JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-13
·
IF 10.435
Chen Tong,Chu Qiang,Li Mengyang,Han Gaorong,Li Xiang
Electrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex tumor microenvironment, including glutathione (GSH) overexpression, acidity and others. Herein for the first time, iron oxide nanoparticles are decorated using platinum nanocrystals (Fe 3 O 4 @Pt NPs) to integrate the current EDT with chemodynamic phenomenon and GSH depletion. Fe 3 O 4 @Pt NPs can effectively induce ROS generation based on the catalytic reaction on the surface of Pt nanoparticles triggered by electric field (E), and meanwhile it may catalyze intracellular H 2 O 2 into ROS via Fenton reaction. In addition, Fe 3+ ions released from Fe 3 O 4 @Pt NPs under the acidic condition in tumor cells consume GSH in a rapid fashion, inhibiting ROS clearance to enhance its antitumor efficacy. As a result, considerable in vitro and in vivo tumor inhibition phenomena are observed. This study has demonstrated an alternative concept of combinational therapeutic modality with superior efficacy.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Huanan Guan,Yanyu Chen,Yue Xue
The self-assembly approach has successfully been used to generate Fe 3 O 4 @Pt, a material that can mimic peroxidase . The material was created by modifying the surface of Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) with -NH 2 functional groups using 3-Aminopropyltriethoxysilane (APTES), and then using the coordination between platinum ions and -NH 2 on the surface of magnetic particles to reduce platinum ions to the surface of magnetic particles under ultrasonic conditions to produce Fe 3 O 4 @Pt composite nanoparticles . The Fe 3 O 4 @Pt core-shell composite material not only has the inert metal Pt to protect Fe 3 O 4 to improve the stability of Fe 3 O 4 in the biological matrix, but also has the high catalytic activity of Fe 3 O 4 and Pt. The catalysts were characterized, and the findings revealed that they were non-homogeneous Fenton catalysts with high dispersion, uniform particle size, and a large specific surface area . Since a large number of free radicals generated during the catalysis of Fe 3 O 4 @Pt mimic enzyme can trigger the Fenton reaction, tetracycline (TC) and oxytetracycline (OTC) were chosen as target substances, and a system for the combined degradation of tetracyclines pollutants by mimic enzyme and Fenton reaction was established, and the catalytic mechanism of this system has been investigated. The findings indicate that by using a concentration of 0.25 mol/L of H 2 O 2 , a catalyst amount of 1.5 g/L, a reaction time of 50 min, and a reaction temperature of 50°C, the degradation rate of TC and OTC can exceed 97 %, following first-order degradation kinetics. Under ideal conditions, over 95 % of each tetracyclines was degraded in the simulated food processing wastewater, effectively achieving tetracyclines degradation in the actual wastewater. In addition, the reusability of the recovered Fe 3 O 4 @Pt mimetic enzyme was investigated. The findings indicated that the Fe 3 O 4 @Pt mimetic enzyme has exceptional activity, stability, and reproducibility. The combination of the Fenton reaction with the Fe 3 O 4 @Pt mimetic enzyme can expedite the degradation of tetracyclines, offering a novel approach for eliminating recalcitrant contaminants in wastewater.
研究领域:
环境科学
·
催化材料
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 37
·25828-25835
·
IF 3.9
Xia Xu,Liming Yang,Yanjun Cui,Bing Hu
The successful development of efficient and stable catalysts for 4-NP reduction reactions is beneficial to the environment and ecology. Fe3O4@Pt exhibits excellent catalytic performance for 4-NP reduction reaction due to the synergistic effect between Fe and Pt. But its structure and catalytic performance are extremely unstable. Here, we utilized the small-scale organic compound 2-hydroxyethylamine as surfactant to construct a stable composite nanomaterial. Then investigated the influence of monochromatic light (650 nm, 808 nm and 980 nm) and temperature on the kinetics of 4-NP reduction reaction by 2-hydroxyethylamine stabilized Fe3O4@Pt. The results indicate that both temperature and monochromatic light radiation can affect kinetic regulation. Increasing temperature can promote the catalytic rate, while monochromatic light radiation can induce agglomeration and inhibit the catalytic rate. This study opens up a new way for developing and regulating catalysts for heterogeneous catalysis reactions.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Shuhuai Li,Chaohai Pang,Xionghui Ma,Yuwei Wu,Mingyue Wang,Zhi Xu,Jinhui Luo
To broaden the applicability of electrochemiluminescence (ECL) sensors toward the sensitive and selective detection of trace antibiotic residues, new ECL reagents are required. Herein, a novel molecularly imprinted sensor based on an aggregation-induced ECL reagent was fabricated for the sensitive detection of ciprofloxacin (CFX). A covalent organic framework with aggregation-induced ECL (COF-AIECL) was synthesised using a boric acid condensation dehydration reaction. Then, an electrode surface was modified with COF-AIECL as a signal element and nanozymatic ferriferrous oxide@platinum nanoparticles (Fe 3 O 4 @Pt NPs) as a signal amplification element. Subsequently, using CFX as a template molecule, a molecularly imprinted polymer (MIP) was fabricated on the modified electrode. The ECL signal of COF-AIECL was catalytically amplified by the Fe 3 O 4 @Pt NPs, whereas CFX effectively quenched this signal. Consequently, the ECL signal was controlled by CFX elution from and adsorption by the MIP, thus establishing a new method for CFX detection. The sensitivity of the sensor was greatly enhanced by the aggregation-induced luminescence effect and nanozyme amplification, whereas the MIP effectively improved the selectivity for CFX. Under optimal conditions, the electrochemical sensor exhibited a linear detection range of 2 × 10 −12 to 3 × 10 −9 mol L −1 , with a detection limit of 5.98 × 10 −13 mol L −1 . Furthermore, in untreated milk samples, CFX recoveries of 92.0%–111% were achieved. Thus, the developed sensor exhibited good reproducibility, stability, and selectivity for CFX detection.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Royal Society Open Science
·
2022
·Vol. 9
·期 9
·
IF 3.653
Ye He,Panlin Wang,Xiaojing Chen,Yahuang Li,Jiajun Wei,Guoxi Cai,Kiyoshi Aoyagi,Wenxiang Wang
A simple strategy to rapidly detect glucose was developed by utilizing core (Fe3O4)–shell (Pt) magnetic nanoparticles (Fe3O4@Pt NPs) as a nanoenzyme and a paper-based colorimetric sensor. In the presence of H2O2, Fe3O4@Pt NPs catalyze the redox reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) and generate a colour change from colourless to blue. On this basis, a colorimetric glucose sensing method assisted by glucose oxidase (GOx) was developed. Under the optimal conditions, the detection limits of the proposed assay for H2O2 and glucose were 0.36 µM and 1.27 µM, respectively. Furthermore, the fabricated colorimetric method was successfully applied to analyze glucose concentrations by using a paper device as a measuring platform without a spectrometer. In addition, this method exhibited satisfactory recovery for glucose detection in human serum samples and urine samples, which satisfied the requirements for normal detection of real samples. This study provides a good candidate for health monitoring of glucose and also expands the applications of nanoenzymes and paper-based colorimetric assays in point-of-care testing.
研究领域:
纳米技术
·
分析化学
·
生物传感器
·
即时检测
✓ 已验证
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 20
·13556-13563
·
IF 3.9
Xia Xu,Mingqiang Li,Liming Yang,Bing Hu
Reasonable design of bimetallic nanomaterials with support is beneficial to improve catalytic performance. This work reports a new kind of sodium sesquicarbonate-supporting Fe2O3@Pt via etching Fe3O4@Pt@SiO2, which exhibits highly efficient and stable catalytic reduction performance towards 4-NP. Sodium sesquicarbonate-supporting Fe2O3@Pt has an interconnected one-dimensional network structure that provides sufficient channels for mass transfer. At the same time, a large amount of Fe2O3@Pt is exposed on its surface, which hinders the aggregation of pt clusters and Fe2O3 nanoparticles, and facilitates the direct contact of Fe2O3@Pt reaction sites with reactant molecules, thus improving the catalytic rate of 4-NP reduction reaction. Moreover, the introduction of non-metallic Fe can not only reduce the consumption of precious metal Pt, but also improve the catalytic efficiency due to the synergistic effect. This study opens up a new avenue to develop robust catalysts for heterogeneous catalytic reactions.
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 47
·21654-21660
·
IF 3.3
Ye He,Panlin Wang,Zhuzheng Wu,Yating Chen,Xiaohao Gan,Fangjie Li,Wenxiang Wang
The precise identification and detection of circulating tumor cells (CTCs) is significant for the early diagnosis and prognostic treatment of cancer. However, it remains a challenge to detect CTCs with high sensitivity and specificity. In this study, a colorimetric sensor for the analysis of CTCs was constructed based on dual-aptamer recognition and core (Fe3O4)–shell (Pt) nanoparticle (Fe3O4@Pt NP) nanozymes coupled with a G-quadruplex as a signal transducer/amplifier. The results show that the linear range of the designed colorimetric sensor is 50–4000 cells and the detection limit is 4 cells. The constructed aptasensor could be extended to identify various CTCs by changing the aptamers, and holds great potential in precise tumor diagnosis.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）