In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.
Recent efforts have focused on preparing drug-loaded hydrogel for wound healing. In order to obtain an ideal hydrogel dressing for skin wound repair, a carboxymethyl chitosan-gelatin hydrogel was prepared for co-delivery of SP (substance P) and DMOG (dimethyloxallyl glycine) by a chemical cross-linking method using genipin as the cross-linking agent. The synthesized hydrogels have good biocompatibility and physicochemical properties due to the low toxicity of the hydrogel material. The three-dimensional network structure of the hydrogels supports cell migration and proliferation, and the combination of SP and DMOG drugs exhibited strong effects on cell proliferation. Moreover, the co-loaded drug hydrogels could significantly promote wound healing in vivo, and provide a potential hydrogel for wound healing.
Introduction: Bone tissue engineering is considered the ideal approach for bone repair. Mesoporous bioactive glass (MBG) possesses the characteristics of high drug-loading capacity and bioactivity. Low-intensity pulsed ultrasound contributes to promoting fracture healing and bone defect repair, and dimethyloxalyl glycine (DMOG) is a small molecular inhibitor that can suppress prolyl hydroxylase, reducing the degradation of hypoxia-inducible factor. Methods: In this study, we proposed to prepare DMOG-loaded MBG/poly(D,L-lactide) composite scaffolds (DMOG-MBG/PDLLA) for promoting bone repair. The effects of ultrasound stimulation and DMOG release on the cell responses of rat bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) and bone repair in vivo were investigated. Results and Discussion: The results showed that both ultrasound stimulation and DMOG release could promote the proliferation, adhesion and differentiation of BMSCs and HUVECs, respectively. After the implantation of scaffolds in rat cranial bone defect model for 8 weeks, the results indicated that the combined ultrasound stimulation and DMOG release contributed to the highest ability for promoting bone repair. Hence, the DMOG-MBG/PDLLA scaffolds with ultrasound stimulation are promising for application in bone repair.
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