COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Yujiao Yan,Jun Li,Ying Huang,Litao Ma,Delian Yang,Haiqin Wan,Shenwen Fang,Yi Xiao,Ming Duan,Yan Xiong
In this work, the adsorption performance of tween surfactant (tween 20, tween 60 and tween 80) on asphaltene surface was investigated by both experimental and calculation methods. For experimental investigation, dual polarization interferometry (DPI) technique was utilized for in-situ measuring the adsorption mass and thickness on natural asphaltene surface. The thermodynamics Langmuir fittings indicated the mono-layer of free molecular, semi-micelle and whole-micelle adsorption for low, middle and high surfactant concentrations, respectively. The kinetic normalization corrections indicated the maximum adsorption rate at 1/2 CMC with semi-micelle form for three surfactants. For calculation insight, molecular dynamics simulation (MDS) was used for analyzing the peak intensity and interaction energy between surfactant molecular and model asphaltene of C5Pe. The RDF fitting revealed the interaction positions from 4.37 Å to 8.69 Å and the COMPASS force field showed the interaction energies from − 45.41 to − 36.34 Kcal/mol for three different surfactant-asphaltene pairs. Combined with experimental and calculation results, this work reveals the interaction forms and interaction processes between surfactant and asphaltene. Based on the mechanism analysis, tween 20 was revealed to show the most excellent interaction performance with asphaltene and can be used as potential flooding reagent for enhanced oil recovery. The results indicated that the proposed method can provide a deep insight into the interfacial behavior of surfactants at oil surface, which is of great significance in oilfield chemical development and enhanced oil recovery.
研究领域:
石油工程
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化学工程
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计算化学
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DOI
高影响因子
Journal of Semiconductors
·
2025
·Vol. 46
·期 8
·082801
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IF 5.3
Jing Guo,Yaru Feng,Jinjun Zhang,Jing Zhang,Ping−An Chen,Huan Wei,Xincan Qiu,Yu Liu,Jiangnan Xia,Huajie Chen,Yugang Bai,Lang Jiang,Yuanyuan Hu
Doping plays a pivotal role in enhancing the performance of organic semiconductors (OSCs) for advanced optoelectronic and thermoelectric applications. In this study, we systematically investigated the doping performance and applicability of the ionic dopant 4-isopropyl-4′-methyldiphenyliodonium tetrakis(penta-fluorophenyl-borate) (DPI-TPFB) as a p-dopant for OSCs. Using the p-type OSC PBBT-2T as a model system, we demonstrated that DPI-TPFB shows significant doping effect, as confirmed by ESR spectra, ultraviolet−visible−near-infrared (UV−vis−NIR) absorption, and work function analysis, and enhances the electronic conductivity of PBBT-2T films by over four orders of magnitude. Furthermore, DPI-TPFB exhibited broad doping applicability, effectively doping various p-type OSCs and even imparting p-type characteristics to the n-type OSC N2200, transforming its intrinsic n-type behavior into p-type. The application of DPI-TPFB-doped PBBT-2T films in organic thermoelectric devices (OTEs) was also explored, achieving a power factor of approximately 10 μW∙m−1∙K−2. These findings highlight the potential of DPI-TPFB as a versatile and efficient dopant for integration into organic optoelectronic and thermoelectric devices.
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高影响因子
Theranostics
·
2020
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IF 8.579
Yue Kuai,Hao Liu,Dongyu Liu,Yunlong Liu,Ye Sun,Jiansheng Xie,Jiachun Sun,Yong Fang,Hongming Pan,Weidong Han
Long-term inflammatory stimulation is considered one of the most important causes of colorectal cancer. Diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, can inhibit a variety of inflammatory responses. However, the systemic toxicity of DPI limits its clinical application. Whether DPI can inhibit colitis-associated colorectal cancer (CAC) at ultralow concentrations remains unknown. Methods : CAC was induced by azoxymethane (AOM) injection followed by treatment with dextran sulfate sodium (DSS), and DPI was intraperitoneally injected (i.p.) in the first cycle for 21 days. Colon tissue was collected and analyzed by western blotting. Immune cell infiltration and macrophage polarization were examined by immunohistochemistry, immunofluorescence, or real-time polymerase-chain reaction (PCR). Reactive oxygen species (ROS) production was measured by flow cytometry. Results : Ultralow dose DPI significantly ameliorated the DSS-induced colitis and attenuated the colon tumorigenesis in the mouse model of AOM/ DSS-induced CAC. Mechanistically, an ultralow dose of DPI inhibited the production of pro-inflammatory cytokines, (tumor necrosis factor (TNF)-α and interleukin (IL)-6), reduced the macrophage infiltration and classical polarization, and induced the ROS generation. These effects were found to be related to the inhibition of the phosphorylation of signal transducer and activator of transcription 3 (STAT3), mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF -κB). Conclusion : The present study revealed that an ultralow dose of DPI, with no significant systemic toxicity involved, may be an effective way to prevent the occurrence and development of CAC.
研究领域:
肿瘤学
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免疫学
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药理学
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胃肠病学
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DOI
PubMed
高影响因子
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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2021
·Vol. 25
·期 11
·4962-4973
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IF 5.31
Mingyu He,Gege Yan,Yang Wang,Rui Gong,Hong Lei,Shuting Yu,Xiaoqi He,Guanghui Li,Weijie Du,Tianshuai Ma,Manqi Gao,Meixi Yu,Shenzhen Liu,Zihang Xu,Elina Idiiatullina,Naufal Zagidullin,Valentin Pavlov,Benzhi Cai,Ye Yuan,Lei Yang
Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light-emitting diodes (LED)-based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of human OS cells, while we observed blue LED irradiation increased ROS production through increased NADPH oxidase enzymes NOX2 and NOX4, as well as decreased Catalase (CAT) expression levels. Furthermore, we revealed blue LED irradiation-induced autophagy characterized by alterations in autophagy protein markers including Beclin-1, LC3-II/LC3-I and P62. Moreover, we demonstrated an enhanced autophagic flux. The blockage of autophagy displayed a remarkable attenuation of anti-tumour activities of blue LED irradiation. Next, ROS scavenger N-acetyl-L-cysteine (NAC) and NOX inhibitor diphenyleneiodonium (DPI) blocked suppression of OS cell growth, indicating that ROS accumulation might play an essential role in blue LED-induced autophagic OS cell death. Additionally, we observed blue LED irradiation decreased EGFR activation (phosphorylation), which in turn led to Beclin-1 release and subsequent autophagy activation in OS cells. Analysis of EGFR colocalization with Beclin-1 and EGFR-immunoprecipitation (IP) assay further revealed the decreased interaction of EGFR and Beclin-1 upon blue LED irradiation in OS cells. In addition, Beclin-1 down-regulation abolished the effects of blue LED irradiation on OS cells. Collectively, we concluded that blue LED irradiation exhibited anti-tumour effects on OS by triggering ROS and EGFR/Beclin-1-mediated autophagy signalling pathway, representing a potential approach for human OS treatment.
研究领域:
肿瘤学
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细胞生物学
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分子生物学
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光生物学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Plant Science
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2018
·
IF 3.677
Li Zhan,Gao Yue,Zhang Yuchan,Lin Cheng,Gong Dongting,Guan Yajing,Hu Jin
Seed germination is a complex process controlled by various mechanisms. To examine the potential contribution of reactive oxygen species (ROS) and gibberellin acid (GA) in regulating seed germination, diphenylene iodonium chloride (DPI) and uniconazole (Uni), as hydrogen peroxide (H2O2) and GA synthesis inhibitor, respectively, were exogenously applied on tobacco seeds using the seed priming method. Seed priming with DPI or Uni decreased germination percentage as compared with priming with H2O, especially the DPI + Uni combination. H2O2 and GA completely reversed the inhibition caused by DPI or Uni. The germination percentages with H2O2 + Uni and GA + DPI combinations kept the same level as with H2O. Meanwhile, GA or H2O2 increased GA content and deceased ABA content through corresponding gene expressions involving homeostasis and signal transduction. In addition, the activation of storage reserve mobilization and the enhancement of soluble sugar content and isocitrate lyase (ICL) activity were also induced by GA or H2O2. These results strongly suggested that H2O2 and GA were essential for tobacco seed germination and by downregulating the ABA/GA ratio and inducing reserve composition mobilization mutually promoted seed germination. Meanwhile, ICL activity was jointly enhanced by a lower ABA/GA ratio and a higher ROS concentration.
研究领域:
植物生理学
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分子生物学
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植物学
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DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2024
·
IF 4.5
Jinxue Cao,Yaping Xiu,Siqi Wang,Fangling Wu,Ji Li,Dongkai Wang
Andrographolide (AG) is known as a "natural antibiotic". It has been clinically developed into capsules, dropping pills, disperse tablets, etc., for the treatment of viral and bacterial upper respiratory tract infections. It has poor water solubility, obvious P-glycoprotein efflux, and low bioavailability, so its wide application in clinical practice is limited. In this work, a novel AG dry powder inhaler (AG-DPI) was developed using experimental design to optimize the prescription and spray-drying process to obtain higher local concentrations in the lungs while lowering the administered dose; avoiding hepatic first-pass effects and gastrointestinal p-glycoprotein efflux. The short-term local anti-inflammatory effects in the lungs were evaluated using a rat model of acute pneumonia compared with oral administration. The prepared AG-DPI showed that (1) it had good aerosolization properties and was suitable for pulmonary administration, with emitted doses >90%, and fine particle fractions >60%; (2) it was superior to oral administration in the assessment of local anti-inflammatory effects in the lungs by acting on acute pneumonia. This study provides some theoretical value and reference for the inhalable dry powder of AG as a potential targeted treatment modality for lung diseases and infections.
研究领域:
药剂学
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药理学
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呼吸病学
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药物递送系统
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DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2021
·
IF 4.291
Junjie Li,Yuanyuan Peng,Jhair Peña,Jinfeng Xing
Nanogels based Polyethylene glycol diacrylate (PEGDA) attracted much attention due to their promising application in drug delivery and tissue engineering. Here, PEGDA photopolymerization at 532 nm with different initiating systems was investigated. Nanogels can be obtained using single 2′,4′,5′,7′-tetrabromofluorescein disodium salt (EY) as the photoinitiator. To increase the polymerization rate, EY, triethanolamine (TEOA), and diphenyl iodonium hexafluorophosphate (DPI) were investigated as a three-component initiating system. With that initiating system, the conversion of PEGDA double bond was higher than 90 % in 1 min at extremely low irradiation energy density (P= 0.95 mW/cm 2 ). However, the conversion of PEGDA double bond was only 51.5 % in 1 min at the same irradiation energy density when using EY and TEOA as two-component initiating system. Subsequently, the corresponding mechanism of the three-component (EY-TEOA-DPI) initiating system was illustrated. DPI might participate in two ways of photooxidation and reduction, which dramatically improved the polymerization rate. The EY-TEOA-DPI initiating system is promising to be applied in the preparation of multifunctional hydrogels.
研究领域:
材料科学
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高分子化学
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生物医学工程
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药学
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Jinwei Zhao,Cheng Xu,Jiali Pu,Yi Xie,Haodong Guo,Baojie Liu,Chengrong Qin,Shuangquan Yao,Chen Liang
Bamboo is a fast-growing, high-biomass, and mechanically strong renewable resource. It shows great potential in cellulose-based materials and bio-based products. However, its complex tissue structure and unique lignin distribution limit the efficiency and applicability of conventional delignification processes. In this study, a synergistic lignin removal strategy combining high-proportion chlorine dioxide (ClO 2 ) pretreatment with oxygen delignification was developed. Two process sequences, O-D PI and D PI -O, were systematically compared in terms of reaction mechanisms during bamboo fiber lignin removal. Results showed that, in the D PI -O process, ClO 2 preferentially oxidized lignin to form quinone-type intermediates. These intermediates were then effectively degraded in the subsequent oxygen delignification stage. This led to a significantly higher lignin removal rate (84.90 %) and a notable reduction in kappa number (2.49) and AOX generation (0.267 kg/t pulp). Multidimensional characterization using 2D HSQC NMR and 31 P NMR confirmed more complete cleavage of S/G units and β-O-4 linkages in the D PI -O system. The carboxyl group content of residual lignin increased significantly to 1.194 mmol/g, revealing the critical role of quinone intermediates in deep oxidative degradation. Kinetic studies further showed that the lignin removal rate was highly sensitive to alkali concentration (a 1 = 0.6012), especially under low oxygen pressure. In low-alkali environments, oxygen pressure became more influential (b 1 = 0.1382). This study elucidates the reaction pathway and key controlling parameters of oxygen-assisted, high-proportion ClO 2 delignification. It provides both theoretical and practical support for efficient lignin degradation and high-purity cellulose fiber production.
研究领域:
木材化学
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制浆造纸技术
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生物炼制
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化学工程
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可持续材料
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DOI
高影响因子
ACS Pharmacology & Translational Science
·
2024
·
IF 4.9
Quan Wang,Xinyue Liu,Han Yuan,Fengcai Zhang,Jiafei Wu,Dongjing Yang,Jiang Qian,Yi-You Huang,Guihong Chai,Hai-Bin Luo,Lei Guo
Idiopathic pulmonary fibrosis (IPF) is a debilitating, incurable, and life-threatening disease that lacks effective therapy. The overexpression of phosphodiesterase 10A (PDE10A) plays a vital role in pulmonary fibrosis (PF). However, the impact of selective PDE10A inhibitors on the tumor growth factor-β (TGF-β)/small mother against decapentaplegic (Smad) signaling pathway remains unclear. Herein, we have exploited a novel carbonyl sulfide (COS)/hydrogen sulfide (H2S)-donor hybrid PDE10A inhibitor called COS-2080 with a well-defined mechanism of H2S-releasing action. It exhibited highly potent inhibitory activity against PDE10A and excellent PDE subfamily selectivity. Moreover, COS-2080 demonstrated significant antifibrotic effects by inhibiting cell proliferation and mitigating fibroblast-to-myofibroblast transition (FMT). A dry powder inhalation formulation called COS-2080-DPI has been developed using the ultrasonic spray freeze drying (USFD) technique, demonstrating significant antifibrotic efficacy in mice with bleomycin-induced PF at a dosage approximately 600 times lower than pirfenidone. This remarkable antifibrotic efficacy of COS-2080 on TGF-β1-induced FMT could be primarily attributed to its inhibition of the Smad2/Smad3 phosphorylation. Moreover, COS-2080 effectively attenuated fibrosis in MRC-5 cells by activating the cAMP/protein kinase A (PKA)/CREB pathway and potentially increasing levels of p53 protein. Our findings suggest that effective inhibition of PDE10A potentially confers a protective effect on FMT in PF by impeding TGF-β signaling and activating the cAMP/PKA/CREB/p53 axis.
研究领域:
肺病学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
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