Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 43
·15654-15661
·
IF 7.393
Yong Zhang,Weilin Liu,Yushen Liu,Conghuan Wang,Guodong Zhu,Weidong Song
The anisotropic electrical properties of organic semiconductors are one of the research hotspots currently. However, there is a great challenge to construct optoelectronic devices by using anisotropic properties of organic semiconductors. Here, we developed anisotropic self-powered photodetectors based on organic polymer semiconducting DPP-DTT and SrTiO3 (DPT/STO) heterojunctions. Two PDs were fabricated where anisotropic DPP-DTT layers were written directly on SrTiO3 with parallel and perpendicular configurations (‖DPT/STO and ⊥DPT/STO). It is found that both devices exhibit anisotropic self-powered characteristics under 400 nm light illumination at zero bias; however, the ‖DPT/STO device shows larger open-circuit voltage (0.71 V) and higher photocurrent (1.0 nA) than the ⊥DPT/STO device (0.26 V and 0.4 nA). Moreover, the anisotropic self-powered feature is also verified on the DPT/GaN devices. The observed phenomenon can be attributed to the anisotropic electrical performance of the directly written DPP-DTT organic polymer. Our work provides a promising way to fabricate anisotropic self-powered devices by employing anisotropic organic semiconductors for broad applications.
研究领域:
材料科学
·
光电材料与器件
·
半导体物理
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Ritian Jin,Jiaqi Shang,Xiangyu Teng,Ligang Zhang,Minhe Liao,Jiaxin Kang,Ran Meng,Dangfeng Wang,Haowei Ren,Ning Liu
Here, we characterize the activities of two depeptidyl peptidase-IV (DPP-IV) inhibitory peptides, VLATSGPG and LDKVFER, using the Caco-2 monolayer model for the intestine. VLATSGPG and LDKVFR inhibited the DPP-IV in the cells via a mixed-type inhibition mode, with in situ IC50 values of 207.3 and 148.5 μM, respectively. Furthermore, VLATSGPG and LDKVFR were transported intact across the cells, with Papp values of 2.41 ± 0.16 and 4.23 ± 0.29 × 10–7 cm/s, respectively. Fragmented peptides were identified in the basolateral side of the membrane. Two of these, GPG and VLA, exhibited high inhibitory activities of 83.6 ± 3.3 and 58.5 ± 2.5%, respectively, at 100 μM concentration. Although 3 mM VLATSGPG and LDKVFR were transported across the epithelium in a concentration-dependent manner, their transport did not damage the tight junction proteins, ZO-1 and occludin. This study demonstrates that the two peptides potentially regulate DPP-IV activity in the intestine.
研究领域:
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2013
·Vol. 1
·期 15
·4858-4863
·
IF 0
Fang Zhang,Ke-Jian Jiang,Jin-Hua Huang,Chun-Chun Yu,Shao-Gang Li,Ming-Gong Chen,Lian-Ming Yang,Yan-Lin Song
A novel compact diketopyrrolopyrrole (DPP) dye was designed and synthesized using DPP core as a bridge to connect bis(4-tert-butylphenyl)phenylamine and cyanoacetic acid units with the D–π–A configuration, and employed as a sensitizer in dye-sensitized solar cells, giving a high power conversion efficiency of 8.61% under AM 1.5 conditions.
研究领域:
材料科学
·
能源科学
·
化学
✓ 已验证
DOI
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yuyang Liu,Yan Zhang,Minghao Liu,Sainan Yu,Zhenglin Tian,Wannan Li,Weiwei Han
Dipeptidyl peptidase-IV (DPP-IV) inhibitors play a critical role in the treatment of diabetes and metabolic diseases. This study combines computational simulations with experimental validation to identify peptides with potential DPP-IV inhibitory activity from wheat proteins. A peptide database was constructed through trypsin digestion simulation, and screening was performed using the ConPLex deep learning algorithm, leading to the identification of four promising peptides: TENEWK (Thr-Glu-Asn-Glu-Trp-Lys), NFVSER (Asn-Phe-Val-Ser-Glu-Arg), LDLPSK (Leu-Asp-Leu-Pro-Ser-Lys) and QHEQR (Gln-His-Glu-Gln-Arg). Experimental results showed that the IC50 values of these four peptides were 4.96 mM, 3.07 mM, 2.89 mM, and 4.18 mM, respectively, and they were all competitive DPP-IV inhibitors with significant inhibitory activity. Molecular dynamics (MD) simulations revealed the inhibitory mechanism by which inhibitory peptides led to the disappearance of the α-helix of the DPP-IV active center. Further tau-random accelerated molecular dynamics (tau-RaMD) simulations were used to calculate the binding residence time of each peptide, providing insights into their binding stability and key interacting residues. The combination of computational and experimental approaches significantly improved the accuracy and efficiency of screening peptides with DPP-IV inhibitory potential, providing a promising research foundation for developing peptide-enriched health foods.
研究领域:
生物化学
·
计算生物学
·
药理学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Yuxiang Gu,Yajie Niu,Yanbo Wang,Baoguo Sun,Shuxing Chen,Lishui Chen,Hao Dong,Yuyu Zhang
This study investigated the DPP-IV inhibitory activity of taste-modulating peptides from porcine bone and elucidated their inhibitory mechanisms. Sensory evaluation identified seven peptides with effects on umami taste or saltiness enhancement. Computational tools predicted that they all possessed DPP-IV inhibitory potential. Post-digestion, GPTAANRM, GPGCKAGL, NLRDNYRF and GVNAMLRK exhibited superior DPP-IV inhibition (IC 50 : 206.16 - 317.59 μmol/L). Molecular docking revealed that all these four peptides interacted with active residues in S1, S2 and S3 pocket of DPP-IV and the Lineweaver-Burk plots indicated their competitive inhibition mechanism. All these peptides alleviated insulin resistance in HepG2 cells to some extent, with GPTAANRM and GPGCKAGL notably reducing the blood glucose curve area in C57BL/6J mice. This research enhances our understanding of the beneficial role of taste-modulating peptides in diabetes management and suggests their potential in developing dietary strategies to optimize glycemic control in diabetic individuals.
研究领域:
生物化学
·
食品科学
·
药理学
·
分子生物学
·
营养学
·
糖尿病研究
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 7
·3777-3784
·
IF 0
Guojian Tian,Shengyun Cai,Xin Li,Hans Ågren,Qiaochun Wang,Jinhai Huang,Jianhua Su
Two new D–A–π–A configuration metal-free organic sensitizers (T1–T2) based on 5,7-dihexyl-6,12-diphenyl-5,7-dihydroindolo[2,3-b]carbazole and a DPP unit with a bulky branched alkyl chain have been synthesized for dye-sensitized solar cells. Due to a bulky branched alkyl chain being attached to the donor and DPP unit, both compounds obtain high Voc values. Under standard global AM 1.5 solar light conditions, the T1 based-device gives a high conversion efficiency of 8.24% with a Jsc of 15.72 mA cm−2, a Voc of 0.74 V and a FF of 0.71. These excellent performances make the donor dihydroindolo[2,3-b] carbazole and DPP unit promising candidates for further application in DSCs.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
Sustainable Energy & Fuels
·
2018
·Vol. 2
·期 10
·2154-2159
·
IF 0
Xing Guo,Bingjuan Zhang,Zhenhua Lin,Jie Su,Zhou Yang,Chunfu Zhang,Jingjing Chang,Shengzhong (Frank) Liu,Yue Hao
The electron/hole transport layer plays a very important role in the planar structure of perovskite solar cells. Conjugated polymers have received considerable attention for use in perovskite solar cells as hole/electron transport layers and passivation layers. Although the devices based on conjugated polymer hole transport layers have achieved much progress, their performance is still inferior to that of devices based on the conventional spiro-OMeTAD hole transport layer. Here, we investigated the solvent vapor annealing (SVA) effect on conjugated polymers as well as the corresponding perovskite solar cell devices. It was found that SVA treatment could enhance the hole charge carrier mobility and thin film crystallinity. Meanwhile, the charge transfer efficiency was enhanced, and charge recombination was reduced. Hence, the conjugated polymer based device exhibited comparable or even better performance compared with the conventional spiro-OMeTAD based device. Moreover, the device stability was also improved.
研究领域:
材料科学
·
光伏技术
·
纳米科技
·
表面与界面化学
·
凝聚态物理
·
能源材料
·
器件物理
✓ 已验证
DOI
JOURNAL OF APPLIED PHYCOLOGY
·
2022
·Vol. 34
·期 3
·1497-1511
·
IF 3.404
Liu Jing,Bai Xinpeng,Fu Pengcheng
Arthrospira platensis proteins are considered as viable ingredients for functional foods with nutraceutical properties and health-promoting effects. In this study, we used five different proteases including pepsin, trypsin, alcalase, papain, and bromelain to hydrolyze A. platensis phycobiliprotein. LC–MS/MS (liquid chromatography-tandem mass spectrometry) was used to determine the composition of the hydrolysates with thousands of bioactive peptides. Based on peptide sequencing, a candidate list of 1,333 bioactive peptides was constructed for the first time for which bioinformatics tools were used to assess the properties of the bioactive peptides. The inhibitory activity of dipeptidyl peptidase IV (DPP-IV) and angiotensin-converting enzyme (ACE), as well as the antioxidant activity of five phycobiliprotein hydrolysates (PBPHs), were verified in vitro. The IC 50 values of PBPH-pepsin, PBPH-trypsin, PBPH-alcalase, PBPH-papain, and PBPH-bromelain for DPP-IV inhibited activity were determined to be 4.059, 5.603, 5.257, 3.819, and 4.195 mg mL −1 , respectively. All the above five PBPHs were also seen to significantly inhibit ACE activity ( P < 0.0001) in the range of 0.1–1.0 mg mL −1 . The activity of five PBPHs fraction was found for the 2-azino-bis (3-ethylbenzothiazoline6-sulfonic acid) diammonium salt (ABTS) assay (the highest was 1.37 mM Trolox equivalent of 30 mg mL −1 of PBPH-trypsin), 1,1diphenyl-2-picrylhydrazyl (DPPH) assay (the highest was 204.67 µM Trolox equivalent of 10 mg mL −1 of PBPH-pepsin), and Fe 2+ chelating ability (the highest was 639.73 µM FeSO 4 equivalent of 10 mg mL −1 of PBPH-trypsin). This study indicated that it was feasible to utilize A. platensis phycobiliprotein as a source of bioactive peptides which may be used as functional food and/or nutritional supplements for human health.
研究领域:
食品科学
·
生物化学
·
营养学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2020
·
IF 3.263
Shumin Jiang,Xueli Wu,Yi Wang,Jingtao Zou,Xiaoping Zhao
Dipeptidyl Peptidase-4 (DPP-4) is a specific enzyme hydrolyzing the incretin hormone glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) to reduce insulin secretion, meanwhile DPP-4 inhibitors play an important role in diabetic therapy. In present study, 14 potential inhibitors were screened with an inhibition over 50% on DPP-4 activity from Xiao-Ke-An formula (XKA) and 12 of them exhibited a dose-dependently inhibitory effect at concentrations of 5–50 μmol/l. We found 10 DPP-4 inhibitors restrained differentiation of 3T3-L1 pre-adipocytes as well as reducing the triglycerides and total cholesterol content in 3T3-L1 adipocytes. Furthermore, 7 DPP-4 inhibitors promoted the glucose consumption in insulin-resistance BNL CL.2 cells. Thereinto, ginsenoside Rk 1 up-regulated the protein kinase B (AKT) and glycogen synthase kinase-3 (GSK-3β) phosphorylation expression, while kukoamine B and coptisine hydrochloride obviously increased the phosphorylation of AKT protein and columbamine , panaxadiol , ginsenoside Ro , timosaponin AI significantly promoted the phosphorylation of GSK-3β protein. It's our first effort to confirm those seven compounds could serve as DPP-4 inhibitors to attenuate DPP-4 activities, accompanied with the ability to adjust glucolipid metabolism. Moreover, activating the AKT/GSK-3β signaling pathway to ameliorate insulin resistant may be the anti-diabetic mechanism of XKA.
研究领域:
药理学
·
糖尿病研究
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
SYNTHETIC METALS
·
2021
·
IF 3.266
Yueqiang Ma,Yuchang Du,Chunxia Li,Yan Zhang,Hongmei Du,Jinsheng Zhao,Junhong Zhang,Yu Xie
In this work, starting from cyclopenta[2,1-b;3,4-b′]dithiophene (CPDT) and tris(thienothiophene) (3TT) as donor units, and diketopyrrolopyrrole (DPP) as the acceptor unit, three new solution-processable donor-acceptor conjugated copolymers (P1, P2, P3) were successfully synthesized through the palladium-catalyzed Stille coupling reaction. The monomer molar feeding ratios (CPDT:DPP:3TT) of the three polymers are 3:2:1, 2:1:1, 3:1:2, respectively, which are named as PCPT-1, PCPT-2, and PCPT-3. For comparison purpose, we also synthesized the binary copolymers between CPDT and DPP (PCP), CPDT and 3TT (PCT), and compared their properties with the ternary copolymers. The optical band gaps of the five polymers were all lower than 1.9 eV, and they all showed abundant color changes. During the oxidation process , PCPT-1 changed from purple to cyan-gray and turned to earthy brown finally, PCPT-2 changed from purple in a neutral state to blue-gray in an oxidized state. Similarly, PCPT-3 turned from purple to cement gray and finally oxidized to light blue. PCP polymer changed from dark green in a neutral state to cement gray in an oxidized state, PCT polymer changed from purple in a neutral state to Light gray purple in an oxidized state. The electrochromic kinetic performance study showed that the response time of the five polymers was about 1 s within a 4-second interval. In the dynamic stability test of 750 cycles (6000 s), the five polymers demonstrated good stability. The contrast retention of polymer PCPT-2 at 570 nm reached to as high as 96.17%.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·224
·
IF 7.8
He Yi,Zhang Yan,Zhang Pengying,Li Jiaying,Li Wannan,Han Weiwei
Type 2 diabetes mellitus (T2DM) poses a significant global health burden, with dipeptidyl peptidase-IV (DPP-IV) inhibitors being critical therapeutic targets for its management. Malt, a natural medicinal food, shows promise for T2DM treatment, yet its active compounds need further exploration. This study integrates molecular docking (Libdock, Autodock Vina), deep learning models (ConPlex, KPGT), molecular dynamics (MD) simulations, and network pharmacology to identify and validate DPP-IV inhibitors from malt. The pentapeptide YPQPQ, derived from malt hordein, exhibited potent DPP-IV inhibition (IC 50 : 23.87 μM) in vitro. Network pharmacology identified MAPK1 and MAPK3 (ERK1 and ERK2) as key targets, with YPQPQ significantly reducing ERK phosphorylation. Molecular dynamics (MD) simulations revealed YPQPQ’s binding similarity to Diprotin A. These findings establish YPQPQ as a novel natural DPP-IV inhibitor, modulating the ERK signaling pathway, offering potential for T2DM therapy.
研究领域:
药理学
·
计算生物学
·
营养科学
·
糖尿病研究
·
生物信息学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EBioMedicine
·
2019
·
IF 6.68
Xiaoyu Liao,Lingyu Song,Benhua Zeng,Bingyao Liu,Yuyang Qiu,Hua Qu,Yi Zheng,Min Long,Houdi Zhou,Yuan Wang,Yingxuan Du,Jing Xu,Rufei Shen,Qiang Tong,Leiqin Cai,Xing Li,Shaodong Guo,Gangyi Yang,Zhiming Zhu,Xiaoyun Pu,Hong Wei,Hongting Zheng
Background Increasing evidence indicates that the gut microbiota contributes to the occurrence and development of metabolic diseases. However, little is known about the effects of commonly used antidiabetic agents on the gut microbiota. In this study, we investigated the roles of dipeptidyl peptidase-4 inhibitors (DPP-4i) and α-glucosidase inhibitor in modulating the gut microbiota. Methods 16S-rDNA sequencing was performed to analyse the effects of DPP-4i and acarbose on the gut microbiota in mice fed a high-fat diet (HFD). Fecal microbiota transplantation (FMT) from type 2 diabetes patients to germ-free mice was performed to investigate the contribution of the altered microbiome to antidiabetic effects of the drugs. Fecal metabolomics was also analysed by untargeted and targeted GC–MS systems. Findings Although DPP-4i and α-glucosidase inhibitor both altered the gut microbial composition, only the microbiome modulation of DPP-4i contributed to its hypoglycemic effect. Specifically, the changes of 68.6% genera induced by HFD were rescued by DPP-4i. FMT showed that the DPP-4i-altered microbiome improved glucose tolerance in colonized mice, while acarbose did not. Moreover, DPP-4i increased the abundance of Bacteroidetes, and also promoted a functional shift in the gut microbiome, especially increasing the production of succinate. Interpretation Our findings demonstrate an important effect of DPP-4i on the gut microbiota, revealing a new hypoglycemic mechanism and an additional benefit of it. Furthermore, modulating the microbial composition, and the functional shift arising from changes in the microbiome, might be a potential strategy for improving glucose homeostasis. Fund This work was supported by grants from the National Natural Science Foundation of China (No. 81700757, No. 81471039, No. 81700714 and No. 81770434), the National Key R&D Program of China (No. 2017YFC1309602, No. 2016YFC1101100, No. 2017YFD0500503 and No. 2017YFD0501001), and the Natural Science Foundation of Chongqing (No. cstc2014jcyjjq10006, No. cstc2016jcyjA0093 and No. cstc2016jcyjA0518).
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）