Nanoscale
·
2024
·Vol. 16
·期 29
·13938-13944
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IF 5.8
Dan Xie,Youyou Deng,Xunlong Ji,Yiyan Zhang,Wentao Zhang,Zijin Hong,Wenjing Liu,Jingjing Du,Zhenli Sun
A novel breakthrough has been achieved in gas detection through the innovative application of surface-enhanced Raman scattering (SERS) to hydrogen (H2) detection for the first time. This study capitalizes on the unique SERS effects of gold nanoparticles coupled with the redox interaction between hydrogen and crystal violet, allowing for the development of a magnetic SERS probe that demonstrated enhanced sensitivity and specificity. This new probe can detect hydrogen concentrations as low as 1% by volume in gaseous environments, offering a substantial improvement over the detection limits of traditional hydrogen alarms. Further, this report comprehensively detailed the synthesis of the FA-CV materials, instrumental analysis, and an in-depth evaluation of the SERS performance of the FA-CV substrate, underlining the outstanding sensitivity, stability, and recyclability of the probe. The introduction of SERS in this novel capacity not only contributes a valuable approach to gas sensing technologies, but also suggests promising avenues for the application of SERS in environmental monitoring and energy security. This illustrates the adaptability and potential impact of this powerful technique.
研究领域:
化学
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材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2021
·Vol. 23
·期 37
·6610-6619
·
IF 3.545
Qunling Fang,Kezhu Xu,Qingshan Xiong,Yunqi Xu,Ailing Hui,Shouhu Xuan
Infectious diseases associated with drug-resistant bacteria increasingly threaten public health. Effective antibacterial nanoplatforms are of special importance for treating bacterial infections. In this work, a novel magnetic Fe3O4–Au–PDA hybrid microcapsule with both photothermal (PTT) and photodynamic (PDT) anti-bacterial functions was developed. First, the Fe3O4@Au/PDA core/shell microspheres with hollow nature were obtained by a simple in situ redox–oxidize polymerization method. Then, they were etched in acid to improve the hollow interior and porous shell. Finally, the tetracarboxyzinc phthalocyanine (ZnPc) was used as the photosensitizer to be loaded into the above Fe3O4–Au–PDA hybrid microcapsule. Owing to the dual-mode photothermal Au–PDA hybrid shell and the ZnPc photosensitizer, the final Fe3O4–Au–PDA/ZnPc hybrid microcapsule serves as a wonderful photothermal/photodynamic (PTT/PDT) synergistic therapy agent. The experimental results show that the Fe3O4–Au–PDA/ZnPc microcapsule possesses excellent photothermal sterilization effect (808 nm laser irradiation) against Escherichia coli, and the experimental results further demonstrate good photodynamic behavior under Xenon lamp irradiation. The product exhibits much higher antibacterial performance by combining the PTT/PDT treatment, which demonstrates that this work provides a novel dual-mode phototheranostic nano-agent for an effective treatment of bacterial infections.
研究领域:
纳米医学
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材料科学
·
微生物学
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产品关联
DOI
高影响因子
ELECTROANALYSIS
·
2021
·Vol. 33
·期 7
·1736-1745
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IF 3.223
Huanan Guan,Bo Peng,Dezhuang Gong,Bolin Han,Na Zhang
Fe 3 O 4 @Au nanomaterials were prepared by the self-assembly method. An enzyme-free, ultrasensitive electrochemical detection of uric acid was achieved based on the peroxidase-like activity of Fe 3 O 4 @Au. The proposed procedure has exhibited excellent catalytic activities and achieved significant enhancements of the current responses to uric acid. The detection range was from 0.1 to 10 mmol/L, and the limit of detection was 0.087 μmol/L. Under the action of external magnetic field, the magnetic particles can be easily separated from the bottom liquid, which has the advantages of simple operation and high separation efficiency. Moreover, this detection method combining a simulated enzyme and electrochemical can enhance the effective output of the overall electrochemical signal without modifying the electrode, and excellent reproducibility can be achieved. Compared to colorimetric assay, the electrochemical one has higher sensitivity and selectivity, and was further applied in ultrasensitive detection of uric acid in food samples. In short, the proposed electrochemical assay has great potential in the fields of food quality control and biomedical analysis.
研究领域:
分析化学
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生物医学工程
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食品科学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Xiaolin Liu,Yongxin Tao,Huihui Mao,Yong Kong,Jian Shen,Linhong Deng,Linsong Yang
Near-infrared (NIR) light has great potential in biomedical applications due to its advantages of deep penetration depth and low photodamage to biological tissues. In this paper, we constructed a novel core-shell structured drug nanocarrier, Fe 3 O 4 @Au@SiO 2 , for the controlled delivery of etoposide (VP16), a chemotherapeutic drug for cancer patients. The novel core-shell structured drug delivery platform is composed of a mesoporous silica shell and a magnetic Fe 3 O 4 core using Au nanoparticles (AuNPs) as the interlayer, which is characterized by atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, N 2 adsorption/desorption isotherms and the magnetic measurements with vibrating-sample magnetometer (VSM). The synergistic effects of AuNPs, mesoporous silica and Fe 3 O 4 make the core-shell structured nanocomposites an excellent candidate for targeted and NIR light irradiation-controlled drug delivery. For the proposed nanocarrier of VP16, the mesopores in silica can enhance the encapsulation capacity of the nanocarrier and the AuNPs can effectively convert the NIR light into heat to speed up the drug deliver; meanwhile, the incorporation of Fe 3 O 4 with high magnetization to the drug delivery platform realize drug targeting under an applied external magnetic field.
研究领域:
生物医学工程
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药学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2015
·
IF 4.097
Guihong Ding,Shi Xie,Yongmei Zhu,Ying Liu,Li Wang,Fugang Xu
An active surface-enhanced Raman scattering (SERS) substrate composed of graphene oxide (GO) wrapped gold nanoparticles (AuNPs) decorated-magnetic sphere Fe 3 O 4 (GO wrapped Fe 3 O 4 @Au hybrid) was prepared and used for aromatic dye detection. The hybrid was characterized by SEM, EDX, XRD, UV–visible spectroscopy and Raman spectroscopy. This hybrid showed high activity for SERS detection of aromatic dye due to the synergistic interaction among GO nanosheet, AuNPs and Fe 3 O 4 sphere. The dosages of AuNPs and GO were optimized to achieve a high sensitivity. The unique GO wrapped Fe 3 O 4 @Au hybrid has several advantages (such as high adsorption to target dye molecules, low noise response and high SERS enhancement ability) as SERS substrate over previously reported Fe 3 O 4 and AuNPs co-decorated GO sheet. Finally, the hybrid was successfully used for SERS detection of aromatic dye pollutant malachite green (MG) and nile blue A (NBA) even at concentration down to 1 nM and 0.1 nM, respectively. Potential of this substrate for multiplex detection of dye mixture (MG and NBA), and practical detection of MG in real sample were also evaluated. Our results suggested that the hybrid of GO wrapped Fe 3 O 4 @Au can be used as an efficient SERS platform for aromatic dye detection.
研究领域:
材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Bing zhang,Yu-lian Li,Li Wang,Haoyuan Cai
Conventional surface plasmon resonance (SPR) sensor often fails to detect low-concentration small molecules due to insufficient refractive index changes. To address this challenge, we have developed an enhanced SPR sensor utilizing Fe 3 O 4 @Au@polydopamine (PDA) core–shell magnetic nanoparticles as signal amplification tags for the detection of tebuconazole (TBZ). These nanoparticles improve sensitivity through their high refractive indices and enable TBZ enrichment from complex matrices via their magnetic properties. The sensor surface is further modified with PDA, which acts as a reducing agent for Au nanoparticle deposition, enhancing monoclonal antibody (Ab) immobilization and boosting the SPR signal. Our optimized sensor reaches a limit of detection (LOD) at 0.61 ng/mL for TBZ, with a linear response from 1-200 ng/mL, and demonstrates high selectivity and reproducibility, ideal for pesticide monitoring in food samples.
研究领域:
分析化学
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食品科学
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Ting Zhang,Lingli Lei,Meiling Tian,Junjie Ren,Zhisong Lu,Yang Liu,Yingshuai Liu
An ultrasensitive lateral flow immunoassay (LFIA) strip has been developed based on a multifunctional photothermal contrast Fe 3 O 4 @Au supraparticle (Fe 3 O 4 @Au SP) for quantitative Ochratoxin A (OTA) detection. The Fe 3 O 4 @Au SP composite not only shows a better photothermal effect over Fe 3 O 4 and gold nanoparticles , but possesses magnetic property and excellent ability to directly adsorb protein (antibody). Under 808 nm irradiation, photothermal images of the test strips are recorded by a portable Infrared thermal camera. A quantitative analysis is easily achieved based on the thermal changes, which are proportional to the concentrations of analytes. Under an optimal condition, a wide linear detection range from 1 pg mL⁻ 1 to 1μgmL⁻ 1 and a limit of detection (LOD) at 0.12 pg mL⁻ 1 have been achieved with OTA as a model analytes. The practical application potential has also been validated by detection of OTA in spiked corn , peanut, and soybean extractives with overall recoveries ranging from 98.6% to 115% and coefficient of variations (CVs) between 6.06% and 12.73%. The photothermal LFIA renders a rapid, sensitive, and quantitative bio-/chemo-sensing platform with only a portable laser source and a thermal camera.
研究领域:
生物医学工程
·
食品安全检测
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2024
·Vol. 53
·期 37
·15618-15629
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IF 3.5
Wei Zhang,Jin Li,Cuilian Sun,Xiujing Xing,Yaokang Lv,Wei Xiong,Hao Li
Surface modification is one of the effective strategies to control the morphology and electrocatalytic performance of noble metal/transition metal oxide matrix composite catalysts. In this work, we successfully introduced modification groups such as –NH2, –COOH, and –SH on the surface of Fe3O4 using the hydrothermal method. It was found that when the modification group –COOH was introduced, the regular spherical morphology of Fe3O4 was still maintained in Fe3O4–COOH, while Fe3O4–COOH had a relatively smaller spherical particle size (≈155.9 nm). Due to its smaller particle size, Fe3O4–COOH has a larger active area than Fe3O4, exposing more active sites. The abundant active sites in Fe3O4–COOH provide more nucleation and growth sites for Au particles, which is beneficial for the recombination between Fe3O4–COOH and Au. In addition, the experimental results of exploring the effect of Au precursor dosage on the synthesis of the Fe3O4–COOH@Au structure and performance show that the synthesized Fe3O4–COOH@Au1.0 catalyst has higher electrocatalytic activity. Due to the larger electrochemically active surface area of the Fe3O4–COOH@Au1.0 catalyst compared to those of Fe3O4–COOH@Au0.5 and Fe3O4–COOH@Au1.5 catalysts, the adsorption and activation of NO2− reactants were accelerated, thereby improving the electrocatalytic performance. Therefore, owing to the morphological and structural characteristics of Fe3O4–COOH combined with the high activity of Au nanoparticles, the synthesized Fe3O4–COOH@Au exhibits effective electrocatalytic activity in the electrocatalytic NO2−RR synthesis of ammonia. At a voltage of −0.8 V (vs. RHE), the ammonia yield reached 2092.8 μg h−1 mgcat−1 and Faraday efficiency reached 81.2%. The findings of this work will enrich our understanding of the construction of efficient Fe3O4@Au catalysts based on surface functionalization and help to design efficient electrocatalytic NO2−RR catalysts for practical applications.
研究领域:
材料科学
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电化学
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催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemosensors
·
2023
·Vol. 11
·期 2
·73
·
IF 4.2
Ying Song,Kunyue Xiao,Qiang Chen,Xiaodong Zhang,Zhi Yu,Wenwen Chen,Xiubing Zhang,De Zhang,Dejiang Ni,Pei Liang
The detection of bifenthrin is closely related to the adsorption of SERS substrates. In this study, superparamagnetic Fe3O4@Au MNPs coated with GO were used to detect the adsorption and enrichment of bifenthrin molecules with benzene rings. Firstly, the thermal solvent method synthesized Fe3O4magnetic nanoparticles (MNPs) with a particle size of ~250 nm. Next, polyethylene imide (PEI) was used as an intermediate layer to modify the surface of Fe3O4to form a positively charged ultra-thin polymer middle layer. Next, the gold shell was developed by adsorption of ~20 nm AuNPs, without affecting the magnetic properties. Then, the additional amount of colloidal gold and GO on SERS performance was systematically studied. Using crystal violet (CV) as the probe, we investigated the SERS performance of composite nanomaterials. The lowest detected concentration reached 10−8mol/L, confirming that the composite functional material had good SERS activity and magnetic properties. Finally, the substrate was used to detect bifenthrin in an acetone solution, and the lowest detection concentration was 10−8mol/L. These results showed that the prepared GO/Fe3O4@Au MNPs were efficient SERS substrates that could detect bifenthrin pesticide residue with high sensitivity.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2015
·
IF 2.219
Chunxiang Zhang,Guangyu Shen,Youming Shen,Xiangyang Zhang
In this work, a novel thiol aromatic aldehyde was synthesized. It can be used as a substrate to directly immobilize antibodies on a gold electrode, for which no additional chemical cross-linker is required. It was also applied as a linker to prepare Fe 3 O 4 @Au/PAMAM/Ab 2 –horseradish peroxidase bioconjugates , which introduced multiple enzymes onto a sensing interface owing to the high surface-to-volume ratio of Fe 3 O 4 @Au nanoparticles and many functional groups of the poly(amidoamine) dendrimer (PAMAM). The introduced multiple enzymes greatly improved the detection signal. Under optimal conditions, the proposed electrochemical immunosensor exhibited desirable performance for detection of IgG in the range 0.005–50 ng ml −1 with a detection limit of 3 pg ml −1 based on a signal-to-noise ratio of 3. It has great potential application in the area of clinical analysis.
研究领域:
生物医学工程
·
分析化学
·
纳米技术
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Na Li,Ting Zhong,Jia-liang Liu,Jun Zheng,Hu-cheng Deng,Wen Zhou,Ming Li,Ming-shi Feng,Qi-jun Liu,Chong-ying Li
Analysis and characterization of micro/nano-sized pore structure are critical issues in shale geology and engineering. Scanning electron microscopy (SEM) imaging is one of the most widespread methods for the analysis of the micro/nano-sized pores in shale, but precise identification of the ultrafine pore structure in shale is still a big challenge because shale is so complex that some components may have overlap with pores based on the simple discrimination of gray scale under SEM microscopy. Here, Fe3O4/Au nanocomposite with magnetic properties is synthesized, characterized, and introduced as a novel pore-marker to improve SEM identification and quantitation of micro/nano-sized pores in shale. Due to the superparamagnetic property, the nanomarker is conveniently controlled by an external magnetic field to fill into pores and offers a sharp contrast imaging between matrix of shale (various gray) and pores (bright), which makes the identification of micro/nano-sized pores in shale much more straightforward and reliable. Furthermore, because gold, as a noble metal, is particularly rare in shale, energy-dispersive X-ray spectroscopy mapping of Au is delicately used to precisely calculate area porosity in shale. Combining with the aforementioned merits of the nanomarker, a precise and practical technique is proposed to promote characterization of micro/nano-sized pores in shale.
研究领域:
地质学
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材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Fang Li,Pengying Zhang,Jiayi Chen,Jiahui Xi,Shuai Gao,Yunhong Liu
Mercury ion (Hg 2+ ), a highly toxic and bioaccumulative pollutant, can contaminate medicinal herbs and pose significant risks to human health via the food chain. With the growing global demand for traditional Chinese medicine (TCM), there is an urgent need to develop reliable and sensitive Hg 2+ detection methods. In this paper, a novel electrochemical sensor based on magnetic nanoparticles and thymine-Hg 2+ -thymine (T-Hg 2+ -T) coordination chemistry was developed for detecting Hg 2+ in TCM. The magnetic Fe 3 O 4 /Au nanoparticles (Fe 3 O 4 /Au NPs) were synthesized and employed as carriers to conjugate with T-rich thiol-modified DNA probes. In the absence of Hg 2+ , the DNA probes hybridized with ferrocene (Fc)-labeled complementary DNA (cDNA), bringing the Fc signal molecules close to the Fe 3 O 4 /Au NPs surface. In the presence of Hg 2+ , these probes preferentially formed stable T-Hg 2+ -T complexes, effectively inhibiting cDNA hybridization. The Hg 2+ concentration was determined by measuring the corresponding changes in the Fc current. The sensor exhibited a good linear response to Hg 2+ in the range of 0.1–100 ng/mL, with a low detection limit of 0.08 ng/mL. Furthermore, the method was successfully applied to determine Hg 2+ in representative TCM matrices (Lotus leaf, Lonicera japonica , Angelica dahurica , and Houttuynia cordata Thunb.) with satisfactory recoveries (96.73 %−104.84 %). This indicates that the proposed method is particularly suitable for Hg 2+ determination in complex TCM samples, providing a practical solution for quality control and safety monitoring in TCM.
研究领域:
分析化学
·
环境科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）