JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Jin Zhang,Pei Lei,Huan Zhong,Nan Zou,Martin Tsz-Ki Tsui,Carl P.J. Mitchell,Chengjun Li,Weiping Cai,Han Meng,Huan He,Fei Dang
The methylation of mercury-containing nanoparticles (Hg-NPs) into neurotoxic methylmercury (MeHg) poses threats to wildlife and humans. However, how autochthonous dissolved organic matter (DOM) affects the occurrence and MeHg production of Hg-NPs remains poorly understood. In this study, the distribution of Hg-NPs and their interactions with autochthonous DOM in the Nanfei River, an urban river in eastern China, were systematically explored. Field investigations revealed that mass concentrations of Hg-NPs increased along the flow path, rising from 0.10 ± 0.06 to 0.91 ± 0.21 ng·L -1 , and were positively correlated with MeHg levels ( p < 0.001), indicating that Hg-NPs (predominantly < 60 nm in diameter) are bioavailable substrates for Hg methylation in the river. The spatial distribution of Hg-NPs was primarily driven by the increasing level and changing composition of DOM along the river, particularly by fractions with a higher degree of humification and higher molecular weight. Laboratory experiments showed that algae-derived DOM, which has a higher content of aromatic protein, was more effective in promoting Hg-NP formation and maintaining their net MeHg production than other DOM sources. These findings highlight the critical role of autochthonous DOM, particularly algae-derived DOM, in regulating the occurrence and methylation of Hg-NPs, providing new insights into MeHg risk prediction under algal blooms.
研究领域:
环境科学
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生态学
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毒理学
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PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2023
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IF 9.8
Roujia Du,Qianxin Zhang,Frank Leresche,Mengmeng Zhong,Ping Chen,Jun Huang,Shubo Deng,Fernando L. Rosario-Ortiz,Gang Yu
To determine and predict the reaction rate between 3 DOM* and PPCPs in various water bodies, this study defines a reaction rate coefficient ( α 3 DOM ∗ ) to describe the reaction between 3 DOM* and PPCPs. As the values also included the inhibition effect of DOM's antioxidant moieties, the calculation of α 3 DOM ∗ is inconsistent with that of a bimolecular rate constant via the steady-state kinetic method. The α 3 DOM ∗ values of 12 selected PPCPs were determined in two DOM solutions and ten DOM-containing water samples collected from typical surface water bodies in Beijing. The Pearson coefficients between nine predictors including the absorbance ratio (E2/E3), specific absorption coefficient at 254 nm (SUVA 254 ), fluorescence index (FI), biological index (BIX), humification index (HIX), pH, total organic carbon (TOC), total fluorescence intensity (TFI) and TOC normalized TFI (TFI/TOC) and α 3 DOM ∗ were examined. Correlation patterns for sulfonamides, β-blockers and diclofenac supported the electron transfer pathway, and was distinctly different from those appeared for FQs where quenching effect played a main part. TFI and TFI/TOC were recognized as the most useful surrogates in empirically predicting α 3 DOM ∗ . For PPCPs that went through the electron transfer pathway, α 3 DOM ∗ could be well fit to the Rehm-Weller model assuming a proportional relationship between TFI and △G et . For FQs, α 3 DOM ∗ was found to linearly correlated with TFI/TOC. The α 3 DOM ∗ values determined in this study enrich the database of PPCPs photolysis parameters, and the correlation analysis provides reference for forecasting PPCPs fate in the aquatic environment.
研究领域:
环境科学
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水处理工程
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DOI
PubMed
高影响因子
WATER RESEARCH
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2025
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IF 12.4
Yuanna Zhang,Wenjun Sun,Wenxuan Yin
The widespread application of UV/H 2 O 2 is limited by the empirical operational practices, which can lead to excessive energy, chemical input and the generation of uncontrollable by-products. This study presents a precise regulation approach based on the characteristics of free radical generation/reaction and the chemical transformation of organics, assessed through a pilot experiment. The findings indicated that increasing H 2 O 2 dosage was more effective than increasing UV dose in enhancing •OH generation and pollutant removal. As the H 2 O 2 dosage and UV dose increased, the relative influence of water quality on pollutant removal gradually diminished. Dissolved organic matter (DOM) in the water quality background accounted for the largest proportion of •OH scavenging (76.4 %) and the most complex component. Moreover, changes in operating conditions were accompanied by the uncontrollable production of low-molecular-weight (LMW) DOM. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) revealed the chemical transformation of LMW DOM at the molecular level. Higher H₂O₂ dosages triggered more extensive oxidative degradation, resulting in more complex effluent compositions. Considering treatment efficiency, energy consumption, and effluent product composition, H₂O₂ dosages of 5–10 mg/L and UV doses of 350–450 mJ/cm² were identified as optimal. This research contributes to the efficient purification of organic micropollutants in water using UV/H 2 O 2 technology with low energy consumption, minimal chemical input, and relatively controllable by-products.
研究领域:
环境科学
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水处理技术
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化学工程
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2022
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IF 7.968
Min-Hui Cai,Ye-Chao Tian,Ai-Min Li,Yan Li,Yu-Ze Han,Jun Li,Hong-Fang Sun,Xin Wang,Qing Zhou,Wen-Tao Li
Semi-coking wastewater treatment has become a difficult issue because of its complexity, heterogeneity and toxicity. In this study, co-metabolism with ethanol or sodium acetate as co-substrates was applied to improve the biological degradation of refractory dissolved organic matter (DOM) in semi-coking wastewater. Kinetic model simulation results indicated that both co-substrates addition improved COD removal efficiency and biodegradation rate. Excitation-emission matrix (EEM) spectroscopy and size exclusion chromatography with organic carbon detector (SEC-OCD) analysis were applied to evaluate the DOM biodegradation in terms of fluorescence and molecular weight (MW). Although co-substrates resulted in a comparable enhanced removal efficiency of protein-like and humic-like fluorophores, there are distinct differences in their specific protein-like fluorescent peaks (Peak C1&C2). Ethanol addition was more conducive to the removal of humic substance with apparent molecular weight (AMW) ranging from 1.1 kDa to 20 kDa. Acetate addition resulted in higher removal of building blocks of humic substances (BB, AMW 0.45–1.1 kDa) and proteinaceous biopolymers (BP, AMW >20 kDa). Co-metabolism triggered the shift of microbial community structure and metabolic functions. Using co-occurrence network analysis, nine keystone genera were identified, which maintained the functional stability of bacterial community responding to organic toxicants stress. LefSe analysis elucidated that the potential major genera involved in refractory organics biodegradation with acetate addition were Stenotrophomonas (40.3%) and Pseudomonas (21.2%), while Pseudoxanthomonas (10.4%) with ethanol addition. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt2) analysis showed that benzoate, styrene , xylene and naphthalene degradation pathway were enhanced by acetate addition as compared to ethanol.
研究领域:
环境工程
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微生物学
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水处理
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生物技术
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DOI
高影响因子
CHEMOSPHERE
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2022
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IF 8.943
Xuelian Xia,Yanguo Teng,Yuanzheng Zhai,Fuxin Zheng,Xinyi Cao
The groundwater in many aquifers contains elevated concentrations of iron (Fe). Although much of this Fe is from its release from water-bearing sediments under natural environmental conditions, sufficient evidence is lacking to clarify whether anthropogenic pollutants, such as dissolved organic matter (DOM), can increase this natural release. In this time series and comparative analysis study, an Fe increasing effect was verified through laboratory leaching tests. The influences of the aqueous environmental conditions, such as pH, were also investigated. DOM can promote the release of Fe from sediments and increase the concentration of Fe in groundwater. In addition, lower or higher pH and temperature can enhance the release of Fe to some extent. Higher concentrations of DOM provided a more thorough release of Fe from the sediment; additional ions such as Cu also affected Fe release. It is possible that complexation between DOM and Fe occurs through ligand dissolution and reduction, thus promoting the release of Fe. The findings indicate that DOM imported through anthropogenic activities can increase the release of Fe from aquifer sediments into groundwater, thus worsening Fe pollution in groundwater. This study explored the mechanism by which different types of DOM release Fe from aquifer sediments and investigated the factors that influence this process. The findings provide insights into the geochemical processes of Fe in the groundwater.
研究领域:
环境科学
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地球化学
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水文地质学
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Zhaoyu Bai,Shanshan Gao,Xiwen Liu,Rui Huang,Jiayu Tian
Membrane fouling and low removal of dissolved organic matter (DOM) are the main obstacles for the wide application of ultrafiltration membrane technology in water treatment. Herein, we reported the preparation and application of a novel ceramic membrane, which embedded the cobalt oxide in the membrane support layer, and simultaneously loaded the CoAl composite bimetallic oxide on membrane surface layer. The double catalytic layer membrane (CoAl@AM-Co) enabled more efficient DOM removal and membrane fouling mitigation via in situ peroxymonosulfate (PMS) activation during filtration of actual raw water. Compared to the ceramic membrane with only single catalytic layer, the CoAl@AM-Co/PMS system could achieve much higher normalized membrane flux (0.79 vs. 0.63 and 0.49) and TOC removal (87.47 % vs. 58.35 % and 47.16 %); meanwhile, the molecular weight of DOM in the permeate water would also be significantly decreased. The FT-ICR MS results indicated that the total amount of DOM molecules of the permeate was reduced; the DOM with high H/C wa and low O/C wa value could be more easily removed, accompanied with the production of DOM with higher oxidation and unsaturation degree. Singlet oxygen and surface-bound radicals were proved to play a critical role in mitigating the membrane fouling by DOM. The design of ceramic membrane equipped with double catalytic layer and its application in advanced water purification were systematically elucidated for the first time in this work, which provided a new pathway for efficient treatment of surface water containing DOM.
研究领域:
环境科学
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水处理
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膜技术
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催化
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Cholnam Ri,Munchol Kim,Hyokchol Mun,Linan Liu,Jingchun Tang
Dissolved organic matter (DOM), which is ubiquitously distributed in groundwater, has a crucial role in the fate and reactivity of iron materials. However, there is a lack of direct evidence on how different DOMs interact with nFe/Ni in promoting or inhibiting the dechlorination efficiency of chlorinated aromatic contaminants. By comparing humic acid (HA), fulvic acid (FA), and biochar-derived dissolved organic matter (BDOM) at different pyrolysis temperatures, we first demonstrated that the dechlorination effect of nFe/Ni on 2,4-dichlorophenol (2,4-DCP) depended on the nature of DOMs and their adsorption on nFe/Ni. HA showed an enhancing effect on the dechlorination of 2,4-DCP by nFe/Ni, while the inhibition effect of other DOMs resulted in the following dechlorination order: BDOM300 ≈FA>BDOM700 ≈BDOM500. The C2 component with higher aromaticity and molecular weight promoted the corrosion of nFe/Ni and the production of reactive hydrogen atoms (H*). The effects of different DOMs on nFe/Ni include that (1) HA accelerates the corrosion and H* production of nFe/Ni, (2) FA and BDOM300 enhance the corrosion but inhibit H* production, and (3) Both nFe/Ni corrosion and H* formation are suppressed by BDOM500/BDOM700. Therefore, this study will provide a reference for understanding the nature of DOM-nFe/Ni interaction and improving the catalytic activity of nFe/Ni when different DOMs coexist in practical applications.
研究领域:
环境科学
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化学工程
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水处理
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Na Wang,Rixing Zhu,Xiaodong Pei,Yiyang Lan,Xudong Zhong,Huifang Xie,Yanfang Feng,Lisha Wang,Ni Ni,Minli Wang,Bingyu Wang
The type of biochar-derived dissolved organic matter (DOM) determines photochemical pathways and differentially controls pollutant photolysis. However, comparative data on the photo-reactivity of pyrochar-derived DOM (DBC) vs. hydrochar-derived DOM (DHC) are lacking. Closing this gap is essential for predicting the photochemical impacts of contrasting biochars in field applications. In this study, we employed complementary techniques to investigate the photophysical properties of DBC and DHC, their roles in the photoproduction of reactive species, and their impact on tetracycline (TC) photolysis. DBC from pyrolysis exhibited a lower E 2 / E 3 ratio and higher SUVA 254 and SUVA 280 values, indicating more aromatic structures with larger clusters. This was supported by molecular evidence of abundant condensed aromatic compounds with narrow molecular weight ranges, which boosted the production of 3 DOM* and 1 O 2 in DBC. In contrast, DHC from hydrothermal carbonization contained more lignin-like compounds, such as phenolics, which partially suppressed reactive species generation. DBC significantly accelerated TC photolysis by producing high-energy 3 DOM* and 1 O 2 that drive reductive demethylation, deamination, and ring-cleavage of TC. Conversely, the phenolic moieties in DHC quenched excited-state TC and reactive species. DBC exhibits enhanced photoreactivity in promoting TC photolysis, with its photodegradation rate influenced by water quality, yet the extent of photolysis remains unaffected. Our findings clarify the molecular-level photochemical differences between DBC and DHC and their relevance to aquatic contaminant photolysis.
研究领域:
环境化学
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光化学
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水环境研究
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环境科学
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污染物降解
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DOI
PubMed
高影响因子
DIABETES OBESITY & METABOLISM
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2026
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IF 6.1
Xingyu Yang,Linglong Zhang,Xiao Li,Yue Wu,Ziwei Yu,Xinyue Jing,Tiancheng Xu,Zhi Yu,Bin Xu,Li An,Mengjiang Lu
Aim Obesity impairs the colonic mucus layer and disrupts intestinal barrier function, leading to chronic inflammation. This study explores whether electroacupuncture can restore intestinal barrier integrity and alleviate chronic intestinal inflammation by promoting goblet cell mucus secretion via the TRPV1–CGRP–RAMP1 axis. It also examines the underlying mechanisms of sensory neuron. Epithelial cell crosstalk in this process, with the goal of providing a new interventional strategy for treating obesity-related intestinal barrier damage and metabolic inflammation. Materials and Methods In a high-fat diet (HFD)-induced obesity model using C57BL/6J mice, we employed tissue-clearing techniques to examine the expression of TRPV1 and CGRP in intact colon tissue. The expression of RAMP1 in goblet cells was assessed by immunohistochemistry. Colon pathology was evaluated using immunofluorescence, haematoxylin and eosin (H&E) staining, and Alcian blue-periodic acid-Schiff (AB-PAS) staining. Furthermore, western blot analysis was performed to measure the expression levels of tight junction proteins and proinflammatory cytokines in the colon tissue. Results HFD feeding resulted in increased intestinal permeability and aggravation of intestinal inflammation. Notably, electroacupuncture intervention reversed HFD-induced intestinal pathologies. Through targeted ablation of TRPV1 and administration of the RAMP1 antagonist BIBN4096, we further established the essential roles of TRPV1 signalling and the CGRP receptor RAMP1 in maintaining mucus layer thickness and intestinal homeostasis. Under these conditions, the therapeutic efficacy of electroacupuncture was abolished. Conclusions We demonstrated that electroacupuncture may promote mucus secretion from goblet cells via the TRPV1-CGRP-RAMP1 axis, thereby suppressing intestinal inflammation. This provides a feasible interventional strategy for treating obesity-related intestinal barrier damage.
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PubMed
高影响因子
DIABETES OBESITY & METABOLISM
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2026
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IF 6.1
Yunxiao Zhang,Bo Zhu,Binhui Peng,Peng Wu,Guyu Zhong,Yongchen Wang,Zhaofeng Wang,Xinyu Feng,Dongfang Tang,Dezheng Peng,Yu Liu
Background The GLP-1 receptor (GLP-1R) and GIP receptor (GIPR) are key targets for diabetes and obesity therapies. Pharmacological agents including GLP-1R agonists (e.g., Semaglutide), dual GLP-1R/GIPR agonists (e.g., Tirzepatide) and a GLP-1R agonist/GIPR antagonist (AMG133) have demonstrated considerable promise in anti-diabetic and weight management applications. However, a systematic comparison of the specific contributions of GIPR activation versus GIPR inhibition to weight loss within the context of GLP-1/GIP dual-targeting therapies remains unexplored. Research Design and Methods To address this, we designed three IgG4 Fc-fusion proteins: a GLP-1R agonist/GIPR agonist, (i) GLP-1(A8G)/GIP(A2G)-Fc; a GLP-1R agonist/GIPR inhibitor, (ii) GLP-1(A8G)/GIP(3–30)-Fc; and a sequential molecule that hypothesised to transition from dual GLP-1R/GIPR agonism to GLP-1R agonism/GIPR inhibition, (iii) GLP-1(A8G)/GIP(1–30)-Fc. Mono-agonist GLP-1(A8G)-Fc and dual-agonist GLP-1(A8G)/GIP(A2G)-Fc were used as controls to investigate the weight loss effects of GIPR activation and inhibition in DIO mice. Results Our findings revealed that the sequential molecule GLP-1(A8G)/GIP(1–30)-Fc produced the greatest body weight reduction (21.59%), significantly outperforming GLP-1(A8G)/GIP(3–30)-Fc (14.5%; p < 0.001). Furthermore, both GIPR activation and inhibition, when combined with GLP-1R agonism, markedly improved serum and hepatic lipid metabolism, as evidenced by reduced triglycerides and total cholesterol. Conclusion Together, these findings validate a peptide-based inhibitory strategy for synergistic weight loss and provide insights into the differential metabolic roles of GIPR activation versus inhibition, guiding the development of novel anti-obesity therapeutics.
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PubMed
高影响因子
DIABETES OBESITY & METABOLISM
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2024
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IF 5.4
Ting Zheng,Ruhao Yang,Xin Li,Zhe Dai,Hongyu Xiang
Background Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease (ESRD), but its mechanism has not been clearly studied. We utilized integrative transcriptome analysis to explore the pathogenesis of DN. Methods We conducted an analysis by combining bulk dataset and single-cell transcriptome dataset. Through this approach, we identified that Serpine2 may regulate the ‘collagen-containing extracellular matrix’ pathway involved in DN. Subsequently, we established DN animal and cell models using db/db mice and mesangial cells (MCs) to validate the role of Serpine2 in DN. In the animal model, we detected the expression level of Serpine2 in DN using western blotting (WB) and immunofluorescence (IF) assays. To further clarify the molecular mechanism of Serpine2 in DN, we knocked down Serpine2 and observed its effects on MCs proliferation and extracellular matrix (ECM) accumulation. Results Our single-cell analysis of DN models highlighted a pivotal role for MCs in the disease's initiation. Next, through Cytoscape analysis of differentially expressed genes (DEGs) in MCs, we identified the following 10 hub genes: Acta2, Angpt2, Ccn1, Col4a1, Col4a2, Col8a1, Kdr, Thbs1, Tpm4 and Serpine2. Subsequently, we identified that Serpine2 and Kdr were also significantly DEGs in the bulk analysis of glomeruli. Additionally, our integrated gene set enrichment analysis of bulk dataset and single-cell RNA dataset revealed that the ‘collagen-containing extracellular matrix’ was a key pathway in DN progression. Serpine2 was one of the crucial genes involved in regulating this pathway. Therefore, we speculated that the regulation of the ‘collagen-containing extracellular matrix’ pathway by Serpine2 was an important mechanism. Importantly, WB and IF staining confirmed that Serpine2 expression was upregulated in the MCs of diabetic mice. Knockdown of Serpine2 in cultured MCs alleviated high-glucose-induced excessive MCs proliferation and ECM accumulation. Finally, we found that ERK agonist Ro 67-7476 eliminated the effect of Serpine2 siRNA. Conclusions In summary, Serpine2 regulates MCs proliferation and ECM synthesis through activation of the ERK1/2 pathway, which is an important pathogenesis mechanism of DN. These findings offer fresh perspectives on the mechanisms of glomerulosclerosis in DN pathogenesis and may provide new targets for treating DN.
研究领域:
分子生物学
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肾脏病学
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DOI
高影响因子
WATER RESEARCH
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2025
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IF 12.4
Jianqiao Xu,Xinyuan Wei,Junyan Wei,Mengqiang He,Xiaolei Teng,Zunyao Wang,Ruijuan Qu
While the reaction mechanism of direct photochemical dechlorination has been extensively studied, significant knowledge gaps remain regarding the specific roles of reactive species in governing dechlorination pathways during indirect photodegradation. By integrating mass spectrometry analysis, probe experiments and theoretical calculations, we propose for the first time an indirect dechlorination reaction mechanism for PCB-209 involving active species commonly found in DOM photosensitive systems, which differs significantly from that of direct photodegradation. Due to the lower bond energy of the C Cl bond at the position opposite the carbon bridge, PCB-209 primarily yielded PCB-208 in direct dechlorination systems. However, our study revealed that active species ( 3 DOM*, •O 2 − and 1 O 2 ) can specifically weaken the meta-positioned C Cl bond at the carbon bridge through electron transfer and cycloaddition mechanisms, thereby fundamentally altering the regioselectivity of dechlorination. Remarkably, our results confirm the indirect degradation of PCB-209 through DOM photosensitization to form dechlorination products dominated by PCB-207, a previously unrecognized transformation pathway in natural photochemical processes. This study refines the mechanism of indirect dechlorination mediated by reactive species and provides a predictive framework for the environmental fate of halogenated pollutants in real complex environmental systems.
研究领域:
环境科学
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化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）