JOURNAL OF CELL BIOLOGY
·
2024
·Vol. 223
·期 12
·e202408061
·
IF 7.4
Sang Yongjuan,Li Boran,Su Tinglin,Zhan Hanyu,Xiong Yue,Huang Zhiming,Wang Changjing,Cong Xiaoxia,Du Mengjie,Wu Yang,Yu Hang,Yang Xi,Ding Kezhi,Wang Xuhua,Miao Xiaolong,Gong Weihua,Wang Liang,Zhao Jingwei,Zhou Yiting,Liu Wei,Hu Xinyang,Sun Qiming
ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize ER-phagy and ER architecture in vivo. We generated two transgenic mouse lines expressing an ER lumen–targeting tandem RFP-GFP (ER-TRG) tag, either constitutively or conditionally. This approach enables precise spatiotemporal measurements of ER-phagy and ER structure at single-cell resolution in vivo. Systemic analysis across diverse organs, tissues, and primary cultures derived from these ER-phagy reporter mice unveiled significant variations in basal ER-phagy, both in vivo and ex vivo. Furthermore, our investigation uncovered substantial remodeling of ER-phagy and the ER network in different tissues under stressed conditions such as starvation, oncogenic transformation, and tissue injury. In summary, both reporter models represent valuable resources with broad applications in fundamental research and translational studies.
研究领域:
细胞生物学
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分子生物学
·
遗传学
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Yue Lei,Wang Bo,Huang Yiheng,Feng Changhao
In this study, gas sensors based on Er-doped ZnFe 2 O 4 nanofibers (E-ZFO NFs) with varying ratios of Er doping were prepared by a facile electrospinning approach. The sensor based on 3% E-ZFO NFs demonstrated an enhanced response value of 30.3 for 100 ppm n -butanol at 175°C, with response and recovery times of 9 s and 94 s, respectively. This is approximately 3.1 times that of undoped ZFO NFs. Moreover, the sensor exhibited a minimum detection limit of 0.1 ppm, with excellent repeatability and selectivity. These results indicate that the sensors utilizing E-ZFO NFs are promising candidates for n -butanol gas sensors.
研究领域:
材料科学
·
传感技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Yajuan Cai,Xiaoyu Li,Kangbing Wu,Xiaofeng Yang
Two lanthanide metal-organic frameworks (Ln-MOFs) using 1,3,5-benzenetricarboxylic acid (H 3 BTC) and Ln(III) nitrate hydrate (Ln = Eu, Er) as precursors have been prepared through a one-step solvothermal approach. The as-synthesized compounds were characterized by X-ray diffraction, X-ray photoelectron spectroscopy and scanning electron microscopy, confirming that the targeted Ln-MOFs were successfully synthesised, with a straw-sheaf appearance. Their sensing properties were studied using cyclic voltammetry and electrochemical impedance spectroscopy , and the results showed that the prepared Ln-BTCs possessed larger electrochemical-response areas and stronger electron-transport capability, especially the Er-BTC. The oxidation behaviour of Sunset Yellow was investigated, and it was found that the Er-BTC exhibited a superior enhancement effect. Chronocoulometry was used to prove that Er-BTC more strongly adsorbs Sunset Yellow, resulting in a larger electrochemical response signal. The novel Sunset Yellow sensor exhibited a linear response in the range of 0.2–100 nM with a low limit of detection (0.05 nM, S/N = 3), and was applied in drink samples. The results were validated by high-performance liquid chromatography , indicating this sensor is a promising tool for Sunset Yellow detection.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2016
·Vol. 63
·期 12
·977-984
·
IF 0.879
Rongjin Sun,Ting Yin,Peng Huang,Guo Gao,Joseph George Shapter,Yulan Shen,Jingjing Zhang,Daxiang Cui
In this paper, we report the development of a facile one-pot hydrothermal method for the controlled synthesis of monodispersed BaGdF 5 :Yb/Er nanoparticles for computed tomography (CT) and magnetic resonance (MR) imaging. The as-prepared nanoparticles have uniform size with a diameter of 20–25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/mL, suggesting that the as-prepared BaGdF 5 :Yb/Er nanoparticles possess low toxicity. For both BaGdF 5 :Yb/Er nanoparticles and iopromide, the Hounsfield unit (HU) values increase with the their concentration. The slope of BaGdF 5 :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF 5 :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF 5 :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging.
研究领域:
材料科学
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医学影像学
·
生物医学工程
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产品关联
DOI
高影响因子
ISRAEL JOURNAL OF CHEMISTRY
·
2015
·Vol. 56
·期 4
·242-248
·
IF 2.221
Junwei Zhao,Jian Wu,Junfei Xue,Qiannan Zhu,Weihai Ni
Graphical Colloidal superparticles (SPs) are nanoparticle (NP) assemblies in the form of colloidal particles. Assembling nanoscopic objects into mesoscopic or macroscopic composite architectures allows for the bottom-up fabrication of functional nanomaterials. In this study, a method for single-step self-assembly synthesis of Au/NaYF 4 : Yb,Er SPs was developed using oil-in-water (O/W) microemulsions to simultaneously encapsulate gold nanoparticles (AuNPs) and NaYF 4 : Yb,Er upconversion nanoparticles (UCNPs) via evaporation at room temperature. The synthesized Au/NaYF 4 : Yb,Er SPs possess good dispersibility and stability. When the number of AuNPs added is increased, the SPs exhibit decreased upconversion luminescence, which can be ascribed to the Förster resonance energy transfer (FRET) from the NaYF 4 : Yb,Er UCNPs to the AuNPs. Time-resolved measurements of the green emission further confirm the existence of a new decay route corresponding to the FRET process. Our research provides a facile and versatile strategy for the synthesis of novel multifunctional nanocomposites with tunable upconversion luminescence properties, which can be of great significance in biological applications.
研究领域:
材料科学
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纳米技术
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2025
·
IF 4.5
Peizhe Wang,Tingyu Zhang,Yanrong Wang,Beixi An,Zhengkun Wu,Yifan Yang,Ruiqi Han,Erqing Xie
Ethylene glycol is a type of volatile organic compound, and its respiratory products pose significant risks to human and biological cells. Therefore, it is necessary to monitor the concentration of ethylene glycol in the environment. Metal oxide semiconductors exhibit good response to ethylene glycol gas. However, previous reports on ethylene glycol sensors have drawbacks such as high operating temperature and high- energy consumption, which cannot perfectly meet the needs of practical life. In this work, the photosensitive material ZnO was chosen as the sensing material for ethylene glycol, and the rare earth element Er was composite into it, achieving high response to ethylene glycol under 70 °C ultraviolet light. The results showed that the response value of 7% Er/ZnO to 100ppm ethylene glycol was as high as 156.6, while retaining high selectivity for ethylene glycol gas. The combination of high response value of ethylene glycol and lower operating temperature near room temperature indicates that the sensor based on 7% Er/ZnO achieves a balance between sensitivity, response value, and operating temperature. UV spectroscopy and PL spectroscopy characterization confirmed that the energy levels of Er2O3 composite ZnO changed, effectively extending the lifetime of photo generated carriers. The mechanism of device performance optimization was analyzed through photocurrent testing. This work has basically achieved the photoactivation of ZnO gas sensors, providing ideas for the practical application of ethylene glycol gas monitoring.
研究领域:
材料科学
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环境监测
·
传感技术
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2020
·
IF 8.724
Yawei Ren,Yajing Han,Zhaoyang Li,Xiangmei Liu,Shengli Zhu,Yanqin Liang,Kelvin Wai Kwok Yeung,Shuilin Wu
Bacterial infection and related diseases are threatening the health of human beings. Photocatalytic disinfection as a simple and low-cost disinfection strategy is attracting more and more attention. In this work, TiO 2 nanoparticles (NPs) were modified by co-doping of Ce and Er using the sol–gel method, which endowed TiO 2 NPs with enhanced visible light photocatalytic performance but not pure ultraviolet photocatalytic properties compared the untreated TiO 2 . Our results disclosed that as the doping content of Er increased, the photocatalytic activity of modified TiO 2 NPs initially increased and subsequently decreased. The same trend occurred for Ce doping. When the doping dose of Er and Ce is 0.5 mol% and 0.2 mol%, the 0.5Ce0.2Ti–O calcined at 800 °C presented the best antibacterial properties, with the antibacterial efficiency of 91.23% and 92.8% for Staphylococcus aureus and Escherichia coli , respectively. The existence of Er ions is thought to successfully turn the near-infrared radiation into visible region, which is easier to be absorbed by TiO 2 NPs. Meanwhile, the addition of Ce ions can effectively extend spectral response range and inhibit the recombination of electrons and holes, enhancing the photocatalytic disinfection activity of co-doped TiO 2 .
研究领域:
材料科学
·
微生物学
·
光催化技术
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产品关联
DOI
PubMed
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2022
·Vol. 57
·期 4
·2100162
·
IF 1.599
Yanli Ding,Zhaohan Li
The low luminous efficiency of upconversion materials limits their practical applications in various fields. The present study focuses on the efficient upconversion enhancement of β-NaYF 4 :Yb,Er induced by Bi 3+ doping. The XRD and SEM results show that introducing Bi 3+ into the matrix lattice changes the microstructure and particle size of the crystal. The photoluminescence spectra show that at 6% Bi 3+ doping, the red and green emission intensities are enhanced by 12 and 8 times, respectively. The reason could be the lattice distortion caused by Bi 3+ doping, breaking the partial forbidden transition of rare-earth ions. The fluorescence lifetime measurement reveals that the Bi 3+ doping changes the environment around erbium ions, affecting the energy level lifetime of erbium ions, explaining the luminescence dynamics law. The present study provides a facile route to achieve nano/microstructures with intense upconversion luminescence with potential applications in optoelectronic devices.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Minerals
·
2024
·Vol. 14
·期 6
·534
·
IF 2.2
Chunhua Bai,Xiaoning Yang,Guanghui Li
The removal of low concentrations of rare-earth ions (e.g., Er(III)) from water has stimulated interest in the field of mineral processing and water treatment. Here, an ion-exchange and complexation-assisted precipitation method for the removal of low concentrations of Er(III) from water using heptadecyl-1,1-bisphosphonic acid (HBPA) was investigated. The results showed that effective cation-exchange between Er(III) ions and the bisphosphonate headgroup was achieved, and the solution pH abruptly decreased from 6.5 to around 3.1 at the first stage, which further led to the formation of less soluble Er(III) heptadecyl-1,1-bisphosphonate complexes. While low concentrations of Er(III) ions in water are typically treated by the addition of HBPA, followed by the addition of sodium bicarbonate (adjusting the pH to 6–8) and activate carbon, Er(III) ions could be efficiently removed from aqueous solution after about 30 min based on the cation-exchange and complexation-assisted precipitation method. Additionally, the removal of ultra trace amounts of Er(III) ions was not significantly affected by coexisting trace amounts of alkaline-earth metal ions (Mg2+, Ca2+and Sr2+). HBPA is an effective Er(III) chelator, which may be a potential and promising alternative technique to remove Er(III) ions from aqueous solutions.
研究领域:
矿物加工
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环境科学
·
化学工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Gongle Shen,Linling Zhong,Yuanhang Bi,Yifan Liu,Jiangqi Zhao,Xin Wen,Yifei Zhu,Lei Feng,Li Geng,Fan Yu,Changjun Hou,Xianfeng Wang
Considering the vital role of sulfide ions (S 2- ) in food safety, environmental pollution and public health, accurate and efficient detection of S 2- is of great importance. In this study, Er-MOFs with the structure of four-pointed star was successfully designed and synthesized using Er(III) as the metal center and TCPP as the ligand. It is found that host-guest effects occur between Er-MOFs and S 2- , blocking the ligand-to-metal charge transfer (LMCT) effect and O-H vibration. This progress leads to the fluorescence signal-on of Er-MOFs and the production of a brown color. In view of this, a Er-MOFs-based sensor was constructed for rapid and on-site monitoring of S 2- in water, which shows the triple-signal outputs including fluorescence, absorbance and smartphone-based RGB analysis with high sensitivity and selectivity. More importantly, the successful measurement of S 2- in real water samples with satisfactory recoveries from 96.26 % to 104.03 %, demonstrating the practicality and effectiveness of Er-MOFs for S 2- recognition. Overall, this assay exhibits the promising applications for S 2- measurement in the fields of environmental pollution and food safety.
研究领域:
材料科学
·
环境科学
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2024
·
IF 2.3
Dong Wenjie,Cai Ao,Wu Sui,Qi Beimeng,Dai Zhixi
A porous Sn–Er–Beta zeolite catalyst was rapidly prepared by introducing Sn source with water bath method and Er source with solid-state ion exchange method. When adding 180 mg catalyst, 225 mg glucose and 10 mL water into a reaction kettle at 200 °C for 2 h, the yield of lactic acid can reach 71.2%. After being recycled 5 times, the lactic acid yield of the catalyst can still reach 45.3%. The physical and chemical properties of Sn–Er–Beta zeolite were characterized, and it was confirmed that the catalyst had a multi-stage pore structure, with Sn and Er elements existing in the zeolite skeleton. Among them, the increase of Lewis acidity, Brønsted acidity and special strong alkaline sites of Sn–Er–Beta zeolite caused by the introduction of Sn, and the Lewis acidic sites are further increased after the introduction of Er. The combination of Sn and Er obviously improves the catalyst’s capability to catalyze glucose and fructose to produce lactic acid. This provides an important reference value for the directional catalytic process of sugars. Graphical abstract
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Yike Fu,Xiang Li,Chuanbin Sun,Zhaohui Ren,Wenjian Weng,Chuanbin Mao,Gaorong Han
The design of multifunctional localized drug delivery systems (LDDSs) has been endeavored in the past decades worldwide. The matrix material of LDDSs is known as a crucial factor for the success of its transformation from the laboratory to clinical practices. Herein, a biocompatible ceramic, strontium titanate (SrTiO3, STO), was utilized as the matrix. A variety of fine Er doped SrTiO3 (STO:Er) nanofibers were fabricated via electrospinning. After the surface functionalization with amino groups, the drug loading capacity of STO:Er nanofibers is dramatically increased. The nanofibers present a rather sustained drug releasing behavior in the media with pH of 7.4, and the release kinetics is significantly accelerated with the decreased pH value from 7.4 to 4.7. Furthermore, the intensity of the spectrum emitted from the STO:Er nanofibers corresponds well with the drug releasing progress under the excitation of near-infrared spectrum (∼980 nm). Fast drug release behavior (in an acid environment) induces a rapid intensity enhancing effect of photoluminescence emission and vice versa. The main mechanism is attributed to the quenching effect induced by the C-Hx groups of IBU molecules with vibration frequencies from 2850 to 3000 cm–1. Such new STO:Er nanofibers with pH-triggered and optically monitored drug delivery functionalities have therefore been considered as another new localized drug delivery platform for modern tumor diagnosis and therapy.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）