Iron-based single-atom catalysts (Fe-SACs) containing Fe–N 4 active sites have shown immense potential in the oxygen reduction reaction (ORR). However, the limited ability to adsorb O 2 and catalyze subsequent O–O bond breaking on Fe–N 4 sites has hindered their full potential, especially in acidic electrolytes. Here, we present an approach by utilizing a tunable curved surface to enhance the activity of Fe–N 4 active sites, with theoretical calculations, demonstrating that Fe–N 4 sites anchored on low–curvature surfaces (lc-Fe-N 4 ) is favirable for ORR. Experimental results show that the catalyst exhibits excellent catalytic activity and stability for ORR in acidic electrolytes, with a half-wave potential of 0.82 V vs. RHE, approaching that of commercial Pt/C. This work develops an approach for promoting the catalytic activity by anchoring atomically dispersed Fe–N 4 sites, unlocking their potential for extended use in electrocatalytic and energy storage applications.
Ruigeng Yang,Yueru Wei,Mengyang Zhao,Mengxiao Shi,Yongxing Zhao,Pengchao Sun
The abuse of antibiotics has led to the emergence of multidrug-resistant bacterial strains worldwide, which greatly threatens human health. In the present work, we developed single-atom catalysts (SACs) with atomically dispersed Fe as catalytic sites (Fe-SACs) to combat multidrug-resistant bacteria by elevating cellular reactive oxygen species (ROS). Our intensive studies confirmed that Fe-SACs were successfully prepared and exhibited excellent catalase (CAT)-, oxidase (OXD)-, and peroxidase (POD)-like activities. To enhance water dispersibility, biosafety and the interactions between the nanodrugs and gram-positive bacteria, phenylboronic acid group-functionalized carboxylated chitosan (CCS-PBA) was coated on the surface of Fe-SACs to yield [email protected] for in vitro and in vivo studies. The synergistic catalytic activity and photothermal activity of [email protected] effectively overcame multidrug-resistant bacterial strains ( MRSA) in vitro and significantly accelerated wound healing in vivo , suggesting the great potential of SACs to overcome infectious disease caused by multidrug-resistant bacteria.
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