JOURNAL OF PHYSICAL CHEMISTRY B
·
2024
·
IF 2.8
Hong-Jie Zhang,Xue-Bin Shang,Xu-Ran Wang,Chen-Xi Zhang,Qing-Lun Wang
SCPEEK@MOF proton exchange membranes, where SCPEEK is sulfinyl chloride polyether ether ketone and MOF is a metal–organic framework, were prepared by doping Fe-MIL-101-NH2 into polymers. The amino group in the MOF and the -SOCl2 group in thionyl chloride polyether ether ketone cross-link to form a covalent bond through the Hinsberg reaction, and the prepared composite membrane has stronger stability than other electrostatic interactions and simple physical doping composite membranes. The formation of covalent bonds improves the water absorption of the composite membrane, which makes it easy for water molecules to form hydrogen bonds. Moreover, SPEEK as a proton conductive polymer and the synergy of MOFs improve the proton conductivity of composite membranes. The composite membranes were characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy, and atomic force microscopy. The swelling rate, water absorption, mechanical stability, ion exchange capacity, and proton conductivity of the pure sulfonated polyether ether ketone (SPEEK) membrane were compared with those of the mechanically doped SPEEK/MOF membrane and the composite membrane SCPEEK@MOF doped with different ratios of Fe-MIL-101-NH2, and all of the SCPEEK@MOF showed superior performance. When the Fe-MIL-101-NH2 loading rate of the composite membrane is 2%, the proton conductivity of the composite membrane can reach 0.202 S cm–1 at 363 K and a 98% relative humidity, which is much higher than that of the SPEEK/MOF membrane obtained by simple physical doping under the same conditions.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2016
·
IF 4.035
Chao Zhao,Zhongwei Jiang,Ruizhu Mu,Yuanfang Li
In this work, a novel sensor based on fluorescence enhancement of Fe-MIL-88- H 2 O 2 -o-phenylenediamine (OPD) system for the determination of dopamine (DA) was developed. Fe-MIL-88 with intrinsic peroxidase-like catalytic activity tended to oxidize the nonfluorescent OPD into the fluorescent 2,3-diaminophenazine (DAP) with the presence of H 2 O 2 . When DA was introduced, the autoxidation of DA to yield hydroxyl radical (·OH) was further enhanced by Fe 3+ site in Fe 3 -μ 3 -oxo clusters exiting in Fe-MIL-88 MOFs , meanwhile the generated Fe 2+ appeared to involve a Fenton type reaction in the presence of H 2 O 2 to cause a continuous production of ·OH radicals which greatly enhanced the conversion efficiency of the OPD to fluorescent DAP. Thus, the turn-on fluorescence method for the DA detection was established. The linear range was from 50 nm to 30 μM with detection limit 46 nm (3σ/s). Furthermore, the proposed method has been reliably applied to determine dopamine content in dopamine hydrochloride injection and human urine with satisfactory results, which suggests its great potential for assay DA in chemical and biological analytical applications.
研究领域:
分析化学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Li Hou,Yuemei Qin,Tianran Lin,Ying Sun,Fanggui Ye,Shulin Zhao
The synthesized Fe-MIL-88NH 2 was used as a nanozyme and fluorescence probe to successfully construct a selective fluorescent sensing platform for one step determination of catechol. Fe-MIL-88NH 2 exhibited excellent peroxidase mimic property as well as fluorescence property. With the addition of H 2 O 2 and catechol, Fe-MIL-88NH 2 would catalyze the H 2 O 2 to form hydroxyl radicals ( OH). Then, the oxidation of catechol would be triggered by the formed OH, which resulted in the generation of 1, 2-benzoquinone. Afterwards, Michael reaction between the oxidation products of catechol (1, 2-benzoquinone) and Fe-MIL-88NH 2 ligands was triggered and then quenched the fluorescence of Fe-MIL-88NH 2 . The principle of the selective determination of catechol was due to the assistant effect of Michael reaction. Based on the above sensing mechanism, a fluorescent sensing platform for the determination of catechol was established. The limit of detection was 0.0913 μmol L −1 (3S 0, n=8 /K) within a fast response of 10 min. This simple and selective strategy, based on the Michael reaction and the superiority of Fe-MIL-88NH 2 nanozyme, provided a concise sensing platform for catechol determination, which broadened the scope of application of nanozyme and showed a great potential application for on-site testing in food and biology analysis.
研究领域:
分析化学
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生物医学工程
·
纳米技术
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DOI
高影响因子
ANALYST
·
2015
·Vol. 140
·期 24
·8201-8208
·
IF 4.107
Zheng Juan Sun,Jun Ze Jiang,Yuan Fang Li
Herein, we present a novel strategy based on a “turn-on” fluorescence system made up of metal–organic frameworks Fe-MIL-88 and H2O2 for detecting biothiols in human serum. The nonfluorescent Fe-MIL-88 gives weak fluorescence in the presence of H2O2. Interestingly, it was found that biothiols such as glutathione (GSH), cysteine (Cys) or homocysteine (Hcy) could induce fluorescence turn-on of the Fe-MIL-88/H2O2 system. Under optimal conditions, the relative fluorescence intensity exhibited a good linear relationship in the range from 50 nM–10 μM for GSH (r = 0.994), 50 nM–10 μM for Cys (r = 0.990), and 50 nM–10 μM (r = 0.992) for Hcy; the detection limits of GSH, Cys and Hcy were 30 nM, 40 nM, and 40 nM respectively. Mechanism investigation reveals that biothiols could associate with Fe-MIL-88 via hydrogen bonding and electrostatic interaction followed by redox reaction between biothiols and Fe3+ present in the Fe-MIL-88, Fe3+ was thus reduced to Fe2+, and then Fe2+ could efficiently catalyze the decomposition of H2O2 to yield ˙OH radicals through the Fenton reaction. Besides, biothiols were able to reduce H2O2 to produce ˙OH radicals directly. Thus the Fe-MIL-88 as well as biothiols could cooperatively contribute to the activation of H2O2 to generate higher amounts of ˙OH radicals, which in turn oxidize the free ligand terephthalic acid (BDC) outside or within the Fe-MIL-88 structure to strongly fluorescent hydroxylated terephthalic acid (OHBDC), thereby turning on the fluorescence.
研究领域:
分析化学
·
生物医学
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Donglian Deng,Jingyuan Xu,Tingting Li,Dongdong Tan,Yibing Ji,Ruijun Li
This work designed a fluorometric/colorimetric dual-mode sensor for detecting 2,6-dipicolinic acid (DPA) based on the blue emission property and peroxidase-like activity of Fe-MIL-88NH 2 . The fluorescence of Fe-MIL-88NH 2 was obviously turned off by Cu 2+ , but DPA was able to bring it back because it has a strong chelate bond with Cu 2+ . Fe-MIL-88NH 2 also displayed high peroxidase-like activity, which accelerated the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to the blue oxidation product (oxTMB) when H 2 O 2 was present. When DPA was added, it efficiently inhibited the peroxidase-like activity of Fe-MIL-88NH 2 , causing less oxTMB and less absorbance at 652 nm. The fluorescence recovery of Fe-MIL-88NH 2 and the change in absorbance at 652 nm were used as analytical signals for dual-mode detection of DPA. The linear responses in the range of 10–60 μM and 60–160 μM were achieved for the fluorometric mode, and the limit of detection (LOD) was 1.46 μM. The respective values of linear range and LOD for the colorimetric mode were 5–25 μM and 3.00 μM, respectively. In summary, the dual-mode testing strategy successfully detected DPA in aqueous environmental samples, suggesting great potential in disease prevention and environmental analysis.
研究领域:
分析化学
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环境科学
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生物传感
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DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2021
·Vol. 11
·期 8
·2864-2872
·
IF 6.119
Xiaoli Li,Yuan Tang,Yue Jiang,Manman Mu,Xiaohong Yin
A series of composites composed of Bi4O5Br2 and Fe-MIL were successfully fabricated for mimicking sunlight-driven photocatalytic reduction of CO2. Herein, Bi4O5Br2, as a modulator of solid acids, could turn NH2-MIL-101(Fe) into NH2-MIL-88B(Fe) completely at 0.07 wt% catalytic loading, where further addition could construct the corresponding composites of Bi4O5Br2 and NH2-MIL-88B(Fe). The highest activity in the photocatalytic reduction of CO2 was achieved at 7.96 μmol g−1 h−1 of CH4 at 3.28 wt% of Bi4O5Br2. Besides, this catalyst possessed high photostability during the recycling experiments and the mechanism of this process was thoroughly explored. This study provides a novel strategy employing solid acid modulators for regulating the structure and morphology of MOFs showing high activity and stability in the photocatalytic reduction of CO2 to CH4.
研究领域:
材料科学
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环境科学
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化学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 5
·1-8
·
IF 5.833
Sun Ying,Lin Tianran,Zeng Cuihong,Jiang Gaoyan,Zhang Xuanhan,Ye Fanggui,Zhao Shulin
A self-correcting fluorescent assay of tyrosinase (TYR) was developed by utilization of Fe-MIL-88B-NH 2 as a peroxidase-like nanozyme and a capture probe. Fe-MIL-88B-NH 2 nanozyme was selected as an electron donor, and the oxidization product (dopamine- o -quinone) acts as an energy acceptor. First, TYR catalyzes the oxidation of tyramine hydrochloride to dopamine and then to dopamine- o -quinone. Second, Fe-MIL-88B-NH 2 with intrinsic peroxidase-like activity decomposes H 2 O 2 to produce ·OH radicals, which further accelerate the oxidation of dopamine to dopamine- o -quinone. Excessive H 2 O 2 and ·OH radicals reduce the interferences from ascorbic acid at the same time providing a self-correcting ability. Dopamine- o -quinone reacts with -NH 2 groups on the ligand of Fe-MIL-88B-NH 2 through Michael reaction which results in fluorescence quenching. Under 365-nm excitation, the fluorescence emission intensity at 452 nm gradually decreased with increasing TYR concentration varying from 0 to 10 U mL −1 . The linear range is from 1 to 5 U mL −1 and the detection limit is 0.05679 U mL −1 . This self-correcting fluorescent assay of tyrosinase exhibits good sensitivity and selectivity which is also successfully applied for tyrosinase inhibitor detection. Graphical abstract
Schematic representation of fluorescent assay for tyrosinase determination based on Fe-MIL-88B-NH 2 nanozyme. A self-correcting fluorescent assay for tyrosinase was developed based on the Fe-MIL-88B-NH 2 nanozyme.
研究领域:
分析化学
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生物化学
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纳米技术
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酶学
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产品关联
DOI
PubMed
高影响因子
ANALYST
·
2013
·Vol. 138
·期 16
·4526-4531
·
IF 3.969
Ya Li Liu,Xi Juan Zhao,Xiao Xi Yang,Yuan Fang Li
In this paper, a nanosized porous metal–organic framework, Fe-MIL-88NH2, was facilely prepared with a uniform octahedral shape by the addition of acetic acid, and for the first time was demonstrated to possess intrinsic peroxidase-like activity. Kinetic analysis and electron spin resonance measurements indicated that the catalytic behavior was consistent with typical Michaelis–Menten kinetics and follows a ping-pong mechanism. As a novel peroxidase mimic material, Fe-MIL-88NH2 shows the advantages of high catalytic efficiency, ultrahigh stability and high biocompatibility in aqueous medium compared with natural enzymes and other peroxidase nanomimetics. Here, Fe-MIL-88NH2 was used to quickly catalyze oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to produce a colored product, which provided a simple, sensitive and selective method for the colorimetric detection of glucose. Glucose could be linearly detected in the range from 2.0 × 10−6 to 3.0 × 10−4 M with a detection limit of 4.8 × 10−7 M, and the color variation for glucose response was also obvious by visual observation at concentrations as low as 2.0 × 10−6 M. More importantly, the colorimetric method could be successfully applied to the determination of glucose in diluted serum samples.
研究领域:
生物分析化学
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纳米生物技术
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酶模拟
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临床检验
·
分子诊断
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DOI
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·
IF 1.193
Yan-Yan XING,Mei-Ling CHEN,Xin-Ai SHEN,Ning LIANG,Xiao-Hong HOU
In consideration of the promising application of peroxidase (POD)-like nanozymes in biomedical analysis, the development of POD mimics with good catalytic performance under neutral conditions remains significant. As a new catalyst, metal-organic frameworks have been explored as candidate nanozymes owing to their high catalytic activity, good stability, flexible and simple synthesis methods, diverse types, and properties. Herein, rod-like Fe-MIL-88A was successfully synthesized via a simple hydrothermal method. Fe-MIL-88A exhibited POD-like properties under neutral conditions and a stronger affinity for substrate 3,3 ' ,5,5 ' -tetramethylbenzidine and H 2 O 2 than natural horseradish POD. This result was primarily due to the additional exposed (100) facets of rod-like Fe-MIL-88A, which can catalyze the decomposition of H 2 O 2 to •OH more easily. Based on the POD-like properties of Fe-MIL-88A under neutral conditions, combined with glucose oxidase, a one-pot colorimetric analysis method for glucose detection was established. The proposed measurement had a linear range of 1–100 µM and a limit of detection of 0.45 µM. The colorimetric method was accurate, reliable, highly selective, convenient, and time-saving. Furthermore, the one-pot method was successfully applied to detect the concentration of glucose in human blood samples, and the measured results were consistent with those of commercial glucose meters, indicating that the proposed method can be a potential candidate for glucose detection.
研究领域:
生物化学
·
纳米技术
·
分析化学
·
生物医学工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xiaomin Fu,Yan Yang,Na Wang,Shihong Chen
Here, the cathodic electrochemiluminescence (ECL) behavior of 3,4,9,10-perylenetetracar-boxylic acid (PTCA) coreacted with hydrogen peroxide was firstly reported. The quenching effect of Fe-MIL-88 MOFs (iron based metal-organic framework) on the ECL of PTCA was found, and the ECL quenching mechanism was investigated, which was speculated to be via the resonance energy transfer from PTCA to Fe-MIL-88 MOFs and steric hindrance effect from Fe-MIL-88 MOFs. Combining with dual molecular recognition strategy and the quenching effect of Fe-MIL-88 MOFs on the ECL of PTCA-H 2 O 2 system, an “on-off” ECL sensor was designed to detect dopamine (DA) with a broad linear range (five orders of magnitude). The detection limit was low to 2.9 × 10 −13 M. The PTCA-H 2 O 2 system would provide a new ECL platform, especially for constructing enzyme based ECL sensor with H 2 O 2 as product in enzymatic reaction. Furthermore, the electrochemiluminescence resonance energy transfer between Fe-MIL-88 metal–organic framework and PTCA would expand a new application of Fe-MIL-88 MOFs in ECL field. The dual molecular recognition strategy ensured the selectivity of the sensor for DA detection.
研究领域:
分析化学
·
材料科学
·
电化学
·
传感器
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Ruya Guo,Li Xue,Gaozhe Cai,Wuzhen Qi,Yuanjie Liu,Jianhan Lin
Early screening of Salmonella is of utmost importance to minimize the incidence of related foodborne diseases. Here, we reported an immunosensor to fast detect Salmonella using Fe-MIL-88NH2 metal–organic framework (Fe-MOF) nanocubes to load platinum nanoparticles (PtNPs) for signal amplification and smartphone thermal imaging to monitor the temperature change. The Fe-MOF nanocubes decorated with PtNPs (Fe-MOF/PtNPs) were prepared as peroxidase mimics to catalyze hydrogen peroxide (H2O2) to produce O2. The immune magnetic nanoparticles (MNPs), the target bacteria, and the immune Fe-MOF/PtNPs were first mixed by the three-dimensional (3D) chaotic micromixer and conjugated in the microfluidic chip to form MNP–bacteria–Fe-MOF/PtNPs sandwich complexes. After magnetic separation and washing, H2O2 was injected and decomposed by Fe-MOF/PtNPs on the sandwich complexes to generate O2 in a sealed chamber. The increase in the pressure pushed the preloaded water to react with calcium oxide powder, resulting in the generation of heat, which was measured using the smartphone-based thermal sensor to determine the bacteria. The microfluidic immunosensor could detect Salmonella as low as 93 CFU/mL within 1 h.
研究领域:
生物传感器
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纳米技术
·
微流控技术
·
食品安全
·
生物医学工程
✓ 已验证
DOI
高影响因子
TALANTA
·
2018
·
IF 4.244
Qian Luan,Xin Xiong,Ning Gan,Yuting Cao,Tianhua Li,Dazhen Wu,Youren Dong,Futao Hu
An ultrasensitive colorimetric aptasensor was developed for antibiotics detection, with chloramphenicol (CAP) as model target, using DNAzyme labeled Fe-MIL-88-Pt as novel peroxidase mimic signal tags and target-triggered circular strand-displacement polymerization (CSDP) for signal amplification. The system consists of two components which can partially hybridize with each other: one is capture probe which was formed through immobilizing hairpin DNA containing aptamer sequence on magnetic beads (MB-cDNA), another is signal tag which was constructed through labeling single strand DNAzyme (G-quadruplex/Hemin) which can partially hybrid with cDNA on platinum nanoparticles functionalized Fe-MIL-88 (MIL-88-Pt-DNAzyme). All components of MIL-88, Pt and DNAzyme in the tag can act as peroxidase mimic to triply catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 into a blue-colored oxidized TMB (oxTMB) for the colorimetric readout. Thus distinctive signal can be observed by naked eye even in presence of 0.02 nM tags. In the presence of target and primer, cDNA loop can open to form cDNA/CAP intermediates, enabling primer to hybridize with the exposed sequences of the cDNA, which initiated target assisted CSDP recycles. Then numerous signal tags were released into supernatant to catalyze TMB for color development. There was a liner relationship between the absorbance and the concentration of CAP in the range of 0.1 pM (0.0323 pg/mL) to 1000 pM (323 pg/mL) with the detection limit of 0.03 pM (0.0097 pg/mL). The ultra-high sensitivity was ascribed to the multiplex catalytic activities from the tags and CSDP based signal amplification. Furthermore, this method can produce signals being observed by naked eye to facilitate in-situ detection and be further extended to detect other antibiotics in food just by simply replacing cDNA on the sensing system.
研究领域:
生物化学
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分析化学
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纳米技术
·
食品科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）