SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Xiaoyi Lv,Xiaoyun Xu,Tian Miao,Xufeng Zang,Chao Geng,Yanping Li,Bo Cui,Yishan Fang
Fluorescent dyes have been considered as one of the most potential candidates for electrochemiluminescence (ECL) reagent due to the excellent photophysical and electrochemical characteristics in recent years. However, the severe self-absorption effect caused by narrow stokes shift inevitably limits its application for ECL. In this work, a new type of ECL emitter, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene derivative, a BF2 complex of hydrazine-schiff base linked bispyrrole, namely BPYHBF, was prepared and employed as a probe to label the competitor of target in the immunosensor, which could emit powerful ECL signal with tri- n -propylamine. The structure and ECL property of BPYHBF were investigated. Additionally, multi-walled carbon nanotube/ferrocenecarboxaldehyde-metal organic framework (MWCNTs/Fc-MOF) as sensing substrate for Ab1 incubation was synthesized, where the large specific surface area and stable internal reference electrochemical signals improved the sensitivity and reliability of the sensor by self-correction. Herein, a novel ratiometric competitive immunosensor based on the ECLBPYHBF/DPVFc was prepared for ultrasensitive detection of aflatoxin B1 (AFB1). The ratio value is linear in the range from 10 fg/mL to 100 ng/mL, and the detection limit is 5.39 fg/mL. The prepared sensor exhibited excellent sensitivity, accuracy and reproducibility, and achieved satisfactory detection towards AFB1 in actual samples, this demonstrates a promising application in biomolecules detection.
研究领域:
分析化学
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食品安全
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生物传感
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产品关联
DOI
高影响因子
Analytical Methods
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2025
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IF 2.6
Baohan Wen,Haoyi Ren,Wenjing Lai,Min Wang,Mingzhe Jiang,Yingying Cheng,Yige Li,Chenglin Hong,Yu Qi
Early cancer diagnosis is crucial due to a significant increase in cancer incidence over the last three decades. A highly sensitive electrochemiluminescence technique was developed for carcinoembryonic antigen (CEA) detection. This method uses Ru(bpy)32+ as the luminescent substance, and the silica and polyacrylamide gel composite as the carrier. Ru(bpy)32+ is loaded into it to prevent its leakage. At the same time, biological molecules such as antibodies or antigens are immobilized, thereby improving the stability and reaction activity of the system. Additionally, Au-Fc-MOF was synthesized to act as a quencher and secondary antibody label, absorbing the emitted energy from the ECL emitter to improve detection accuracy across various CEA concentrations. Potassium persulfate was employed as a co-reactant to generate SO4•- radicals, intensifying the luminescence output of the system. The findings revealed that the developed immunosensor exhibited strong linearity within the concentration range of 10-5 ng/mL to 10 ng/mL, with a remarkably low detection limit of 5.03 fg/mL. This electrochemical luminescence immunosensor, characterized by its simple preparation, cost-effectiveness, and superior performance, demonstrates significant potential in advancing early CEA detection methodologies.
研究领域:
分析化学
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生物传感器
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癌症诊断
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纳米材料
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电分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
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2025
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IF 9.5
Yuchen Zhao,Jingyun Guo,Bo Yang,Panyouwen Zhang,Xinyi Wan,Lei Wang,Pingwei Ye,Xinsheng Peng
Solar-driven interfacial water evaporation (SDIWE) technology is an promising way to solve the shortage of fresh water scarcity. However, it is still challenging to generate clean water from organic compound contaminated water through SDIWE. Herein, a 3D multilayer inverted cone solar evaporator based on flexible MOF/graphene oxide composite membrane (CFG membrane) is designed for efficient water evaporation and purification. The Co-Ferrocene (Co-Fc) MOF loaded in the CFG membrane expands the interlayer spacing of GO, providing channels for water transport and enhancing the photothermal performance. The 3D multilayer inverted cone structure enhances the absorption of sunlight through multiple reflections of light between different layers. Based on the above design, the 3D evaporator with three layer CFG membranes demonstrates an evaporation rate of 2.28 kg m-2 h-1 under 1-sun illumination, good salt-resistance and long-term stability. Meanwhile, the Co-Fc MOF in the evaporator acts as an effective Fenton catalyst and promote the generation of ˙OH for the degradation of organic pollutants in wastewater. The degradation rate of pollutants in mixed wastewater (MB: 80 mg L-1; TC: 40 mg L-1; phenol: 40 mg L-1) by CFG-3 evaporator is all over 95%. Almost no volatile organic compounds (VOCs) were detected in the distilled water. This may provide a promising strategy for the efficient solar-driven evaporation and treatment of organic wastewater.
研究领域:
环境科学
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材料科学
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化学工程
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纳米技术
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水处理
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能量转换
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xiaolei Zhang,Nan Gao,Zong Tan,Dongjun Lv,Zhongmin Liu,Qi Tang,Fei Yang,Xiaoli Wang,Hui Zhao,Xueting Liu,Jinyang Li,Jiahao Wang
ER-Fc-MOF@CF monolith integrates PE capture and Fenton-like oxidation. • Carbonization tunes conductivity, defects, and MOF anchoring on CF. • CF-900 achieves 91.14% PE removal under flow-through conditions. • Captured PE undergoes localized ROS-mediated surface oxidation. • Monolithic design reduces powder catalyst loss and secondary release. Microplastic remediation requires efficient particle capture and interfacial oxidation because dispersed polymers have limited contact with short-lived reactive oxygen species (ROS) in bulk solution. Here, an electroresponsive ferrocene metal–organic framework (ER-Fc-MOF) was grown in situ on thermally engineered foam carbon (CF) to construct ER-Fc-MOF@CF monoliths for polyethylene microplastic capture and subsequent electro-Fenton-like treatment. Carbonization temperature regulated the scaffold architecture, surface chemistry, defect structure, electrical resistivity, and ER-Fc-MOF coverage. Among the investigated samples, CF-900 retained accessible hierarchical porosity while exhibiting the lowest resistivity and densest ER-Fc-MOF coverage. The optimized ER-Fc-MOF@CF-900 achieved 91.14% flow-through removal from a 100 mg·L −1 polyethylene (PE) suspension. Zeta-potential, FTIR, and XPS analyses suggested pH-dependent electrostatic attraction and localized polar interactions involving oxygen-containing groups, while the interconnected monolith facilitated particle interception and retention. The low-resistance CF-900 scaffold supported electron transport and H 2 O 2 activation at ER-Fc-MOF domains. SEM, EDS, FTIR, and XPS showed progressive PE surface oxidation, including roughening, oxygen enrichment, and increased C O, C O, and O–C=O signals, while EPR identified ·OH, ·O 2 − , and 1 O 2 . After 36 h, dissolved organic carbon (DOC) reached 67.21 mg·L −1 in the PE-containing system versus 8.80 mg·L −1 in the PE-free control, supporting PE-associated dissolved organic carbon release. This work establishes a self-supporting MOF–carbon platform coupling PE capture, flow-through interception, and interfacial oxidative transformation. Download: Download high-res image (205KB) Download: Download full-size image
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Zheng Deng,Chao Fang,Xu Ma,Xiang Li,Yu-Jia Zeng,Xinsheng Peng
Metal–organic frameworks (MOFs) have been identified as promising materials for the delivery of therapeutics to cure cancer owing to their intrinsic porous structure. However, in a majority of cases, MOFs act as only a delivery cargo for anticancer drugs while little attention has been focused on the utilization of their intriguing physical and chemical properties for potential anticancer purposes. Herein for the first time, an ultrathin (16.4 nm thick) ferrocene-based MOF (Zr-Fc MOF) nanosheet has been synthesized for synergistic photothermal therapy (PTT) and Fenton reaction-based chemodynamic (CDT) therapy to cure cancer without additional drugs. The Zr-Fc MOF nanosheet acts not only as an excellent photothermal agent with a prominent photothermal conversion efficiency of 53% at 808 nm but also as an efficient Fenton catalyst to promote the conversion of H2O2 into hydroxyl radical (•OH). As a consequence, an excellent therapeutic performance has been achieved in vitro as well as in vivo through this combinational effect. This work aims to construct an “all-in-one” MOF nanoplatform for PTT and CDT treatments without incorporating any additional therapeutics, which may launch a new era in the investigation of MOF-based synergistic therapy platforms for cancer therapy.
研究领域:
纳米技术
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癌症研究
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材料科学
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药物递送
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Haotian Wu,Li Tian,Haijuan Qin,Xiao Zhou,Xiying Chen,Weiran Li,Jing Zhang,Shuo Wang,Yaqing Liu
An injectable hydrogel dressing, Zr/Fc-MOF@CuO 2 @FH, was constructed by combing acid-triggered chemodynamic treatment (CDT) with low-temperature photothermal treatment (LT-PTT) to effectively eliminate bacteria without harming the surrounding normal tissues. The Zr/Fc-MOF acts as both photothermal reagent and nanozyme to generate reactive oxygen species (ROS). The CuO 2 nanolayer can be decomposed by the acidic microenvironment of the bacterial infection to release Cu 2+ and H 2 O 2 , which not only induces Fenton-like reaction but also enhances the catalytic capability of the Zr/Fc-MOF. The generated heat augments ROS production, resulting in highly efficient bacterial elimination at low temperature. Precisely, injectable hydrogel dressing can match irregular wound sites, which shortens the distance of heat dissipation and ROS diffusion to bacteria, thus improving sterilization efficacy and decreasing non-specific systemic toxicity. Both in vitro and in vivo experiments validated the predominant sterilization efficiency of drug-resistant methicillin-resistant Staphylococcus aureus (MRSA) and kanamycin-resistant Escherichia coli (KREC), presenting great potential for application in clinical therapy.
研究领域:
纳米医学
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生物材料
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生物医学工程
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传染病学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）