JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Yingqing Zhan,Shuangjiang He,Jiaxin Hu,Shumei Zhao,Guangyong Zeng,Mi Zhou,Guiyuan Zhang,Arijit Sengupta
Super-wetting MOFs@graphene hybrid has shown promising application for oil/water separation, due to high porosity, low density, and controllable wettability, however, achieving excellent stability and recyclability are found to be still challenging. In this study, sandwich-like UIO-66-F 4 @rGO hybrid was synthesized by immobilization of UIO-66-F 4 nanoparticles on rGO matrix, which featured the unique micro/nano hierarchy with hydrophobic characteristics. In order to realize the oil/water separation, as-prepared sandwich-like UIO-66-F 4 @rGO hybrid was applied as a potential candidate for constructing robust super-hydrophobic/super-oleophilic interfaces by using filter paper (FP) and melamine sponge (MS) as substrates. Typically, the surface modification of substrates can be easily achieved by simple dip-coating method, and interfacial adhesion between substrates and UIO-66-F 4 @rGO was enhanced by cross-linking of hydroxyl-fluoropolysiloxane (FPSO). Consequently, the super-hydrophobic/oleophilic UIO-66-F 4 @rGO/FP exhibited high contact angle of 169.3 ± 0.6° and was capable of separating various water-in-oil emulsions effectively. The flux and separation efficiency were 990.45 ± 36.28 Lm −2 h −1 and 99.73 ± 0.19 % driven by gravity, respectively. The super-hydrophobic/super-oleophilic UIO-66-F 4 @rGO/MS possessed selective oil absorption with absorption capacity of 26∼61 g/g depending on the viscosity of oils and continuous cleaning of oil spill. Furthermore, the UIO-66-F 4 @rGO composite could tolerate high/low temperature, corrosive solutions, and physical damage, displaying robust and stable super-hydrophobic/super-oleophilic interfaces for treating oily wastewater in harsh environments.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Hanhui Wang,Yi Zhang,Tingting Li,Zhiming Zhang,Libao An,Yeqi Zhang,Xinyu Sui
A hydrophobic metal-organic framework (MOF) nanofibrous membrane (NFM) with excellent comprehensive properties was successfully fabricated by a simple method. Benefiting from the excellent hydrophobicity, chemical stability, thermal stability and good structural fit of UiO-66-F 4 and polysulfone (PSF), the UiO-66-F 4 /PSF NFM has been directly prepared via co-electrospinning of UiO-66-F 4 and PSF without any additional modifications. Characterization with PXRD, FT-IR and XPS indicated that UiO-66-F 4 crystals were effectively incorporated into PSF fibers and their crystal structure was not destroyed. The obtained UiO-66-F 4 /PSF NFM exhibited improved hydrophobicity compared with the parent materials, even after the treatment with heat, acid or alkali solutions. Therefore, it was competent for separating different forms of oil-contaminated water, including oil-water mixture and water-in-oil emulsion, even in harsh conditions. In the case of hot oil-water mixture, UiO-66-F 4 /PSF NFM still showed a separation efficiency of about 99 % and an oil flux of 1036 L m −2 h −1 . More importantly, the separation efficiency remained relatively stable during 30 cycles of separation, indicating that UiO-66-F 4 /PSF NFM can meet the requirements of long-term use. In view of this, UiO-66-F 4 /PSF NFM had the potential to treat practical oily wastewater in harsh environments.
研究领域:
材料科学
·
化学工程
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
World Journal of Gastrointestinal Oncology
·
2025
·Vol. 17
·期 9
·108892
·
IF 2.5
Wei Xie,Xue-Jian Li,Yu-Sen Zhong,Jie Fang,Hui Qi,Meng Yang,Hua-Zhong Ying,Chen-Huan Yu
BACKGROUND Immunotherapy that employs dendritic cells (DCs) to activate the patient’s immune system has emerged as a promising therapeutic strategy to combat cancer; however, effective targeting agents are still limited. Ginsenoside F4, as a rare ginsenoside found in Panax ginseng , exhibits stronger antitumor and immunomodulatory activities than primary ginsenosides. However, its therapeutic effects on various diseases remain limited. AIM To investigate the antitumor effect of Ginsenoside F4 and mechanism on the maturation of DCs in colorectal cancer (CRC). METHODS The changes in mature DC markers and cytokines generated after DCs were exposed to F4 were assessed using flow cytometry and enzyme-linked immunosorbent assay, respectively. The viability of CRC CT26 cells co-cultured with T lymphocytes was monitored by cell counting kit-8 assay. Furthermore, the histopathological characteristics and immune cell infiltration in tumor tissues of CT26-bearing mice were analyzed by hematoxylin-eosin and immunofluorescent staining. The expressions of apoptosis-relative proteins were detected by western blot assay. RESULTS Treatment with F4 promoted the maturation of DCs, elevated the expressions of cluster of differentiation (CD) 83 and CD86, increased the secretion of interleukin (IL)-2, IL-10, and IL-12 p70, and upregulated the expressions of phosphorylated phosphoinositide 3-kinase, phosphorylated protein kinase B, and nuclear factor kappa-B (NF-κB) phosphorylated p65 in DCs, which enhanced antigen-specific CD8+ T-cell responses. However, these benefits could be reversed by the sphingosine-1-phosphate 1 (S1PR1) inhibitor fingolimod hydrochloride. Furthermore, oral administration with F4 inhibited tumor growth and increased DC and CD8+ T-cell infiltration in the tumor tissues of CT26-bearing mice. CONCLUSION The results demonstrated that F4 inhibited the growth of CRC by maturing DCs through activating S1PR1-mediated phosphoinositide 3-kinase/protein kinase B and NF-κB pathways, which triggered the antitumor effects of CD8+ T cells. Therefore, F4 could serve as an antitumor immunomodulator for CRC treatment.
研究领域:
肿瘤学
·
免疫学
·
药理学
·
天然产物
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 21
·3586-3599
·
IF 4.776
Xiaoqin Chen,Jing Sun,Huan Zhao,Ke Yang,Yuda Zhu,Hongrong Luo,Kui Yu,Hongsong Fan,Xingdong Zhang
For synchronous theranostic systems, there are two areas of focus. These are: excellent in vivo imaging and a multi-drug resistance (MDR) reversing ability for chemotherapy. Upconversion nanoparticles (UCNPs) exhibiting bright red emission in the “optical window in biological tissue (600–1100 nm)” could be a very useful candidate, although there have only been a few reports on UCNP-based conjugates with a MDR reversal ability explored for chemotherapy. Herein, we report an innovative theranostic system (D-UNT) via binding of an antitumor drug (DOX) and a MDR reversal agent (TPGS) to NaY(Mn)F4:Yb/Er UCNPs (UN) with synthetic optimized red emission and properties. The in vitro study demonstrated that the D-UNT was uptaken into drug-resistant MCF-7/ADR cells via caveolin dependent endocytosis and overcame P-gp mediated efflux. The cytotoxicity was significantly promoted to be much higher than that of free DOX. Accordingly, our D-UNT illustrates an enhanced reversal ability for chemotherapy. Our in vivo study further indicated that the D-UNT had excellent therapeutic efficacy against MDR tumors with minimal organ toxicity detected. In vivo deep-tissue imaging showed that the D-UNT accurately diagnosed MDR tumors at a 1.5 cm depth with high-contrast luminescent signals. Thus, the D-UNT is an effective theranostic system for the diagnosis and therapeutic treatment of MDR tumors. The present work opens new pathways to engineering powerful theranostic agents to simultaneously target, image and kill deep-tissue MDR tumor cells.
研究领域:
纳米技术
·
癌症研究
·
药学科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 27
·1-12
·
IF 2.8
Zhang Wei,Qin Lizhong,Qi Xiaohui,Na Liyan,Hua Ruinian
Photocatalytic hydrogen evolution on specific semiconductor material has been the most promising method to meet the future energy demands. To increase the efficiency of the photocatalysis, the β -NaY(Gd)F 4 :Yb 3+ ,Er 3+ @W 18 O 49 nanocomposites were successfully synthesized by a two-step hydrothermal method. It can be observed that the as-prepared nanocomposites have a layered structure; the inner layer is hexagonal-phase β -NaY(Gd)F 4 :Yb 3+ ,Er 3+ nanorods, and the outer layer is W 18 O 49 nanowires (NWs). Compared to the W 18 O 49 samples, the nanocomposites show 160% increase in hydrogen production efficiency in a BH 3 NH 3 aqueous solution under 980 nm irradiation. The enhanced photocatalytic activity of the nanocomposites can be attributed to their particular hierarchical structure. The effect of localized surface plasmon resonance (LSPR) on the surface of the W 18 O 49 NWs and the upconversion luminescence of nanorods in inner layer can be simultaneously triggered at 980 nm. Subsequently, the luminescence of the nanorods can be partially absorbed by the W 18 O 49 NWs to re-excite the LSPR oscillation of the nanocomposite. The reexcited LSPR effect improves the photocatalytic efficiency of the nanocomposite.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Ginseng Research
·
2025
·
IF 5.6
Weimin Wang,Kaixuan Zhou,Zengshuai Fu,Yucheng Huang,Jianjun Deng,Daidi Fan,Haixia Yang
Background Alcohol-induced liver injury contributes to various liver diseases, with dietary interventions of ginsenosides being a promising solution. Ginsenosides, the major active compounds of Panax ginseng Meyer , are divided into protopanaxadiol (PPD) and protopanaxatriol (PPT) based on C-3 or C-6 glycosylation, which have anti-inflammatory and antioxidant effects, but structure-activity relationships remain unclear. Methods Using C57BL/C mice with alcohol-induced liver injury, we evaluated Rg5 and F4 effects on liver function, inflammation, lipid deposition, apoptosis, alcohol metabolism, and lipid synthesis. Results Rg5 (60 mg/kg) demonstrated significantly superior efficacy to F4 in alleviating alcohol-induced liver injury, reducing lipid deposition through 33.9% and 25.8% decreases in serum triglyceride (TG) and total cholesterol (TC) levels versus the F4 group. Additionally, Rg5 attenuated hepatic apoptosis by reducing BAX and cleaved-CASPASE-3 protein expression by 26.3% and 28.4% compared to F4. Rg5 enhanced alcohol metabolism through activation of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), thereby restoring AMP-activated protein kinase (AMPK) phosphorylation by 26.1% while reducing sterol regulatory element-binding protein 1 (SREBP-1) expression by 27.8% (compared to F4), with efficacy approaching that of positive control silymarin. Molecular docking revealed that the C-6 sugar moiety of F4 induced hydrogen bond donor repulsion, increasing hydrogen bond length and weakening binding stability with ADH, ALDH and AMPK, providing a structural basis for Rg5's superior hepatoprotective activity. Conclusion These findings highlight the critical influence of glycosylation position on hepatoprotective activity of ginsenosides, and provide insights into the structural modification of ginsenosides, which could contribute to the treatment of alcohol-related liver disease.
研究领域:
药理学
·
生物化学
·
药物化学
·
分子生物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Yujie Qi,Xing Huang,Haoqi Zhai,Mengquan Shi,Yuxi Zhang,Yunlong Zhang,Yuxia Zhao
Lignin could generate active free radicals under light irradiation and be directly used as photoinitiator (PI). However, the photoinitiation unit is unclear due to its complex molecular structure. Some previous studies indicate that the photoyellowing of lignin is due to the photosensitivity of Cα‑carbonyl β-O-4 unit in its molecular structure. Herein, four lignin model compounds D2 , S3 , G4 and F4 containing Cα‑carbonyl β-O-4 structure unit were synthesized and characterized. Among them, F4 was obtained by introducing co-initiator 4-(dimethylamino) benzoic acid ethyl ester (EDAB) to the lignin structural unit. The results demonstrated that under 365 nm LED irradiation, the four model compounds all could directly initiate the polymerization of acrylate monomer PEGDA but their photoinitiation efficiency was quite different. F4 exhibited the best photoinitiation performance compared with the other three PIs. As a one-component photoinitiator (PI), the photoinitiation efficiency of F4 was equal to that of a commercial two-component system benzophenone (BP)/EDAB. In addition, when combined with a hydrogen donor triethanolamine (TEOA), the photoinitiation efficiency of the two-component system F4 /TEOA was higher than that of BP/TEOA. Furthermore, the photolysis mechanism of F4 was clarified through identifying the generated active species under light irradiation by electron spin resonance and laser flash photolysis.
研究领域:
材料科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
TURKISH JOURNAL OF CHEMISTRY
·
2026
·Vol. 50
·期 3
·285-299
·
IF 2
LI JUANHONG,WANG SUQIN,LIU XIN,LIU FENG
A [H]-accelerated catalytic Fenton system was developed using Pd/UiO-66(Zr)-F4 as the catalyst. This system enabled the regeneration of Fe²⁺ and facilitated the continuous generation of both ·OH and 1O2 through [H]-mediated electron transfer at ambient temperature and pressure. Under the conditions of 0.2 g L−1 catalyst (Pd loading 0.516 wt%), 25 μM Fe2+, 60 mL min−1 H2 flow (as the [H] source), 20 mM H2O2, and pH 3, approximately 89% of carbamazepine (initial concentration 20 mg L−1) was degraded within 3 h using trace iron. However, the catalytic activity of Pd/UiO-66(Zr)-F4 gradually declined from 89% to 53% over six reaction cycles. This decrease was likely due to loss of specific surface area caused by microstructural degradation associated with hydrogen spillover effects.
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2021
·
IF 5.221
Feng Qilong,Zheng Wenjing,Pu Jie,Chen Qiaoli,Shao Wei
The availability of colloidal nano-materials with high efficiency, stability, and non-toxicity in the near infrared-II range is beneficial for biological diagnosis and therapy. Rare earth doped nanoparticles are ideal luminescent agents for bio-applications in the near infrared-II range due to the abundant energy level distribution. Among them, both excitation and emission range of Er3+ ions can be tuned into second biological window range. Herein, we report the synthesis of ∼15 nm LiYF4, NaYF4, and NaGdF4 nanoparticles doped with Er3+ ions and their core-shell structures. The luminescent properties are compared, showing that Er3+ ions with single-doped LiYF4 and NaYF4 nanoparticles generate stronger luminescence than Er3+ ions with doped NaGdF4, despite the difference in relative intensity at different regions. By epitaxial growth an inert homogeneous protective layer, the surface luminescence of the core-shell structure is further enhanced by about 5.1 times, 6.5 times, and 167.7 times for LiYF4, NaYF4, and NaGdF4, respectively. The excellent luminescence in both visible and NIR range of these core-shell nanoparticles makes them potential candidate for bio-applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2026
·
IF 6
Jiaqi Duan,Weiguo Ma,Jian-Yong Hu
Organic near-infrared (NIR) photodetectors have attracted considerable interest as candidates for flexible, lightweight, and low-cost optoelectronic technologies. However, achieving efficient NIR absorption and high photodetection sensitivity simultaneously remains a significant challenge for most organic semiconductor systems. Here, a high-performance hybrid organic phototransistor is developed by combining a PBTTT-C 14 /F4-TCNQ donor–acceptor charge-transfer complex with monolayer graphene. Strong intermolecular charge-transfer interactions generate low-energy electronic transitions, resulting in broadband optical absorption spanning 400–1300 nm. Meanwhile, the incorporation of graphene provides an efficient transport pathway for photogenerated carriers and promotes charge separation, thereby enhancing photoconductive gain. As a result, the hybrid device exhibits excellent NIR photodetection performance under 800 nm illumination, delivering a responsivity of 1.67 × 10 5 A/W, a detectivity of 3.26 × 10 12 Jones, and an external quantum efficiency of 2.92% × 10 7 %. Notably, a measurable photoresponse is maintained even under extremely weak irradiation, demonstrating outstanding sensitivity toward low-intensity optical signals. In addition, the device shows stable switching behavior with millisecond-scale response characteristics. Integration into a phototransistor array further enables spatially resolved NIR imaging. These results highlight the effectiveness of integrating charge-transfer complexes with two-dimensional conductive materials and provide a viable strategy for next-generation high-gain organic infrared sensing and imaging applications.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2014
·
IF 4.384
Min Liu,Hui Liu,Shufen Sun,Xuejiao Li,Yanmin Zhou,Zhiyao Hou,Jun Lin
Porous hydroxyapatite (HAp) composite fibers functionalized with up-conversion (UC) luminescent and magnetic Na(Y/Gd)F4:Yb3+,Er3+ nanocrystals (NCs) have been fabricated via electrospinning. After transferring hydrophobic oleic acid-capped Na(Y/Gd)F4:Yb3+,Er3+ NCs into aqueous solution, these water-dispersible NCs were dispersed into precursor electrospun solution containing CTAB. Na(Y/Gd)F4:Yb3+,Er3+@HAp composite fibers were fabricated by the high temperature treatment of the electrospun Na(Y/Gd)F4:Yb3+,Er3+ NCs decorated precursor fibers. The biocompatibility test on MC 3T3-E1 cells using MTT assay shows that the HAp composite fibers have negligible cytotoxity, which reveals the HAp composite fibers could be a drug carrier for drug delivery. Because the contrast brightening is enhanced at increased concentrations of Gd3+, the HAp composite fibers can serve as T1 magnetic resonance imaging contrast agents. In addition, the composites uptaken by MC 3T3-E1 cells present the UC luminescent emission of Er3+ under the excitation of a 980 nm near-infrared laser. The above findings reveal Na(Y/Gd)F4:Yb3+,Er3+@HAp composite fibers have potential applications in drug storage/release and magnetic resonance/UC luminescence imaging.
研究领域:
生物材料学
·
医学影像学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Xia Xu,Zhuo Wang,Pengpeng Lei,Yingning Yu,Shuang Yao,Shuyan Song,Xiuling Liu,Yue Su,Lile Dong,Jing Feng,Hongjie Zhang
Novel flower-like α-NaYb(Mn)F4:Er3+/Tm3+@NaYF4 upconversion nanoparticles (UCNPs) as luminescent nanothermometers have been developed by combining liquid–solid solution hydrothermal strategy with thermal decomposition strategy. Under 980 nm excitation, they exhibit intense upconversion luminescence and temperature-dependent upconversion luminescence over a wide temperature range. The influence of temperature on “band-shape” upconversion luminescence (UCL) spectra and the intensity of emission bands are analyzed and discussed in detail. We further successfully test and verify that intensity ratios REr of 2H11/2 → 4I15/2 and 4S3/2 → 4I15/2 and RTm of 1G4 → 3H5 and 3H4 → 3H6 are sensitive to temperature, and the population of active ions follows Boltzmann-type population distribution very well. These luminescent nanothermometers could be applied over a wide temperature range from 123 to 423 K with high sensitivity, which enable them to be excellent candidates for temperature sensors.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）