Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-10
·
IF 38.104
Wu Jiajing,Nie Jianhui,Zhang Li,Song Hao,An Yimeng,Liang Ziteng,Yang Jing,Ding Ruxia,Liu Shuo,Li Qianqian,Li Tao,Cui Zhimin,Zhang Mengyi,He Peng,Wang Youchun,Qu Xiaowang,Hu Zhongyu,Wang Qihui,Huang Weijin
Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment. To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine, the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared. The neutralization activities of Alpha, Beta and Gamma variants’ spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant, which were constructed using pseudotyped viruses. Meanwhile, the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants. Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019. Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds, whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold. Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results. This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain.
研究领域:
病毒学
·
免疫学
·
流行病学
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DOI
PubMed
高影响因子
International Journal of Polymer Science
·
2018
·
IF 1.718
Ruijiang Li,Peng Wang,Haohao Ren,Hong Li,Zhengwen Ding,Yonggang Yan
Poly(delta-gluconolactone) (PGL) and poly(delta-gluconolactone--caprolactone) (P(GL-CL)) were synthesized through ring-opening polymerization (ROP) and characterized by FT-IR, NMR, XRD, intrinsic viscosity, GPC, DSC, and TGA. The crystallinity of P(GL-CL) with various d-GL/CL ratios (d-GL/CL = 5 : 5, 4 : 6, 3 : 7, 2 : 8, and 1 : 9) was 12.09 to 59.78% while PGL was amorphous. Melting temperature () of these polymers was 49.8 to 62.0°C and decomposition temperature was 282 to 489°C depending on the d-GL/CL ratios. In addition, all these polymers were degradable and the degradation rates could be controlled by adjusting d-GL/CL ratios. These results indicated that PGL and P(GL-CL) might be promising novel absorbable materials.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Heliyon
·
2024
·
IF 3.4
Quang Nhat Tran,Nhi Ngoc Thi Vo,Thao Thi Pham,Hai Son Truong-Lam
Freshwater scarcity is a critical issue in Vietnam, particularly in the Mekong Delta, a densely populated region with an agriculture-based economy. This scarcity is largely driven by saltwater intrusion during the dry season, severely affecting both agriculture and the local economy. In response, advanced desalination technologies have been proposed. In this study, we investigated the use of cyclopentane (CP), a liquid guest molecule, and 1,1,1,2-tetrafluoroethane (R134a), a gaseous guest molecule, as hydrate formers to desalinate saline water from the Mekong Delta. This study aimed to evaluate and compare the freshwater recovery efficiencies of these hydrate formers and assess the potential of hydrate technology for practical application in the region. We performed thermodynamic and kinetic investigations on sodium chloride solutions (1.0–3.5 wt%), representing the salinity levels of seawater in the Mekong Delta, to establish a laboratory-scale desalination system. The results showed a consistent thermodynamic trend: the higher concentration of samples leads to the longer time of hydrate formation to achieve the conversion of water into hydrates exceeding 60 %. Additionally, the CP and R134a hydrate structures were characterized using Raman spectroscopy, which revealed significant changes in the water peak and C–H band signal during the hydrate formation process. After a single-stage hydrate treatment using CP and R134a, the removal efficiencies for ions and total dissolved solids in saline water samples from the Mekong Delta exceeded 75 % and 70 %, respectively. These findings serve as a reference for developing a larger-scale hydrate-based desalination technology to address the challenges of saltwater intrusion in the Mekong Delta region.
研究领域:
环境科学
·
化学工程
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DOI
PubMed
高影响因子
Materials Futures
·
2022
·Vol. 1
·期 4
·045201
·
IF 0
Kangqiao Cheng,Wei Xie,Shuo Zou,Huanpeng Bu,Jin-Ke Bao,Zengwei Zhu,Hanjie Guo,Chao Cao,Yongkang Luo
Rhodium-containing compounds offer a fertile playground to explore novel materials with superconductivity (SC) and other fantastic electronic correlation effects. A new ternary rhodium-antimonide La2Rh_{3+\delta}Sb4 (\delta\approx 1/8) has been synthesized by a Bi-flux method. It crystallizes in the orthorhombic Pr2Ir3Sb4-like structure, with the space group Pnma (No. 62). The crystalline structure appears as stacking the two-dimensional RhSb4- and RhSb5-polyhedra networks along b axis, and the La atoms embed in the cavities of these networks. Band structure calculations confirm it as a multi-band metal with a van-Hove singularity like feature at the Fermi level, whose density of states are mainly of Rh-4d and Sb-5p characters. The calculations also imply that the redundant Rh acts as charge dopant. SC is observed in this material with onset transition at T_c^\mathrm{on}\approx 0.8 K. Ultra-low temperature magnetic susceptibility and specific heat measurements suggest that it is an s-wave type-II superconductor. Our work may also imply that the broad Ln_2Tm_{3+\delta}Sb4 (Ln = rare earth, Tm = Rh, Ir) family may host new material bases where new superconductors, quantum magnetism and other electronic correlation effects could be found.
研究领域:
凝聚态物理学
·
材料科学
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DOI
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 317
·期 3
·1399-1408
·
IF 1.181
Yang Chao,Zhong Yilong,Li Lei,Ren Xuemei,Sun Yuan,Niu Deqing,Liu Yang,Yin Maowei,Zhang Dafeng
In present paper, delta manganese dioxide is prepared with a hydrothermal method, and the adsorption is investigated with a batch method. The maximum sorption capacity for uranium and lead are calculated to be 41.32 and 492.61 mg g −1 respectively. Pseudo-second-order kinetic is proved to regulate the sorption kinetics, and Langmuir equation fits well with the isotherms. Results show that the mechanism of sorption is controlled by cation exchange and inner-sphere surface complexation. The study provides basic data for revealing the adsorption kinetics, rate-controlling mechanisms, and thermodynamic parameters of the adsorption process.
研究领域:
环境科学
·
化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MIDDLE EAST STUDIES
·
2018
·Vol. 50
·期 3
·405-425
·
IF 0.911
Caterina Scaramelli
This article analyzes the transformation of the Kızılırmak Delta on the Black Sea coast of Turkey into a Turkish wetland. This production involved the transformation of international categories of wetlands into national imaginaries, as well as the material remaking of landscapes themselves. Population and agro-economic shifts concurrent to the formation of the Turkish nation-state transformed the delta into an agricultural landscape, and subsequently into a contested conservation area whose use is informed by changing Turkish and international notions of wetlands. I focus on the situated, local processes and practices through which wetlands are produced and become relevant to different social groups as subjects of scientific knowledge and environmental imaginations. These, I argue, have rendered the wetland an open-air laboratory and an object of care for environmental advocates, scientists, and residents.
研究领域:
环境人类学
·
生态学
·
地理学
·
环境政策
·
农业研究
·
自然保护
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Hong Sun,Jingli Yang,Xue Lin,Congfa Li,Yongjin He,Zhigang Cai,Guoyin Zhang,Hao Song
Delta-tocotrienol as a vitamin E isomer has received much attention because of its diverse biomedical applications. Microbial biosynthesis of delta-tocotrienol is a promising strategy for its economic and environmental advantages. Here, we accomplished complete biosynthesis of delta-tocotrienol in Saccharomyces cerevisiae from glucose. We first constructed and incorporated a heterologous pathway into the genome of S. cerevisiae by incorporating the genes hpd (from Pseudomonas putida KT2440), hpt (from Synechocystis sp. PCC 6803), and vte1 (from Arabidopsis thaliana) for the biosynthesis of delta-tocotrienol. We further enhanced the biosynthesis of the precursor geranylgeranyl diphosphate by overexpressing the thmg1 and ggppssa (from Sulfolobus acidocaldarius) genes, leading to a production titer of delta-tocotrienol of 1.39 ± 0.01 mg/L. Finally, we optimized the fermentation medium using the response surface methodology, enabling a high-titer production of delta-tocotrienol (3.56 ± 0.25 mg/L), ∼2.6-fold of that of the initial culture medium. Fed-batch fermentation in a 2 L fermenter was further used to enhance the production titer of delta-tocotrienol (4.10 ± 0.10 mg/L). To the best of our knowledge, this is the first report on the de novo biosynthesis of delta-tocotrienol in S. cerevisiae, and the highest titer obtained for microbial production of delta-tocotrienol.
研究领域:
生物技术
·
微生物学
·
代谢工程
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DOI
PubMed
高影响因子
Toxics
·
2025
·Vol. 13
·期 11
·1004
·
IF 4.1
Yong’an Chen,Zhenxian He,Haochuan Wu,Xueqin Tao,Xiaolong Yu,Xiaojun Niu,Jianteng Sun
Excessive antibiotic use and their release into soils leads to alterations in soil processes, adversely affecting terrestrial organisms and presenting a serious threat to crop growth and productivity. Herein, the spatial patterns and prevalence of 22 typical antibiotics in agricultural soils throughout the Pearl River Delta area of China. In addition, the contamination characteristics and health risks were evaluated by integrating ArcGIS 10.7 spatial analysis, spearman correlation, and Risk Quotient (RQ) modeling. Antibiotics were detected in all the 240 soil samples with the total concentrations ranging from ND to 897 μg·kg−1dry weight. The concentrations of seven antibiotic classes followed the order: quinolones (21.0 μg/kg) > β-lactams (15.1 μg/kg) > tetracyclines (9.65 μg/kg) > sulfonamides (3.91 μg/kg) > macrolides (0.26 μg/kg) > chloramphenicol (0.18 μg/kg) > lincosamides (0.03 μg/kg). Among the 240 sampling sites, quinolone antibiotics had the highest average contribution rate (41.89%), followed by β-lactams (30.09%), tetracyclines (19.28%), sulfonamides (7.81%), macrolides (0.52%), and chloramphenicol (0.36%), while lincomycin had the lowest contribution rate (0.06%). Spatial distribution demonstrated a significant positive correlation with per capita livestock/poultry product consumption, while 82.5% of sampling sites exhibited medium-high ecological risk primarily linked to livestock, poultry, and aquaculture. Quinolones, β-lactams, and tetracyclines were identified as the dominant ecological risk drivers in current regions. Mitigation requires synergistic measures including regulated veterinary drug use in aquaculture, enhanced manure treatment, and pollution remediation systems. These findings provide a scientific basis for supervising antibiotic pollution in agriculture soil and improving the sustainability and health of soil in the Pearl River Delta.
研究领域:
环境科学
·
土壤生态学
·
污染评估
·
环境风险评估
·
农业环境管理
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2022
·
IF 6.556
Bin Yang,Xiaowei Zeng,Jin Zhang,Jilie Kong,Xueen Fang
Delta (B.1.617.2), a highly infectious variant of SARS-CoV-2, has been sweeping the world, and threatening the safety of human life seriously. It is urgent to develop a highly selective and sensitive assay to accurately identify the SARS-CoV-2 variant Delta. In this work, we constructed a graphene/CRISPR-dCas9 electrochemical biosensor to accurately identify SARS-CoV-2 variant Delta, where the signal was further amplified by embedded electrochemical probe [Ru(phen) 2 dppz]BF 4 . This detection assay could be finished within 47 min totally, with the detection limit of 1.2 pM and good reproducibility with a C·V.% of 2.48% (n = 5). And the biosensor could selectively identify Delta among SARS-CoV-2 and other variants, including Alpha, Beta, Gamma. This assay was further validated by 26 real clinical samples, showing 100% clinical sensitivity and 100% clinical specificity, which provides a new direction for identifying other SARS-CoV-2 variants in the future.
研究领域:
生物技术
·
电化学
·
分子生物学
·
病毒学
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DOI
PubMed
高影响因子
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·Vol. 122
·期 3
·e70184
·
IF 2
Wang-Xi Shen,Jia-Min Yu,Xin-Yi Liu,Yu-Xing Zhang,Mao-Ye Li,De-Xin Chen,Su Liu
Glutathione S -transferases (GSTs) constitute a critical enzyme superfamily responsible for xenobiotic detoxification in insects. The green peach aphid, Myzus persicae , is a globally significant agricultural pest that has exhibited declining field susceptibility to λ-cyhalothrin (LCT), a widely applied pyrethroid insecticide. While elevated GST activity has been correlated with LCT tolerance in various aphid populations, the precise molecular mechanisms driving this process have not been fully elucidated. In this study, we functionally characterized a delta-class GST gene (designated MpGSTd1 ) from M. persicae . The encoded protein possesses hallmark structural motifs of the GST family, including distinct glutathione-binding (G-site) and hydrophobic substrate-binding (H-site) pockets. Transcriptional profiling revealed maximal MpGSTd1 expression during the late nymphal to adult stages, and its transcript levels were markedly induced following LCT challenge. Biochemical analysis of the recombinant MpGSTd1 protein confirmed its catalytic competency toward the model substrate CDNB, exhibiting a V max of 0.91 µmol/min/mg and a K m of 2.73 mM. Notably, LCT exposure inhibited the enzyme's activity in vitro with an IC 50 of 0.02 mM, and high-performance liquid chromatography (HPLC) assays demonstrated that MpGSTd1 can directly deplete LCT by 11.4%. Furthermore, RNA interference (RNAi)-mediated suppression of MpGSTd1 in vivo significantly elevated aphid mortality upon subsequent LCT exposure. Collectively, these findings delineate an essential role for MpGSTd1 in modulating LCT susceptibility in M. persicae and underscore its potential utility as a molecular target for future aphid management strategies. Summary A delta-class GST from Myzus persicae was characterized. MpGSTd1 transcription is induced by LCT exposure. Recombinant MpGSTd1 depletes LCT in vitro . Knockdown of MpGSTd1 increases insect susceptibility to LCT.
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DOI
PubMed
高影响因子
Systems
·
2022
·Vol. 10
·期 1
·16
·
IF 2.895
Chunmei Zhang,Ziwen Feng,Qilong Ren,Wei-Lng Hsu
Ecological land has two definitions: the broad category and the narrow category. This paper studied the narrow category, which refers to the land whose main purpose is to provide ecological services, such as environmental regulation and biological conservation. Ecological land areas are likely to decrease with the development of urbanisation all over the world, which poses potential risks to the environment, society, and public health, and low utilisation efficiency of ecological land will exacerbate this risk. Based on the actual input–output situation of ecological land utilisation, we constructed an index system in the Yangtze Delta to measure the ecological land utilisation efficiency with a Slack-Based Model (SBM) in the data envelopment analysis (DEA). The results revealed that the comprehensive efficiency exhibited an increasing trend from 2012 to 2020, and more high-efficiency cities appeared in the areas closer to Shanghai. Both the technical efficiency and scale efficiency increased over the research period. The technical efficiencies in most cities were efficient and equal to the scale efficiencies. Among the remaining cities, the technical efficiencies and scale efficiencies were inefficient and not synchronous. In addition, we found that the that poor efficiencies of some cities can mainly be attributed to low-technology, an unsuited-scale, or a combination of these. In the future, improvement should be focused on the economical and intensive use of ecological land, technical innovations, and the optimal scale. The present results can provide references for making scientific decisions regarding the efficient utilisation of ecological land in the Yangtze Delta and other similar rapid-urbanization areas.
研究领域:
环境科学
·
城市规划
·
系统建模
·
可持续发展
·
土地利用管理
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DOI
高影响因子
SAGE Open
·
2022
·
IF 2.032
Yue Gong,Yanning Wei
Constrained by the hukou system and market mechanisms, Chinese rural migrants normally live in dormitories and urban villages (villages-in-the-city or chengzhongcun) quite distinct from the dwellings of more privileged social groups yet they are often located quite close together. This pattern may be described as a hukou-based yet market-driven form of residential segregation. This paper addresses an extreme level of segregation in China’s newest urban developments. By examining six key development zones in the Pearl River Delta (PRD), this paper argues that besides hukou and the market, urban planning contextualized in state-market engagement and socialist features is a crucial factor creating extreme residential segregation in these zones. This paper also argues that two planning instruments—large-scale land use zoning and the provision of public housing to migrants—play a significant role in creating segregation. The extreme segregation created by the state’s dominant planning practices in new urban developments demonstrates a transformation of China’s prevalent market-driven segregation.
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DOI
高影响因子
危险品化学品经营许可证（带存储）