JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Hongyang Lv,Fengyu Tian,Xingxing Cui,Zhenkun Chen,Guangzheng Sun,Yuan Pan,Yichuan Li,Bin Dong,Bin Liu,Yongming Chai,Chenguang Liu
With the trend of heavy and inferior crude oil, the design of hydrodesulfurization (HDS) catalysts with excellent activity and high active metal utilization is an inevitable trend for the upgrading of refining technology. In this study, a highly dispersed Mo catalyst confined within nitrogen-doped porous carbon (xMo@NC) was prepared using an in situ encapsulation-pyrolysis approach and used in the HDS reaction of dibenzothiophene (DBT). The methods of XRD, HRTEM, HAADF-STEM, N 2 physisorption, FT-IR, Raman, and XPS were used to carry out thorough microstructural characterization. The results demonstrated that the Mo species in xMo@NC were highly dispersed, exhibiting superior intrinsic HDS activity compared to MoS 2 /NC* catalysts and conventional supported catalyst MoS 2 /Al 2 O 3 . The xMo@NC catalyst exhibited significant direct desulfurization (DDS) pathway in the HDS reaction of DBT. Differential charge density and bader charge suggested that significant electron transfer between the sulfur atom of DBT and the Mo species of xMo@NC, which weakened the C S bond and made it easier to remove sulfur via DDS pathway during the HDS reaction. This work presents a new catalytic material with high intrinsic activity and enhanced DDS desulfurization selectivity, providing fresh perspectives on the creation of high-performance HDS catalysts.
研究领域:
催化化学
·
化学工程
·
材料科学
·
石油炼制
·
表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2019
·
IF 1.584
Haoran Zhou,Xupeng Fan,Changwei Liu,Chunyan Qu,Zhen Yuan,Jiaqi Jing,Yao Tang,Daoxiang Zhao,Wanbao Xiao,Kai Su
The choice of basic epoxy resin (ER) is especially important for the design of epoxy adhesive formulations. In the present study, performance of several high-temperature ER systems, prepared using 4,4-diaminodiphenylsulfone as the curing agent by the same curing process, was investigated. The curing behavior was studied by dynamic rheometry and differential scanning calorimetry. The thermal properties of the cured resins were investigated by dynamic thermomechanical analysis, thermomechanical analysis, and thermogravimetric analysis. The peeling properties, mechanical behaviors, and moisture absorptivities of the cured resins were also studied. The results showed traditional diglycidyl ether of bisphenol A epoxy to be insufficient in heat resistance. Naphthalene-based ER and bifunctional cardo ER showed higher glass transition temperature values. However, the processability and adhesive properties may not comply with the application requirements. Biphenyl novolac ER has excellent performance in all aspects, which is suitable for use as a high-temperature adhesive.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Materials Today Communications
·
2021
·
IF 3.383
Tingyu Yang,Yangyang Ao,Juanjuan Feng,Cuiyan Wang,Jianbin Zhang
Calcium carbonate (CaCO 3 ) is an ideal candidate for use in drug delivery system (DDS) for cancer cure due to good biocompatibility, pH-sensitivity and low-toxicity. However, developing a method that is fast and green, and have large-scale production of CaCO 3 -based DDS remains a challenge. Here, inspired by biomineralization, for the first time, we develop a one-pot, l -lysine (Lys)-mediated biomineralization method using a CO 2 bubbling procedure to green, simply and quickly prepare CaCO 3 -based DDS. The presence of Lys not only improved the yield of CaCO 3 , but also controled morphology and crystal phase of CaCO 3 . Meanwhile, two different crystal forms of CaCO 3 microspheres were used in the pH-responsive release of cancer drug Sanguinarine (SAN): calcite CaCO 3 (CC) and vaterite CaCO 3 (VC). The structure of the as-prepared CC and VC was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Brunauer-Emmett-Teller analysis (BET). The possible formation mechanism was proposed. As a potential DDS, both different DDS showed good drug-loading capacity (CC: 63.5 %; VC: 51.9 %), good biocompatibility, pH-sensitivity and low-toxicity. Meanwhile, after loading the SAN, it had obvious inhibitory effects to cancer cells. However, they presented significant differences in drug loading rate, loading capacity and pH-sensitivity due to differences in crystal form and morphology. This biomineralization method of green synthesis of CaCO 3 -based DDS using CO 2 provided a possibility for industrial application of DDS, and the comparative study of CaCO 3 with different morphologies and crystal forms gave a good idea for the design of DDS.
研究领域:
材料科学
·
纳米技术
·
药物递送
·
生物矿化
·
癌症治疗
✓ 已验证
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2013
·
IF 2.77
Hua Yan,Chunxiang Lu,Deqi Jing,Xianglin Hou
Chemical decomposition of an epoxy system made of tetraglycidyl 4,4′-diaminodiphenylmethane (TGDDM) and 4,4′-diaminodiphenylsulfone (DDS) in supercritical 1-propanol was investigated under different reaction temperature and time. The GC–MS results suggested that the epoxy system was decomposed to the products including aniline, N-propylbenzenamine, and 4,4′-diaminodiphenylsulfone. The change of the products' yield with time was measured by GC . In addition, the formed chars were characterized by SEM, elemental analysis , Raman and XRD . The results implied the presence of some graphite microcrystals and disordered structure in the solid residue. Upon the addition of KOH, the Guerbet reaction of 1-propanol was promoted to generate more hydrogen. A possible free-radical reaction mechanism was proposed for the depolymerization of TGDDM/DDS epoxy resin . Hydrogenation of radicals had a promotion effect on thermolysis of TGDDM/DDS epoxy resin.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2014
·
IF 4.835
Nana Qian,Zhiming Duan,Yongheng Zhu,Qun Xiang,Jiaqiang Xu
4,4′-Diaminodiphenyl sulfone functionalized SBA-15 (DDS/SBA-15) with various loading amounts of DDS has been prepared via a postsynthesis grafting method. The 2D hexagonal mesoporous structures of these hybrids have been confirmed by small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM), and N2 adsorption–desorption isotherms. The covalent grafting of DDS onto the SBA-15 was further confirmed by Fourier transform infrared spectroscopy (FT-IR). DDS/SBA-15 based quartz crystal microbalance (QCM) sensor shows good selectivity and quick response toward toluene vapor, and the detection limit is down to 20 ppb. Impedance spectroscopy measurements showed that the proton conductivity properties of DDS/SBA-15 depended on the loading amount of DDS. These hybrids demonstrated improved proton conductivities compared with pristine SBA-15, and a highest value of 2.26 × 10–4 S cm–1 has been observed when the DDS loading amount is 0.37 mmol g–1. Therefore, DDS/SBA-15 could serve as a promising candidate for both volatile organic compound (VOC) vapor sensing and proton conducting materials.
研究领域:
材料科学
·
化学传感器
·
能源材料
✓ 已验证
DOI
高影响因子
Materials
·
2020
·Vol. 13
·期 18
·3950
·
IF 3.057
Minmin Chen,Jinxia Hu,Cancan Bian,Chenghao Zhu,Chen Chen,Zhijun Guo,Zhimin Zhang,Godfred Amfo Agyekum,Zhuoqi Zhang,Xichuan Cao
As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca2+and PO43−into the MSNs’ framework. The in vitro doxorubicin hydrochloride (DOX) release was inhibited at neutral pH 7.4 but triggered significantly at pH 5.0 due to the dissociation of ZnO caps. The internalization behavior and cytotoxicity of 4T1 cells indicated MSCNs-ZnO could efficiently deliver DOX into the cells with significant antitumor activity. Such a DDS with pH-responsive biodegradation and controlled drug release has promising potential for cancer therapy.Keywords:mesoporous silica composite nanoparticles (MSCNs);ZnO QDs;pH-responsive biodegradability;pH-responsive drug delivery
研究领域:
纳米技术
·
药物递送
·
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Wen-Xing Zhang,Ze-Lei Zhou,Qi-Yan Lv,Xiejie Song,Junyang Chen,Chang-Bin Niu,Hui-Fang Cui
Cancer starvation/photothermal combined tumor therapy (CST/PTT) has attracted great interest attributed to their mutual compensation and synergistically enhanced effect. However, the very low O2 supply in the tumor microenvironment (TME) greatly limits the CST efficiency of glucose oxidase (GOx). Additionally, the easy degradation in blood circulation and significant off-target effects are big challenges for clinical applications of the GOx-based CST. In this study, a drug delivery system (DDS) with specific tumor-targeted GOx delivery, near-infrared (NIR) light and TME responsive O2 generation, NIR-responsive glucose consumption, high GOx loading, and efficient NIR photothermia was developed. Positively charged AuNRs@MnO2@SiO2 nanoparticles (named AMS+ NPs) were synthesized. GOx was covalently loaded with a high loading ratio of 36.0%. Finally, a thermosensitive biomimetic hybrid membrane composed of a thermosensitive lipid (TSL) membrane, red blood cell membrane (RBCM), and 4T1 cancer cell membrane (CCM) was coated on the NPs through a double-layer strategy. The AMS+-G@TSL@[RBC-CC-TSL]M NPs consumed 32.7 times glucose at 50 °C as that at 37 °C and generated 4.9 times O2 upon NIR laser irradiation. The thermosensitive biomimetic NPs showed an efficient targeting capability to the homotypic 4T1 cancer cells/tumors accompanied by good biocompatibility, macrophage evading capability, high cancer cell cytotoxicity, and excellent antitumor efficacy. The tumor growth inhibition ratio with NIR laser irradiation reached 92.8%. The AMS+-GOx@TSL@[RBC-CC-TSL]M NPs provide a smart, efficient, safe, PTT/CST combined DDS for highly efficient tumor therapy.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Xiaomin Zhi,Yuqian Jiang,Linlin Xie,Yanbo Li,Chen-Jie Fang
Multidrug resistance (MDR) and adverse effects of chemotherapeutic agents are severe issues in clinical cancer treatment. Due to the dysregulation of enzymes in the cancer cells, enzyme-responsive drug delivery systems (DDSs) have been considered as a viable technology for cancer chemotherapy. In the present work, doxorubicin (DOX) is visible after leaving from AuNR–LAX. After treatment with AuNR–LAX, the drug resistance index of DOX-resistant MCF-7/ADR cells was reduced from extremely high 955.0 to 1.7, implying high potential of AuNR–LAX in the MDR phenotype cancer treatment. In addition, the cellular viability of both MCF-7 and MCF-7/ADR cells decreased from 50% to 80% after treatment with AuNR–LAX along (equivalent DOX concentration = 2.3 μg/mL, Au concentration = 30 μg/mL) to below 10% after AuNR–LAX treatment plus radiation of 808 nm, due to the NIR photothermal effect of AuNRs. Human bronchial epithelial cell line 16HBE was chosen to evaluate the adverse effect of AuNR–LAX on the normal cells. At the low concentration, the cytotoxicity of LAX and AuNR–LAX is comparable for breast cancer cell MCF-7 and normal cell 16HBE. It is noted that, at high concentration (with equivalent DOX concentration = 13.1 μg/mL, Au concentration = 167.7 μg/mL), the cellular viability of 16HBE cells is over 50%, whereas that of MCF-7 cancer cells is close to 0, implying the potential of AuNR–LAX in reducing the adverse effects of DOX against normal cells/tissues. Overall, AuNR–LAX showed high potential in overcoming MDR and alleviating adverse effect on normal cells.
研究领域:
纳米技术
·
药学
·
癌症研究
·
生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Yupeng Guan,Chengyuan Xing,Tongyu Tong,Xinyi Zhang,Jun Li,Huikun Chen,Junfeng Zhu,Yang Kang,Jun Pang
Conventional chemotherapy efficacy is impeded by poor water solubility, inferior tissue targeting, and severe systemic toxic effect. Synergistic chemotherapy has become prominent with the stimulus–response drug delivery system (DDS) to treat solid malignancies. The most popularly employed responsive stimulus is reactive oxygen species (ROS), which is proven to primarily sensitize chemotherapy and enhance antitumor impact. In this study, we have successfully developed smart dual responsive nanocarriers with ROS self-amplification, particularly responding to disassemble under the high levels of ROS and esterase in the tumor microenvironment (TME) and to release docetaxel (DTX) efficiently. Additionally, we utilized palmitoyl ascorbate (PA) as a stabilizer by taking advantage of its amphiphilic structure. PA is also an excellent ROS generator that produces a large amount of hydrogen peroxide (H 2 O 2 ) in TME to achieve ROS self-amplification. Also, elevated levels of ROS could continue to activate ROS-sensitive thioketal and make the remaining nanocarriers disassemble for sustaining the release of chemotherapeutics, realizing a positive feedback loop for ROS generation and ROS amplification, as well as sensitizing chemotherapy efficacy. The smart dual responsive nanocarriers may serve as a promising and prospective strategy for treating prostate cancer and promoting synergistic cancer therapy.
研究领域:
纳米技术
·
癌症治疗
·
药学科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yu Qi,Zhihuan Weng,Yan Kou,Lequn Song,Jiahui Li,Jinyan Wang,Shouhai Zhang,Cheng Liu,Xigao Jian
Developing bio-based epoxy resins with high thermal stability and mechanical properties as well as satisfactory intrinsic flame retardancy is of increasing demand, though this has always been limited by the lack of bio-based polyaromatic building blocks. Herein, a simple and universal method was proposed to synthesize an aromatic s-triazine derivative from biomass feedstock, vanillin, and the obtained compound can be employed to construct a bio-based epoxy precursor (THMT-EP). With 4,4′-diaminodiphenyl sulfone (DDS) as curing agent, thanks to the unique structures of aromatic s-triazine, the resulting cured THMT-EP/DDS presented remarkable integrated properties outperforming than commercial petroleum-based bisphenol A epoxy resin (DGEBA), including a record glass transition temperature of 300 °C, as well as a high flexural modulus of 4137 MPa and a flexural strength of 134.2 MPa, which were 120 °C, 53.9% and 14.3% higher than those of DGEBA/DDS, respectively. Furthermore, the cured THMT-EP/DDS also showed excellent intrinsic flame retardancy, passing the V-0 rating in UL-94 test. This study opens an avenue for the synthesis of bio-based feedstocks with rigid aromatic and functional structure, and contributes to the development of bio-based high-performance polymers.
研究领域:
材料科学
·
聚合物化学
·
可持续材料
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Pengli Zhang,Yanfang Zhao,Rentong Yu,Jianhe Liao
Six-arm star polycaprolactone with core of cyclotriphosphazene ( s -PCL) was synthesized via ring-opening polymerization and characterized by NMR and GPC . Epoxy thermosets incorporating 10–40 wt % of this copolymer were cured with 4,4′-methylenebis(2-chloroaniline) (MOCA) and 4,4′-diaminodiphenyl sulfone (DDS), respectively. In these thermosets, intermolecular specific interactions had a significant impact on their morphologies. Specifically, no discernable macroscopic phase separation was found in FESEM images of MOCA-cured epoxy resins . However, for the DDS-cured system, s -PCL was partially miscible with the epoxy thermosets, as evidenced with FTIR and DMA. This is may be owning to enriched concentration of hydroxyl groups in the s -PCL favored the miscibility between PCL subchains of carbonyl and the epoxy matrix. Dispersed phase, further confirmed by XRD to be amorphous , with a diameter of 0.34–0.44 μm could be observed ( s -PCL’ content ≤ 20 wt %) in this system. Nevertheless, crystallization of PCL could not be suppressed completely ( s -PCL’ content > 30 wt %). Besides, epoxy thermosets containing crystalline PCL were found to be more resistant to thermal degradation but sensitive to alkaline degradation (10% NaOH aqueous solution) according to TGA and FESEM results. This work presented here is a meaningful report on the presence of alkaline-labile crosslinking points through the whole networks.
研究领域:
高分子科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Guosheng Li,Yu Ding,Xiaohan Li,Kunhong Li,Xinrui Yin,Liang Zhao,Shenyong Ren,Chunming Xu,Baojian Shen
Regulation of electronic structure of metal active phase for catalysts has been known as efficient in promoting its catalytic activity; however, manipulating the activity of catalysts via controllable metal active phase electronic structure is still challenging. A non-equilibrium electronic structure Fe-based bulk catalyst has been developed via controllably adding P species, where the non-equilibrium electronic structure of Fe species is formed through the electron transfer from the Zn species through the P electronic channel. As a result, the catalytic activity of the modified Fe-based bulk catalysts has increased by 24.4–50.4%. Meanwhile, the sulfurization degree (SD) of the modified Fe-based bulk catalysts has increased by 5.6–25.9%. In addition, the HDS reaction rate constant ( k HDS ) has increased by about 2.0 times, and the DDS reaction rate constant ( k DDS ) has increased by about 2.4 times. The P modifying can regulate the directional transfer of unpaired free electrons between Fe and Zn species to form a more non-equilibrium electronic structure of Fe species, which can reduce the energy barrier of the C–S bond adsorbed on the P-modified Fe-based bulk catalysts. Importantly, the P species can be used as an active site to adsorb S-containing compounds in the modified Fe-based bulk catalysts, which is conducive to generating more coordinatively unsaturated sites (CUSs). The former can promote the formation of the more non-equilibrium electronic structure of Fe species, and the latter can adjust the adsorption active site of S-containing on the catalyst surface. Therefore, an electron transfer channel is formed among Fe, Zn, and P species, and another one is formed among Fe, P, and S-containing compounds, which form a dual-channel electron transfer behavior. Furthermore, the specific surface area, total pore volume, and reducibility of the modified Fe-based bulk catalysts have also shown varying degrees of improvement via the controllable addition of P species.
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）