DALTON TRANSACTIONS
·
2011
·Vol. 40
·期 48
·12818-12825
·
IF 3.647
Xuefeng Zhai,Min Yu,Ziyong Cheng,Zhiyao Hou,Ping'an Ma,Dongmei Yang,Xiaojiao Kang,Yunlu Dai,Dong Wang,Jun Lin
Rattle-type hollow nanocapsules are among of the most promising candidates as drug carriers owing to their huge inner space and multifunctional material combination. In this paper, rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules with a diameter of 100–110 nm and a wall thickness around 10 nm were fabricated. The hollow silica nanospheres were used as nano-reactors and the luminescent core of CaWO4:Tb3+ was post-filled into the nano-reactors by a vacuum nano-casting route combined with a Pechini-type sol–gel method. Subsequently, doxorubicin hydrochloride (DOX), a model of an anti-cancer drug, is loaded into the CaWO4:Tb3+@SiO2 nanocapsules and their cell cytotoxicity, cancer cell uptake and drug release behavior are investigated in vitro. The prepared multifunctional inorganic nanocapsules show a loading capacity for DOX as high as 124 mg g−1 and sustained-release properties. The release profile of the drug from DOX-loaded nanocapsules can last over five days. Besides, the blank CaWO4:Tb3+@SiO2 shows very low cytotoxicity against cancer cell lines (HeLa cell) while the DOX-loaded nanocapsules exhibit relatively high efficiency for killing of HeLa cells. The rapid cancer cell uptake process is observed by confocal laser scanning microscopy. The results indicate that a rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsule has the potential to be used as drug carrier in therapy. Moreover, it is possible to extend the synthetic strategy in this study to other rattle-type multifunctional composites to meet various demands.
研究领域:
纳米医学
·
肿瘤学
·
药剂学
·
生物材料
·
分子影像
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Peng Yang,Xianfu Luo,Sheng Wang,Fang Wang,Chuanbing Tang,Changchun Wang
A new class of uniform biodegradable yolk-shell Fe 3 O 4 @PFH@PMAA-DOX microspheres was developed as ultrasound/MR dual-modality imaging contrast agents and drug delivery system. PMAA shells exhibit excellent drug loading capability and efficiency, the DOX-loading capacity is 15.4 wt% and the drug loading efficiency is 91%. In vivo ultrasound and MRI experiments indicate that the as-prepared Fe 3 O 4 @PFH@PMAA-DOX microspheres successfully reach tumor tissues and possess robust dual-modality imaging capability, the r 2 value of MRI is 71.82 mM −1 s −1 . In vitro cytotoxicity and in vivo tissues biopsies show that the loaded DOX can be control-released under pH, redox and ultrasound multi-stimuli and kill cancer cells effectively. Furthermore, disulfide-crosslinked PMAA shells and PGA-stabilized Fe 3 O 4 cores can be respectively degraded into short hydrophilic polymer chains and iron ions, reducing their cumulative toxicity in organisms. Thus, the multifunctional biodegradable microspheres are safer for normal tissues and more beneficial in actual clinical applications.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 12
·8070-8077
·
IF 1.354
Zhao Hongli,Sun Shanshan,Wang Zhaodong,Hong Yayun,Shi Lulu,Lan Minbo
In this work, a novel combination of drug therapy and cryotherapy for tumor treatment was developed. Pluronic F127 modified with poly(acrylic acid) at two terminals (denoted as PAA-PF127-PAA) was used as carriers for doxorubicin (DOX) delivery. Due to the pH-sensitive property endowed
by PAA, the DOX-loaded PAA-PF127-PAA micelles released DOX faster in the slightly acidic physiological environment of the tumor site than that in the neutral physiological environment. Three-group rats bearing Walker 256 carcinosarcoma were respectively treated with cryotherapy, combination
of DOX-loaded micelles and cryotherapy, and saline injection to investigate the effect of the combined therapy. The apoptosis rate of TdT-mediated dUTP nick-end labeling (TUNEL) slices indicated that compared with cryotherapy alone, the DOX-loaded PAA-PF127-PAA micelles combining with cryotherapy
showed increased apoptosis. Thus, the combination of drug therapy and cryotherapy can be used as an effective technique for tumor treatment.
研究领域:
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Haiqing Gao,Bin Chi,Feng Tian,Mingyue Xu,Zushun Xu,Ling Li,Jing Wang
In this study, a hybrid material UIO-66-NH 2 /PB were synthesized through the modification of Prussian Blue on the surface of Metal Organic Frameworks for synergetic tumor therapy with hypoxia modulation. It was found that UIO-66-NH 2 /PB has good photo-thermal performance and photo-thermal stability, suitable for photo-thermal treatment. Dissolved oxygen analysis showed that UIO-66-NH 2 /PB can catalyze H 2 O 2 into O 2 . It was proved that this process is accompanied by the generation of ·OH. Furthermore, with the irradiation of 808 nm for 5min, the TMB solution becomes darker blue, proving that more free radicals are produced. The produced O 2 can be used to modulate the hypoxia of tumor to improve the anti-cancer efficiency, and the generated ·OH can kill cancer cells to achieve chemo-dynamic therapy. Doxorubicin (DOX) was selected as a model drug and the DOX loading of UIO-66-NH 2 /PB was 67%. Drug release experiments showed that DOX was not nearly released in pH 7.4, while 78% DOX was released in pH5.8 after 40 h, demonstrating the excellent pH-responsive release. In addition, with the irradiation of 808 nm for 5min, 87% DOX was released in pH 5.8, indicating photo-thermal effect could help achieve better release effect. The different cytotoxicity to L-02 cells and HeLa cells of UIO-66-NH 2 /PB shows UIO-66-NH 2 /PB is only harmful to cancer cells, indicating that Fenton-like reaction only occurred in tumor to generate ·OH. In vivo experiment showed synergetic therapy can achieve satisfactory treatment efficiency. Therefore, UIO-66-NH 2 /PB is expected to combine multiple treatments to improve anti-cancer effect.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤治疗
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）