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Antiviral effect of copper chloride on feline calicivirus and synergy with ribavirin in vitro

Li Dengliang,Cui Zhanding,Li Guohua,Zhang Liangting,Zhang Ying,Zhao Han,Zhang Shuang,Guo Yanbing,Zhao Yanli,Men Fanxing,Zhao Shihui,Shao Jiang,Du Dongju,Huang Hailong,Wang Kai,Hu Guixue,Li Tiansong,Zhao Yongkun

Background Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention.Results In this study, we found that copper chloride had dose-dependent antiviral effects on FCV in F81 cells. We also found that the combination of copper chloride and ribavirin had a synergistic protective effect against FCV in F81 cells. In contrast, the combination of copper chloride and horse anti-FCV immunoglobulin F (ab’)2 showed an antagonistic effect, likely because copper chloride has an effect on F (ab’)2 immunoglobulin; however, further research is needed to clarify this supposition.Conclusion sIn summary, we found that copper chloride had low cytotoxicity and significant antiviral effects on FCV in F81 cells, providing a new drug candidate for the prevention and treatment of FCV infection.