JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
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2025
·
IF 3.1
Jianping Mu,Ran Hai,Yupeng Yang,Mingzhe Zhao,Cong Li,Ding Wu,Hongbin Ding
Tungsten impurities deposited on the plasma-facing components (PFCs) of the inner walls of tokamak devices pose a significant risk to steady-state operation and safety. Nevertheless, a quantitative chemical analysis of the co-deposited layer on PFCs is a critical task. Laser-induced breakdown spectroscopy (LIBS) is a promising technique for assessing the deposition of impurities on PFCs, enabling in-situ monitoring, real-time analysis, and simultaneous detection of all elements. However, the accuracy of the quantitative analysis is affected by the effects of the material matrix. Diffuse reflectance spectroscopy (DRS) provides complementary information about the material matrix, such as optical properties. Herein, we present a novel data fusion model of LIBS and DRS techniques, providing more accurate results compared to the models based on each of these single methods. 66 standard samples were prepared to simulate the impurities deposited on PFCs in EAST. 15 samples were randomly selected as prediction set, while the remaining 51 samples were used as calibration set. The average relative errors of the data fusion model for W, Li, Fe, and O were 2.23, 1.95, 2.08, and 0.39%, respectively. Compared with the single LIBS data model, the root mean square errors of prediction(RMSEP) of four elements W, Fe, Li, and O in the data fusion model are reduced by 19.4, 18.5, 21.4, and 20.9%, respectively. The results show that the fusion of LIBS and DRS data enables an improved quantitative analysis of co-deposited impurities on PFCs.
研究领域:
光谱学
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等离子体诊断
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材料分析
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核聚变
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分析化学
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DOI
高影响因子
Games and Culture
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2024
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IF 2.4
Ahmed Al-Rawi
This article critically explores the historical representation of the Middle East in video games until 2002 and following the 9/11 event. Using thematic analysis, we identify four main themes and discuss how this representation shifts with time, offering a brief overview of the broader context. I argue that there is a clear association between political developments and this western representation, for we can clearly observe changes from the romantic, exotic, and orientalist views of the region and Arab and Muslim figure shown within the realms of the Arabian Nights theme to a more militant figure and dangerous place due to featuring armed conflict in the Middle East such as the first Gulf War. Though not included in the discussion, 9/11 introduced a more negative and Islamophobic representation that is associated with Islamist terrorism, and it marks the latest development in these themes.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Xinyu Huang,Meng Li,Yurui Xu,Jikang Zhang,Xia Meng,Xueying An,Lei Sun,Leilei Guo,Xue Shan,Junliang Ge,Jiao Chen,Yadong Luo,Heming Wu,Yu Zhang,Qing Jiang,Xinghai Ning
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute respiratory syndrome-like illness with high pathogenicity and mortality due to the lack of effective therapeutics. Currently, only few antiviral agents are available for the treatment of MERS, but their effects have been greatly impaired by low antiviral activity, poor metabolic stability, and serious adverse effects. Therefore, the development of effective treatment for MERS is urgently needed. In this study, a series of heptad repeat 1 (HR1) peptide inhibitors have been developed to inhibit HR1/HR2-mediated membrane fusion between MERS-CoV and host cells, which is the major pathway of MERS-CoV-induced host infections. Particularly, peptide pregnancy-induced hypertension (PIH) exhibits potent inhibitory activity with IC50 of 1.171 μM, and its inhibitory effects can be further increased to 10-fold by forming a gold nanorod complex (PIH-AuNRs). In addition, PIH-AuNRs display enhanced metabolic stability and biocompatibility in vitro and in vivo and, therefore, effectively prevent MERS-CoV-associated membrane fusion. In summary, PIH-AuNRs represent a novel class of antiviral agents and have a great potential in treating MERS in the clinic.
研究领域:
病毒学
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纳米医学
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药剂学
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DOI
PubMed
高影响因子
ACTA OCEANOLOGICA SINICA
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2014
·Vol. 33
·期 9
·100-108
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IF 0.684
Kang Xuming,Liu Sumei,Zhang Guoling
Cold diffusion methods are used to separate and quantify the three reduced inorganic sulfur species into acid volatile sulfide (AVS), pyrite-S and element sulfur (ES) in the sediments of the Yellow and East China Seas. The results show that up to 25.02 μmol/g of AVS, 113.1 μmol/g of pyrite-S and 44.4 μmol/g of ES are observed in the sediments of the Yellow Sea and East China Sea. Pyrite-S is the predominant sulfide mineral in the sediments, while the concentration of AVS is quite low at most stations in the study area. The amounts and reactivity of organic matter are the primary limited factor for the sulfide formation, while an iron limitation and a sulfate limitation are not observed in the sediments of the Yellow Sea and East China Sea. The irregular profiles of the three reduced inorganic sulfur species also reflected the comprehensive influence of sediment composition and sedimentation rates.
研究领域:
海洋学
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环境科学
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DOI
高影响因子
MARINE POLLUTION BULLETIN
·
2025
·
IF 4.9
Shuai Sun,Xing Liu,Wenbin Yuan,Yun Luo,Xiumei Sun,Yanhui Ao,Lei Wang,Ningbo Geng
Benzotriazole ultraviolet absorbers (BUAs) are regarded as emerging contaminants due to their persistent, bioaccumulative, and toxic (PBT) or very persistent and very bioaccumulative (vPvB) properties, raising concerns about their presence in aquatic environments. This study explored BUAs in the northwest nearshore of the East China Sea, revealing their prevalent occurrence in both seawater and sediments. The total concentrations of eight BUAs ranged from 4.96 to 620 ng/L in seawater and from 7.41 to 131 ng/g dry weight in sediments. Their distribution between sediments and seawater was basically dependent on log K ow, though UV-P presented an unusual preference for sediment due to its lower steric hindrance. Environmental factors had limited effects on BUAs distribution, and their decreasing concentrations from nearshore to offshore indicate terrestrial inputs and coastal anthropogenic activities are the primary sources of marine BUAs. Results of the initial ecological risk assessment suggested the occurrence of BUAs may pose potential ecological risks to the local marine environments. This study provides an overview of BUAs spatial distribution in the northwest nearshore of the East China Sea, emphasizing the urgent need for toxicological studies to fully understand their potential risks and establish regulatory measures for mitigating coastal pollution.
研究领域:
环境科学
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海洋环境学
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污染物生态毒理学
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环境化学
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近岸生态系统
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
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2025
·
IF 7.7
Li-Xin Kou,Xiao-Yu Zhang,Zi-Cen Zuo,Na Liu,Zhen He,Gui-Peng Yang
Polyhalogenated carbazoles (PHCZs), an emerging class of halogenated organic pollutants, have been widely detected in various environmental media, including sediments, soil, air, and organisms. The East China Sea (ECS) is a vital region for marine and fishery resource development in China, yet research on the pollution levels and sources of PHCZs in its sediments remains limited. This study reports the occurrence of seven PHCZs in the surface sediments of the ECS, with detection rates exceeding 90%. The concentrations of Σ 7 PHCZs ranged from 3.5 to 27 ng/g, with an average of 9.9 ng/g. The predominant congeners were 1368-BCZ and 3-ICZ. The sources of PHCZs included a non-specific source transported via terrestrial runoff (39%), industrial wastewater discharge (35%), and optoelectronic material pollution (26%), as identified by the positive matrix factorization model. The ecological risk assessment, based on TEQ, indicated a range of 0.18–5.0 pg TEQ/g across the study area. These findings highlight the potential ecological concerns associated with PHCZs in the ECS and emphasize the need for enhanced environmental monitoring and source mitigation efforts to reduce their potential environmental impacts.
研究领域:
环境科学
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海洋学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2021
·
IF 10.588
Zhisong Cui,Xiao Luan,Shujun Li,Yingchao Li,Xinqi Bian,Guoqing Li,Qinsheng Wei,Xiangbin Ran,Mutai Bao,David L. Valentine
Cyclic alkanes (c-alkanes) are toxic compounds that are abundant in subsurface oil reservoirs and spilled condensate; hence, their environmental risk is significant. Although numerous studies have focused on the decomposition of other compound classes, e.g., acyclic alkanes and aromatic hydrocarbons, very little is known about the biodegradation of c-alkanes in the marine environment. Here, we enriched methylcyclohexane (MCH)-degrading bacteria derived from the cold bottom water (10–20 °C) of China’s marginal seas in summer and characterized the changes to the bacterial community using high-throughput amplicon sequencing. MCH-consuming bacteria failed to grow from the warmer surface water (25–29 °C) in the same geographic sites and seasons. Notably, MCH-consuming communities derived from the cold bottom water in the Yellow Sea exhibit distinct structures compared to the other treatments. Furthermore, almost all dominant species in this setting appear to be specifically adapted to deeper cold water as indicated by significantly negative correlations to temperature ( P < 0.01). From these results, we proposed that the biodegradation of MCH is effectively limited to the colder waters (10–20 °C) of China’s marginal seas, with uncultured psychrophiles acting as the key taxa for MCH decomposition. Overall, this study indicates key functions for uncultivated microbes in the marine environment.
研究领域:
微生物学
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环境科学
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海洋生物学
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DOI
PubMed
高影响因子
CHINESE SCIENCE BULLETIN
·
2005
·Vol. 50
·期 23
·2765-2769
·
IF 0.683
Xiuyang Jiang,Yongjin Wang,Xinggong Kong,Jiangying Wu,Xiaohua Shao,Zhifeng Xia,Hai Cheng
230 Th ages and oxygen isotope data of a stalagmite from Shanbao Cave in Hubei Province characterize the East Asian Monsoon precipitation from 133 to 127 ka. The decadal-scale high-resolution δ 18 O record reveals a detailed transitional process from the Penultimate Glaciation to the Last Interglaciation. As established with 230 Th dates, the age of the Termination II is determined to be 129.5±1.0 kaBP, which supports the Northern Hemisphere insolation as the triggers for the ice-age cycles. In our δ 18 O record, the glacial/ interglacial fluctuation reaches about 4‰, almost the same level as in other Asian Monsoon cave stalagmite δ 18 O records. The transition of the glacial/interglacial period in our record can be recognized as four stepwise stages, among which, a rapid rise of monsoon precipitation follows the stage of “Termination II pause”. The rapid rise is synchronous with the abrupt change of global methane concentration, which reflects that an increase in both Asian Monsoon precipitation and tropical wetland plays an important role in the global climate changes.
研究领域:
古气候学
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第四纪科学
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同位素地球化学
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气候变化
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季风动力学
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DOI
高影响因子
Virulence
·
2024
·
IF 5.5
Xiaofei Ji,Qianwen Wu,Xinying Cao,Shuzhen Liu,Jianhui Zhang,Si Chen,Jiangfan Shan,Ying Zhang,Boqing Li,Huilin Zhao
CagA is a significant oncogenic factor injected into host cells by Helicobacter pylori, which is divided into two subtypes: East Asian type (CagAE), characterized by the EPIYA-D motif, and western type (CagAW), harboring the EPIYA-C motif. CagAE has been reported to have higher carcinogenicity than CagAW, although the underlying reason is not fully understood. SHIP2 is an intracellular phosphatase that can be recruited by CagA to perturb the homeostasis of intracellular signaling pathways. In this study, we found that SHIP2 contributes to the higher oncogenicity of CagAE. Co-Immunoprecipitation and Pull-down assays showed that CagAE bind more SHIP2 than CagAW. Immunofluorescence staining showed that a higher amount of SHIP2 recruited by CagAE to the plasma membrane catalyzes the conversion of PI(3,4,5)P3 into PI(3,4)P2. This alteration causes higher activation of Akt signaling, which results in enhanced IL-8 secretion, migration, and invasion of the infected cells. SPR analysis showed that this stronger interaction between CagAE and SHIP2 stems from the higher affinity between the EPIYA-D motif of CagAE and the SH2 domain of SHIP2. Structural analysis revealed the crucial role of the Phe residue at the Y + 5 position in EPIYA-D. After mutating Phe of CagAE into Asp (the corresponding residue in the EPIYA-C motif) or Ala, the activation of downstream Akt signaling was reduced and the malignant transformation of infected cells was alleviated. These findings revealed that CagAE hijacks SHIP2 through its EPIYA-D motif to enhance its carcinogenicity, which provides a better understanding of the higher oncogenic risk of H. pylori CagAE.
研究领域:
微生物学
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分子生物学
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肿瘤学
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细胞生物学
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DOI
PubMed
高影响因子
MARINE POLLUTION BULLETIN
·
2024
·
IF 5.3
Peng Zhang,Yaqing Cui,Ren Shi,Jing Wang,Linke Ge,Qinglin Mu
This study investigated 17 organophosphate esters (OPEs) in the surface sediments of Hangzhou Bay and the East China Sea. The mean concentration of ∑OPEs in Hangzhou Bay (235.3 ng/g) was slightly lower than that in the East China Sea (273.5 ng/g), with detected analytes dominated by Diethyl phosphate, Tris(2-chloropropyl) phosphate, and Tris(1-chloro-2-propyl) phosphate. Based on principal component analysis and cluster analysis for the source apportionment of OPEs, the results indicated that the high levels of OPEs in the East China Sea close to Yangtze River estuary can be attributed to a significant large-scale OPEs production site located along the southern Yellow Sea and the western coast of the East China Sea. Furthermore, the risk assessment conducted on aquatic organisms indicated the non-ecological risk of OPEs. However, future research should focus on the potential composite impacts of OPEs on the water systems and human health.
研究领域:
环境科学
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海洋学
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产品关联
DOI
PubMed
高影响因子
Microorganisms
·
2024
·Vol. 12
·期 1
·144
·
IF 4.1
Hongcai Zhang,Zekai Wang,Xi Yu,Junwei Cao,Tianqiang Bao,Jie Liu,Chengwen Sun,Jiahua Wang,Jiasong Fang
Lignocellulosic materials are composed of cellulose, hemicellulose and lignin and are one of the most abundant biopolymers in marine environments. The extent of the involvement of marine microorganisms in lignin degradation and their contribution to the oceanic carbon cycle remains elusive. In this study, a novel lignin-degrading bacterial strain, LCG003, was isolated from intertidal seawater in Lu Chao Harbor, East China Sea. Phylogenetically, strain LCG003 was affiliated with the genusAliiglaciecolawithin the familyAlteromonadaceae. Metabolically, strain LCG003 contains various extracellular (signal-fused) glycoside hydrolase genes and carbohydrate transporter genes and can grow with various carbohydrates as the sole carbon source, including glucose, fructose, sucrose, rhamnose, maltose, stachyose and cellulose. Moreover, strain LCG003 contains many genes of amino acid and oligopeptide transporters and extracellular peptidases and can grow with peptone as the sole carbon and nitrogen source, indicating a proteolytic lifestyle. Notably, strain LCG003 contains a gene of dyp-type peroxidase and strain-specific genes involved in the degradation of 4-hydroxy-benzoate and vanillate. We further confirmed that it can decolorize aniline blue and grow with lignin as the sole carbon source. Our results indicate that theAliiglaciecolaspecies can depolymerize and mineralize lignocellulosic materials and potentially play an important role in the marine carbon cycle.
研究领域:
海洋微生物学
·
环境基因组学
·
生物降解与代谢
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2021
·
IF 9.028
Ye Tian,Ke-Ke Wang,Gui-Peng Yang,Pei-Feng Li,Chun-Ying Liu,Riel Carlo O. Ingeniero,Hermann W. Bange
Nitric oxide (NO) is a short-lived intermediate of the oceanic nitrogen cycle, and it is produced by biological and photochemical processes in the ocean. Nitrogen dioxide (NO2) is a reactive atmospheric compound which has not been determined in the ocean so far. Here, we present the setup and validation of a novel continuous underway measurement system to measure dissolved NO and NO2 in the surface ocean. The system consists of a seawater/gas equilibration component coupled to a chemiluminescence detector. It was successfully deployed during a 12 day cruise to the East China Sea in May 2018. Dissolved NO and NO2 surface concentrations ranged from
研究领域:
海洋学
·
环境科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）