Biomaterials Advances
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2024
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IF 5.5
Wenying Wei,Haifei Kang,Chenxi Lian,Jiawei Liu,Jinwei Lin,Junwei Yang,Zhangmancang Xu,Ziqi Wang,Meizhen Yin,Honglian Dai
Chemodynamic therapy (CDT) guided by Fenton chemistry and iron-containing materials can induce ferroptosis as a prospective cancer treatment method, but the inefficient Fe 3+ /Fe 2+ conversion restricts the monotherapeutic performances. Here, an iron-based nanoplatform (Fe 3 O 4 -SRF@FeTA) including a magnetic core and a reductive film is developed for combined CDT and photothermal therapy (PTT) through ferroptosis augmentation. The inner iron oxide core serves as a photothermal transducer, a magnet-responsive module, and an iron reservoir for CDT. The coated Fe 3+ -tannic acid film (FeTA) provides extra iron and reductants for Fe 3+ /Fe 2+ conversion acceleration, and functions as a door keeper for the pH- and light-responsive release of the embedded ferroptosis inducer sorafenib (SRF). The in vitro results demonstrate that the iron-based nanocomplexes promote the production of lipid peroxide through the amplified Fenton activity, and downregulate glutathione involved in lipid peroxide repair system through the responsively released SRF. Upon accumulation in tumor by magnetic targeting and sequential laser irradiation locoregionally, Fe 3 O 4 -SRF@FeTA nanocomplexes present prominent in vivo anticancer efficacy by leveraging PTT and CDT-enhanced ferroptosis.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
Nano Research
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2021
·Vol. 15
·期 2
·1509-1516
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IF 8.897
Ye Xinhui,Li Yu,Luo Peipei,He Bingcai,Cao Xinxing,Lu Tongbu
Sunlight-driven activation of molecular oxygen (O 2 ) for organic oxidation reactions offers an appealing strategy to cut down the reliance on fossil fuels in chemical industry, yet it remains a great challenge to simultaneously tailor the charge kinetics and promote reactant chemisorption on semiconductor catalysts for enhanced photocatalytic performance. Herein, we report iron sites immobilized on defective BiOBr nanosheets as an efficient and selective photocatalyst for activation of O 2 to singlet oxygen ( 1 O 2 ). These Fe 3+ species anchored by oxygen vacancies can not only facilitate the separation and migration of photogenerated charge carrier, but also serve as active sites for effective adsorption of O 2 . Moreover, low-temperature phosphorescence spectra combined with X-ray photoelectron spectroscopy (XPS) and electronic paramagnetic resonance (EPR) spectra under illumination reveal that the Fe species can boost the quantum yield of excited triplet state and accelerate the energy transfer from excited triplet state to adsorbed O 2 via a chemical loop of Fe 3+ /Fe 2+ , thereby achieving highly efficient and selective generation of 1 O 2 . As a result, the versatile iron sites on defective BiOBr nanosheets contributes to near-unity conversion rate and selectivity in both aerobic oxidative coupling of amines to imines and sulfoxidation of organic sulfides. This work highlights the significant role of metal sites anchored on semiconductors in regulating the charge/energy transfer during the heterogeneous photocatalytic process, and provides a new angle for designing high-performance photocatalysts.
研究领域:
材料科学
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催化
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光化学
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有机合成
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DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
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IF 16.6
Chen Na,Du Na,Shen Ruichen,He Tianpei,Xi Jing,Tan Jie,Bian Guangkai,Yang Yanbing,Liu Tiangang,Tan Weihong,Yu Lilei,Yuan Quan
Microbial communication can drive coordinated functions through sensing, analyzing and processing signal information, playing critical roles in biomanufacturing and life evolution. However, it is still a great challenge to develop effective methods to construct a microbial communication system with coordinated behaviors. Here, we report an electron transfer triggered redox communication network consisting of three building blocks including signal router, optical verifier and bio-actuator for microbial metabolism regulation and coordination. In the redox communication network, the Fe 3+ /Fe 2+ redox signal can be dynamically and reversibly transduced, channeling electrons directly and specifically into bio-actuator cells through iron oxidation pathway. The redox communication network drives gene expression of electron transfer proteins and simultaneously facilitates the critical reducing power regeneration in the bio-actuator, thus enabling regulation of microbial metabolism. In this way, the redox communication system efficiently promotes the biomanufacturing yield and CO 2 fixation rate of bio-actuator. Furthermore, the results demonstrate that this redox communication strategy is applicable both in co-culture and microbial consortia. The proposed electron transfer triggered redox communication strategy in this work could provide an approach for reducing power regeneration and metabolic optimization and could offer insights into improving biomanufacturing efficiency.
研究领域:
生物技术
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微生物学
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生物工程
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合成生物学
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代谢工程
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DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2018
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IF 6.945
Peng Zhang,Xiaotong Yang,Tong Wang,Nobuyuki Imanishi,Osamu Yamamoto,Miao Wang
We demonstrate a novel rechargeable energy storage system having a metallic lithium negative electrode and a liquid–solid hybrid positive electrode of Fe 3+ /Fe 2+ /Fe in N,N-Dimethylformamide, which are separated by an impermeable NASICON–type Li 1.4 Al 0.4 Ge 0.2 Ti 1.4 (PO 4 ) 3 –epoxy resin composite film with a lithium ion conductivity of ca. 5.0 × 10 −4 S cm −1 . The discharge curve for the battery shows two plateaus. The first plateau corresponds to Li + FeCl 3 = LiCl + FeCl 2 , while the second one is associated with 2 Li + FeCl 2 = 2 LiCl + Fe. In the process of reduction of Fe 3+ to Fe 2+ , it delivers a stable discharge capacity of ca. 110 mAh g FeCl3 −1 with a Coulombic efficiency higher than 95% and is capable of enduring over 60 circles at a high current density of 1.0 mA cm −2 without any catalyst. Furthermore, a stable discharge capacity up to ca. 455 mAh g FeCl3 −1 is achieved for conversion of FeCl 3 /FeCl 2 /Fe with a three–electron reaction. This work demonstrates a proof of feasibility of hybrid liquid–solid hybrid positive electrode, since these reactions are reversible confirmed by x–ray diffraction patterns and EDX mapping test.
研究领域:
材料科学
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电化学
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能源存储系统
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电池技术
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Pengyao Guo,Xiaomin Hu
To improve the degradation efficiency of g-C 3 N 4 (CN), transition metal elements (Fe and Co) were doped into CN. A novel Co, Fe co-doped CN (Co/Fe-CN) photocatalysts with small size and irregular flake structure were successfully prepared by thermal polymerization of melamine . Co/Fe-CN has a large specific surface area (55.76 m 2 /g), which provides more adsorption sites and reaction sites for the activation of peroxymonosulfate (PMS). Good visible light response performance (474 nm) and suitable band gap (2.83 eV) ensure that it could be excited by visible light. The active species of • O 2 - , 1 O 2 , • OH and SO 4 •- could be stably produced in Co/Fe-CN/Vis/PMS system with appropriate redox potential . Meanwhile, Co and Fe elements doped in CN also could effectively activate PMS and promote the generation of active species. Besides, the continuous generation of photogenerated electrons promoted the cycling of Co 3+ /Co 2+ and Fe 3+ /Fe 2+ , and further enhanced the degradation efficiency of Co/Fe-CN/Vis/PMS towards Levofloxacin (LVFX). LVFX could be rapidly removed, reaching 92.1% within 50 min under visible light illumination, and the kinetic rate constant of LVFX was 0.0638 min -1 . The quenching experiments verified that the 1 O 2 was the main active species in the reaction process. The cycling experiments revealed that the Co/Fe-CN/Vis/PMS system had favorable stability and applicability. This work provides a simple preparation method to fabricate bimetallic co-doped CN for the enhancement of degradation rate in the Photocatalyst/Vis/PMS system.
研究领域:
环境科学
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材料科学
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光催化
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水处理
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）