ANALYST
·
2020
·Vol. 145
·期 15
·5307-5313
·
IF 3.978
Huan Lin,Xin Cheng,Ming-Jie Yin,Zhouzhou Bao,Xunbin Wei,Bobo Gu
With the rapid growth of anti-terrorist activities worldwide, it becomes an emerging requirement to rapidly and accurately detect hidden explosive threats. However, the safety issue during the explosive material detection, e.g. unexpected explosion, is still an insurmountable challenge. In this study, we design and mass-produce a novel kind of flexible 5,10,15,20-tetrakis(4-aminophenyl)porphyrin doped polymer optical fiber (PPOF) for rapid and accurate detection of trace 2,4-dinitrotoluene (DNT) vapor based on the DNT induced florescence quenching mechanism. The influence of doping concentration, bending, and temperature on the sensing performance is investigated. PPOF shows immunity to bending, enabling it to work in a harsh environment. It is experimentally demonstrated that the limit of detection and response time of the proposed PPOF could reach around 120 ppb and 3 minutes, respectively, which make it much better than other techniques. Owning to its inherent advantages including low-cost, remote-control capability, and compatibility with optical communication networking, PPOF can be constructed the quasi-distributed sensing networking of explosive matters in the future, providing a new strategy for anti-terrorism.
研究领域:
材料科学
·
光学工程
·
化学传感
·
安全技术
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xiao-Shuang Ma,Dong-Hao Wang,Yue-Zhi Cui,Fu-Rong Tao,Yong-Tao Wang,Tian-Duo Li
A novel hydrophilic polymer based on hydroxyl group grafted onto the side chain of polymer was successfully synthesized. Due to the hydrophilic of hydroxyl groups, the hydrophilic polymer overcame the drawback of fluorescent conjugated polymer insoluble in water. Polymer chains evenly distributed in aqueous solution and possessed the signal amplification effect in the aqueous phase. The hydroxyl groups in polymer could effectively absorb nitroaromatics (NACs) by hydrogen bonding interaction between NACs and hydroxyl groups. When the TNT and DNT concentration was 1.08 × 10 −4 mol/L and 1.44 × 10 −4 mol/L respectively, the quenching efficiency ( η EP ) of polymer reached 93% and 91%. The limit of detection of the polymer to DNT and TNT solution are 7.4 × 10 −7 mol/L and 1.1 × 10 −6 mol/L, respectively. Fluorescence quenching studies demonstrated that the hydrophilic polymer was highly sensitive towards NACs. Moreover, the excellent property of selectivity indicated the hydrophilic polymer might be a promising sensor in the monitoring field of the underwater hidden explosives and water environmental quality.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
PLANT CELL AND ENVIRONMENT
·
2021
·Vol. 44
·期 9
·3173-3183
·
IF 7.228
Kunlong Su,Zhenying Wu,Yuchen Liu,Shanshan Jiang,Dongmei Ma,Yan Wang,Chunxiang Fu
Dinitrotoluene (DNT) has been extensively used in manufacturing munitions, polyurethane foams and other important chemical products. However, it is highly toxic and mutagenic to most organisms. Here, we synthesized a codon-optimized bacterial nitroreductase gene, NfsI, for plant expression. The kinetic analysis indicates that the recombinant NfsI can detoxify both 2,4-DNT and its sulfonate (DNTS), while it has a 97.6-fold higher catalytic efficiency for 2,4-DNT than DNTS. Furthermore, we overexpressed NfsI in switchgrass ( Panicum virgatum L.), which is a multiple-purpose crop used for fodder and biofuel production as well as phytoremediation. The 2,4-DNT treatment inhibited root elongation of wild-type switchgrass plants and promoted reactive oxygen species (ROS) accumulation in roots. In contrast, overexpression of NfsI in switchgrass significantly alleviated 2,4-DNT-induced root growth inhibition and ROS overproduction. Thus, the NfsI overexpressing transgenic switchgrass plant removed 94.1% 2,4-DNT after 6 days, whose efficiency was 1.7-fold higher than control plants. Moreover, the comparative transcriptome analysis suggests that 22.9% of differentially expressed genes induced by 2,4-DNT may participate in NfsI-mediated 2,4-DNT detoxification in switchgrass. Our work sheds light on the function of NfsI during DNT phytoremediation for the first time, revealing the application potential of switchgrass plants engineered with NfsI .
研究领域:
植物学
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环境科学
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遗传工程
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DOI
高影响因子
ANALYTICAL SCIENCES
·
2022
·Vol. 39
·期 1
·115-121
·
IF 1.967
Zhu Yongbing,Li Boyan,Huang Wei,He Yi,Liu Xiaodong
The Janowski reaction is a critical reaction for visual colorimetric detection of nitro-aromatic explosives. However, the solvent effect is still not well explored. Herein, we report the solvent-dependent activity of the Janowski reaction between 2,4-dinitrotoluene (DNT)/2,4,6-trinitrotoluene (TNT) and NaOH. Four common solvents are studied. It is found that acetone with high donor number and low polarity is able to readily dissolve the product of Janowski reaction (Meisenheimer complexes) via Lewis acid–base interactions and solvation rules, facilitating the Janowski reactions between DNT/TNT and NaOH. Based on the color change of the Janowski reactions within acetone, a visual colorimetric assay is established. The present assay can detect DNT and TNT with a detection limit of 1.4 μM and 1.2 μM, which allows for naked-eye detection. In addition, this assay is highly selective and applicable to DNT/TNT detection in soil samples. Our work reveals the solvent effect on the Janowski reaction, providing a simple and rapid method for detection of nitro-aromatic explosives. Graphical abstract
研究领域:
化学
·
分析化学
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环境科学
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DOI
PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2024
·Vol. 149
·期 24
·14715-14725
·
IF 3
Chen Peng,Chen Liping,Zhou Juan,Wu Wenqian,Guo Zichao,Chen Wanghua
Thermal analysis and calorimetry techniques with sealed sample cells are frequently employed to investigate the thermal stability of hazardous materials. However, the influence of sample mass on thermal decomposition is often ignored. To investigate the effect of sample mass on autocatalytic decomposition substances under sealed condition, 2,4-DNT was chosen for test and analysis. The techniques including differential scanning calorimetry (DSC), rapid screening calorimetry(RSC), high-performance liquid chromatography-mass spectrometry (HPLC–MS), and gas chromatography-mass spectrometry (GC–MS) were utilized for in-depth research on the decomposition of 2,4-DNT. The results revealed that an increase in sample mass led to an significant elevation in gaseous products such as CO 2 and CO with a negative heat of formation (ΔH f ). Then the system pressure and decomposition heat of 2,4-DNT increase significantly, thereby enhancing the thermal decomposition process. After that, it has been determined that o–nitrotoluene, m–nitroaniline, and o–nitrobenzoic acid can catalyze the decomposition of 2,4-DNT. Finally, it is advisable to increase the sample mass as much as possible when testing and analyzing such nitro compounds which would help ensure that the predicted results are closer to the actual conditions of production, transport, storage.
研究领域:
化学工程
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材料科学
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安全科学
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DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 37
·e04026
·
IF 2
Hongwei Li,Zhibin Liu,Pengju Lei,Jichong Xia,Shoudeng Wang,Guixian Li,Xinhong Zhao,Dong ji
A PEG-400-assisted impregnation-precipitation method synthesized 50 wt% Ni/AC catalysts for dinitrotoluene (DNT) hydrogenation. Optimal PEG-400 dosage (0.4 g) suppressed Ni agglomeration via steric hindrance, yielding uniform 10.9-nm Ni nanoparticles and mesopores (12.24 nm). This enhanced dispersion and mass transfer, achieving complete DNT conversion in 5 min under mild conditions (120 °C, 2.1 MPa H 2 ) with 99.99% TDA selectivity and zero tar. The catalyst retained > 95.5% conversion and > 97.3% selectivity over 10 cycles, demonstrating exceptional stability. PEG's dual role in structural control and pore engineering effectively addresses the dispersion challenges inherent to high-loading catalysts. Graphical PEG-400 directs the synthesis of a 50 wt% Ni/AC catalyst via impregnation-precipitation. Optimal PEG dosage (0.4 g) enables steric hindrance control, yielding uniform 10.9-nm Ni nanoparticles and mesopores. This catalyst achieves complete DNT hydrogenation to TDA in 5 min (120 °C; 2.1 MPa H 2 ) with > 99.99% selectivity and zero tar, retaining high performance over 10 cycles.
研究领域:
催化化学
·
材料化学
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化学工程
·
纳米催化
·
有机合成
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Dong-Hao Wang,Yue-Zhi Cui,Fu-Rong Tao,Qing-Fen Niu,Tian-Duo Li,He Xu
A novel sensing material (Gel-P) based on conjugated carbazole polymer grafted onto gelatin was successfully synthesized by spin-coating way. The grafting reaction between gelatin and Polymer P was confirmed by ATR-FTIR spectra of Polymer P and the content of residual amino group in gelatin solution. After UV irradiation for 30 min, the fluorescence intensity of Gel-P only reduced by 7.6%, while the polystyrene film doped with polymer P (Ps + P) decreased by 32.4%, indicating higher capability in inhibiting photobleaching for Gel-P due to the presence of tryptophan in gelatin and the fixation effect of gelatin molecules to polymer chains via hydrogen bonds between amino and hydroxyl . Exposed to saturated DNT vapor, the Gel-P sensor exhibited a high quenching efficiency ( Q f ) of 60% after 50 s and the fluorescence of P in Gel-P film was completely quenched for 300 s owing to the plenty of NH 2 and OH groups in gelatin, which could effectively absorb nitroaromatics (NACs) by hydrogen bonding interaction between NACs and gelatin. After being exposed to saturated DNT vapor for 300 s, the Gel-P sensor showed good reversibility of quenching process .
研究领域:
材料科学
·
化学传感
·
聚合物化学
·
环境监测
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产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2012
·Vol. 72
·期 3
·206-211
·
IF 2.479
HongFei Leng,WenHui Wu
A novel fluorene-based conjugated polymer with phenylene spacers and steric bulky adamantane moieties in side chains has been synthesized by palladium-catalyzed Suzuki coupling reactions. This design strategy offers several advantages for the detection of trace 2,4-dinitrotoluene (DNT) vapor. The incorporation of the two groups into polymer side chains could retain an effective conjugation length and prevent the π -stacking of polymer chains. The detection of DNT vapor indicated that the polymer displayed higher fluorescence quenching sensitivity toward the explosives in films compared to reference polymers. The fluorescence quenching efficiency of the fluorescent polymer achieved 33.3% in 10 s and 71.1% in 60 s. The pathways or cavities generated by the two spacers are beneficial for the rapid diffusion of explosive vapor into the film interiors and increase the fluorescence quenching efficiency of the film.
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DOI
高影响因子
Science China-Life Sciences
·
2024
·
IF 8
Zheng Cheng,Song Lanlan,Yu Chang,Zhu Lingye,Zhang Jing,Wang Ning,Liu Mengchu,Li Shini,Wang Liangxing,Shen Zhifa,Huang Xiaoying
Chemotherapy is regarded as a widely used and effective treatment strategy for lung cancer, although most conventional chemotherapeutics cause severe toxic side-effects due to their indiscriminate attacks on both cancerous and normal cells. Although nucleic acid nanomaterials are emerging as a promising drug delivery strategy, their clinical applications are limited by rapid degradation by nucleases and difficulties in targeting cancer cells. In this study, we have developed a Rhein-loaded aptamer-based DNA nanotube (DNT-S6@Rhein) for the targeted and efficient therapy of non-small cell lung cancer. Through the palindrome segments, two specified oligonucleotides were hybridized and folded into the well-defined nanotubes (DNT-S6), with the S6 aptamer distributed outside. The obtained nanotubes exhibited excellent serum stability and targeting ability towards A549 cells due to the firm structure and decoration of the S6 aptamer. Rhein, as an antitumor drug and DNA intercalator, can be effectively inserted into the DNT-S6. The drug-loaded nanotubes rapidly disassembled in intracellular environment and then the released Rhein was found to activate cellular apoptotic process and significantly suppress proliferation, migration and invasion of A549 cells. Moreover, DNT-S6@Rhein could efficiently accumulate in tumor regions, offering compelling therapeutic efficacy and biocompatibility under both in vitro and in vivo settings. These findings of this study provide a promising strategy for mitigating the inevitable systemic side-effects of chemotherapy and expand the potential application of DNA nanostructure on targeted drug delivery.
研究领域:
癌症研究
·
纳米技术
·
药物递送系统
·
分子生物学
·
肿瘤学
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DOI
PubMed
高影响因子
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