JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 140
·期 5
·e53408
·
IF 3.057
Jia Liu,Yiyang Cong,Yawen Zeng,Yiming He,Ying Luo,Weifei Lu,Haixing Xu,Yihua Yin,Hao Hong,Wenjin Xu
Nanoscale metal–organic frameworks (nMOFs) have attracted much attention as emerging porous materials as drug delivery carriers. Appropriate surface modification of them can greatly improve stability and introduce biocompatibility and cancer targeting functionality into drug delivery systems. Herein, we prepared nano-sized MIL-101(Fe)-N 3 and loaded anticancer drug doxorubicin (DOX) into it. The synthetic polymer layer Alkyne-PLA-PEG was then attached to the F3 peptide (labeled as Alkyne-PLA-PEG-F3), and the surface of DOX/MIL-101(Fe)-N 3 was covalently modified with it to obtain DOX/MIL-101-PLA-PEG-F3. Nano-sized MIL-101(Fe)-N 3 has high drug loading capacity and the modification of MIL-101(Fe)-N 3 by polymer Alkyne-PLA-PEG not only improved the dispersion, but also avoided the sudden release of the drugs and increased the biocompatibility of nanocarriers. The F3 peptide introduced into the nanocarriers also enabled it to specifically target tumor tissues and achieved active targeted drug delivery. As a nucleolin-mediated endocytosis drug delivery system, DOX/MIL-101-PLA-PEG-F3 can not only deliver anticancer drugs to tumors accurately, but also participate in Fenton-like reaction to generate hydroxyl radicals (•OH) for chemodynamic therapy (CDT), thus enabling combination therapy. It holds great promise as drug candidates to reduce systemic toxicity and improve the efficacy of cancer treatment.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2016
·Vol. 18
·期 8
·1384-1392
·
IF 3.849
S. Ding,X. F. Yang,T. T. Deng,E. H. Song,Z. J. Ma,S. Ye,M. M. Wu,Q. Y. Zhang
Solid-solution phase K(Mn,Zn)F3 mesoporous microspheres have been successfully prepared via a simple one-pot hydrothermal method by using citrate ions as a chelating agent. Effects of the reaction time on the phase transformation and morphological evolution of the K(Mn,Zn)F3 microspheres have been carefully investigated. The results revealed that the hierarchical mesoporous spherical structures with a solid-solution phase were formed from a core–shell structure with mixed phases via the nanoscale Kirkendall effect. It is noted that Yb3+/Er3+-codoped K(Mn,Zn)F3 microspheres exhibit intense single-band red up-conversion emission with environmental responsivity upon excitation using a 980 nm laser diode, indicating a promising potential biomedical application for drug delivery.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2019
·Vol. 14
·期 1
·1-11
·
IF 3.159
Wang Shuya,Cui Bin,Zhuang Quanchao,Shi Yueli,Zheng Hong
Potassium-ion batteries (KIBs) are favored by researchers because of the unique advantages. In this work, KIB cathode material nano-perovskite K(Mn 0.95 Ni 0.05 )F 3 with concentration gradient was synthesized by EDTA-assisted homogeneous precipitation method for the first time and characterized. The solid solution material was deposited on the multi-walled carbon nanotubes (MWCNTs) to form K(Mn 0.95 Ni 0.05 )F 3 /MWCNT nanocomposites to improve the electron conductivity of the electrode material so as to obtain the excellent electrochemical performance. As expected, the charge and discharge capacities of K(Mn 0.95 Ni 0.05 )F 3 /MWCNTs after the 60th cycle can still reach 106.8 and 98.5 mAh g −1 over the voltage range 4.2–1.2 V vs. K/K + at the current density of 35 mA g −1 , respectively. Electrochemical performance studies showed that solid solution K(Mn 0.95 Ni 0.05 )F 3 had the potential applications as the cathode material for KIBs. Electrochemical impedance spectroscopy (EIS) was used to study the transport and reaction processes of ions at the solid–liquid interface. The main factors affecting electrochemical performance could be analyzed from the Nyquist plot of the EIS test.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2017
·Vol. 33
·期 7
·1446-1452
·
IF 0.767
CHEN Fan,WANG Zhong-Yue,ZHANG Yan-Yan,YU Ke-Han,WENG Li-Xing,WEI Wei
Monodisperse La1-x
Eu
x
F3 nanoparticles (NPs) were functionalized by poly(acrylic acid) (PAA) via a one-pot modified hydrothermal method. The morphology, crystal structure, surface groups, and luminescence properties of the as-produced
La1-x
Eu
x
F3@PAA NPs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL) spectroscopy. The produced nanoparticles were (7±3) nm
in size, water soluble, and buffer stable, with good photostability and biocompatibility. In vitro imaging revealed the low cytotoxicity of the as-synthesized NPs incubated with HeLa cancer cells. Thus, the colloidal La1-x
Eu
x
F3@PAA NPs
exhibit great potential for use as optical imaging probes in biological applications.
研究领域:
材料科学
·
生物学
·
医学影像
✓ 已验证
DOI
高影响因子
BIOCONJUGATE CHEMISTRY
·
2021
·
IF 4.774
Yawen Zeng,Jinling Xiao,Yiyang Cong,Jia Liu,Yiming He,Brian D. Ross,Haixing Xu,Yihua Yin,Hao Hong,Wenjin Xu
Nanoscale metal–organic frameworks (nMOFs) are a unique type of hybrid materials, which are broadly applicable as cargo delivery systems. However, the relatively low material stability and insufficient cancer cell interacting capacity have limited nMOFs’ applications in cancer theranostics. Herein, a zirconium-based nMOF UiO-66-N3 was synthesized, and its surface was covalently functionalized with alkyne-containing polyethylene glycol (PEG) via the azide–alkyne click chemistry. After that, F3 peptide was attached for targeting of cancer cells (the material was denoted as UiO-66-PEG-F3). Doxorubicin (DOX) served as a therapeutic drug and a fluorescent label in this study, and it was transported into UiO-66-PEG conjugates with sufficient drug loading efficiency. pH-responsive release of DOX from UiO-66 conjugates was witnessed. The structural integrity of UiO-66-N3 was maintained post the surface modification process. Flow cytometry and confocal fluorescence microscopy revealed that DOX/UiO-66-PEG-F3 had stronger accumulation in MDA-MB-231 cells (nucleolin+) compared with DOX/UiO-66-PEG. In order to track the pharmacokinetic behavior (organ distribution profile) in vivo, the positron-emitting zirconium-89 (89Zr) was incorporated into UiO-66-N3. Similar PEGylation and F3 peptide conjugation resulted in the formation of 89Zr-UiO-66-PEG-F3. Serial positron emission tomography (PET) imaging demonstrated that the preferential accumulation of 89Zr-UiO-66-PEG-F3 in MDA-MB-231 tumors, and their liver clearance was faster than PEGylated UiO-66 using noncovalent methods. Thus, the PEGylated nMOFs using covalent strategies may find broad application in future cancer theranostics.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Lihua Huang,Ying Luo,Yiyang Cong,Jia Liu,Caiyan Xu,Zhaoxiang Zeng,Yihua Yin,Hao Hong,Wenjin Xu
Metal–organic frameworks (MOFs) are unique coordination polymers that have emerged as important candidates for drug delivery in recent years. Herein, we designed a drug delivery system for multi-modal combination therapy (IR-820/DOX@MIL-101-PDA-PEG-F3, simplified as ID@MIL-PPF3). In this study, pH-sensitive nanocarriers MIL-101(Fe) were prepared and loaded with the effective chemotherapy agent doxorubicin (DOX) and the phototherapeutic reagent new indocyanine green (IR-820) using a physical adsorption method. Dopamine was spontaneously polymerized in alkaline solutions to form a hybrid coating on MIL-101(Fe) (denoted as ID@MIL-101-PDA). The surface of ID@MIL-101-PDA was functionalized by the synthesized polymer NH2-PEG-OCH3/F3 to obtain ID@MIL-PPF3. Characterization results show that ID@MIL-PPF3 has a good drug loading rate (27.7%) and photothermal conversion efficiency (28.89%). In addition, Fe3+ released from MIL-101(Fe) can engage in a Fenton-like reaction to generate hydroxyl radicals (˙OH) to realize chemodynamic therapy (CDT). ID@MIL-PPF3 not only demonstrates the ability to intelligently release drugs, but also realizes chemotherapy combined with PDT/PTT/CDT therapy for tumor cells, which was proved by in vitro evaluation. In conclusion, ID@MIL-PPF3 provides a new idea and method for building a multi-modal combination therapy targeted drug delivery platform.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2021
·
IF 9.776
Yudi Deng,Zhijie Jiang,Yincheng Jin,Jianan Qiao,Shan Yang,Hui Xiong,Jing Yao
Detrimental tumor microenvironment (TME) relies on distorted tumor vasculature for further tumor expansion. Vascular normalization therapy partly improves TME through vessel repairing, while these therapies enter an unbreakable Möbius ring due to each attempt hindered by pro-angiogenic factors from TME, leading to limited duration and extent of vascular normalization. Here, we developed a nanosystem including FLG and MAR/MPA nanodrugs to regulate both tumor vasculature and TME. FLG nanodrugs were constructed by connecting VEGF/VEGFR2 inhibitory low molecular weight heparin and gambogic acid with F3 peptide decoration for directly regulating on vascular endothelial cells and inducing vascular normalization. Meanwhile, MAR/MPA nanodrugs encapsulating CCL5/CCR5 blocker maraviroc were designed to restrict cytokine functions of angiogenesis and TME deterioration, contributing to vasculature repairing and TME reconstruction. Our results demonstrated this combined nanosystem synergistically induced vascular normalization window lasting 9 days and restored vascular permeability and oxygen supply in Panc-1 tumor. Furthermore, in melanoma, our nanosystem achieved immune improvements with increased infiltration of CD4 + and CD8 + T cells in a remodeled TME. The two nanodrugs assisting each other in terms of both vascular repairing and TME improvements successfully reversed the vicious crosstalk to a positive one, achieving overall TME remodeling and promoting therapeutic efficiency.
研究领域:
肿瘤学
·
纳米技术
·
药理学
·
免疫学
·
癌症生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）