DESIGNED MONOMERS AND POLYMERS
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2020
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IF 1.75
Yazhen Wang,Zhen Shi,Yu Sun,Xueying Wu,Shuang Li,Shaobo Dong,Tianyu Lan
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work’s development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.
研究领域:
药剂学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Omega
·
2021
·
IF 3.512
Zhen Shi,Yazhen Wang,Tianyuan Xiao,Shaobo Dong,Tianyu Lan
We have designed a new magnetic targeting drug carrier Fe3O4-PVA with a core of triiron tetroxide (Fe3O4) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe3O4. With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe3O4-PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe3O4-PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe3O4-PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe3O4-PVA exhibited high drug loading levels and excellent release levels.
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Wei Zhang,ChengLin Zheng,Song Feng,Xinfei Zhang,Jianing Lin
Interfacial water states are regulated by PDA@Fe 3 O 4 -crosslinked PVA. • Heat localization and mass transport are balanced via triple-layer hydrogels. • Optimized H-bond relaxation kinetics are revealed by spectroscopy and MD. • Hypersaline wastewater treatment is achieved by the robust system. Solar-driven interfacial evaporation (SIE) holds immense potential for decentralized clean water production, yet intrinsic transport bottlenecks and high kinetic barriers of vaporization often limit its practical outputs. Here, we present a functionally graded triple-layer evaporator designed through interfacial barrier engineering to decouple heat localization from mass transport. By constructing a hydration-regulated gradient—comprising a photothermal PDA@Fe 3 O 4 top-layer, a crosslinking-tuned intermediate hydrogel, and a macroporous scaffold—we demonstrate precise control over water states. Crucially, our results suggest that the evaporation enhancement is more closely associated with interfacial water-state regulation and hydrogen-bond relaxation behavior than with a simple ‘enthalpy reduction’ interpretation, as consistently supported by the combined spectroscopic observations and molecular dynamics analysis. This gradient architecture enables an evaporation rate of 3.10 kg m −2 h −1 with approximately 92% efficiency under one-sun. Our work provides a mechanistic framework for overcoming the transport-energetics trade-off in SIE, offering a robust solution for treating diverse hypersaline and complex wastewater.
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Jiaojiao Li,Jihua Wang,Jianye Li,Xin Yang,Jiangling Wan,Chuansheng Zheng,Qing Du,Guofeng Zhou,Xiangliang Yang
Magnetic resonance imaging (MRI) has attracted increasing attention as a feasible alternative or adjunctive imaging modality for X-ray digital subtraction angiography because of the high tissue resolution and non-ionization radiation. In this study, a one-step electrospray method was developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles . Fe 3 O 4 @PVA microspheres were mono-dispersed black spheres with a wide range of sizes (262–958 µm). The in situ -synthesized Fe 3 O 4 nanoparticles were used as the contrast agent of MRI and the cross-linkers of PVA matrixes for the embolization purpose. In vivo evaluation of renal arteries of normal rabbits showed that Fe 3 O 4 @PVA microspheres had good embolic effect and enhanced capability of MRI. In vitro and in vivo biosafety assessment confirmed that Fe 3 O 4 @PVA microspheres had favorable biocompatibility. The DOX-loaded Fe 3 O 4 @PVA microspheres showed a typical drug-sustained release profile. These results suggest that the prepared DOX-loaded Fe 3 O 4 @PVA microspheres have the function of MRI, embolotherapy and chemotherapy. We expect our study could provide a simple and useful approach for the systematic design , fabrication, and application of a new type of magnetic microspheres as a triple-functional embolic agent for the development of MRI-guided TACE. Statement of significance Due to the low tissue resolution and hazardous ionization radiation of X-ray digital subtraction angiography, it is beneficial to study MR imaging embolic microspheres for the development of MRI-guided TACE. In this study, a one-step electrospray method was firstly developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles. Then, chemotherapeutic agent (DOX), contrast media of MRI (Fe 3 O 4 ) and embolic agent (PVA matrix) were combined together in one body (DOX-loaded Fe 3 O 4 @PVA microspheres) to achieve the triple effects of chemotherapy, MR imaging and embolization. This triple-functional embolic agent offers potential for the future development of MRI-guided TACE.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Siyuan Zhang,Zisen Li,Jinlei Tao,Jian Jiao
Optimizing the composition and structure of polymers and carbon nanomaterials to obtain composite films with excellent mechanical and electromagnetic wave (EMW) properties is an excellent solution for exploring EMW absorbing materials. In this work, a flexible composite film with a regular three-dimensional network structure was designed and prepared. The modified rGO@MWCNTs/Fe 3 O 4 -PVA composite nanofilm with optimized composition and structure has a multi-component heterogeneous interface, three-dimensional network structure. The composite film has high EMW absorption performance, excellent flexibility, mechanical strength and stability, and can be used in a wide range of application scenarios. At a thickness of 2.8 mm, the effective absorption bandwidth ( f E ) reaches 3.72 GHz, the minimum reflection loss (RL min ) is -48.99 dB, and the tensile stress reaches 32 MPa. This work realizes the regulation of the mechanical properties and EMW absorbing properties of the composite film, and provides an efficient and stable flexible composite EMW absorbing material.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）