifying the pharmacodynamic basis of SGNI in treating DHJS. Furthermore, metabolic pathway enrichment analysis was performed to explore the endogenous core metabolites and key metabolic pathways, providing insights into the mechanism of SGNI in treating DHJS from the metabolic perspective. Finally, a total of 25 metabolites were identified as biomarkers for DHJS, along with 24 prototype migratory components and 38 migratory metabolites of SGNI. It was established that the pharmacodynamic substance basis of SGNI in the treatment of DHJS comprises 15 components. These components primarily exert their effects through key metabolic pathways, including pentose and glucuronate interconversions, arachidonic acid metabolism, and primary bile acid biosynthesis. In conclusion, SGNI demonstrates a significant therapeutic effect on DHJS. It has preliminarily elucidated the pharmacodynamic substance basis and mechanism of action at the metabolic level, offering a scientific foundation for the clinical application and further development of SGNI.
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高影响因子
Drug Design Development and Therapy
·
2024
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IF 4.7
Qi Wu,Kexin Liu,Ruijuan Hou,Xingxing Wu,Xiaoyu Ruan,Mao Wang,Zhiting Sun,Lingchang Meng,Guoliang Dai,Changyin Li,Jing Wu,Genglin Mu
Purpose Inflammatory bowel disease (IBD) is a serious disease that affects the metabolism and inflammatory responses of human beings. From the perspective of traditional Chinese medicine, damp-heat syndrome is one of the main syndromes of IBD. Rhizoma Paridis, also known as the root of Paris polyphylla, a well-known herbal medicine used in China, is used to treat IBD with damp-heat syndrome (IBD-DH). However, uncertainty still exists regarding the underlying mechanisms and the impact of Rhizoma Paridis on IBD-DH.Methods The rats in the model (DAT) and medication administration (Rhizoma Paridis total saponins (RPTS) and Pennogenin (PN)) groups were given a high temperature and high humidity environment, high fat and high sugar diet combined with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to establish the model of experimental colitis of damp-heat type, and the normal control group (RNC) rats were given a normal diet at normal temperature and humidity. Damp-heat control group (DNC) was set with the same condition as DAT without TNBS. Hematoxylin-Eosin (HE) staining was used to observe the histopathological morphology of the rat colorectum. The expression of the metabolism-related genes (Phospholipase A2 (sPLA2, cPLA2), and phosphatidylethanolamine N-methyltransferase (PEMT)) was assessed by using real-time quantitative PCR analysis (RT–qPCR). And the levels of the metabolism-related proteins (sPLA2, cPLA2), S100A8/9, Arg-1, and cytokines were detected by enzyme-linked immunosorbent assay (ELISA) kit. To investigate lipids and amino acids which closely associated with the IBD and IBD-DH, lipid pseudotargeted metabolomics with UHPLC-TQ/MS analysis method, as well as targeted quantitative amino acid analysis were performed.Results Our data showed that RPTS (50 mg/kg) and PN (20 mg/kg) significantly ameliorated the severity of TNBS-induced colitis and downregulated the levels of circulating proinflammatory cytokines. Compared with RNC group, lipid pseudotargeted metabolomics demonstrated that glycerophospholipids, sphingolipids, carnitine, and glycerolipids were the four most perturbed lipid classes, and amino acids targeted metabolomics demonstrated that serine, N-acetylneuraminic acid, histidine, proline, taurine, and kynurenine changed significantly in DAT group . Correlation analyses showed tight associations between most of differential metabolites and proinflammatory cytokines. RPTS and PN both regulated glycerophospholipid metabolism and sphingolipid metabolism. However, both of them did not have a significant effect on amino acid modulation. RPTS and PN potentially regulated sPLA2, cPLA2, and PEMT.Conclusion These results showed that RPTS (50 mg/kg) and PN (20 mg/kg) effectively alleviated rats’ colitis of damp-heat type, affected cytokines, and altered lipid metabolism without significant modulation on amino acid metabolism.
研究领域:
中医
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药理学
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代谢组学
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炎症
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胃肠病学
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PubMed
高影响因子
ANNALS OF MEDICINE
·
2025
·
IF 4.3
Yun Yang,Lengqiu Guo,Jinghua Yu,Wei Peng,Qi Wang,Lan Wei,Xihua Chen,Chunyan Min,Xiaogang Jiang,Song Zhu,Haixin Zhao,Zhenyu Xuan,Jianzhong Yu,Jian Zhang
Background Da-Yuan-Yin Decoction (DYY), used since the early Qing Dynasty in China for damp-heat syndrome, was evaluated for its comprehensive protective effects.Materials and methods Rats received a high-fat/high-sugar diet for 14 days, then daily exposure to high temperature/humidity (31.0 ± 0.5°C, 85%-95%) for 10 hours over 14 days. Damp-heat syndrome was induced on day 29 via intraperitoneal lipopolysaccharide (LPS) injections (1 mg/kg and 0.5 mg/kg after 4 hours). Two hours post-modeling, rats received DYY (400 or 800 mg/kg/day) orally for 5 days. Symptoms were scored. On day 33, kidney, spleen, tongue, lung, liver, stomach, and colon tissues underwent histopathological and immunochemical/immunofluorescence analysis. Serum levels of inflammation factors, C-reactive protein (CRP), cell-free DNA (cfDNA), myeloperoxidase (MPO), and superoxide dismutase (SOD) were quantified. Complete blood count (CBC), blood biochemistry, short-chain fatty acids (SCFAs), gut microbiota composition in the colon, and metabolites in the cecum were analyzed.Results DYY significantly reduced symptom scores and decreased CRP level, while also regulating parameters in CBC and biochemical profiles. The treatment ameliorated tissue damage in the kidney, spleen, tongue, lung, liver, stomach, and colon. DYY downregulated citrullinated histone H3 (Cit H3), polyclonal peptidylarginine deiminase 4 (PADI4), and MPO expressions in the lung, stomach, and colon. Furthermore, it modulated inflammatory responses, suppressed the interleukin-23 (IL-23)/janus kinase-2 (JAK2)/signal transduction and transcription activator-3 (STAT3) signaling pathway and enhanced antioxidant activity. DYY administration significantly increased total SCFA content. The intervention restored gut microbiota diversity and abundance, while ameliorating metabolic dysregulation.Conclusion Systemic pathophysiological alterations were observed in rats with damp-heat syndrome. The comprehensive protective effects of DYY involved suppression of neutrophil extracellular traps (NETs) formation through downregulation of PADI4 expression, modulation of inflammatory responses, inhibition of the IL-23/JAK2/STAT3 signaling pathway, restoration of intestinal microecological balance and metabolic homeostasis, and enhancement of antioxidant.
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RSC Advances
·
2016
·Vol. 6
·期 18
·15210-15219
·
IF 3.289
Zhi Cheng,Shi Mo,Jing Jia,Ji Feng,Hong Qun Luo,Nian Bing Li
The inhibition effect of 4,6-diamino-2-mercaptopyrimidine (DAMP) as a copper corrosion inhibitor in 3.5 wt% NaCl solution was investigated by weight loss, electrochemical impedance spectroscopy, and potentiodynamic polarization. The inhibition efficiency increased with increasing DAMP concentration in the range of 1.0 to 2.0 mM DAMP and decreased with increasing temperature. The obtained results showed that DAMP inhibited both the anodic and cathodic currents and the maximum inhibition efficiency reached 93.2% at 2.0 mM DAMP. The inhibition performance of DAMP was confirmed by SEM and EDS. Quantum chemical calculations revealed that the DAMP molecule was adsorbed on the copper surface in a paralleled way through S and N atoms and the pyrimidine ring. Adsorption of DAMP was found to obey the Langmuir adsorption isotherm.
研究领域:
腐蚀科学
·
电化学
·
材料科学
·
量子化学
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高影响因子
危险品化学品经营许可证（带存储）