RSC Advances
·
2025
·Vol. 15
·期 20
·15639-15650
·
IF 4.6
Zicheng Wan,Dongyang Li,Yang Zhou,Tun Wang,Benyin Zhu,Changhai Du,Yimin Li,Chang Shu
This study presents a preliminary investigation of porous nickel-titanium (NiTi) materials with controllable porosity fabricated through metal injection molding combined with the powder space-holder method (MIM-PSH). The thermosensitive hydrogel Pluronic F-127 was utilized as a drug carrier to load the anti-proliferative drug rapamycin, resulting in porous NiTi-hydrogel composite materials for controlled drug release. By tuning the NiTi matrix porosity (0%, 20%, and 40%), the system achieved precise modulation of drug loading capacity and release kinetics. Notably, the 40% porous NiTi composite exhibited a threefold increase in the drug-loading capacity and sustained release over 17 days. This hybrid design leveraged the thermoresponsive properties of the hydrogel and the tailored pore architecture to enable spatiotemporal control of rapamycin delivery, effectively inhibiting human aortic smooth muscle cell proliferation and mitigating in vivo vascular tissue hyperplasia. This study provides a foundational framework for the development of multifunctional biomaterial systems for vascular therapy.
研究领域:
生物医学工程
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材料科学
·
药理学
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产品关联
DOI
PubMed
高影响因子
CYTOKINE
·
2024
·
IF 3.7
Chenggang Huang,Jiajia Teng,Wei Liu,Junzhe Wang,An Liu
Background Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed to explore whether a novel constructed combination of thermosensitive hydrogel Pluronic F-127 (PF-127) and phillyrin (PH, the main active compound of forsythia suspensa) could improve skin wound healing. Methods Firstly, the biological effects of pH on the phenotype and inflammation of macrophages were assessed by flow cytometry and ELISA. The biocompatibility of the PF-127 plus PH combination was investigated on keratinocytes and red blood cells. The biological effect of PF-127/PH hydrogel on the migratory ability of keratinocytes in vitro was evaluated using the scratch and transwell migration assays. In addition, S. aureus and E. coli were employed to test the antibacterial properties of the PF-127 plus PH combination. Finally, PF-127 plus PH scaffold was applied to the full-thickness skin defect in mice. Histomorphological evaluation and immunochemistry were performed to explore the wound-healing activity of PF-127/PH hydrogel. Results PH can promote the polarization of macrophages from the M1 (pro-inflammatory) phenotype to the M2 (anti-inflammatory) phenotype. The PF-127/PH hydrogel was highly biocompatible and showed a potent stimulative effect on the migration of keratinocytes in vitro. The combination of PF-127 and PH exerted a pronounced antibacterial activity on S. aureus and E. coli in vitro. PF-127/PH hydrogel potently accelerates the healing of full-thickness skin defects by promoting skin cell proliferation, accelerating angiogenesis, and inhibiting inflammation. Conclusions Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.
研究领域:
医学
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生物材料学
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免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lianlong Zhan,Wei Lu,Qin Xiang,Zhiping Chen,Wenlu Luo,Cailin Xu,Renting Huang,Shuagnfei Wang,Hui He
Using biomass for the production of low-energy regenerative carbon capture materials represents an effective strategy to advance carbon dioxide capture and storage technologies. In this study, a low-energy regenerative bagasse-based CO 2 capture material is synthesized through a one-step, rapid crosslinking strategy. In this method, epichlorohydrin is used to crosslink bagasse with temperature sensitive Pluronic® F-127 and polyethyleneimine, thereby addressing the challenge of simultaneously incorporating multiple functional groups into the biomass matrix. The resulting material with abundant amino adsorption sites demonstrates a high adsorption capacity of 4.52 mmol/g. Interestingly, the temperature-sensitive response of the material facilitates the grafted amine chain segments on bagasse to stretch and shrink reversibly within a narrow temperature range of 25 °C for adsorption and 55 °C for desorption. The shrinkage state is conducive to the CO 2 desorption process, resulting in an ultralow regeneration temperature of 55 °C. Additionally, the water contained in the material enhances its cyclic stability in extreme environments, such as pure CO 2 atmosphere at high temperature. Overall, this research not only provides new ideas for enhancing the long-term stability and economic viability of CO 2 capture materials but also offers feasible solutions for combating climate change and promoting sustainable development.
研究领域:
材料科学
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环境科学
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生物质工程
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Guohong Ren,Xichen Zhang,Zhicheng Zhang,Ying Liang,Shishan Wu,Jian Shen
Pt-based nanomaterials have been proven to be effective catalysts for direct alcohol fuel cells (DAFCs). Specifically, the ternary nanoalloys (NAs) composed of Pt with other noble metals and transition metals can not only reduce the component of Pt but also enhance the electrocatalytic property and durability for alcohol oxidation. Herein, ternary PdPtCu NAs were synthesized through the solvothermal method using ethylene glycol as the solvent and reducing agent. The morphology and composition of PdPtCu NAs can be effectively controlled via selecting suitable surfactants and adjusting the proportion of precursors. The three-dimensional (3D) PdPtCu NAs with spiny rambutan-like morphology were obtained using the triblock copolymer Pluronic F-127 (PF-127) as the surfactant and adding three precursors with an equal molar ratio. The unique structure of PdPtCu NAs and the synergistic effect between the components significantly improved the electrocatalytic activity toward ethanol oxidation. Compared with different atomic ratio binary or ternary nanomaterials, 3D PdPtCu NAs manifested the best electrocatalytic performance.
研究领域:
材料科学
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电化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Yupeng Qian,Xukun Qin,Yongjun Peng
Slime coating is a common problem in mineral flotation and this study explored a novel idea to mitigate slime coating to improve mineral flotation. Guided by the previous work, Pluronic triblock copolymer F-127 (PEO 100 PPO 65 PEO 100 ) was chosen to mitigate fine quartz coating in fluorite flotation. Then the mechanism underpinning the mitigation of fine quartz coating on fluorite surface by F-127 and the interaction of F-127 with collector sodium oleate on quartz and fluorite surfaces were studied. It was found that F-127 adsorbed on both quartz and fluorite surfaces and therefore mitigated fine quartz coating on fluorite surface through steric repulsion. The adsorbed F-127 on fluorite surface also enhanced the adsorption of sodium oleate but had little effect on the adsorption of sodium oleate on quartz surface. The mitigation of fine quartz coating and enhanced adsorption of sodium oleate on fluorite surface explain the significantly improved fluorite flotation in the presence of fine quartz particles after the addition of F-127.
研究领域:
矿物加工工程
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材料科学与工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
研究领域:
药学
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生物医学工程
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伤口愈合
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糖尿病研究
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炎症
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产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
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2023
·
IF 3
Zhe Chen,Yu Han,Pengfei Cai,Xiumei Mo,Yunlong Zhang,Jinglei Wu,Binbin Sun
Clinical applications of soft tissue using 3D bio-printing have been limited due to the difficulty of forming bio-ink materials. In this study, we propose a simple and feasible gel suspension printing system with high printing accuracy using a temperature-sensitive material, Pluronic F-127. The detailed printing parameters of the printing system were confirmed. A heart organ model was successfully fabricated using this printing system, and in vitro cell experiments have demonstrated its good biocompatibility. The results showed that the printing system has the practical ability to prepare soft tissues for application.
研究领域:
生物医学工程
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再生医学
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组织工程
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 10
·1243
·
IF 4.9
Yiqiong Xie,Ying Ma,Lu Xu,Hongwen Liu,Weihong Ge,Baojuan Wu,Hongjue Duan,Hongmei Zhang,Yuping Fu,Hang Xu,Yuxiang Sun,Zhou Han,Yun Zhu
Background: Inflammatory bowel disease (IBD), characterized by chronic inflammation of the digestive tract, involves angiogenesis as a key pathogenic mechanism. Ginsenoside Rg3, derived from the traditional Chinese herb ginseng, is recognized for its anti-angiogenic properties but is limited by low oral bioavailability. This necessitates the development of an alternative delivery system to improve its therapeutic effectiveness.Methods: Pluronic F-127 (F127) and Pluronic F-68 (F68) were used to construct Rg3-loaded thermosensitive hydrogel Gel-Rg3. Meanwhile, a series of physicochemical properties were determined. Then the safety and pharmacological activity of Gel-Rg3 were evaluated in vitro and in vivo using human umbilical vein endothelial cells (HUVECs) and colitis mouse model, in order to initially validate the potential of Gel-Rg3 for the treatment of IBD.Results: We engineered a rectally administrable, thermosensitive Gel-Rg3 hydrogel using F127 and F68, which forms at body temperature, enhancing Rg3’s intestinal retention and slowly releasing the drug. In vitro, Gel-Rg3 demonstrated superior anti-angiogenic activity by inhibiting HUVEC proliferation, migration, and tube formation. It also proved safer and better suited for IBD’s delicate intestinal environment than unformulated Rg3. In vivo assessments confirmed increased intestinal adhesion and anti-angiogenic efficacy.Conclusions: The Gel-Rg3 hydrogel shows promise for IBD therapy by effectively inhibiting angiogenesis via rectal delivery, overcoming Rg3’s bioavailability limitations with improved safety and efficacy. This study provides new inspiration and data support for the design of treatment strategies for IBD.
研究领域:
药学
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药理学
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生物医学工程
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炎症研究
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 8
·1370
·
IF 5.719
Cong Tian,Zhe Tang,Yike Hou,Asim Mushtaq,Shafaq Naz,Zhangsen Yu,Jabeen Farheen,Muhammad Zubair Iqbal,Xiangdong Kong
Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synergistic properties for biomedical applications. Here, a facile method was employed to prepare plasmonic magnetic Au-MnO heterostructured hybrid nanoparticles for imaging-guided photothermal therapy of cancers in vitro, with the view to reducing the serious drawbacks of chemotherapy and gadolinium-based contrast agents. The biocompatibility of the prepared Au-MnO nanocomposites was further enhanced by Food and Drug Administration (FDA)-approved triblock copolymers Pluronic®F-127 and chitosan oligosaccharide (COS), with complementary support to enhance the absorption in the near-infrared (NIR) region. In addition, synthesized[email protected]nanocomposites exhibited promising contrast enhancement in T1MR imaging with a good r1relaxivity value (1.2 mM−1s−1), demonstrating a capable substitute to Gd-based toxic contrast agents. In addition, prepared[email protected]hybrid nanoparticles (HNPs) produced sufficient heat (62 °C at 200 μg/mL) to ablate cancerous cells upon 808 nm laser irradiation, inducing cell toxicity, and apoptosis. The promising diagnostic and photothermal therapeutic performance demonstrated the appropriateness of the[email protected]HNPs as a potential theranostic agent.Keywords:plasmonic nanoparticles;magnetic nanocomposites;T Magnetic contrast agents;photothermal therapy;cancer theranostics
研究领域:
纳米技术
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生物医学工程
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材料科学
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癌症研究
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诊疗学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Asim Mushtaq,Xuehua Ma,Jabeen Farheen,Xiaoqing Lin,Muhammad Tayyab,M. Zubair Iqbal,Xiangdong Kong
Magnetic hydroxyapatite nanocomposites are promising candidates for various biomedical applications. However, the uncontrolled growth with the unfavorable size limits their widespread utilization in real-time applications. Herein, a facile method was utilized to fabricate uniform spherical-shaped nanocomposites of manganese oxide combined hydroxyapatite (Mn 3 O 4 -HAp) with an average size of about 28 nm. The structural characterization reveals the presence of Mn 3 O 4 in the crystalline phase, confined by HAp to give a composite structure. The biocompatibility and drug loading capability of Mn 3 O 4 -HAp nanocomposites are improved by surface modification using Food and Drug Administration-approved triblock copolymer Pluronic® F-127, followed by folic acid (FA) for targeting ability. Taking advantage of the surface properties of the polymer and the drug delivery potential of HAp, metformin was encapsulated in the prepared nanocomposites with a loading capacity of 98 %. The prepared nanocomposites indicate promising cell viability up to 87 % and an excellent drug release profile in an acidic atmosphere. Moreover, the magnetic component Mn 3 O 4 presents auspicious T 1 -Magnetic resonance imaging with notable r 1 relaxivity of 2.166 mM −1 s −1 . Further, the Mn 3 O 4 [email protected] nanocomposites demonstrate good cellular uptake and excellent reactive oxygen species (ROS) production under low-intensity UV irradiation , resulting in a remarkable photodynamic therapeutic effect. The results showed that the designed Mn 3 O 4 -HAp nanocomposites are promising targeted chemo-theranostic agents.
研究领域:
生物医学工程
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纳米技术
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材料科学
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癌症治疗
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医学影像
✓ 已验证
产品关联
DOI
高影响因子
Science China-Materials
·
2025
·
IF 7.4
Huang Lin,Wang Wantao,Liu Lei,Ma Wenzheng,Fan Jinghao,Zhou Dan,Zhao Lei,Zheng Zhaomin,Liu Hongmei,Wu Decheng
The treatment of intervertebral disc (IVD) degeneration remains a significant challenge due to the unique ischemic structure of the IVD, which comprises the scavenging of inflammatory cytokines, alleviation of cellular oxidative stress responses, restoration of nuclei pulposus (NP) cell viability, and recovery of IVD biomechanical function. Herein, we developed an injectable microsphere (CS-MnO 2 @PC) by incorporating chitosan microspheres (CS) with manganese dioxide (MnO 2 ) nanozymes and celecoxib encapsulated in Pluronic F-127 (PC) nanosized micelles, via in situ redox or Schiff base reaction. The hybrid carrier demonstrates robust capabilities in scavenging free radicals, alleviating extracellular oxidative stress, and reducing inflammatory cytokines in NP cells, as evidenced by RT-qPCR and immuno-fluorescence staining assays. In vivo evaluations further indicate that this hybrid carrier helps preserve NP hydration and the lamellar structure of the annulus fibrosus (AF), as confirmed by radiological analysis and histological staining evaluations. These injectable chitosan microspheres, combining nanozymes and nanosized drug micelles, represent a promising therapeutic strategy for degenerative IVD.
研究领域:
生物医学工程
·
骨科
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材料科学
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2025
·
IF 3.4
Lv Changshun,Wang Qingshuang,Li Zhaoxin,Jiang Xue,Liu Tianhui,Xu Xiaoru,Feng Xiangru
Chitosan-based pluronic thermo-sensitive hydrogels represent a class of biomaterials characterized by their favorable biocompatibility and exceptional thermo-sensitive properties. The purpose of this study was to investigate their potential as carriers for embedding α-Mangostin (α-M), a bioactive compound derived from mangosteen peel, with the aim of inhibiting methicillin-resistant Staphylococcus aureus (MRSA). During the synthesis process, chitosan (CS), tannic acid (TA), pluronic F-127 (F127), and pluronic F-68 (F68) were combined to form the thermo-sensitive hydrogel, into which α-M was physically incorporated through crosslinking (designated as CTFF@α-M). We are very interested in the results obtained during the research process. The results of fluorescence imaging in small animals showed that CTFF extended the residence time of α-M in the body from 3 to 9 days, improved the bioavailability of α-M, and achieved the goal of sustained drug release. In vitro antibacterial experiments showed that CTFF@α-M (30 mg/mL) had an inhibition rate of 79.69% against MRSA, which was higher than CTFF@amoxicillin (AM) (5 mg/mL) increased by 71.68%. This study is expected to provide new insights into the integration of biomaterials and natural therapy, and emphasize the therapeutic potential of thermosensitive hydrogels and α-M in antibacterial treatment, especially in the fight against MRSA infection. Graphic In this study, a CTPP hydrogel was prepared using a physical cross-linking method, and α-M was encapsulated to create the CTPP@α-M drug-loaded hydrogel. Various characterization techniques, including SEM, FT-IR, and XRD, were employed to confirm its physicochemical properties. The hydrogel exhibited excellent water solubility, swelling capacity, sustained release characteristics, and biocompatibility, with the ability to transform into a semi-solid gel at 37 °C. In vitro experiments demonstrated that the CTPP@α-M hydrogel showed a powerful inhibitory effect on MRSA, exhibiting strong resistance to antibiotic resistance. Infection experiments using a mouse model confirmed that CTPP@α-M not only accelerated wound healing but also significantly reduced bacterial counts at the wound site. Moreover, the CTPP@α-M group significantly decreased the expression of pro-inflammatory cytokines while increasing the levels of anti-inflammatory factors, indicating its promising anti-inflammatory properties. Collectively, these data suggest that CTPP@α-M is a highly effective antibacterial thermo-sensitive hydrogel with excellent performance.
Diagram of the preparation of protocol CTFF@α-M and the treatment process of bacterial infection wounds
研究领域:
生物材料
·
药学
·
抗菌治疗
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伤口修复
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纳米医学
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高分子科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）