ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2024
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IF 10.8
Qian Bao,Yi Yang,Dahang Shen,Feiyang Ye,Jiageng Yu,Osama Alam,Wei Wang
Decabromodiphenyl ethane (DBDPE), a key alternative to deca-BDE (BDE-209), has been ubiquitous in the receiving ecosystem. However, little is known about its uptake process and fate in plants. Here, the plant absorption, distribution, and metabolism of 14C-DBDPE under two distinct exposure pathways (i.e., soil-root and airborne dust-leaf) were investigated with three vegetables (cherry radish, water spinach, and eggplant). DBDPE was absorbed and primarily accumulated in directly exposed roots and leaves, with translocation factors to other tissues of 0.04–0.77 and 0.73–12.80 × 10–3, respectively. DBDPE in exposed leaves was more difficult to transport as most DBDPE did not enter the interior of the leaves but was stored in waxes (>90%). Furthermore, DBDPE within leaves was found to enter mostly through waxy layer penetration (>97%). The majority of 14C-DBDPE was localized in cell walls (52.6 and 75.6%, respectively) and organelles (22.7 and 45.5%, respectively) of exposed tissues, substantially restricting its in-plant translocation. Debrominated products were detected in exposed roots, but barely found in exposed leaves, as most DBDPE was blocked by the waxy layer. Moreover, DBDPE was stable in soils and dust without degradation. Our findings contribute to a deeper understanding of the environmental fate of DBDPE in soil-plant and airborne dust-plant systems.
研究领域:
环境科学
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植物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SOILS AND SEDIMENTS
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2025
·
IF 3
Jin Meiqing,Sun Yuanchao,Chai Bing,Wang Minghu,Wu Yuping,Wu Weihong,Zhou Qingwei,Qiu Linlin,Du Jia,Fu Li
Purpose Decabromodiphenyl ethane (DBDPE) and lead (Pb), two prevalent contaminants in e-waste dismantling areas, pose significant threats to soil ecosystem health. However, the ecotoxicological effects of their co-exposure on soil invertebrates remain poorly characterized. Methods Avoidance behavior, survival rate, and growth-inhibition assays were performed to assess the combined toxic effects of DBDPE and Pb on earthworm ( Eisenia fetida ) in an artificial soil system over exposure periods of 7–21 d. Responses from multiple biochemical biomarkers, including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione S-transferase (GST), and acid phosphatase (ACP) were also measured, and the data were integrated by the biomarker response index (BRI). Interaction between Pb and DBDPE on BRI was further analyzed by calculation of effect addition index (EAI). Results Avoidance behavior emerged as the most sensitive endpoint and exhibited concentration-dependent escalation under co-exposure conditions. While individual exposure to DBDPE (0–0.75 mg/kg) induced negligible impacts on growth and mortality, its combination with Pb (1000 mg/kg) resulted in significant synergistic effects. Similarly, biochemical biomarkers—including SOD, CAT, MDA, GST, and ACP—showed markedly greater alterations in co-exposure groups compared to single DBDPE treatments. The BRI revealed only slight alterations in biological health across most treatments. The EAI values indicated that antagonistic effects dominated the interaction between DBDPE and Pb. Conclusion Our findings demonstrated significant variation in biomarker sensitivity to pollutant exposure. Notably, short-term sub-lethal co-exposures may elicit synergistic effects on avoidance, growth, and mortality, revealing a time-concentration toxicity dependency. These results provide novel insights into the interaction between heavy metals and organo-pollutants and highlight the ecological hazards posed by emerging brominated flame retardants (e.g., DBDPE) in heavy metal-contaminated soil systems.
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Lumei Xie,Hongli Liu,Xinyue Hu,Jiacheng Xu,Bingdi Chao,Jie Wang,Lujia Sun,Xiyao Liu,Niya Zhou,Luming Sun,Hongbo Qi,Xin Luo
Decabromodiphenyl ethane (DBDPE), a newly emerging brominated flame retardant (BFR), has garnered increasing attention due to its high production volumes and widespread usage, prompting worries about its possible impacts on human well-being. Prior investigations have highlighted the substantial toxicity of DBDPE to the thyroid, liver, and cardiovascular systems, yet its effects on fetal growth and development remain inadequately understood. This investigation aims to elucidate the underlying mechanisms and consequences of DBDPE exposure on fetal growth and development through both in vivo and in vitro models. Pregnant mice were administered DBDPE orally at doses of 0, 0.05, 0.5, and 5 mg/kg bw/day. Results revealed that gestational DBDPE exposure caused placental damage, resulting in fetal growth restriction (FGR). A significant reduction in the phosphorylation level of AIFM1 Ser116 in placental trophoblasts was observed, specifically correlating with the activation of oxeiptosis. Metabolomic and transcriptomic analyses further suggested that DBDPE exposure disrupts the oxidative phosphorylation (OXPHOS) pathway, thereby impairing mitochondrial function. Notably, treatment with MitoQ, a mitochondria-targeted antioxidant, effectively reversed DBDPE-induced oxeiptosis in placental trophoblasts, alleviating the negative effects of DBDPE on placental damage and FGR. Mechanistically, the mitochondrial dysfunction induced by gestational DBDPE exposure initiates oxeiptosis in placental trophoblasts, exacerbating placental injury and ultimately leading to FGR. In summary, this study integrates the roles of environmental pollutants, oxeiptosis, and mitochondrial dysfunction, offering new insights into the toxicological mechanisms by which DBDPE and other emerging pollutants impact fetal growth and development.
研究领域:
环境毒理学
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生殖生物学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2022
·
IF 13.352
Chen Wang,Lingjun Zeng,Yeyong Li,Chongli Shi,Yi Peng,Ruolin Pan,Mengyan Huang,Susu Wang,Jin Zhang,Hui Li
As a major alternative to traditional brominated flame retardants (BFRs), decabromodiphenyl ethane (DBDPE) is widely used and has been commonly detected in various environmental media and organisms. Few previous studies have focused on DBDPE-induced locomotion neurotoxicity, and the exact molecular mechanisms and related health risks remain unclear. In this study, we first analyzed the locomotion indicators of nematodes following DBDPE exposure, demonstrated that DBDPE caused locomotion neurotoxicity, and identified that a series of the transthyretin (TTR)-like genes participated in the regulation of nematode motility by transcriptomic analysis, gene transcription validation and TTR-like mutant verification. Subsequently, this study demonstrated that DBDPE exacerbated amyloid-beta (Aβ) deposition by repressing TTR/TTR-like gene transcription based on Alzheimer’s disease (AD) model nematodes and human SH-SY5Y cells following DBDPE exposure and further revealed that DBDPE reduced the binding between TTR and Aβ by competing with the strand G region sites on the TTR/TTR-like protein, ultimately exacerbating Aβ deposition and the risk of AD. In short, our study demonstrated that DBDPE induced locomotion neurotoxicity and potential AD risks through intensifying Aβ deposition by inhibiting TTR/TTR-like proteins, providing reference support for risk management and policy formulation related to DBDPE and similarly structured novel BFRs.
研究领域:
环境科学
·
毒理学
·
神经生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）