The development of nanotheranostic agents integrating diagnosis and therapy has gained tremendous attention in the past few decades, but many of them are inherently hydrophobic and need complicated phase-transfer and tedious surface modifications. This work proposed a facile method of transferring hydrophobic Fe3O4@Cu2−xS nanoparticles from oil to water by using red blood cell membrane to create theranostic nanobeads for T2-weighted MRI and second near-infrared photothermal ablation. The obtained nanoplatform, namely SCS@RBCM, showed a core–shell structure with the inner core densely packed with Fe3O4@Cu2−xS nanoclusters and the surface coated with a layer of RBCM. SCS@RBCM displayed a stable nanostructure, high NIR II light absorption and photothermal conversion ability, T2-weighted MR imaging and magnetic field targeting ability. Meanwhile, the RBCM cloaking endowed SCS with reduced elimination by macrophages. With the navigation of an external magnetic field (MF), the tumor accumulation of SCS@RBCM was dramatically increased, thus achieving good performance of MR imaging and antitumor efficacy through the PTT effect under NIR II irradiation. Therefore, our strategy presents a new and desirable paradigm in the phase-transfer of hydrophobic nanotheranostics for optimizing their biomedical performance.
Wen Zhang,Bo Li,Yuhan Zhu,Xin Yao,Xiaohe Tian,Shengli Li,Yupeng Tian,Dandan Li
It is considerably meaningful to fabricate a second near-infrared spectral region (NIR-II, 1000–1700 nm) responsive theranostic nanoplatform simultaneously possessing good stability and biocompatibility for efficient and safe cancer treatment. In this work, as a flexible strategy, an intelligent nanoplatform was prepared by using water-soluble cyclic oligosaccharides α-cyclodextrin (α-CD) to load photosensitizer Chlorin e6 (Ce6) onto Fe 3 O 4 @Cu 2−x S core−shell nanoparticles (NPs). The as-synthesized Fe 3 O 4 @Cu 2−x S-Ce6/α-CD NPs are ultrasmall (≈5 nm) and aqueously dispersible, which offer both biocompatibility and renal clearance. Resultly, the obtained Fe 3 O 4 @Cu 2−x S-Ce6/α-CD NPs feature remarkable absorption in the second near-infrared region (NIR-II), which can provide advantages of large penetration depth and high photothermal conversion efficiency (η = 67.88%). Additionally, the introduction of Ce6 can trigger the generation of 1 O 2 under visible light irradiation. Therefore, it provides the proof-of-concept application of functional materials in photodynamic and photothermal combination cancer therapy.
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