Fundamental Research
·
2024
·
IF 5.7
Jiaojiao Zhang,Jing Liu,Wen Hu,Xue Jiang,Long Zhou,Yumin Tang,Zhong Lin Wang,Rusen Yang
Piezoelectric biomaterials have shown good energy conversion capability and promising future for biomedical applications. However, their performance is still limited by their relatively low piezoelectric constant, and increasing the power by connecting multiple devices is restricted by the challenge of synchronizing all individual devices. Herein, we develop double-layer FF peptide microrods arrays with independently controlled polarization in each layer. The resultant piezoelectric nanogenerator showed much enhanced performance because the synchronous deformation and the appropriate polarization directions of microrods in each individual layer enable the constructive contribution of voltage and current output from all microrods. The nanogenerator generated an open circuit voltage of 2.05 V in a serial connection mode, which doubles the output from a single-layer device. When two layers are connected in parallel and the polarization is in a head-to-head configuration, a twofold increase in the current output is also achieved. This work provides a new strategy to design integrated devices with much improved performance for wearable technology and therapeutic systems.
研究领域:
生物材料学
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纳米技术
·
能源科学
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2015
·
IF 3.088
Xiao Gong,Christopher Branford-White,Lei Tao,Shubai Li,Jing Quan,Huali Nie,Limin Zhu
Dipeptides and their derivatives have attracted tremendous attention owning to their excellent abilities of self-assemble assembling into various structures which have great potentials for applications in biology and/or nanotechnology. In the present study, we dedicate to fabricate a rigid and structure controllable Fmoc-FF/SA composite hydrogel. We found that the modified dipeptide, fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) can self-assemble into rigid hydrogels with structures of nanowires, layered thin films or honeycombs as the change of sodium alginate (SA) concentration. Meanwhile, CD-spectroscopy demonstrated that SA appeared to control the process, but it did not change the arrangement of the Fmoc-FF peptide. Our results demonstrated that the formed hydrogel showed physical and chemical stability as well as possessing good biocompatibility. Rheological measurements showed that the addition of SA could improve the stability of the hydrogel. Cell viability assay revealed that the Fmoc-FF and Fmoc-FF/SA hydrogels are both beneficial for cell proliferation in-vitro . Our results indicated that the fabricated Fmoc-FF/SA composite hydrogels could be used in tissue engineering and drug delivery in the future.
研究领域:
生物材料学
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纳米技术
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Yuqing Liu,Huiqing Ma,Ang Li,Haixia Pan,Xianliang Yi,Yang Liu,Jingjing Zhan,Hao Zhou
Tellurium (Te) is a rare element within the chalcogen group, and its biogeochemical cycle has been studied extensively. Tellurite (Te(IV)) is the most soluble Te species and is highly toxic to organisms. Chemical or biological Te(IV) reduction to elemental tellurium (Te 0 ) is generally considered an effective detoxification route for Te(IV)-containing wastewater. This study unveils a previously unnoticed Te 0 oxidation process mediated by the manganese-oxidizing bacterium Bacillus sp. FF-1. This bacterium, which exhibits both Mn(II)-oxidizing and Te(IV)-reducing abilities, can produce manganese oxides (BioMnO x ) and Te 0 (BioTe 0 ) when exposed to Mn(II) and Te(IV), respectively. When 5 mM Mn(II) was added after incubating 0.1 mM or 1 mM Te(IV) with strain FF-1 for 16 h, BioTe 0 was certainly re-oxidized to Te(IV) by BioMnOx. Chemogenic and exogenous biogenic Te 0 can also be oxidized by BioMnOx, although at different rates. This study highlights a new transformation process of tellurium species mediated by manganese-oxidizing bacteria, revealing that the environmental fate and ecological risks of Te 0 need to be re-evaluated.
研究领域:
微生物学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Shuaihua Wang,Xianxiu Li,Yan Sun
Ion exchangers of high binding capacity and uptake rate are desired for high performance purification of proteins by ion exchange chromatography. For this purpose, we have herein developed a new anion exchanger by grafting N,N - Dimethylaminopropyl acrylamide (DMAPAA) onto Sepharose FF by atom transfer radical polymerization. Six DMAPAA-grafted Sepharose FF resins of the same grafting density but different chain lengths (ionic capacities, ICs) were prepared, and named as FF-pDMAPAA n ( n denotes IC value, 65–831 mmol/L). Bovine serum albumin (BSA) adsorption and its chromatography were studied to evaluate the anion exchange resins. It was found that the equilibrium protein adsorption capacity ( q m ) increased rapidly from 91 mg/mL at IC = 65 mmol/L till reaching a peak value (368 mg/mL) at IC = 458 mmol/L and then decreased slightly with further increasing IC (chain length) to 831 mmol/L. The uptake rate, D e / D 0 , defined as the ratio of effective diffusion coefficient ( D e ) to free diffusivity of the protein ( D 0 ), also presented similar changes as a function of IC. Namely, D e / D 0 increased from 0.25 to 2.45 in the IC range of 65 to 458 mmol/L, kept almost unchanged from 458 to 573 mmol/L and then decreased slightly with further increase of IC to 831 mmol/L. Therefore, FF-pDMAPAA458 presented the best performance of the six resins for BSA adsorption, possessing very high q m and D e / D 0 values (368 mg/mL and 2.45, respectively). The resin was thus extensively characterized in the effect of ionic strength and column chromatography. The q m and D e / D 0 of FF-pDMAPAA458 were much higher than other anion exchangers reported in literatures and kept over 230 mg/mL and 2.3, respectively, at salt concentrations up to 100 mmol/L. Therefore, the dynamic binding capacity of the FF-pDMAPAA458 column was remarkably higher than Q Sepharose FF and other two typical polymer-grafted anion exchangers reported in literatures in the salt concentration range, and kept as high as 180–220 mg/mL in the superficial flow velocity rang of 150–1350 cm/h. Taken together, the results demonstrated that FF-pDMAPAA resins of appropriate ionic capacities are promising for high-performance protein chromatography.
研究领域:
生物化学
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分离科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Qing Tan,Yuan Yang,Linshan Yang,Dandan Wang,Xiaoling Hou,Kerage Dorothy Mokeira,Jialun Wu,Guibin Lv,Shuxia Xu,Chengbin Zheng
Background The evaluation of particle-bound mercury (PBM) exposure is a crucial aspect of assessing the global cycle of mercury (Hg) and its adverse effects on human health and ecosystems. Nevertheless, the precise and reliable measurement of PBM remains a formidable task because of the costly and cumbersome equipment required, as well as the inadequate sensitivities exhibited by current analytical techniques. In this study, we provided a unique and straightforward approach utilising filter fiber-assisted matrix solid-phase dispersion (FF-MSPD) in conjunction with single-drop solution electrode discharge-induced cold vapor generation atomic fluorescence spectrometry (SD-SEGD-CVG-AFS) for the precise quantification of PBM. The PBM contained in a small filter was efficiently extracted with 200 μL of eluent (0.2 % L-cysteine and 4 % HCOOH) by FF-MSPD and subsequently converted to Hg 0 using SD-SEGD-CVG, before being subjected to examination using AFS. Results The resulted limit of detection (LOD, 3 σ ) was 0.17 pg m −3 , obtained with a sample volume of 12 m 3 , which was much higher than that of the techniques published in the literatures. The aforementioned technique was effectively utilised for the detection of mercury in 19 samples of PM 2.5 and PM 10 which were collected over a span of several months. Signiffcance Contrast to conventional methods, the proposed method offers a range of distinct advantages, including simplified operation, absence of memory effects , enhanced sensitivity, substantial reduction in reagent usage, and decreased secondary pollution. These advantages are particularly valuable for advancing research on the fate, transport, and exposure routes of environmental mercury.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale Research Letters
·
2016
·Vol. 11
·期 1
·1-9
·
IF 2.584
Xie Yanyan,Zhao Jun,Huang Renliang,Qi Wei,Wang Yuefei,Su Rongxin,He Zhimin
We report a new approach to constructing a peptide–polysaccharide hybrid hydrogel via the calcium-ion-triggered co-assembly of fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) peptide and alginate. Calcium ions triggered the self-assembly of Fmoc-FF peptide into nanofibers with diameter of about 30 nm. Meanwhile, alginate was rapidly crosslinked by the calcium ions, leading to the formation of stable hybrid hydrogel beads. Compared to alginate or Fmoc-FF hydrogel alone, the hybrid Fmoc-FF/alginate hydrogel had much better stability in both water and a phosphate-buffered solution (PBS), probably because of the synergistic effect of noncovalent and ionic interactions. Furthermore, docetaxel was chosen as a drug model, and it was encapsulated by hydrogel beads to study the in vitro release behavior. The sustained and controlled docetaxel release was obtained by varying the concentration ratio between Fmoc-FF peptide and alginate.
研究领域:
生物材料学
·
药剂学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2026
·
IF 5.5
Yuqi Liu,Chengfeng Ma,Haoyu Guo,Rui Zhou,Wei Tao,Yujie Cang,Kang Wu,Yanmin Huang,Shaoying Wang,Weibo Yan,Hao Xin
Wide-bandgap chalcopyrite copper indium sulfide CuInS2 (CIS) thin-film solar cells have significant potential as top cells in tandem configuration and for indoor photovoltaic devices. Among various fabrication routes, solution-processing is particularly attractive due to its low cost, simplicity, and adaptability to large areas and flexible substrates. However, the efficiency of CIS solar cells is still lower than that achieved by vacuum-based methods. A major factor limiting the performance of CIS solar cells is the poor crystallinity of the absorber, which leads to a high density of grain boundaries and defects, facilitating nonradiative recombination. In this work, we report a highly efficient CIS solar cell by in situ potassium (K) doping via easily adding KCl into the precursor solution. The introduction of K significantly promotes grain growth and suppresses interface defects, leading to remarkable improvements in device performance. At an optimal K doping concentration (K/Cu = 7%), the champion CIS thin-film solar cell achieves an efficiency of 11.58%, enhanced by 60% compared to nondoped devices. In addition, a fill factor (FF) of 70.10% has been achieved, the highest FF reported for solution-processed CIS thin-film solar cells. Our results demonstrate a facile and efficient K doping strategy to realize high-performance wide-bandgap CIS thin-film solar cells.
✓ 已验证
DOI
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 3.226
Xianxiu Li,Yang Liu,Yan Sun
Alginate (Alg)-grafted Sepharose FF with an ionic capacity (IC) of 230 mmol/L (Alg-FF-230) was first prepared and then sulfonated to synthesize two cation exchangers of higher ICs (270 and 370 mmol/L, denoted as S-Alg-FF-IC). It was found that lysozyme adsorption capacity increased with increasing IC value, but the uptake rate ( D e / D 0 ) on S-Alg-FF-370 was small (0.070) at 0 mmol/L NaCl because of the strong binding that limited surface diffusion of the bound protein. However, the dynamic binding capacity (DBC) of S-Alg-FF-370 was much higher in the salt concentration range of 0–150 mmol/L than the lower IC resins due to its high adsorption capacity and increased uptake rate. Especially at 150 mmol/L NaCl, the DBC of S-Alg-FF-370 was about 7.3 times higher than Alg-FF-230 and kept over 70 mg/mL at the flow rate up to 1350 cm/ h . The results proved the high salt-tolerant feature of S-Alg-FF-370. By contrast, S-Alg-FF-270 showed higher DBC values than S-Alg-FF-370 in the same flow rate range at 50 mmol/L NaCl. Hence, S-Alg-FF-270 and S-Alg-FF-370 displayed different properties that would make them favorable for use in protein purification at different salt concentrations. The work thus proved that the sequential alginate grafting and sulfonation strategy is promising for creation of ion exchangers for high-performance and cost-effective purification of proteins from feedstocks of different ionic strengths.
✓ 已验证
DOI
高影响因子
Small
·
2024
·
IF 13
Chunxiao Li,Yuying Feng,Jiahui Jiang,Ting Zhao,Guancheng Xu,Li Zhang
Transition metal-based tellurides (TMTs) with excellent electrical conductivity are expected to be ideal electrocatalysts for overall water splitting. However, compared to transition metal sulfides and selenides, the reported applications of TMTs in overall water splitting are fewer. Herein, the NiTe/FeTe/Fe 3 O 4 /FF carnation flower-like with a semi-coherent interface is successfully constructed to enhance the electrochemical overall water splitting performance. Specifically, it achieves low overpotentials of 54 and 176 mV at 10 mA cm −2 for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER), respectively. What's more, the electrolyzer requires a cell voltage of 1.5 V to sustain a current density of 10 mA cm −2 and maintains remarkable stability for an extensive duration of 450 h even at a current density of 100 mA cm −2 . Semi-coherent interface engineering and vacancy engineering not only improve the OH⁻ adsorption capacity of catalysts but also promote the desorption of adsorbed hydrogen (H ads ). In situ Raman spectroscopy reveals that FeOOH and NiOOH formed by NiTe/FeTe/Fe 3 O 4 /FF during the OER are the genuine active sites. This study provides a promising approach for the electrochemical water splitting of TMTs by combining semi-coherent interface engineering and vacancy engineering.
研究领域:
材料科学
·
电催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 63
·39523-39529
·
IF 3.108
Wenhui Zhang,Yang Ding,Yue Jiang,MingZhi Zheng,Sujuan Wu,Xubing Lu,Min Zeng,Xingsen Gao,Qianming Wang,Guofu Zhou,Jun-ming Liu,Krzysztof Kempa,Jinwei Gao
Interface engineering has been proved to be a practical strategy to enhance power conversion efficiency (PCE) and stability of perovskite solar cells. Recently approaches involving ultra-thin layer deposition and vacuum-processing, while improving PCE, increase the processing complexity, and thus the overall cost. In this paper, we demonstrate a high-efficiency inverted planar perovskite solar cell, obtained with a simple wet-chemistry based, room-temperature, and cost-effective process, which synthesizes two interfacial layers: solution processed molybdenum oxide (named s-MoOx) for anode and titanium(IV) oxide bis(2,4-pentanedionate) (TOPD) for cathode buffer layers. Steady-state photoluminescence (PL), time resolved photoluminescence (TRPL) and electrochemical impedance spectroscopy (EIS) are conducted to characterize the charge transport properties, confirming an enhanced charge extraction efficiency and a suppressed charge recombination. In addition, the introduction of the interfacial layers facilities formation of an ohmic contact with the metal electrode, reducing the charge transfer resistance and increasing the FF to as high as 80.7%. The optimized solar cells achieve the best PCE of 16.04% which far exceeds the PCE of devices without these interfacial layers (PCE = 11.2%).
研究领域:
材料科学
·
能源科学
·
纳米技术
·
表面与界面化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Linling Yu,Qiuhong Zhai,Yan Sun
Our previous studies on protein adsorption to the anion-exchangers of poly(ethylenimine) (PEI)-grafted Sepharose FF found that both adsorption capacity and uptake rate of bovine serum albumin (BSA) increased greatly when the PEI grafting density reached over a critical ionic capacity (cIC) due to the 3D protein binding and occurrence of “chain delivery” of bound proteins. Moreover, by the investigation on the anion-exchangers of diethylaminoethyl (DEAE)-modified and DEAE-dextran-grafted Sepharose FF, we found the unique role of surface ligand in facilitating protein uptake kinetics on dextran-functionalized anion exchangers as the “transfer station” for the “chain delivery” of bound proteins. However, what would be the contribution of surface ligands on the transport of bound proteins on PEI chains at a wide range across cIC, particularly at the lower IC range where no “chain delivery” was present? We have thus designed this research to answer the question. To this purpose, we fabricated three series of PEI-Sepharose FF resins, one without surface ligand (i.e., FF-PEI) and two with surface DEAE modifications at DEAE coupling densities of 60 and 90 mmol/L (i.e., FF-D60-PEI and FF-D90-PEI), and focused on the role of surface DEAE at different PEI densities in BSA adsorption equilibrium and uptake kinetics in a wide IC range of PEI across cIC (∼600 mmol/L for BSA). It was found that, at low grafting-ligand densities (IC cIC, however, both adsorption capacity and uptake rate changed only slightly (<5% and <10%, respectively) by the addition of surface DEAE groups. The results revealed that at IC < cIC, the surface DEAE groups provided the supplement of available binding sites and facilitated the happenings of the “chain delivery” of bound proteins as the “transfer station”, both of which were limited at the low IC range. However, at IC > cIC, the extended flexible PEI chains have already afforded 3D binding space with high accessibility and easy happening of “chain delivery” of bound proteins, so the surface DEAE groups between neighboring PEI chains did not work in assisting the transport of bound proteins. Moreover, when the IC was lower but close to the cIC, the FF-D-PEI resins exhibited higher uptake rates than FF-PEI resins at a similar or even lower IC values. These findings indicate that surface modification of charged groups in PEI-based anion exchangers of low grafting density would be an efficient strategy to fabricate high performance protein ion exchangers.
研究领域:
生物化学
·
分离科学
·
蛋白质工程
✓ 已验证
DOI
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 3.475
Changsen Li,Xianxiu Li,Yang Liu,Yan Sun
Our previous study reported a novel protein ion-exchanger, N,N-dimethylaminopropyl acrylamide (DMAPAA)-grafted Sepharose FF, of very high protein adsorption capacity and uptake rate. To gain new insight into the polymer grafting effects on protein adsorption and chromatography, 18 DMAPAA-grafted anion exchangers of four grafting densities and various chain lengths (i.e., ionic capacities, ICs) were prepared and named as FF-Br x -pDMAPAA n ( x represents grafting density and n stands for IC in mmol/L). It was found that an optimal IC existed at each grafting density to present a maximal capacity. Of the four optimal-IC resins, FF-Br3-pDMAPAA587 showed the highest capacity (377 mg/mL), but the protein uptake rate, defined as the ratio of effective pore diffusivity to free diffusivity ( D e / D 0 ), was smaller than the resin of a similar ionic capacity but lower grafting density (FF-Br2-pDMAPAA592). Consequently, the dynamic binding capacity (DBC) of FF-Br2-pDMAPAA592 was higher than that of FF-Br3-pDMAPAA587 at flow velocities higher than 450 cm/h. Moreover, FF-Br3-pDMAPAA587 showed higher adsorption capacity than FF-Br2-pDMAPAA592 at 0−150 mmol/L NaCl, leading to its higher DBC values as compared to FF-Br2-pDMAPAA592 in the same salt concentration range. Taken together, DMAPAA-grafted resins of different grafting densities would be useful for purifying feedstocks of different ionic strengths.
研究领域:
生物化学
·
分离科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）