ANALYTICAL LETTERS
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2024
·
IF 1.6
Yan Li,Yaru Li,Fubin Wu,Jie Zhou,Yaoyao Wang,Guoliang Li,Jing Lan,Zongshan Zhao,Rongguang Shi
Hydrogen peroxide (H2O2) is widely used in the food industry as a bactericide due to its strong oxidizing ability. However, excess H2O2 in food can lead to chronic diseases, making it necessary to develop a rapid monitoring method. An electrochemical electrode based upon a glassy carbon electrode (GCE) modified with combined covalent organic framework (COF) and amino-modified multi-walled carbon nanotubes (MWNT-NH2) has been developed. The modifier was prepared by assembling the COF onto the surface of MWNT-NH2. Under optimal conditions, the performance of the modified electrode was evaluated by differential pulse voltammetry (DPV) with a linear range from 20 to 140 μM and a detection limit of 0.14 μM. In addition, the modified electrode had good stability and reproducibility. Good selectivity in presence of potential interferences and the successful application for the determination H2O2 in environmental water and chicken feet suggest its potential for practical analysis.
研究领域:
分析化学
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电化学
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纳米材料
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环境科学
·
食品安全
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DOI
高影响因子
ELECTROANALYSIS
·
2019
·Vol. 32
·期 3
·620-625
·
IF 2.691
Xiangyu Ma,Kun Qian,Martha Kandawa-Schulz,Weimin Miao,Yihong Wang
Copper ion (Cu 2+ ) is one of the heavy metal ions which has been considered as a severe pollutant affecting the environment and human health. Therefore, it is necessary to detect Cu 2+ sensitively and conveniently in food and drinks. However, the gold standard method that inductively coupled plasma mass spectrometry (ICP-MS) is expensive equipment required and time-consuming. In this work, a highly sensitive and facile electrochemical method was studied to directly determine the concentration of Cu 2+ without cumbersome modification on the surface of glassy carbon electrode (GCE). In the presence of ferric ion (Fe 3+ ), Cu 2+ could play a role of catalyst in the detection system, and the electrochemical signal of differential pulse voltammetry (DPV) response to Cu 2+ could be amplified obviously. Under the optimal conditions, a good linear relationship was obtained in the range of 1 nM to 5 μM with a detection limit of 57.5 pM (S/N=3) were obtained. Besides, the proposed method has good applicability for the detection of Cu 2+ in tap water. Furthermore, the copper complex was detected and the results were indicated the proposed method was effective and sensitive.
研究领域:
环境科学
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分析化学
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DOI
高影响因子
IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Zhikang Rao,Boyu Guo,Jixiang Zu,Weiqiang Zheng,Ying Xu,Yuting Yang
In clinical diagnosis, the detection of dopamine (DA) is often interfered by epinephrine (EP), a neurotransmitter drug that shares a similar structure with DA, which affects the accurate prediction of DA concentration. In this study, an electrochemiluminescence (ECL) and differential pulse voltammetry (DPV) dual model biosensor combined with machine learning algorithm was proposed for improving the selective detection of DA under EP interference. First, reduced graphene and gold nanoparticles were applied to enhance the sensitivity and stability of the sensor in ECL and DPV measurement. Compared with single model sensing, the dual model sensor could combine the superiority of ECL and DPV while improving the accuracy and reliability of experimental data. Then, nine graphic features related to concentration prediction were extracted from the ECL and DPV response curves, and Pearson’s correlation coefficient (PCC), as well as random forest (RF) algorithm, was adopted for feature importance analysis. To achieve accurate signal decoupling, an intelligent biologically inspired algorithm, particle swarm optimization (PSO) algorithm, was introduced to optimize initial weights and thresholds of the traditional artificial neural network (ANN) for further model training based on multi-feature fusion, which greatly increased the prediction accuracy of DA in the presence of EP. The results demonstrated that DA could be accurately predicted in the concentration range of 9– 200 μM , and the R2 between the true and predicted values of DA concentration reached 0.99. The root-mean-square error (RMSE) and mean absolute error (MAE) of the test dataset were 5.77 and 4.32 μM , respectively. In addition, the PSO-ANN-assisted ECL-DPV dual model detection scheme has been successfully applied for the determination of DA in real samples, such as goat serum and artificial urine.
研究领域:
生物医学工程
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临床诊断
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电化学传感
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DOI
高影响因子
ANALYTICAL LETTERS
·
2023
·
IF 2
Yu Yan,Si Zeng,Fang Xu,Yongmei Hu,Haiping Huang
Acetaminophen (AP) is one of the most commonly used antipyretics. Accurate and efficient determination of its concentration is of great significance to human health. In this work, FeNi alloy nanoparticles and reduced graphene oxide (rGO) were compounded by an ultrasonic method to obtain FeNi/rGO nanocomposites. The nanocomposites were analyzed by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and cyclic voltammetry (CV). Due to the catalytic activity of FeNi alloy nanoparticles and the synergy between the high specific surface area and conductivity of reduced graphene oxice (rGO), a FeNi/rGO nanocomposite showed excellent electrocatalysis for acetaminophen determination. With differential pulse voltammetry (DPV) as the analytical method, the linear range for acetaminophen is from 1 to 100 and 100 to 3,000 μM with a limit of detection (LOD) equal to 0.3 μM. Moreover, the sensor also has good reproducibility and selectivity with high recoveries in practical analysis.
研究领域:
分析化学
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材料科学
·
电化学
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DOI
高影响因子
ANALYTICAL LETTERS
·
2023
·
IF 2
Xinyue Ma,Baozhong Zhang,Jintao He,Jingnan Jin,Min Lin,Lina Lv,Huina Zhu,Hanyu Chen,Liping Li,Baoshan He
A target-induced strand displacement (TISD) electrochemical aptasensor is reported for the sensitive determination of tobramycin (TOB). A novel substrate was synthesized by loading cerium-based metal organic framework (Ce-MOF) that was modified by Pd nanoparticles (PdNPs), onto polyethyleneimine (PEI)-modified molybdenum disulfide (MoS2). The substrate (denoted by PEI-MoS2/Ce-MOF@PdNPs) was used to modify the Au electrode (AuE) to expand the electrode surface area for subsequent cDNA loading. Gold-platinum core–shell particles (Au@Pt) loaded with aptamers (Apt) were introduced as signal tags and mimetic peroxidase to hybridize with cDNA and form a double-stranded structure. When the target was present, strand displacement dominated by TISD occurred and the signal tag was released from the electrode surface, turning the signal off. Using the optimal conditions, the linear range of the sensor was from 5 × 10−11 to 1 × 10−6 mol/L and the detection limit was 1.05 × 10−12 mol/L with good stability, reproducibility, and specificity. The aptasensor provided good performance for the determination of tobramycin in milk.
研究领域:
分析化学
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电化学
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生物传感器
·
药物分析
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DOI
高影响因子
ANALYTICAL LETTERS
·
2022
·
IF 2.267
Xing Wu,Rongbin Kang,Yiyuan Zhang,Weiming Li,Tao Zhang
The concentration of alkaline phosphatase (ALP) in serum is an important biomarker for human health, thus the development of a simple method for its determination is important. In this work, the gold nanoparticles/Ti3C2Tx (Au/Ti3C2Tx) MXenes nanohybrids were prepared via a simple self-reduction step and introduced as the sensing platform to immobilize ALP antibodies. Meanwhile, because ALP dephosphorylates 4-amino phenyl phosphate to produce electroactive 4-aminophenol (AP), a simple labeled-free immunosensor was constructed for ALP by recording the differential pulse voltammetry signal of AP. The detection conditions were optimized and the analytical performance was evaluated. Under the optimized conditions, a wide linear range (10.0 to 1500 U L−1) and low detection limit for ALP (4.0 U L−1) were achieved. Furthermore, the selectivity, stability and reproducibility of the immunosensor were investigated, demonstrating desirable results. The results show that the proposed immunosensor has potential applications for practical ALP determination.
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高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Zixuan Wang,Ganghui Chu,Juan Peng,Shiyi Chen
Internal reference probes can effectively eliminate internal and external interferences. Hence, finding a suitable internal reference probe is the key to ratiometric electrochemistry. In this study, a simple and sensitive ratiometric electrochemical sensor for the determination of rutin was prepared for the first time using rhodamine B (Rh B) as an internal reference probe. The modified electrochemical sensor was constructed by electrodepositing gold nanoparticles (AuNPs) on a glassy carbon electrode followed by drop-coating chitosan-immobilized rhodamine B (CS@Rh B). Rh B has a dual function in that it has a stable electrochemical signal (1.18 V) (vs. Ag/AgCl) that is completely separated from the oxidation peak of rutin (0.52 V) to serve as an internal reference probe. At the same time, it synergistically enhances the electrochemical signal of rutin with AuNPs. When differential pulse voltammetry was used for the determination of rutin, the current ratio of IRutin/IRh B was employed as the signal for rutin determination with a wide linear range (0.1 to 70 μM) and a low detection line (0.028 μM). The recoveries for the determination of rutin in Coreopsis tinctoria and Buckwheat tea were 95.4%–106% and 95.3%–104%, respectively. This work successfully demonstrated the feasibility of Rh B as an internal reference probe.
研究领域:
分析化学
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电化学传感器
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DOI
高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2020
·Vol. 51
·期 2
·307-316
·
IF 2.384
Feng Yanlong,Wang Fuyue,Wang Luyu,Guo Manli,Lei Yanming,Feng Ye,Cao Yujuan,Yu Ying
Abstract Three-dimensional porous carbon network (3D-C) was used as the substrate for the in situ growth of molybdenum disulfide (MoS 2 ) through a wet chemistry method. The obtained 3D-C@MoS 2 nanocomposite exhibited a porous structure, high surface area and good electrical conductivity. By using the 3D-C@MoS 2 nanocomposite as a novel electrode modifier, the electrochemical oxidation peak current of bisphenol A (BPA) was greatly enhanced with a lowered background current. The improved sensitivity benefits from adsorption of BPA onto MoS 2 surface, the large surface area and good conductivity of the 3D-C@MoS 2 nanohybrid. By using differential pulse voltammetry (DPV), we observed a good linearity with BPA levels in the range of 0.001–10 μM, with a detection limit estimated to be 0.5 nM (S/N = 3). The 3D-C@MoS 2 modified electrode could be reused for several times in spite of the accumulation of BPA, and the fabrication reproducibility is excellent. The prepared 3D-C@MoS 2 modified electrode showed higher selectivity to BPA than several other phenolic compounds due to their different electrochemical oxidation potentials and the enhanced accumulation property of BPA at the 3D-C@MoS 2 surface. The BPA contents in plastic product and environmental water samples were determined with the proposed method. Graphic abstract
研究领域:
材料科学
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分析化学
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环境科学
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DOI
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Nana Feng,Yuguo Wang,Wei Li
A rapid and simple solid-state microwave method was used for the synthesis of a ternary nanocomposite comprising nickel sulfide/nickel oxide/carbon nanotubes (NiSx/NiO/CNT). This nanocomposite was subsequently utilized for the electrochemical determination of melamine. Various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDX), X-ray diffraction (XRD), and Raman spectroscopy, were employed to characterize the structure and morphology of the material. Additionally, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were utilized to investigate the electrochemical properties. The results indicated that the NiSx/NiO/CNT nanocomposite electrode demonstrated a favorable electrochemical reactivity toward melamine. It displayed a linear range from 10 to 2000 μg/L, a detection limit (DL) as low as 0.017 μg/L, and a sensitivity of up to 83.5 μA/(μM·cm2). The NiSx/NiO/CNT composite demonstrated the ability to detect trace melamine in milk samples, demonstrating its practical application.
研究领域:
材料科学
·
分析化学
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2023
·
IF 2
Hongdan Wang,Wei Yuan,Liqiu Zhang,Baogang Xie,Qiong Cheng,Ningwen Zhang
To precisely detect CA199 antigen, a novel electrochemical immunosensor based on horseradish peroxidase (HRP) and glucose oxidase (GOD) double enzyme system was prepared. Thiol was adsorbed on the surface of nano-octahedral gold through Au-S self-assembly; the second antibody was labeled by glutaraldehyde ligase as a signal amplification reagent. Amino magnetic microspheres were used to connect GOD and bovine serum albumin (BSA) through glutaraldehyde. The biosensor displayed low detection limits of 0.2 U/mL and wide linear range (0.5–200 U/mL). This novel immunosensor improves the sensitivity of current detection, showing promising application prospects in the clinical immunoassay detection of CA199.
研究领域:
生物医学工程
·
临床检验
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DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-13
·
IF 5.3
Wang Yuefan,Chen Yinzhi,Zhou Yuhe,Wang Yilin,Wu Yingjie,Xie Yixi,Zhao Pengcheng,Hu Xiayi,Fei Junjie
Rutin extracted from natural plants has important medical value, so developing accurate and sensitive quantitative detection methods is one of the most important tasks. In this work, HKUST-1@GN/MoO 3 -Ppy NWs were utilized to develop a high-performance rutin electrochemical sensor in virtue of its high conductivity and electrocatalytic activity. The morphology, crystal structure, and chemical element composition of the fabricated sensor composites were characterized by SEM, TEM, XPS, and XRD. Electrochemical techniques including EIS, CV, and DPV were used to investigate the electrocatalytic properties of the prepared materials. The electrochemical test conditions were optimized to achieve efficient detection of rutin. The 2-electron 2-proton mechanism, consisting of several rapid and sequential phases, is postulated to occur during rutin oxidation. The results show that HKUST-1@GN/MoO 3 -Ppy NWs have the characteristics of large specific surface area, excellent conductivity, and outstanding electrocatalytic ability. There is a significant linear relationship between rutin concentration and the oxidation peak current of DPV. The linear range is 0.50–2000 nM, and the limit of detection is 0.27 nM (S/N = 3). In addition, the prepared electrode has been confirmed to be useful for rutin analysis in orange juice. Graphical Abstract
研究领域:
分析化学
·
材料科学
·
电化学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL LETTERS
·
2023
·
IF 2
Jie Zhang,Yulin Fu,Lin Li,Liqiang Yan,Xiongzhi Wu,Chenghong Lei
Ascorbic acid (AA) determination is of high importance in the diagnosis and treatment of diseases. Herein, we report a new ratiometric electrochemical sensor for ascorbic acid using a glassy carbon electrode (GCE) modified with a copper nanoparticle@resin nanosphere nanocomposite (CuNPs@RNS). The ratiometric strategy was established by immobilizing an internal reference (thionine) on the modified electrode using cyclic voltammetry (CV). The performance of the modified electrodes as well as the newly established ratiometric strategy was explored. The sensing platform had good electrocatalytic ability, reproducibility, and stability. In addition, the ratiometric strategy significantly improved the performance of electrochemical sensing with a wide linear range (0.0837 to 15.5 μM) and a low detection limit of 0.0279 μM under the optimal conditions. The original ratiometric electrochemical sensor was successfully applied to monitor ascorbic acid in tablets and urine. These results showed that the sensor provides a new strategy and broad prospects for biomolecular sensing with reliability and high sensitivity.
研究领域:
分析化学
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生物医学工程
·
电化学传感
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）