SENSORS
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2024
·Vol. 24
·期 14
·4477
·
IF 3.4
Junyi Wang,Yanpei Xu,Yutong Song,Qi Wang
Hematite (α-Fe2O3) is widely used in sensor sensitization due to its excellent optical properties. In this study, we present a sensitivity-enhanced surface plasmon resonance alcohol sensor based on Fe2O3/Au. We describe the fabrication process of the sensor and characterize its structure. We conduct performance testing on sensors coated multiple times and use solutions with the same gradient of refractive indices as the sensing medium. Within the refractive index range of 1.3335–1.3635, the sensor that was coated twice achieved the highest sensitivity, reaching 2933.2 nm/RIU. This represents a 30.26% enhancement in sensitivity compared to a sensor with a pure gold monolayer film structure. Additionally, we demonstrated the application of this sensor in alcohol concentration detection by testing the alcohol content of common beverages, showing excellent agreement with theoretical values and highlighting the sensor’s potential in food testing.
研究领域:
传感器技术
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材料科学
·
光学
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产品关联
DOI
PubMed
高影响因子
Materials Research Express
·
2020
·Vol. 6
·期 12
·1250b5
·
IF 1.929
Shouyi Huang,Guoqing Jiang,Xinchang Wu,Hua Zhang,Zhe Chen,Anran Chen,Jin Zhang
In terms of developing high-performing, multifunctional hetero-nanostructures, an exact control of the growth dynamics at the interface of metal nanoparticles (NPs) and metal oxides is of great significance. Having this in mind, we reported a facile and efficient approach to anchor and control the growth process of Au NPs on the surface of iron oxide, and to synthesis α–Fe2O3–Au heterogeneous structure. The nanocomposite exhibits its outstanding multifunctional performance, the energy absorption rate and energy transfer efficiency of α–Fe2O3–Au heterogeneous structure is obviously more than that of α–Fe2O3 materials. FDTD simulation results also show that α–Fe2O3–Au heterogeneous structure have excellent absorption light property and surface Raman effect compared to the single materials, and exhibit enhanced analysis enhancement factor (to 5 × 104) with R6G molecule probe in SERS measurement. Furthermore, for the electrocatalytic activity of H2O2, the sensitivity and detection limit is 42.265 μA mM−1 cm−2 and 1.166 μM, respectively. This work provides an innovative synthetic route for new heterogeneously structured nanocomposites.
研究领域:
纳米材料
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生物医学工程
·
化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Guangjin Yu,Jing Wang,Qingshan Xiong,Yunqi Xu,Shouhu Xuan,Ken Cham-Fai Leung,Qunling Fang
With the prevalence of drug-resistant bacteria and the waning effects of antibiotics, nanoplatform has become an effective strategy for fighting infections. This work reports a dipolar-hollowed α-Fe 2 O 3 @Au/Polydopamine (PDA) nanospindle which possesses both photothermal-photodynamic (PTT-PDT) coupling antibacterial and drug carrying performance. Firstly, the spindle type α-Fe 2 O 3 @Au/PDA particle was prepared by a simple one-step strategy and then the dipolar-hollow structure was obtained by controlling etching the inside α-Fe 2 O 3 core with hydrochloric acid. After further loading the photosensitizer zinc phthalocyanine (ZnPc), the dipolar-hollowed α-Fe 2 O 3 @Au/PDA-ZnPc nanospindles were obtained. Owing to the dipolar-hollowed interior, the nanospindles are also effective in carrying antitumor drug doxorubicin (DOX) and shows a good drug loading-release behavior. The dipolar-hollowed α-Fe 2 O 3 @Au/PDA nanospindles exhibits a high antibacterial performance against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) under near-infrared (NIR) and Xenon lamp irradiation. When α-Fe 2 O 3 @Au/PDA-ZnPc nanospindles concentration was increased to 100 μg/mL, the antibacterial rate was close to 100 %. In comparison to the original α-Fe 2 O 3 @Au/PDA nanospindles, the product achieved a lower effective antibacterial temperature. This triple-mode therapy (PTT/PDT/Drug) provides an interesting design idea for anisotropic therapeutic nanoplatform which can be applied in low-temperature antibacterial and drug delivery.
研究领域:
纳米医学
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生物材料学
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抗菌研究
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2023
·
IF 11.9
Lin Li,Fenglian Qi,Jiong Guo,Jing Fan,Wenxiang Zheng,MURTAZA GHULAM,Weizhi Wang,Zihui Meng,Lili Qiu
Plasmonic nanostructures have attracted extensive attentions for killing cancer cells in photothermal therapy due to their significant absorption activities and photothermal conversion capabilities. However, the development of anisotropic plasmonic nanostructures with tunable near-infrared (NIR) absorptions remains a great challenge. In this study, Fe2O3@Au hexagonal nanodisks (NDs) are prepared by a space-confined growth approach. By choosing the uniform and size-tunable Fe2O3 nanodisks as initial templates, the localized surface plasmon resonance (LSPR) peaks of Au NDs are accurately tuned in the NIR therapeutic window. In addition, by improving the effective photothermal absorption, a high photothermal conversion effect that can exceed 70 °C with 808 nm laser irradiation for 7 min is achieved by 120 nm Fe2O3@Au NDs. We further demonstrate that these Fe2O3@Au NDs simultaneously have both low cytotoxicity and high photothermal therapy (PTT) performance of 89 % cancer cell inactivation rate, which can be employed as photothermal therapeutic agents for effective photothermal therapy for cancer cells. This study will provide new insights into a wide range of applications for designing anisotropic plasmonic structures with LSPR enhancement activities.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 43
·26502-26508
·
IF 3.361
Meirong Fu,Mingqiang Li,Yingying Zhao,Yunxiang Bai,Xingzhong Fang,Xiaolong Kang,Min Yang,Yanping Wei,Xia Xu
Precious metal nanometric catalysts are widely used in the removal of harmful substances. In the process of synthesis and catalytic reaction, it is particularly important to study green and simple synthesis methods and high catalytic efficiency. In this paper, a green one-step method was used to synthesize the Fe(OH)3/Fe2O3@Au composite catalyst, in which Au was single atom-dispersed. The removal of 4-nitrophenol (4-NP), a typical dangerous chemical widely existing in factory waste gas, waste water and automobile exhaust gas, was catalysed by Fe(OH)3/Fe2O3@Au. The catalytic performance of Fe(OH)3/Fe2O3@Au with different synthesis conditions (different amounts of MES, NaBH4, FeSO4, Au and Pt) on the 4-NP reduction reaction were systematically studied. Finally, the stability and recyclability of Fe(OH)3/Fe2O3@Au composite nanocatalyst were investigated thoroughly.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 40
·14235-14243
·
IF 4.39
Qingshan Xiong,Qunling Fang,Kezhu Xu,Guanghui Liu,Min Sang,Yunqi Xu,Lingyun Hao,Shouhu Xuan
Antimicrobial materials are expected to be alternatives for antibiotics against multidrug-resistant bacteria. In this paper, non-spherical α-Fe2O3@Au/PDA core/shell nanoparticles with tunable shapes are synthesized by a one-step in situ oxidation-redox polymerization method toward near infrared light-responsive antibacterial therapy. The thickness and composition of the Au/PDA hybrid shell can be controlled by varying the concentration of HAuCl4 and the dopamine precursor. Owing to the wonderful photothermal characteristics originating from the Au/PDA shell, the spindle α-Fe2O3@Au/PDA core shell nanoparticles exhibit excellent photothermal sterilization effects against both Escherichia coli and Staphylococcus aureus at low concentrations. Meanwhile, the NIR photothermal induced bactericidal performance indicates that α-Fe2O3@Au/PDA hybrid particles with tunable non-spherical shapes possess unique controllable antibacterial effects. As a result, this finding provides a simple strategy for fabricating high performance photothermal antibacterial agents and the final products possess high potential in synergistic antimicrobial therapy.
研究领域:
材料科学
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微生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2016
·
IF 3.169
Yan Lin,Guanhong Xu,Fangdi Wei,Aixia Zhang,Jing Yang,Qin Hu
In this present work, a rapid and simple method to detect carcinoembryonic antigen (CEA) was developed by using surface-enhanced Raman spectroscopy (SERS) coupled with antibody-modified Au and γ-Fe 2 O 3 @Au nanoparticles. First, [email protected] reporter and γ-Fe 2 O 3 @Au were prepared, and then modified with CEA antibody. When CEA was present, the [email protected] reporter and immuno-γ-Fe 2 O 3 @Au formed a complex through antibody-antigen-antibody interaction. The selective and sensitive detection of CEA could be achieved by SERS after magnetic separation. Under the optimal conditions, a linear relationship was observed between the Raman peak intensity and the concentration of CEA in the range of 1–50 ng mL −1 with an excellent correlation coefficient of 0.9942. The limit of detection based on two times ratio of signal to noise was 0.1 ng/mL. The recoveries of CEA standard solution spiked with human serum samples were in the range of 88.5–105.9% with the relative standard deviations less than 17.4%. The method built was applied to the detection of CEA in human serum, and the relative deviations of the analysis results between the present method and electrochemiluminescence immunoassay were all less than 16.6%. The proposed method is practical and has a potential for clinic test of CEA.
研究领域:
分析化学
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纳米技术
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生物传感器
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癌症诊断
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 103
·84980-84987
·
IF 3.84
Hongda Chen,Fuyao Liu,Zhen Lei,Lina Ma,Zhenxin Wang
Herein, we present the synthesis and application of a new type of graphene-based magnetic and plasmonic nanocomposite for magnetic-field-assisted drug delivery and chemo-photothermal synergistic therapy. The nanocomposites were prepared via conjugation of the PEGylated Fe2O3@Au core/shell nanoparticles (Fe2O3@Au NPs) with reduced graphene oxide (rGO). The hybrid nanostructures (rGO–Fe2O3@Au NPs) are superparamagnetic and show great photothermal conversion efficiency under 808 nm near-infrared (NIR) laser irradiation and high drug loading ability (1.0 mg mg−1). MTT cell viability assay demonstrates that the chemotherapeutic drug, doxorubicin loaded rGO–Fe2O3@Au NPs (DOX–rGO–Fe2O3@Au NPs) have synergistic interaction between photothermal therapy (PTT) and chemotherapy. Furthermore, in vitro studies using HeLa cells show that the chemo-photothermal therapeutic efficacy of DOX–rGO–Fe2O3@Au NPs can be dramatically improved by the assistance of magnetic-field-guided drug delivery.
研究领域:
纳米技术
·
生物医学工程
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癌症治疗
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xuemei Zeng,Yihang Ruan,Qi Chen,Shuangqian Yan,Wei Huang
Designing nanozyme hybrids with cascade catalytic activities and coupling effects has significant promises in tumor therapy through concerted effects. In this work, a goethite-derived porous Fe 2 O 3 /Au hybrid nanozyme was fabricated for synergistic treatment of triple negative breast cancer. The as-prepared porous Fe 2 O 3 nanoparticle exhibits excellent peroxidase-like activity compared to goethite particles, which can generate hydroxyl radicals in the tumor microenvironment. Furthermore, the Fe 2 O 3 nanoparticle induces ferroptosis through intracellular lipoperoxide accumulation. After decorating glucose oxidase-mimicking gold nanoparticles, the Fe 2 O 3 /Au hybrid nanozyme is able to catalyze glucose into gluconic acid and H 2 O 2 . The glucose consumption deprives the energy of the tumor cell, and the generated H 2 O 2 can be converted to hydroxyl radicals through the biocatalytic reaction. Importantly, the coupling of gold nanoparticles enhances the photothermal conversion of the porous Fe 2 O 3 nanoparticle. Thus, the designed Fe 2 O 3 /Au hybrid nanozyme can be used for tumor therapy through starvation, cascade catalytic reactions, ferroptosis, and photothermal manners. This work presents a derivative method that transforms minerals into nanozyme and couples nanozymes for synergistic tumor therapy, shedding light on the rational design of nanozyme composites for biomedicine.
研究领域:
肿瘤学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Yanling Zhang,Min Liu,Shuai Pan,Lulu Yu,Shaoshuai Zhang,Ruijiang Liu
Based on magnetic Fe 3 O 4 /Fe 2 O 3 @Au nanoparticles (Fe 3 O 4 /Fe 2 O 3 @Au NPs), to detect an important tumor screening marker, vascular endothelial growth factor 165 (VEGF 165 ), a label-free electrochemical aptasensor was constructed. Magnetic glassy carbon electrode (MGCE) after Fe 3 O 4 /Fe 2 O 3 @Au NPs surface modification by a magnetic-induced self-assembly technique was the platform. Fe 3 O 4 /Fe 2 O 3 @Au NPs were used as the signal amplifier to enhance electron transfer, which was essential for the detection of trace amounts of biological analytes, and were prepared via heating hydrolyzation-combustion calcination and trisodium citrate reduction. Meanwhile, aptamers bound to the as-prepared nanomaterial via Au-s bonds and specifically recognized VEGF 165. The electrochemical properties of the aptasensor were evaluated with [Fe(CN) 6 ] 3−/4 − as redox probes. When in optimal detection conditions, an excellent linear relationship (between 0.01 and 10 pg mL −1 , R 2 = 0.9973) was obtained for the electrochemical aptasensor. The limit of detection (LOD) and the limit of quantitation (LOQ) of the electrode were 0.01 and 0.03 pg mL −1 . This proposed aptasensor exhibited favourable selectivity, stability, reproducibility, and regenerability. The results demonstrated that the sensor was promising to provide an efficient, accurate, and low-cost auxiliary detection method for the early screening of VEGF 165 -related diseases, which had important clinical practical value for the research of human precision medicine.
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
癌症研究
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）