RSC Advances
·
2016
·Vol. 6
·期 68
·63704-63710
·
IF 3.289
Aihua Li,Hongjing Ma,Jingquan Liu
A novel GO coated porous magnetic NPs (Fe3O4@mSiO2@GO) for bioimaging was synthesized. First, Fe3O4 magnetic NPs were prepared through a solvothermal reaction. Second, through a surfactant-templating approach with cetyltrimethylammonium bromide (CTAB) as a template, a mesostructured CTAB/SiO2 composite was deposited on Fe3O4 NPs surfaces. Third, CTAB templates were removed to form a mesoporous SiO2 shell, resulting in mesoporous magnetic (Fe3O4@mSiO2) NPs. Forth, the magnetic NPs surfaces were functionalized with amino groups by (3-aminopropyl)triethoxysilane (APTES). Finally, the dye rhodamine B (RB) was loaded inside porous magnetic NPs, and the magnetic NPs surfaces were then wrapped with graphene oxide (GO) nanosheets. SEM analysis revealed that GO sheets have been successfully coated on magnetic NPs surfaces. The hysteresis loops analysis indicated that these magnetic NPs still retained strongly magnetic property. Furthermore, Fe3O4@mSiO2@GO NPs could efficiently protect the loaded dye from releasing. In addition, MTT assay revealed that the RB loaded Fe3O4@mSiO2@GO NPs exhibited insignificant cytotoxicity at moderate concentrations and the RB loaded Fe3O4@mSiO2@GO NPs could undergo target-directed move under the action of a magnetic field. The noncytotoxic magnetic hybrids presented significant potential for applications in cell imaging.
研究领域:
材料科学
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生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Chemistry-An Asian Journal
·
2012
·Vol. 8
·期 2
·385-391
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IF 4.5
Jingguo Li,Hao Jiang,Zhiqiang Yu,Hongyan Xia,Gang Zou,Qijin Zhang,Yue Yu
Graphical The best of both worlds : Indocyanine green (ICG), a near-infrared (NIR) imaging agent and perfect NIR light absorber for laser-mediated photothermal therapy, was successfully incorporated into superparamagnetic Fe 3 O 4 @mSiO 2 core–shell nanoparticles to combine the merit of NIR/MR bimodal imaging properties with NIR photothermal therapy. Multimodal imaging and simultaneous therapy is highly desirable because it can provide complementary information from each imaging modality for accurate diagnosis and, at the same time, afford an imaging-guided focused tumor therapy. In this study, indocyanine green (ICG), a near-infrared (NIR) imaging agent and perfect NIR light absorber for laser-mediated photothermal therapy, was successfully incorporated into superparamagnetic Fe 3 O 4 @mSiO 2 core–shell nanoparticles to combine the merit of NIR/magnetic resonance (MR) bimodal imaging properties with NIR photothermal therapy. The resultant nanoparticles were homogenously coated with poly(allylamine hydrochloride) (PAH) to make the surface of the composite nanoparticles positively charged, which would enhance cellular uptake driven by electrostatic interactions between the positive surface of the nanoparticles and the negative surface of the cancer cell. A high biocompatibility of the achieved nanoparticles was demonstrated by using a cell cytotoxicity assay. Moreover, confocal laser scanning microscopy (CLSM) observations indicated excellent NIR fluorescent imaging properties of the ICG-loaded nanoparticles. The relatively high r 2 value (171.6 m M −1 s −1 ) of the nanoparticles implies its excellent capability as a contrast agent for MRI. More importantly, the ICG-loaded nanoparticles showed perfect NIR photothermal therapy properties, thus indicating their potential for simultaneous cancer diagnosis as highly effective NIR/MR bimodal imaging probes and for NIR photothermal therapy of cancerous cells.
研究领域:
生物医学工程
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纳米医学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 113
·112232-112240
·
IF 3.289
Xiangjie Luo,Ying Wang,Huiming Lin,Fengyu Qu
The integration of multiple therapies into one nanoplatform was considered to be the most efficient method to give an enhanced therapeutic effect for anti-cancer treatments. In this research, pH sensitive drug release and near-infrared (NIR)-induced photothermal therapy (PTT) were placed in one nanocomposite using iron(II,III) oxide@meso-silica (Fe3O4@mSiO2) NPs as the host. Then, a sensitive ketal modified silane coupling agent (PO linker) was prepared to encapsulate the anti-cancer drug, doxorubicin hydrochloride (DOX), into the mSiO2 shell, ensuring the few leakage. Based on the different pH conditions of normal and cancer cells, the DOX-Fe3O4@mSiO2-PO nanocomposite exhibits the specific drug release in cancer cells (acid conditions) before that the few leakage makes sure there are a low number of side effects. Furthermore, the release kinetics can also be easily adjusted by varying the amount of PO linker. Under NIR (808 nm) irradiation, the photothermal effect derived from magnetic Fe3O4 NPs can also induce the apoptosis of the cancer cells which is how PTT is achieved. HeLa cells (cervical cancer cell line) were used as the typical cancer cell and the detailed cell experiments further display the enhanced specific cytotoxicity of the method to HeLa cells. The multifunctional nanocomposite has great potential as an application for anti-cancer therapy.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Arabian Journal of Chemistry
·
2023
·
IF 6
Li Wu,Qijie Mo,Shoulian Wei,Ruiping Gao,Shuai Zhang,Xiaohua Zhu
This study demonstrates a novel colorimetric method for clenbuterol (CLB) detection based on the peroxidase-like activity of SiO 2 -coated Fe 3 O 4 nanoparticles (Fe 3 O 4 @mSiO 2 ) modified with montmorillonite (MMT) and sodium dodecyl sulfate (SDS), namely, Fe 3 O 4 @mSiO 2 @MMT-SDS. Fe 3 O 4 @mSiO 2 @MMT-SDS nanoparticles were prepared by modifying Fe 3 O 4 @mSiO 2 with MMT and SDS to impart negative charges to the particle surfaces. The structural properties, steady-state kinetics, catalytic performance, and reaction conditions of the as-prepared nanoparticles were analyzed. Fe 3 O 4 @mSiO 2 @MMT-SDS nanoparticles exhibited excellent dispersion and enzyme-like activity, which improved the affinity with substrate (TMB and H 2 O 2 ) for the catalytic oxidation of CLB by H 2 O 2 , turning the solution blue in the presence of the 3,3ʹ, 5,5ʹ-tetramethylbenzidine chromogen. Under optimal reaction conditions, a strong linear correlation between the absorbance of solution and CLB concentration (R 2 = 0.9983) was observed. Here, the limit of detection, spike recovery, and relative standard deviation were 9.6 × 10 -9 mol · L -1 , 94.2 %–102.2 %, and 2.2 %–4.4 %, respectively. The proposed method is a simple, fast, cost-efficient, and sensitive assay, which can be used to rapidly and accurately screen CLB in pork and animal feeds.
研究领域:
分析化学
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食品安全
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生物医学工程
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2014
·Vol. 43
·期 48
·18056-18065
·
IF 4.097
Wei Guo,Chunyu Yang,Huiming Lin,Fengyu Qu
The Fe3O4@mSiO2 nanocarrier that consisted of a magnetic Fe3O4 nanoparticle core and a mesoporous silica (mSiO2) shell was synthesized. It shows a uniform sphere morphology about 65 nm in diameter. Considering the magnetic hyperthermia of Fe3O4 under an alternating magnetic field (AMF), a thermo-sensitive polymer, poly[(ethylene glycol)-co-(L-lactide)] (P(EO-co-LLA)), was used as “gatekeeper” coating outside Fe3O4@mSiO2 to regulate the drug release behavior. The design of the nanocarrier was expected to block off the pores at low temperature and to reopen them at high temperature reversibly. The obtained hybrid nanocomposites were capable of loading the anti-cancer drug doxorubicin (DOX) and controlled drug release behavior trigged by the hyperthermia of Fe3O4 under AMF. Besides, the nanocarriers also show pH-sensitive drug release based on the slight differences between the tumor (weakly acid) and the normal tissue (weakly alkaline). What's more, the chemotherapy of DOX combined with magnetic hyperthermia can improve the cytotoxicity obviously. On the basis of the high stability and excellent controlled release performance, the multifunctional nanocarriers exhibit potential applications in targeted-control drug release and hyperthermia for cancer treatment.
研究领域:
纳米技术
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生物医学工程
·
材料科学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2014
·Vol. 2014
·期 36
·6156-6164
·
IF 2.965
Liru Cui,Huiming Lin,Chunyu Yang,Xiao Han,Ting Zhang,Fengyu Qu
Graphical A pH-responsive and magnetic-targeted drug-delivery system was prepared with a Fe 3 O 4 @mesoporous silica core–shell nanostructure as host. Au nanoparticles were used as the capping agent. These were connected to the surface of the mesopore through the hydrazone linkage to restrict the drug release. The system has potential applications in low-pH tissue-targeted therapy. A multifunctional nanocomposite has been successfully prepared for pH-responsive and magnetic-targeting drug delivery. First, Fe 3 O 4 @mesoporous silic (mSiO 2 ) core–shell nanoparticles were synthesized as the nanocapsules. Doxorubicin hydrochloride was adopted as the model drug; after drug loading, gold nanoparticles (5 nm) were connected to block the mesopore through the hydrazone linkage. The hydrazone bond, a typical acid-sensitive bond, could undergo hydrolysis in an acidic environment to induce the release of the capping agent, so that the multifunctional nanocomposite revealed acid-enhanced release performance. What's more, before reaching acid conditions, little premature release was found to take place. Cell experiments were also carried out to reveal the good biocompatibility, fast uptake, and improved toxicity toward HeLa cells. Thus, in association with the magnetic target, the multifunctional nanocomposite shows the potential application for some low-pH tissue-targeted therapy, such as for inflammation and tumors.
研究领域:
纳米医学
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生物材料学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2016
·Vol. 45
·期 34
·13456-13465
·
IF 4.177
Zhifang Gao,Xijian Liu,Guoying Deng,Feng Zhou,Lijuan Zhang,Qian Wang,Jie Lu
In this work, a new multifunctional nanoplatform (Fe3O4@mSiO2-FA-CuS-PEG nanocomposite) for magnetic resonance imaging (MRI) and targeted chemo-photothermal therapy, was firstly fabricated on the basis of magnetic mesoporous silica nanoparticles (Fe3O4@mSiO2), on which folic acid (FA) was grafted as the targeting reagent, CuS nanocrystals were attached as the photothermal agent, and polyethylene glycol (PEG) was coupled to improve biocompatibility. The characterization results demonstrated that the fabricated Fe3O4@mSiO2-FA-CuS-PEG nanocomposites not only showed strong magnetism and excellent MRI performance, but also had a high doxorubicin (DOX, an anticancer drug) loading capacity (22.1%). The loaded DOX can be sustainably released, which was apt to be controlled by pH adjustment and near infrared (NIR) laser irradiation. More importantly, targeted delivery of the DOX-loaded Fe3O4@mSiO2-FA-CuS-PEG nanocomposites could be accomplished in HeLa cells via the receptor-mediated endocytosis pathway, and this exhibited synergistic effect of chemotherapy and photothermal therapy against HeLa cells under irradiation with a 915 nm laser. Therefore, the fabricated multifunctional Fe3O4@mSiO2-FA-CuS-PEG nanocomposite has a great potential in image-guided therapy of cancers.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 130
·107670-107679
·
IF 3.84
Shoulian Wei,Jianwen Li,Yong Liu
Magnetic mesoporous nanoparticles of Fe3O4@mSiO2 were prepared through co-precipitation and tetraethoxysilane hydrolysis at 60 °C and pH 10 with hexadecyl trimethyl ammonium bromide as the template. Hydroxypropyl β-cyclodextrin was modified onto Fe3O4@mSiO2 under sodium citrate and N2 protection via an ultrasound process to increase the catalytic efficiency. The prepared nanoparticles were characterized by Fourier transform infrared spectrometry, X-ray diffraction, scanning electron microscopy and a peroxidase-like activity assay. The results showed that the prepared nanoparticles have magnetic properties, peroxidase-like activity and a loose spherical cluster structure. Compared with Fe3O4@mSiO2 nanoparticles, Fe3O4@mSiO2@HP-β-CD nanoparticles exhibit higher catalytic ability toward both H2O2 and 3,3′,5,5′-tetramethylbenzidine. Fe3O4@mSiO2@HP-β-CD nanoparticles can catalyse β-estradiol (β-E2) oxidation in the presence of H2O2 and be used as a colourimetric sensor for indirect detection of β-E2. A good linear relationship was obtained from 0.8 μM to 16 μM. The limit of detection of the proposed method was 0.2 μM. The visual method was successfully used in the analysis of β-E2 in commercial tablets and animal feeds, with recovery ranging from 92.6% to 110%.
研究领域:
生物化学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 3
·期 6
·1010-1019
·
IF 0
Chunyu Yang,Wei Guo,Liru Cui,Na An,Ting Zhang,Gang Guo,Huiming Lin,Fengyu Qu
Multifunctional nanocarriers based on the magnetic Fe3O4 nanoparticle core and bis-(3-carboxy-4-hydroxy phenyl) disulfide (R–S–S–R1) modified mesoporous silica shell (Fe3O4@mSiO2@R–S–S–R1) were synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release. Anti-cancer drug doxorubicin (DOX) was used as the model cargo to reveal the release behavior of the system. The drug loading system (DOX–Fe3O4@mSiO2@R–S–S–R1) retains the drug until it reaches the tumor tissue where glutathione reductase (GSH) can degrade the disulfide bonds and release the drug. Furthermore, the grafting amount of R–S–S–R1 can be used to adjust the release performance. All the release behaviors fit the Higuchi model very well and the release kinetics are predominated by disulfide bond degradation and mesoporous structure. With good bioactivity and targeted release performance, the system could play an important role in the development of intracellular delivery nanodevices for cancer therapy.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤治疗
✓ 已验证
产品关联
DOI
PubMed
ACS Applied Nano Materials
·
2021
·
IF 5.097
Bin Zuo,Qinyue Deng,Han Shao,Bingbing Cao,Yunhui Fan,Wanfang Li,Mingxian Huang
In this work, we designed the Fe3O4@mesoporous-SiO2@chitosan@polyaniline core–shell nanoparticles (Fe3O4@mSiO2@CS@PANI, hence abbr. FSCP), which can be used to capture Cr(VI) in wastewater. Rapid adsorption behavior and high removal capability (249.6 mg Cr(VI) per gram of FSCP) were exhibited by this material. X-ray photoelectron spectroscopy (XPS) analysis demonstrates that Cr(VI) was adsorbed and in situ reduced on FSCP at pH 2. Adsorption was facilitated by the electrostatic attraction of HCrO4– and −N+═C–/–N+H–, while the active −NH–/–N+H– sparked the reduction of Cr(VI) to Cr(III). Moreover, the coordination of the resulting Cr(III) with the amino group promoted adsorption, thus achieving detoxification of Cr(VI) in wastewater. After eight recycling experiments, the Cr(VI) removal efficiency of this material is still more than 90%, indicating that this material has excellent stability and good application potential. Therefore, this magnetic adsorbent offers a potential solution for the successful handling of chromium-containing wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-11
·
IF 5.833
Liu Bin,Wang Baichun,Yan Yinghua,Tang Keqi,Ding Chuan-Fan
A strategy for effectively enriching global phosphopeptides was successfully developed by using ammonia methyl phosphate (APA) as a novel chelating ligand and Ti 4+ and Nb 5+ as double functional ions (referred to as Fe 3 O 4 @mSiO 2 @APA@Ti 4+ /Nb 5+ ). With the advantage of large specific surface area (151.1 m 2 /g), preeminent immobilized ability for metal ions (about 8% of total atoms), and unbiased enrichment towards phosphopeptides, Fe 3 O 4 @mSiO 2 @APA@Ti 4+ /Nb 5+ displays high selectivity (maximum mass ratio β-casein to BSA is 1:1500), low limit of detection (LOD, as low as 0.05 fmol), good relative standard deviation (RSD, lower than 7%), recovery rate of 87% ( 18 O isotope labeling method), outstanding phosphopeptide loading capacity (330 μg/mg), and at least five times re-use abilities. In the examination of the actual sample, 24 phosphopeptides were successfully detected in saliva and 4 phosphopeptides were also selectively extracted from human serum. All experiments have shown that Fe 3 O 4 @mSiO 2 @APA@Ti 4+ /Nb 5+ exhibits exciting potential in view of the challenge of low abundance of phosphopeptides.
Graphical abstract
研究领域:
生物化学
·
蛋白质组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Yining Jiang,Ziyang Qiu,Siyang Deng,Han Yan,Xiao Song,Qian Chen,Liping Ruan
In this investigation, we successfully synthesized a core–shell nanomaterial featuring ternary Fe3O4@mSiO2@Carbon nanoparticles by utilizing mesoporous silica as the interlayer to disperse small particles of Fe3O4, which served as the core of the particles. The ternary nanoparticles Fe3O4@mSiO2@Carbon have demonstrated impressive electromagnetic wave (EW) absorption characteristics, with the most outstanding particle obtained by adding 0.2 g of resorcinol, achieving a minimum reflection loss (RLmin) value of −72.06 dB at an absorber thickness of 4.3 mm. In addition, it has the widest effective absorption bandwidth (EAB), reaching 6.21 GHz at a thickness of 2.7 mm. The radar cross section (RCS) reduction of the composite has been verified by CST simulation in the far field, and the strongest RCS reduction value was up to 38.06 dBm2 with a scattering angle of 33°. Our findings indicate that the addition of the mesoporous silica layer benefits the uniform dispersion of the magnetic small particles of Fe3O4, improves the impedance matching of the material, and enhances the absorption ability of EW. We posit that our synthesis process can serve as a valuable reference for the development of high-performance, lightweight, and low-density carbon-based EW absorbing nanomaterials.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）