SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Haocheng Song,Qiang Li,Yuxuan Ye,Fei Pan,Dajie Zhang,Dongsheng Xia
Antibiotic contamination has become a serious environmental problem and much attention has been paid to its purification. The sulfate radical (SO 4 − ) based advanced oxidation processes (AOPs) exhibited significant potential in the treatment of antibiotics. In this study, the magnetic biochar (Fe 2 O 3 @LBC) derived from loofah was prepared to activate persulfate (PS) for cephalexin (CEX) degradation. Under the optimal conditions, 73.9% of CEX was removed in the Fe 2 O 3 @LBC/PS system. Free radicals quenching experiments and electron paramagnetic resonance (EPR) analysis revealed that HO and SO 4 − were responsible for the degradation of CEX. The C-OH of the catalyst played a crucial role in the degradation process. In addition, the conversion between Fe 3+ and Fe 2+ enhanced the degradation of CEX by producing SO 4 − . The degradation performance of other antibiotics and CEX in different water matrices indicated the broad adaptability and applications of Fe 2 O 3 @LBC. The main intermediates and the possible transformation pathways were proposed. These results provided a potential insight into biochar based catalysts for the degradation of antibiotics by activation of persulfate.
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
LIFE SCIENCES
·
2024
·
IF 5.2
Sijia Liu,Fang Guo,Tianli Zhang,Ying Zhu,Meng Lu,Xiayu Wu,Fuqin He,Ruiying Yu,Dan Yan,Zhangyin Ming,Dan Shu
Aims This research aimed to study the changes in platelet function and their underlying mechanisms in iron deficiency anemia. Main methods Initially, we evaluated platelet function in an IDA mice model. Due to the inability to accurately reduce intracellular Fe 2+ concentrations, we investigated the impact of Fe 2+ on platelet function by introducing varying concentrations of Fe 2+ . To probe the underlying mechanism, we simultaneously examined the dynamics of calcium in the cytosol, and integrin αIIbβ3 activation in Fe 2+ -treated platelets. Ferroptosis inhibitors Lip-1 and Fer-1 were applied to determine whether ferroptosis was involved in this process. Key findings Our study revealed that platelet function was suppressed in IDA mice. Fe 2+ concentration-dependently facilitated platelet activation and function in vitro. Mechanistically, Fe 2+ promoted calcium mobilization, integrin αIIbβ3 activation, and its downstream outside-in signaling. Additionally, we also demonstrated that ferroptosis might play a role in this process. Significance Our data suggest an association between iron and platelet activation, with iron deficiency resulting in impaired platelet function, while high concentrations of Fe 2+ contribute to platelet activation and function by promoting calcium mobilization, αIIbβ3 activation, and ferroptosis.
研究领域:
血液学
·
细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 1
·e202204011
·
IF 2.1
Chuan Chen,Tianhao Yao,Sen Qian,Qiang Zhang,Ximin Zhang
Graphical A series of Ni x Zn 1−x Fe 2 O 4 (x=0, 0.25, 0.5, 0.75 and 1) sponges have been fabricated through a facile blowing-combustion method. The optimized Ni 0.75 Zn 0.25 Fe 2 O 4 sponge showed pure phase of spinel ferrite and displayed enhanced magnetic satuaratiuon of 44.98 emu/g. Spinel ferrites have been widely used in various fields, among which nickel-zinc (NiZn) ferrites have drawn much attention due to their high electrical resistivity as well as low eddy current loss. To accommodate highly-integrated modern electronic devices, the preparation methods for nano/micro-sized NiZn ferrites have been widely discussed. Nevertheless, these current synthesis routes are usually cost/time-consuming, which hinders their large-scale production for practical applications. Herein, we present a facile, low-cost synthesis strategy for NiZn ferrites (Ni x Zn 1−x Fe 2 O 4 , x=0, 0.25, 0.5, 0.75 and 1) through a blowing-combustion method. The effect of Ni/Zn molar concentration on the structure, morphology as well as magnetic properties has been thoroughly investigated through X-ray diffraction, Raman spectroscopy, scanning electron microscopy and vibrating sample magnetometer. Thanks to the synergetic effect of the pure phase and moderate Ni molar concentration, the Ni 0.75 Zn 0.25 Fe 2 O 4 shows an enhanced saturation magnetization of 44.98 emu/g. More importantly, this blowing-combustion method may also be commonly applied to other spinel ferrites with different stoichiometric ratios and heteroatom doping.
研究领域:
材料科学
·
纳米技术
·
磁学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Yan Wang,Yue Zhang,Jinglong Xue,Leqiang Gao,Xiangyang Li,Moxuan Zhao,Dong Zhao,Xianqing Zhou
Decabromodiphenyl ether (BDE-209) is an environmental toxin. Increasing evidence showed that BDE-209 exposure induced liver injury, but the mechanism still remains unknown. The present study explored the effect and mechanism of ferroptosis on hepatotoxicity triggered by BDE-209 in vivo and in vitro . In vivo experiment, ICR mice were exposed to BDE-209 for 50 days, and then recovered for 50 days; HepG2 and L02 cells were treated with BDE-209 or/and ferrostatin-1 (Fer-1) for establishing in vitro model. In vivo , the results showed that BDE-209 accumulated in liver and induced liver damage, increased Fe 2+ and MDA contents, and blocked the activation of SLC7A11/GSH/GPX4 pathway in liver; BDE-209 also activated IKK/IκB/NF-κB pathway and elevated inflammatory cytokines levels in liver after exposure for 50 days. After BDE-209 stopping exposure 50 days, the severity of liver damage, ferroptosis and inflammatory response were still higher than the corresponding control group. In vitro , ferroptosis inhibitor Fer-1 rescued ferroptotic damage and attenuated cell death in BDE-209-treated HepG2 and L02 cells. In addition, Fer-1 reversed the activation of IKK/IκB/NF-κB pathway and the increase of pro-inflammatory cytokines levels in BDE-209-treated HepG2 and L02 cells. Together, the above results suggested that BDE-209 induced tissue damage and inflammatory response by activating ferroptosis through increasing iron-dependent lipid peroxidation and blocking the activation of SLC7A11/GSH/GPX4 pathway in liver, indicating that ferroptosis is a potential mechanism for BDE-209-induced hepatotoxicity.
研究领域:
毒理学
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肝病学
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细胞生物学
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环境科学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2019
·Vol. 6
·期 10
·1802112
·
IF 15.804
Ke Meng,Chi Yao,Qianmin Ma,Zhaohui Xue,Yaping Du,Wenguang Liu,Dayong Yang
Fluorochromic materials that are dynamic in response to external stimuli are of great interest for the development of advanced sensors and luminescent materials. Herein, a design based on a lanthanide-containing polymeric hydrogel possessing characteristic emission of lanthanides (Eu and Tb) and showing response to stimuli of metal ions is reported. The fluorochromic hydrogel is prepared using a lanthanide–mannose complex in gelation matrix. The lanthanide–mannose complex shows tunable fluorescent emission in response to Fe 2+ , due to the inhibition of the “antenna effect” between metal ions and ligands upon stimulation. The fluorescent hydrogel shows reversible “On/Off” fluorochromic response to Fe 2+ /ethylenediaminetetraacetic acid (EDTA). Remarkably, the fluorescent hydrogel is proven nontoxic and biocompatible; and a proof-of-application as in situ 3D cell culture extracellular matrix with reversible fluorochromic “On/Off” switch upon Fe 2+ /EDTA is demonstrated. This reversibly responsive fluorochromic hydrogel demonstrates a way to fabricate smart optical materials, particularly for biological-related applications where reversible response is required.
研究领域:
材料科学
·
生物材料
·
传感器
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Qian Wang,Xiaoyun Li,Haiyan Zhang,Heng Wei,Jin Han,Guangzhou Xu,Jianlei Chao,Kun Wang,Tao Jiang
In this work, a novel sensitive colorimetric sensor was constructed for the determination of Iron (II) (Fe 2+) via by modifying 3,3',5,5'-tetramethylbenzidine and 3-mercaptopropionic acid on the surface of silver nanoparticles. In the presence of Fe 2+ , the modifying groups interacted with Fe 2+, which caused the color of the solution changed, and the absorption peak at 395 nm decreased, while a new absorption peak appeared at 525 nm. This method exhibited good selectivity and sensitivity for the determination of Fe 2+ by observing the color of the system with the naked eye and calculating the ratio of A525 and A404, the linear range was from 0.5×10 -6 M to 1.00×10 -5 M and the limit of visual colorimetric detection was 500 nM. This method has great potential for the rapid detection of iron(II) in environmental samples, including successful applications in tap water and lake water analysis.
研究领域:
分析化学
·
纳米技术
·
环境监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2021
·Vol. 79
·期 11
·9397-9406
·
IF 2.87
Cai Yifeng,Wang Zuohua,Zhang Jian,Li Qingfang,Zhang Qiuhong
High molecular weight partial hydrolysis polyacrylamide (HPAM) is widely used in the oil recovery, and however, these high molecular weight HPAM will experience a rapid degradation when Fe 2+ was existed in the system. Some studies have implied it was a radical assisted decomposition process. However, no direct evidence had been provided in the reported works. Here, we investigated the effect of different metal ions, and the addition of (2,2,6,6-tetramethylpiperidinooxy) TEMPO to know the polymer degradations of the system. Further, by conducting electron paramagnetic resonance (EPR) on the Fe 2+ /HPAM system, we firstly provide a solid proof of the radical assist degradation process for the HPAM in the presence of Fe 2+ and oxygen. The mechanism has also been provided based on the observations. Graphical abstract The degradation mechanism is first revealed by EPR measurements for a Fe 2+ containing HPAM solution. A solid proof of the radical assists degradation process for the HPAM in the presence of Fe 2+ and oxygen.
研究领域:
聚合物科学
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环境化学
·
石油回收
✓ 已验证
DOI
高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2020
·
IF 5.546
Tao Bai,Ruopeng Liang,Rongtao Zhu,Weijie Wang,Lin Zhou,Yuling Sun
Primary liver cancer is the second most frequent cause of cancer-related deaths. Ferroptosis, a recognized form of regulated cell death, recently gains attention. MicroRNA-214-3p (miR-214) plays a regulatory role in hepatocarcinogenesis. However, the role of miR-214 in cellular ferroptosis is unclear. This study aimed at elucidating whether miR-214 could regulate ferroptosis of liver cancer. In vitro, HepG2 and Hep3B cancer cells were treated with erastin, a ferroptosis inducer, and then erastin was demonstrated to suppress the cell viability. Moreover, pre-miR-214 overexpression caused that HepG2 and Hep3B cells were more susceptible to erastin, whereas anti-miR-214 sponge showed the opposite effect. Additionally, pre-miR-214 overexpression increased the malondialdehyde and reactive oxygen species levels, upregulated Fe 2+ concentration, and decreased glutathione levels in cancer cells exposed to erastin. Further, erastin enhanced the activation of transcription factor 4 (ATF4) in HepG2 and Hep3B cells, and pre-miR-214 overexpression inhibited ATF4 expression. The luciferase reporter data validated ATF4 as a direct target of miR-214. Cancer cells transfected with ATF4 overexpression plasmid rendered lower susceptible to miR-214-induced ferroptotic death. In vivo, erastin significantly reduced the size and weight of xenografted tumors, and miR-214 elevated the ferroptosis-promoting effects of erastin and decreased ATF4 expression. In summary, our study demonstrates that the ferroptosis-promoting effects of miR-214 in hepatoma cells are attributed at least to its inhibitory effects on ATF4, which may provide a new target for therapy of hepatoma regarding ferroptosis.
研究领域:
肿瘤学
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分子生物学
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细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2023
·
IF 4
Zhang Xue-Feng,Chang Tian-Long,Guo Na,Jia Guo-Liang,Li Xiao-Bing,Zhao Zhao-Ye,Wang Hui,Wang Jun-Chuan,Wu Xiang-Feng,Pan Cheng-Si,Liu Lei,Yang Lin-Lin
Fe-based MOFs (Fe-MOFs) are excellent photocatalysts and have synergy well with Fenton reagents relative to other MOFs. In this work, a series of uniformly covered NH 2 -Fe-MIL-88B@TpPa-1-COF composites were synthesized using an in-situ anchoring growth strategy, which used F127 as functional molecule to decorate NH 2 -Fe-MIL-88B nanoparticles to eliminate their surface electrostatic repulsion with Tp molecules during the subsequent coating procedure. Meanwhile, the -NH 2 groups in the skeleton of NH 2 -Fe-MIL-88B could also be used as anchors to covalently connect TpPa-1-COF shell and migration channels for effective charge transfer. This uniformly covered core–shell structure would endow these composites with much more contact area and imine bond linkage between the Fe-MOFs core and COFs shell. Compared with the random packing structure, the uniformly covered Fe-MOF@COF-3 composite possessed a higher proportion of Fe 2+ to Fe 3+ . As a result, the optimized Fe-MOF@COF-3 catalyst could achieve the highest photo-Fenton degradation efficiency of 93.9% for tetracycline hydrochloride (TC⋅HCl), which was much higher than 54.8% of pure NH 2 -Fe-MIL-88B. In addition, the uniform TpPa-1-COF shell could further effectively enhance the stability of NH 2 -Fe-MIL-88B by protecting Fe ions from leaching, and the toxicity of the water samples treated with our photo-Fenton degradation process declined obviously. All these merits will endow Fe-MOF@COF-3 photo-Fenton catalyst great potential application value as in the field of environmental governance.
研究领域:
材料科学
·
环境科学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2021
·
IF 6.475
Qiandai Shi,Jing Jing Wang,Lu Chen,Zhiyun Peng,Qiao-Hui Zeng,Yongheng Zhu,Yong Zhao
Photodynamic inactivation (PDI) is an effective alternative to traditional antibiotics to broadly kill bacteria. This study aimed to develop a potent PDI system by coupling calcinated melamine sponges (CMSs) with the Fenton reaction. The results showed that CMS calcined at 350 ℃ was successfully carbonized with intact and porous structures, and it possessed excellent hydrophilicity and photothermal conversion performance. When Fe 2+ was added and internalized, the Fenton reaction in which Fe 2+ reacted with H 2 O 2 in cells occurred to produce reactive oxygen species (ROS) ( OH, OOH, etc.) and O 2 , and notably, the O 2 molecules could serve as a raw material to absorb the photothermal energy of CMS to generate highly reactive 1 O 2 . Under synergistic effects, CMS-350 coupled with Fe 2+ potently inactivated > 6 Log CFU/mL (>99.9999%) of Salmonella under 201.6 J/cm 2 blue LED illumination by destroying Na + /K + -ATPase and Ca 2+ /Mg 2+ -ATPase, DNA synthesis-related enzymes, cell membranes, etc. Meanwhile, the composite photocatalyst was proven to be nontoxic and could inactivate Salmonella in various foods, including vegetables ( Brassica chinensis L), eggs and fresh cucumber juice. As a result, CMS coupled with the Fenton reaction greatly improves the inactivation potency of PDI against harmful bacteria.
研究领域:
生物技术
·
微生物学
·
食品安全
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yanping Zhu,Runliang Zhu,Yunfei Xi,Tianyuan Xu,Lixia Yan,Jianxi Zhu,Gangqiang Zhu,Hongping He
The conventional heterogeneous Fenton reaction is often confined by the lower regeneration of Fe 2+ , which then inhibits the decomposition of H 2 O 2 and the generation of OH. Here we propose a novel idea to significantly accelerate the redox cycling of Fe 2+ /Fe 3+ in heterogeneous Fenton reaction by introducing photo-generated electrons from plasmonic particles. Towards this aim, novel plasmonic Ag/AgCl nanoparticles coated ferrihydrite (Ag/AgCl/Fh) have been synthesized. Compared with pure Fh, a remarkable enhancement in the photo-Fenton degradation towards bisphenol (BPA) can be observed for all Ag/AgCl/Fh samples under visible light. Noticeably, the rate constant of 6%Ag/AgCl/Fh is 0.0506 min −1 , which is about 5.1 times as high as that of pure Fh (0.0099 min −1 ). Moreover, the catalytic activity of 6%Ag/AgCl/Fh on the degradation of BPA remains quite efficient with a low Fe leaching after 4 recycles. The results of the effect of initial pH indicates that Ag/AgCl/Fh samples exhibit relatively high photo-Fenton catalytic activity even at pH 6. The electron spin resonance (ESR) analysis reveals that OH plays a significant role in the photo-Fenton reaction. The concentration of OH can even reach 267.6 μmol/L after 60 min, which is much higher than that of pure Fh (69.2 μmol/L). The measurement of Fe 2+ concentration and the XPS Fe2p spectra of Ag/AgCl/Fh before and after the degradation of BPA indicate the loading of Ag/AgCl can accelerate the conversion of Fe 3+ /Fe 2+ by the photo generated electrons from Ag nanoparticles due to the surface plasmon resonance (SPR) effect under the visible light irradiation.
研究领域:
环境科学
·
催化
·
材料科学
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Lulu Chen,Xiaona Dong,Ruonan Feng,Wanying Li,Dahu Ding,Tianming Cai,Canlan Jiang
Triclosan (TCS) is a compound in pharmaceutical and personal care products (PPCPs) that preferentially accumulates in soil and may threaten human health. Iron-based persulfate activation processes (Fe-PAPs) are a promising technique in soil remediation but are limited by their narrow pH application range and resultant iron precipitation. In this study, oxalic acid (OA) was specifically introduced to improve the efficiency of Fe 2+ -activated persulfate (PS) processes for TCS degradation in soil. The complexation of OA and Fe 2+ improved the total iron concentration in the Fe 2+ /OA/PS system and prevented iron precipitation. Fe-minerals in soil were also dissolved by OA, which participated in PS activation. The most appropriate proportion of Fe 2+ /OA/PS is 1:1:1, and approximately 85% of the TCS was degraded within 240 min compared with 45% in the Fe 2+ /PS system. SO 4 • - and 1 O 2 played important roles on TCS oxidation, while O 2 • - and CO 2 • - mainly participated in the iron cycle. The weak stretch of Fe-O in OA containing treatments in ATR-FTIR measurements provided evidence that OA dissolved the Fe-minerals. The introduction of OA in the Fe 2+ /PS system in four different soils reduced the negative effect of soil organic matter on TCS degradation. Three types of intermediates including hydroxylation, cleavage of ether bonds and cyclization products, were identified by LC-Q-TOF-MS. Column experiments were used to study the feasibility of in situ chemical oxidation (ISCO) remediation of TCS in the Fe 2+ /OA/PS system. Our findings indicated the ability of OA to be used as a cheating agent in Fe-PAPs for TCS soil remediation.
研究领域:
环境科学
·
土壤化学
·
污染物降解
·
修复技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）