FeMo6 integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages
An efficient and readable sensor is desirable for food safety and diagnosis. Herein, a homogeneous mimicking enzyme was constructed by encapsulating polyoxometalate (NH₄)₃[FeMo₆O₁₈(OH)₆]·6H₂O (FeMo 6 ) into the covalent organic framework (FeMo 6 @COF). Coordinating the spatial confinement effect of COF, FeMo 6 exhibited superior peroxide-like activity to catalyze H 2 O 2 to •O− 2, which achieved the “on-off” consecutive sensing of H 2 O 2 and AA via a readable colorimetric mode, with the limit of detection (LOD) at 30 μM and 0.35 μM, respectively. A convenient smartphone assistant platform was established and realized rapid, portable, visual monitoring of AA with LOD of 0.06 μM, and satisfied recoveries with 96.88–104.65 % in human serum and 98.37–107.61 % in commercial beverages. Furthermore, a logic gate circuit was designed to illustrate the potential utilization of combining the intelligent facilities with the experiment. This strategy provides efficient, swift, convenient sensor FeMo 6 @COF with great potential contribution in food safety and diagnosis.
危险品化学品经营许可证（带存储）