Low back pain (LBP) resulting from sciatic nerve compression presents major challenges in pain management, as traditional therapies provide only short-term relief and pose risks of systemic toxicity. In this study, an innovative Fe 3 O 4 @ZIF-8-RVC (FZR) dual-responsive nanoplatform is introduced that integrates magnetic targeting with pH-sensitive, sustained drug release to overcome these limitations. The FZR nanoplatform encapsulates ropivacaine (RVC) within the ZIF-8-coated Fe 3 O 4 core, enabling precise and prolonged analgesia at the injury site through magnetic guidance and acid-triggered release. In vitro and in vivo assessments indicate that FZR achieves high drug loading, sustained release in acidic environments, and excellent biocompatibility, significantly extending analgesic effects in chronic nerve injury models while minimizing systemic exposure. Behavioral tests and molecular analyses in LBP rat models confirm that FZR effectively suppresses pain-related neuronal activity and central sensitization markers. This dual-responsive nanoplatform FZR offers a safe, long-lasting, and targeted therapeutic approach, holding strong potential for advancing pain relief in LBP and related neuropathic pain conditions.
Antibiotics like doxorubicin hydrochloride (DOX) are widely used in medicine, but their environmental residues pose risks to human health and ecosystems. This study optimized the synthesis of C-Fe₃O₄@ZIF-8 composites using response surface methodology (RSM) to enhance DOX release efficiency, thereby mitigating environmental antibiotic contamination. Under optimized conditions (37 °C, pH 5.0), the C-Fe₃O₄@ZIF-8 composite achieved a significant increase in cumulative DOX release, from 40.8% to 61.1%. The pH-responsive release further validated the optimization strategy. Characterization via scanning electron microscopy (SEM) and X-ray diffraction (XRD) revealed a structural transformation from rhombic dodecahedral crystals to more stable spherical particles with enhanced crystallinity. Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) confirmed an increase in surface-active sites and oxygen-containing functional groups, contributing to improved drug release efficiency. These findings provide valuable insights into optimizing C-Fe₃O₄@ZIF-8 for drug delivery, advancing environmentally friendly antibiotic management strategies.
危险品化学品经营许可证（带存储）