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FITOTERAPIA · 2016 · IF 2.408

New chalcone and pterocarpoid derivatives from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property

Wen-Jia Kang,Da-Hong Li,Tong Han,Lin Sun,Yan-Bin Fu,Chun-Mei Sai,Zhan-Lin Li,Hui-Ming Hua

Investigation of the roots of Flemingia philippinensis resulted in the isolation of two new chalcones , flemiphilippinones B ( 1 ) and C ( 2 ), and one new pterocarpoid, demethylwedelolactone-11-methyl ether ( 3 ), together with 12 known compounds ( 4 - 15 ). The antiproliferative activity against PC-3 cells was evaluated and most compounds showed cytotoxicity, among which, compound 2 exhibited GI 50 value of 14.12 μM. The antiproliferative activity of 2 against Bel-7402 and CaEs-17 cells was also measured, with GI 50 values of 1.91 and 2.58 μM, respectively. Intensive mechanism study showed that 2 caused cell-cycle arrest at S/G 2 phase and induced apoptosis in Bel-7402 cells through mitochondria-related pathway.

CAS / MDL: 51-21-8

研究领域: 药用植物化学 · 肿瘤生物学 · 细胞信号通路研究

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MICROCHEMICAL JOURNAL · 2024 · IF 4.9

Fabrication of molecularly imprinted polymers based on magnetic covalent organic framework for highly selective and sensitive analysis of genistein in F. Philippinensis

Yu-Zhen Zhang,Yi-Le Li,Zhi Jin,Mao-Fang He,Yi-Mei Tang,Jian Zhang,Bo Zhang

Flemingia philippinensis Merr.et Rolfe ( F. philippinensis ) is an important food ingredient as well as a traditional Chinese medicine with numerous pharmacological actions. Unfortunately, there was no defined method for monitoring the quality of F. philippinensis in the Chinese Pharmacopoeia. In this study, a magnetic covalent organic framework molecularly imprinted polymers (MCOFs-MIPs) was prepared using MCOFs as a support material, genistein (Gen), which was abundant in F. philippinensis , as a template molecule, and acrylamide as a functional monomer. The preparation process of MCOFs-MIPs was optimized and their structures and adsorption characteristics were characterized. In the selectivity test, the imprinting factor of Gen was 1.93, demonstrating that the imprinting effect of MCOFs-MIPs could selectively enrich Gen in complex samples. Following that, a new and effective quality control method (Gen-MCOFs-MIPs-HPLC) was established to determine Gen content in F. philippinensis roots. The method showed good linearity (R 2 = 0.9936) in the range of 0.12–80 µg mL −1 . The recoveries of Gen in F. philippinensis high, medium and low samples were 90.5–91.0 %, 92.1–100.1 and 92.8–100.8, respectively. Stability and reproducibility tests revealed that this method was stable (RSD of 1.20 %) and reproducible (RSD of 0.70 %). Moreover, the calculation showed that the amount of Gen in the F. philippinensis powder was 0.4489 mg g −1 . As a result, the approach was shown to be simple, repeatable, and stable, and it provided a sensitive and reliable method for the extraction and detection of Gen in natural products.

CAS / MDL: 78-67-1 79-06-1 477-90-7 97-90-5 520-18-3 79-41-4 100-43-6 1403-66-3

研究领域: 植物化学 · 药物分析 · 食品科学

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New chalcone and pterocarpoid derivatives from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property

Fabrication of molecularly imprinted polymers based on magnetic covalent organic framework for highly selective and sensitive analysis of genistein in F. Philippinensis