FOOD CHEMISTRY
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2025
·
IF 9.8
Hao Fang,Huihui Chen,Qian Guo,Sicheng Xiong,Mingjian Yao,Xiangmin Li,Xiaolin Huang,Yonghua Xiong
A bifunctional competitive antigen-enhanced dynamic light scattering (BCA-DLS) immunosensor was developed for the ultrasensitive detection of furosemide in slimming products. The bifunctional competitive antigen (Furo@BSA@GA) was synthesized by co-labeling furosemide and gallic acid with a cis- diol structure on bovine serum albumin (BSA). This innovative BCA-DLS immunosensor employs monoclonal antibody-coated magnetic nanoparticles (MNP@mAbs) as DLS probes to competitively bind the furosemide with bifunctional competitive antigen. Then, the polyvalent phenylboronic acid-labeled bovine serum albumin (PBA@BSA) further triggers the aggregation of the MNP@mAbs and Furo@BSA@GA complex, and the variation in the hydrodynamic diameter of the DLS probe is inversely proportional to the concentration of furosemide. The highly efficient boronate-affinity interaction between PBA@BSA and Furo@BSA@GA significantly reduces the detection time to 25 min and significantly improves the sensitivity of the DLS immunosensor, achieving a detection limit of 196.33 fg mL −1 , which is 1251 times lower than that of traditional enzyme-linked immunosorbent assays.
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DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2022
·
IF 5.195
Zhijia Wang,Wen Li,Jihui Lu,Zhihua Yuan,Wenmin Pi,Yaozhi Zhang,Haimin Lei,Wenguang Jing,Penglong Wang
Ethnopharmacological relevance Glycyrrhiza uralensis Fisch (RC) and Coptis chinensis Franch (RG) are traditional Chinese medicines , which are classic drug pair in prescriptions to treat gastrointestinal diseases . Multi-herb therapy is one of the most important features of traditional Chinese medicine, but due to the complex components of herbal decoctions, the substances that actually exert their medicinal effects have not been fully elucidated. The discovery of Glycyrrhiza uralensis Fisch and Coptis chinensis Franch supramolecular parts (RC-RG SA) can provide a new perspective for explaining the mechanism of drug-pair compatibility. Aim of the study The purpose of this study was to explore the active composition and identification of chemical constituents of RC-RG SA, and to explore the inhibitory effects of supramolecular parts on S. aureus and biofilm. Materials and methods The micromorphology of RC-RG SA was characterized by SEM and DLS . Intermolecular forces between Glycyrrhiza uralensis Fisch and Coptis chinensis Franch determined by ITC. The chemical constituents of RC-RG SA were systematically analyzed by UPLC-ESI-MS n . The inhibitory effect of RC-RG SA on S. aureus was determined by turbidimetric method and plate coating method. The scavenging effect of RC-RG SA supramolecular parts on S. aureus biofilm were observed by MTT method, SEM and LSCM, respectively. Results The microstructure of RC-RG SA was spherical with a particle size of 161.6 nm . ITC proved that the reaction between decoction of RC and RG was exothermic. A total of 70 compounds were preliminarily identified in RC-RG SA, including 34 flavonoids , 34 alkaloids and 2 triterpenoids . The inhibitory effect of RC-RG supramolecular parts on S. aureus proliferation and the ability to clear S. aureus biofilm were better than RC-RG co-decoction and RC-RG non-supramolecular parts. Conclusions The Glycyrrhiza uralensis Fisch and Coptis chinensis Franch co-decoctions’ supramolecular components were an important substance that exerts its medicinal effect. Current study provided supramolecular strategies to reveal the active ingredients and the medicinal effect of the traditional Chinese medicine decoction.
研究领域:
药理学
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民族药理学
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微生物学
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分析化学
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传统医学
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DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2019
·
IF 3.78
Tian Liu,Xingrong Zeng,Xuejun Lai,Hongqiang Li,Yanlin Wang
Organosilicon materials with high capacity of organic-to-inorganic conversion at elevated temperature are always favorable in the field of high-temperature-resistant materials, flame retardant materials, chemical engineering and functional materials in electrical engineering. In this work, it was found out that the platinum-nitrogen catalytic system could obviously enhance the organic-to-inorganic conversion efficiency of silicone rubber (SiR) at elevated temperature. The residual rate of Pt/N/SiR (SiR containing 0.33 phr Karstedt's catalyst (Pt) and 2 phr nitrogenous silane (N)) at 1000 °C was significantly improved from 3.0% to 44.8% in comparison with SiR and its thermal stability was also enhanced. DLS , TEM and UV–vis absorption spectrometry revealed that the platinum in Karstedt's catalyst would aggregate at elevated temperature and deteriorate its catalytic activity for organic-to-inorganic conversion of SiR. And the addition of nitrogenous silane can efficiently inhibit the aggregation and retain the high catalytic efficiency of platinum. A thorough TG-FTIR study, together with SEM/EDX and XPS analyses suggested that the platinum-nitrogen system might suppress the intramolecular cyclic transition and enhance the radical coupling between polymer chains of SiR during thermal degradation , which resulted in the high capacity of organic-to-inorganic conversion of Pt/N/SiR at elevated temperature.
研究领域:
材料科学
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化学工程
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电气工程
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DOI
高影响因子
DYES AND PIGMENTS
·
2016
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IF 4.055
Chenglong Wang,Lili Wang,Yi Huang,Xuying Nan,Qinguo Fan,Jianzhong Shao
A novel reactive organic pigment complex was prepared by 3-(Trimethoxysilyl) propyl methacrylate encapsulated on the surface of the organic pigment. The preparation conditions of the reactive organic pigment complex were optimized and the properties were characterized by FT-IR, DLS and UV–vis. The reactive organic pigment complex was used in blue-light curable pigment inks. The results showed that the photo-polymerization performance of the novel blue light curable pigment ink system was markedly increased in comparison with conventional pigment-based ink systems. The physical shielding effect of pigment particles on photo-polymerization performance can be reduced by increasing the photoinitiator concentration and irradiation intensities. The colorfastness to crocking of printed fabric was remarkably improved. However, the particle size of reactive organic pigment complex was slightly increased.
研究领域:
材料科学
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化学
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纺织工程
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印刷技术
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 9
·2625-2634
·
IF 1.865
Li Ping,Yang Xiaoyi,Guo Chaohua,Wang Guoyong,Zhang Wei
The adsorption and aggregation behavior of three tetrasiloxane surface active room temperature ionic liquids, N -(2-aminoethyl)-3-aminopropyltetrasiloxane carboxylic acid ammonium, [Si(4)N(2)-2CA(n) ( n = 1, 2, 3)], have been studied on the basis of static/dynamic surface tension, conductivity, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The static surface tension of the Si(4)N(2)-2CA(n) aqueous solutions measured at the critical aggregation concentration (CAC) is observed to be significantly lower than that of amide-functionalized ILs and is comparable to those reported for trisiloxane RT-SAILs, N -(2-aminoethyl)-3-aminopropyltrisiloxane carboxylic acid ammonium and 3-aminopropyltrisiloxane carboxylic acid ammonium. The dynamic surface tension results indicate that adsorption process is a mixed diffusion-kinetic adsorption mechanism. DLS and TEM analysis of Si(4)N(2)-2CA(n) solutions reveal that they can self-assemble into vesicles with an average diameter in the range of 70–500 nm.
研究领域:
化学
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材料科学
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胶体与界面化学
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DOI
高影响因子
Scientific Reports
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2017
·Vol. 7
·期 1
·1-12
·
IF 4.259
Wang Hongwei,Li Xiaoxi,Chen Ling,Huang Xiaoyi,Li Lin
This study aims at developing biocompatible starch based gene carriers with good gene delivery and transfection efficacy. By controlling the molecular weight and aggregation behavior of spermine modified cationic starch (CS) molecules, nanocomplexes spontaneously formed through electrostatic interaction using CS and plasmid pAcGFP1-C1 (pDNA) displaying different structural changes (particle size, zeta potential, shape, compactness) response to the simulated intracellular pH variation. Results indicated that CS2 with weight average molecular weight ( Mw ) of 6.337 × 10 4 g/mol displayed relatively higher transfection efficacy (~30%) in HepG2 cells than others and revealed significantly low cytotoxicity. By simulating the intracellular pH variation, Dynamic Light Scattering (DLS) and Small Angle X-ray Scattering (SAXS) results demonstrated that CS2 could bind to pDNA tightly and form nanocomplexes with smaller and compact internal aggregate structure at acidic conditions, which facilitated the effective pDNA protection under endosome pH change, while larger and loose internal aggregate structure at physiological pH which promoted the disintegration of CS2/pDNA nanocomplexes. Therefore, CS with suitable Mw of around 6.0 × 10 4 g/mol represents a potential gene carrier for gene delivery. This study also demonstrated that controlling the internal nanostructure change of polymer/gene nanocomplexes could provide guidance in designing effective starch based gene carriers.
研究领域:
生物技术
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基因治疗
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材料科学
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分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Long Wang,Hanyu Gao,Shimin Song,Weiguang Zhou,Na Xue,Yimiao Nie,Bo Feng
The ions activation of quartz is a thorny problem that deteriorates the flotation of metal ore. Polymer inhibitors have exhibited excellent depression performance in the selective flotation of metal-ion activated minerals. In this study, the inhibitory role of sodium alginate (NaAl) in the flotation of Ca 2+ -activated quartz was thoroughly explored by zeta potential, dynamic light scattering (DLS), Fourier transform infrared (FTIR) analysis, X-ray photoelectron spectroscopy (XPS) analysis and adsorption test. The flotation results suggested that NaAl could inhibit the flotation of Ca 2+ -activated quartz in sodium oleate (NaOl) system to different degrees, depending on the addition sequence of NaOl and NaAl. More significant depression of Ca 2+ -activated quartz could be achieved when NaAl was added prior to NaOl. It was found that prominent mutual interaction existed among Ca 2+ , NaOl and NaAl in the bulk solution, probably forming calcium alginate–calcium oleate crosslink product, which was not affected by the addition sequence of these two reagents. However, the interfacial behaviors of these two reagents on Ca 2+ -activated quartz surfaces differed under different reagent conditions. The addition of NaAl after NaOl could not only partially desorb the pre-adsorbed NaOl from mineral surfaces, but also decrease the mineral surface hydrophobicity by polymer coating, which therefore deteriorated the flotation of Ca 2+ -activated quartz. In contrast, when NaAl was added prior to NaOl, the pre-adsorption of NaAl made the further adsorption of NaOl rather difficult, which was likely attributed to the reticulated structure of NaAl and the associated steric hindrance effect. As a result, the flotation of Ca 2+ -activated quartz was tightly depressed.
研究领域:
矿物加工
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化学工程
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材料科学
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高影响因子
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
·
2015
·Vol. 123
·期 1441
·719-724
·
IF 0.698
Liguo LI,Shengyu FENG,Hongzhi LIU
Multicarboxy (8, 16) functionalized cage silsesquioxanes were synthesized through the photochemical thiol-ene reaction of octavinylsilsesquioxane with 3-mercaptopropionic acid and mercaptosuccinic acid, respectively. These two cage precursors acted as ligands to coordinate with terbium ion (Tb3+) to obtain two novel hybrid luminescent materials, which exhibited fine luminescent properties and good thermal stabilities. Their morphologies were investigated by XRD, SAXS, SEM, TEM and DLS. And the results showed that self-assembly particle size of the hybrid complex with octacarboxyl cage was larger size than that of cage with 16 carboxyl groups.
研究领域:
材料科学
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化学
·
纳米技术
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yunlai Zhang,Yan Zhang,Mengqi Jian,Ying Pei,Jie Liu,Xuejing Zheng,Keyong Tang
In this work, carboxymethylated curdlan (CMCD) was utilized as a capping and stabilizing agent for the green synthesis of silver nanoparticles. Subsequently, quaternized curdlan (QCD) was introduced as the second capping layer through electrostatic attraction, leading to the preparation of double-capped silver nanoparticles (AgNPs@CQ). The successful synthesis of silver nanoparticles was characterized using UV–vis, FTIR, XRD, TEM, and DLS. AgNPs@CQ were incorporated into gelatin and a AgNPs@CQ/Gel composite hydrogel was obtained. The incorporation of AgNPs@CQ imparts excellent antibacterial properties to the composite hydrogel, thereby enhancing its antimicrobial efficacy. The presence of double-capping layers significantly retards the release rate of silver, contributing to prolonged antimicrobial activity. The MTT and live/dead fluorescence staining results demonstrate that the gelatin hydrogel incorporating double-capped AgNPs exhibits enhanced cell viability compared to the one incorporating single-capped AgNPs. Additionally, the composite hydrogel exhibits remarkable mechanical strength and adhesive performance. The AgNPs@CQ/Gel composite hydrogel demonstrates a cost-effective and facile preparation, showing significant potential in the field of dressings.
研究领域:
材料科学
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纳米技术
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生物医学工程
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药学
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DOI
PubMed
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
·
2019
·Vol. 22
·期 3
·411-419
·
IF 1.672
Ruijuan Wang,Dong Wang,Zhigang Yin,Xuzhao Yang,Quan Liu
The carboxylic acid-type Gemini surfactant (CGS12) was synthesized, and its micellization in aqueous solution at different pH values at 25.0 °C was investigated. The results show that the critical micelle concentration (CMC) of CGS12 at different pH values is only 10 −6 order of magnitude, and the pH has little effect on the CMC. Moreover, the interaction of CGS12 with amino acid surfactant of sodium N-lauroyl sarcosinate (SLS) at 25.0 °C and pH 7.0 was investigated using surface tension, dynamic light scattering (DLS), cryogenic transmission electron microscopy (Cryo-TEM), and Ross–Miles foam measurements. The CGS12/SLS mixture shows a low CMC, and as a whole the CMC value becomes smaller with increasing molar fraction of CGS12 (X CGS12 ). Under different X CGS12 , the mixtures form soluble aggregates with different hydration radii ( R h ). Moreover, the mixture aggregates are mainly in the form of vesicles. The foaming height of CGS12 is worse than that of SLS, but the CGS12/SLS mixture has good foaming stability. This work reveals that the surfactant mixture has good surface activity and good foam stability.
研究领域:
表面活性剂化学
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胶体科学
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物理化学
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DOI
高影响因子
ANALYTICAL SCIENCES
·
2024
·
IF 1.8
Liu Zhili,Yan Yumei,Li Jing,Zhou Wenfeng,Gao Haixiang,Lu Runhua
Heavy metal pollution has always been a great threat to human health and safety. Compared with other heavy metals, although zirconium ion (Zr(IV)) is equally harmful, due to the lack of research on Zr(IV) in the biological systems and environment, its detection does not seem to have received the attention it deserves. Herein, a rapid visual dual-mode detection (colorimetric and chrominance method) of Zr(IV) based on l -histidine functionalized gold nanoparticles (HIS-AuNPs) has been reported. AuNPs and HIS-AuNPs before and after adding Zr(IV) were characterized by UV–Vis, TEM, DLS, Zeta potential, EDS and FT-IR, etc. These results showed that l -histidine was successfully modified on the surface of AuNPs by forming a stable Au–N bond, and its modification had little effect on the dispersion degree of AuNPs. After the addition of Zr(IV), interaction of this metal ion with the imidazolyl group on l -histidine can obviously cause the aggregation of HIS-AuNPs within 12 min, and the dispersion state and particle size of HIS-AuNPs can be significantly changed. These two detection modes were established by means of absorbance and color change of solution, and being used in addition and recovery experiments of Zr(IV) in natural water. Under the optimal conditions, these two modes exhibited good linearity within 15–70 and 20–100 μmol L −1 , and limit of detection of 2.62 and 6.25 μmol L −1 . The proposed method was highly sensitive and selective, which provided a new convenient way to realize the detection of Zr(IV). Graphical abstract
研究领域:
环境科学
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分析化学
·
纳米技术
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DOI
PubMed
高影响因子
POLYMER
·
2011
·
IF 3.829
Qianling Cui,Feipeng Wu,Erjian Wang
A novel oxazolidine based acid-labile monomer N -acryloyl-2,2-dimethyl-1,3-oxazolidine (ADMO) was synthesized and polymerized by reversible addition fragmentation chain transfer (RAFT) polymerization using poly(ethylene glycol) based chain transfer agent (PEG-CTA). The diblock copolymers PEG- b -PADMO were composed of hydrophilic PEG with fixed length and hydrophobic PADMO with different lengths, which formed core-shell micelles in water. Morphologies and sizes of micelles were obtained by transmission electron microscopy (TEM) and dynamic light scattering (DLS), which showed that the shapes of polymeric aggregates developed from small spherical micelles, worm-like micelles to larger size of vesicles, as the length of PADMO increased. The hydrolysis kinetics of the micelles was studied using 1 H NMR, DLS and release of loaded Nile Red dye, whose rate strongly depended on pH and micellar structure . It led to the disruption of polymeric micelles and concomitant release of the guest molecules, due to the transformation of hydrophobic PADMO into hydrophilic poly(2-hydroxyethyl acrylamide) (PHEAM).
研究领域:
聚合物化学
·
材料科学
·
纳米技术
·
胶体科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）