Surfaces and Interfaces
·
2024
·
IF 5.7
Weitao Song,Huiping Song,Shirui Zhang,Zhenlian Fan,Fangqin Cheng
Superhydrophobic coatings have garnered immense attention in recent years. Nevertheless, the creation of superhydrophobic coatings is often associated with high production costs and comparatively intricate fabrication processes. In this paper, we utilize cheap and easily available ultrafine fly ash(FA) as the main raw material to replace the expensive filler substances traditionally used for constructing rough structures, and Polydimethylsiloxane(PDMS) as a low surface energy modification to construct FA-based superhydrophobic coatings by a simple spraying method. The PDMS/FA coating surface exhibits a water contact angle(WCA) of 157.65°and a water sliding angle(WSA) of 2.00° The irregular morphology of the FA is conducive to forming a rough texture on the coating surface, which captures more air, leading to the formation of a stable air layer. Molecular dynamics (MD) simulations provide an insight into the anti-wetting mechanism of the superhydrophobic surface through an analysis of energetic and dynamic properties. PDMS/FA coatings remain superhydrophobic at 150 °C, in UV, and in varying pH environments. In addition, PDMS/FA coatings offer excellent mechanical, self-cleaning and anti-icing properties. This innovative approach to superhydrophobic coating, utilizing solid waste material as a basic material, demonstrates potential applicative value in fields such as self-cleaning and anti-icing.
研究领域:
材料科学
·
表面工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2025
·
IF 4.3
Mingmin Li,Liang Qi,Jin Huang,Haonan Li,Wei Cheng,Zihan Shi,Xianxing Jiang,Yifeng Zhou,Wanxiang Jiang
Liver fibrosis can progress to cirrhosis and hepatocellular carcinoma. Currently, there is no effective drug for liver fibrosis. The peptide 6 (T6) is an endogenous peptide derived from human intrauterine adhesion tissues and has antifibrotic potential. Here, to improve the long-term efficacy and activity of T6, we conducted the rational modified of T6 through studying structure–activity, and synthesized a series of analogues. Among them, S6 and S6-FA exhibited optimal antihepatic fibrosis activity, and S6-FA had a stronger long-acting effect than T6 and S6. The two analogues inhibited the expression of α-SMA and Collagen 1 in TGF-β-induced LX2 cells model and CCl4-induced mouse model of liver fibrosis. Besides, we discovered that S6 and S6-FA remarkably reduced the AST and ALT serum levels. Mechanistic studies have demonstrated that analogues inhibited liver fibrosis through inhibiting Erk, Smad and P65 pathways. This study provided that the novel peptide S6 and S6-FA is potential candidate compounds for treating liver fibrosis.
研究领域:
医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Yi Ma,Jingan Li,Yifan Zhou
Magnesium alloys have become the focus of attention as a new generation of vascular stent materials due to their excellent mechanical properties and degradability. However, their rapid degradation rate and poor surface endothelialization performance have become key factors limiting their clinical application. In this study, the Mg-Zn-Y-Nd (ZE21B) surface was modified with the magnesium fluoride (MgF 2 ) corrosion-resistant layer, and the polydopamine (PDA) layer was used to immobilize the chitosan (CS)-ferulic acid (FA)/vanillic acid (VA) bioactive composite coating. The results of the electrochemical and hydrogen evolution experiments showed that the corrosion current density and hydrogen release of the modified ZE21B alloy significantly decreased, and its corrosion resistance was enhanced; the results of the hemolysis rate and whole blood experiments showed that the adhesion of blood components such as white blood cells and platelets on the surface of the modified ZE21B alloy significantly decreased, improving the blood compatibility of the magnesium alloy; the results of in vitro cell experiments showed that the modified ZE21B alloy effectively promoted endothelial cell (ECs) adhesion and proliferation, and inhibited smooth muscle cell (SMCs) pathological proliferation. These enhancements suggest that the CS-FA/VA coating significantly improves both the corrosion resistance and biological compatibility of the ZE21B alloy.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2023
·Vol. 18
·期 6
·065006
·
IF 4
Jing Zhang,Miaomiao Hu,Changchun Wen,Jian Liu,Fang Yu,Juan Long,Xiang-Cheng Lin
Single tumor treatment method usually has some defects, which makes it difficult to achieve good therapeutic effect. The ingenious combination of multiple tumor treatment methods on a single nanoplatform to achieve multifunctional treatment can effectively improve the efficiency of treatment. The targeted modification of nanomaterials can augment the precision of nanotherapeutic drugs in tumor treatment. Herein, a multifunctional nanoplatform (CeO2@CuS@PDA-FA) based on cerium dioxide nanoparticles engineered with copper sulfide (CeO2@CuS) has been constructed for synergistic photothermal therapy (PTT) and chemodynamic therapy (CDT). The CeO2@CuS were coated using polydopamine (PDA), and the modification of PDA surface by folic acid, in order to achieve the targeted effect for tumors. The localized hyperthermia induced by PTT can further improve the CDT efficiency of the nanoplatform, leading to a PTT/CDT synergistic effect. The nanoplatform possessed the capability of cancer cell-targeted and achieved better therapeutic efficacy in vitro. This work provided a new strategy for combined multifunctional theranostic platform and shows strong potential in practical applications.
研究领域:
纳米医学
·
癌症治疗
·
生物材料
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xue Yang,Yuxuan Wang,Jingxian Hua,Rujing Hou,Jinfeng Chen,Qihan Gong,Chongqing Wang,Yichang Pan
Plate-like or sheet-like porous materials with nanometer thickness have been considered as the preferred fillers to improve mixed-matrix membranes (mmms)-based separation. Herein, hexagonal Co-fa (HG-Co-fa) nanoplates were simply synthesized without the addition of any modifier and used as fillers to construct 6FDA-DAM-based MMMs for efficient CO 2 /CH 4 separation. HG-Co-fa nanoplates exhibit high dispersion and interface compatibility in 6FDA-DAM matrix. The results demonstrated that the CO 2 /CH 4 separation performance of 6FDA-DAM was obviously improved after the incorporation of HG-Co-fa nanoplates. The resultant MMMs with nanoplate loading of 10 wt% showed CO 2 /CH 4 selectivity of 27 and CO 2 permeability of 1419 Barrer at 25 ℃ and 0.2 MPa, surpassing 2008 Robeson upper bound. Meanwhile, the high lattice integrity and structural stability of HG-Co-fa nanoplates contribute to the excellent thermal and mechanical stability of MMMs, contributing to their anti-plasticization property up to 14 bar and long-term stability up to 240 h, indicating their potential for natural gas separation.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 27
·5478-5489
·
IF 4.726
Yong Sun,Yaning Wang,Yani Cui,Wen Zou,Yanfei Tan,Jie Liang,Yujiang Fan,Xingdong Zhang
Stimuli-responsive targeted polymeric micelles as drug delivery systems have recently attracted significant attention for the treatment of various cancers, which could improve delivery efficiency by tumor-specific recognition via active targeting strategies. In this research, DOX-incorporated bioreducible polymeric micelles based on PAA-g-PEG/PEG–Fa conjugated polymers were prepared and characterized as nanocarriers for promoting intracellular anti-tumor drug delivery efficiency via folate receptor-mediated endocytosis. The anti-proliferative activity on cancer cells, biodistribution, active-/passive-targeting efficiency, tumor growth inhibition efficiency, and biological toxicity were evaluated in vitro and in vivo. The MTT assay demonstrated that the DOX-encapsulated active-targeting PAA-g-PEG/PEG–Fa micelles had much greater growth inhibition effect against 4T1 and KB than passive-targeting micelles. These active-targeting micelles showed superior tumor accumulation and excellent tumor growth inhibition effect as revealed by the fluorescence optical imaging technique and tumor volume change investigation, as well as the survival study of the tumor-bearing Balb/c mice. Furthermore, the active targeting micelles greatly decreased the toxicity of DOX on the heart and other organs. These potential results encouraged us to further optimize the molecular structure to achieve more excellent targeted therapeutic effect.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 113
·112232-112240
·
IF 3.289
Xiangjie Luo,Ying Wang,Huiming Lin,Fengyu Qu
The integration of multiple therapies into one nanoplatform was considered to be the most efficient method to give an enhanced therapeutic effect for anti-cancer treatments. In this research, pH sensitive drug release and near-infrared (NIR)-induced photothermal therapy (PTT) were placed in one nanocomposite using iron(II,III) oxide@meso-silica (Fe3O4@mSiO2) NPs as the host. Then, a sensitive ketal modified silane coupling agent (PO linker) was prepared to encapsulate the anti-cancer drug, doxorubicin hydrochloride (DOX), into the mSiO2 shell, ensuring the few leakage. Based on the different pH conditions of normal and cancer cells, the DOX-Fe3O4@mSiO2-PO nanocomposite exhibits the specific drug release in cancer cells (acid conditions) before that the few leakage makes sure there are a low number of side effects. Furthermore, the release kinetics can also be easily adjusted by varying the amount of PO linker. Under NIR (808 nm) irradiation, the photothermal effect derived from magnetic Fe3O4 NPs can also induce the apoptosis of the cancer cells which is how PTT is achieved. HeLa cells (cervical cancer cell line) were used as the typical cancer cell and the detailed cell experiments further display the enhanced specific cytotoxicity of the method to HeLa cells. The multifunctional nanocomposite has great potential as an application for anti-cancer therapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF TOXICOLOGICAL SCIENCES
·
2019
·
IF 1.732
Yuan Chen,Xiaoxiao Fei,Chenqiao Ye,Qinqing Qian,Zhiqiu Ye,Siqi Xie,Jiamin Chen,Mingliao Zhu,Na Ran,Mingsheng Hou,Lin Xu,Zhangsen Yu
In the past few decades, upconversion nanoparticles (abbreviated as UCNPs) have been more widely applied in the biomedical fields, such as in vitro and in vivo upconversion fluorescent bioimaging, photodynamic therapy, biological macromolecular detection, imaging mediated drug delivery and so on. But meanwhile, there is still not much research on the acute toxicity of upconversion nanoparticles in vivo, such as acute hepatotoxicity. In this work, we studied the in vivo biodistribution and acute hepatotoxicity of multimodal targeted contrast agent NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoprobe, which were synthesized by the solvothermal method and modified with Polyethylene glycol (PEG), Polyetherimide (PEI), folic acid (FA) on the surface. The acute hepatotoxicity in mice was systematically assessed after tail vein injection of different concentration of UCNPs. The results showed that NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoparticles with an average diameter of 44.5 ± 10.4 nm, and three typical upconversion fluorescence emission bands at 520 nm, 540 nm and 660 nm under the excitation of 980 nm laser. In vivo distribution experiments results demonstrated that approximately 87% of UCNPs injected through the tail vein accumulate in the liver. In the acute hepatotoxicity test, the intravenously injection dose of UCNPs was 10, 40, 70 and 100 mg/kg, respectively. The body weight, blood routine, serum biochemistry, histomorphology and liver oxidative stress were detected and observed no significant acute hepatotoxicity damage under the injection dose of 100 mg/kg. In conclusion, NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoprobes are safe and reliable, and have potential applications in the field of tumor targeted multimodal imaging.
研究领域:
生物医学工程
·
毒理学
·
纳米技术
·
分子影像
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2020
·Vol. 49
·期 12
·7054-7064
·
IF 1.774
Luo Jundong,Wei Aixiang,Luo Ningqi,Liu Jun,Zhao Yu,Xiao Zhiming
The effects of the formamidinium (FA) + alloy fraction x and the dipping time on the properties of FA x MA 1− x PbI 3 thin films (where MA = methylammonium ) as well as the photovoltaic performance of perovskite solar cells (PSCs) have been studied. Mixed-organic-cation FA x MA 1− x PbI 3 thin films were prepared using a two-step solution deposition method in ambient air. PSCs with fluorine-doped tin oxide glass/compact TiO 2 /mesoporous TiO 2 /FA x MA 1− x PbI 3 /carbon electrode structure were fabricated, aiming to reduce the fabrication costs and improve the stability of PSCs. The results indicated that, when the FA + alloy fraction x was increased from 0 to 1, the x-ray diffraction (XRD) peaks shifted continuously to lower angle, while the absorption edge and photoluminescence (PL) peak shifted continuously towards longer wavelength. The Raman spectra of the FA x MA 1− x PbI 3 thin films, consisting of five typical peaks at 68.5 cm −1 , 77.5 cm −1 , 84.6 cm −1 , 139.1 cm −1 , and 283.2 cm −1 , barely shifted with incorporation of FA + . In addition, the dipping time was shortened by using mixed solvents to prepare the PbI 2 thin films. The PSCs based on FA 0.4 MA 0.6 PbI 3 prepared with a dipping time of 15 min exhibited the highest average power conversion efficiency (PCE) of 8.64%, with 74.4% of the initial efficiency being retained after exposure to ambient air at room temperature with approximately 50% humidity for 700 h.
研究领域:
材料科学
·
能源技术
·
光伏器件
✓ 已验证
产品关联
DOI
高影响因子
CEMENT & CONCRETE COMPOSITES
·
2023
·
IF 10.5
Jun Liu,Jiaying Liu,Lei Cheng,Jihua Zhu,Feng Xing,Xu Fan,Luping Tang
A novel modified Rapid Iodide Migration (RIM) test method was used to determine the influence of LC2 and FA on iodide ion diffusion coefficient of seawater and sea sand concrete (SSC). A 0.1 mol/L AgNO 3 solution was selected as the indicator to develop the colour of iodide in SSC, and a lowered mass fraction of NaI solution was selected to improve the RIM test. An X-Ray Fluorescence (XRF) test was employed to detect the feasibility of the modified RIM test. Additionally, the effects of the w/c ratio, the type and substitution rate of supplementary cementitious materials (SCMs), and the compressive strength on the iodide ion diffusion coefficient of SSC were studied using the modified RIM test. The results show that it is completely feasible to use AgNO 3 solution as an indicator. A lower mass fraction of NaI solution not only does not change the iodide ion diffusion coefficient of concrete but also reduces the test cost by 77.46% when using a 5 wt% NaI solution. Moreover, using SCMs to replace cement, liking fly ash (FA) and calcined clay and limestone (LC2), significantly reduces the iodide ion permeability of SSC, especially the use of LC2. Furthermore, there is a nonlinear relationship between the compressive strength and the iodide ion diffusion coefficient of SSC. This work is beneficial for the promotion of the application of modified RIM tests in studies of concrete contaminated with chloride and can provide a theoretical basis for the application of seawater and sea sand in engineering practices.
研究领域:
土木工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2022
·Vol. 223
·期 19
·2200141
·
IF 2.996
Yuke Zou,Rui Yan,Haibo Wang,Kai Zhong,Shuang Wang
At present, high-performance antibacterial polymer materials have attracted widespread attention, possessing huge application prospects in the fields of medical and biological science, and packaging. In this work, polydopamine nanoparticles (PDA NPs) with photothermal ability and active sites are designed to adsorb fusidic acid (FA) molecules with targeted antibacterial capability; then, polydopamine@fusidic acid (PDA@FA) is introduced into the polyurethane (PU) to obtain multifunctional and antibacterial PU materials (PUDA@FA). The structures and morphologies of PDA NPs and PDA@FA are successfully characterized by Fourier transform-infrared spectroscopy and scanning electron microscopy. With the introduction of PDA@FA, the nano-sized reinforcement not only greatly improves the mechanical properties (tensile strength 19.31 MPa and toughness 10.6 MJ m −3 ) of PU film but also due to the photothermal effect of PDA NPs and the antibacterial of FA, the scavenging activities of DPPH and ABTS reach 70–85% and 55–70%, respectively. The antibacterial rate of Staphylococcus aureus reaches more than 99.9% and presents long-term antibacterial ability. In this way, this work provides new guidance for the preparation of high-performance PU materials with both antibacterial and anti-oxidation properties, broadening the application scope of antibacterial materials.
研究领域:
材料科学
·
生物医学工程
·
高分子科学
·
纳米技术
✓ 已验证
DOI
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Shiyu Duan,Nan Tian,Jicheng Zhang,Zhaoxuan Huang,Disheng Yao,Guoyuan Zheng,Jilin Wang,Yanhan Yang,Bing Zhou,Fei Long
Cs-rich FA-Cs perovskites theoretically have good humidity stability, photothermal stability, and suitable band gap for top cells of tandem solar cells. However, the phase separation of Cs-rich FA-Cs perovskite films occurs when the Cs content exceeds 30%, so it is difficult to synthesize pure Cs-rich FA-Cs perovskite films. Here, pure Cs-rich FA-Cs perovskite Cs1–xFAxPbI2Br(0 ≤ x ≤ 0.6) films without any impurity phase are first synthesized by reducing its phase formation energy barrier through assistance of PbI2(DMSO) and PbBr2(DMSO) admixtures. Compared with the pristine CsPbI2Br films, the humidity stability of those films is significantly improved and a remarkably enhanced power conversion efficiency (PCE) of 14.55% in α-Cs0.7FA0.3PbI2Br solar cells is achieved. Meanwhile, after annealing at 140 °C for 1 h or irradiating with ultraviolet light in N2 or dry air for 12 h, no phase separation and band gap change are found in Cs0.7FA0.3PbI2Br. The distributions of the PCE are similar, and the champion PCE of the corresponding Cs0.7FA0.3PbI2Br solar cells remains within 14.24–14.55%. This shows that α-Cs0.7FA0.3PbI2Br has good thermal and ultraviolet radiation stability.
研究领域:
材料科学
·
光伏技术
·
能源研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）