JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Jianyong Feng,Xing Li,Hang Li,Yanling Yang
Membrane biofouling is a challenge for biocarriers facilitated gravity-driven membrane (GDM) systems to achieve high-efficiency filtration in decentralized drinking water treatment . The purpose of this study was to investigate the effects of vacuum ultraviolet (VUV) as a pretreatment on membrane fouling , permeate water quality and bacterial communities. VUV pretreatment was found to significantly reduce the cake layer resistance by 24.4% and the membrane pore resistance by 40.0% ( p < 0.05), resulting in a 22.2% increase in stable flux. The removal of low molecular weight neutrals and protein-like materials was enhanced by 22.5% and 40.1% respectively after VUV pretreatment. The heterogeneity of the biofouling layer was improved by VUV pretreatment, and the porosity and roughness were increased by 227.5% and 46.5%, respectively. The application of VUV pretreatment resulted in a larger nanoparticle size in the biofouling layer suspension (peak at 85.4 nm), improvement in the membrane hydrophilicity, and a decrease in protein-like substances adhesion. The richness and diversity of the bacterial community were decreased by VUV pretreatment. The bacterial community structure had the highest mantel correlation with biopolymers (r = 0.89). Overall, VUV pretreatment can be a promising strategy to effectively alleviate membrane biofouling in biocarriers facilitated GDM systems.
研究领域:
环境工程
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水处理技术
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微生物学
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产品关联
DOI
高影响因子
Communications Biology
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2025
·Vol. 8
·期 1
·1-17
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IF 5.1
Wang He,Kang Tianyang,Li Weiwei
Gestational diabetes during pregnancy is associated with an increased risk of developmental abnormalities in offspring, but the underlying mechanisms remain unclear. It is not known how maternal metabolism and gut microbes influence kidney development in the fetus. Here we show that gestational diabetes alters maternal gut microbiota and reduces the production of key fatty acids that normally support kidney development in offspring. We find that these changes impair a molecular pathway involving the receptor GPR43 , which promotes the growth and migration of kidney cells. In a mouse model, restoring short-chain fatty acids or transferring gut bacteria from healthy donors improves kidney development in offspring, while blocking GPR43 reverses this effect. This study reveals a previously unknown link between maternal gut metabolism and fetal kidney formation and may guide future strategies to prevent congenital kidney disorders in children born to mothers with gestational diabetes.
研究领域:
发育生物学
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微生物学
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代谢学
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分子生物学
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肾脏病学
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妇产科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Rui Wang,Huizhi Hu,Danting Shi,Jinsong Liang,Senlin Shao
Biogenic manganese oxides (BioMnO x ) can effectively remove Mn(II) from drinking water. In the gravity-driven membrane (GDM) system for Mn(II)-containing water treatment, both BioMnO x and Mn(II)-oxidizing bacteria (MnOB) present in the cake layer, and their role in Mn(II) oxidation is still controversial. To address this issue, in this study, we naturally formed a cake layer containing BioMnO x and MnOB using the GDM process and identified the different roles of BioMnO x and MnOB in the removal of Mn(II). The experimental results showed that the BioMnO x accounted for a major proportion of the cake layer of GDM, and it played a principal role in the removal of Mn(II) through the combination of adsorption and catalytic oxidation. However, this removal efficiency would be continuously reduced in the absence of MnOB, while stabilized in the presence of MnOB. XPS analysis revealed that the proportion of Mn(III) and Mn(IV) in BioMnO x with MnOB reached 64.1% and 35.8%, respectively, while BioMnO x without MnOB did not contain Mn(IV). These findings suggest that BioMnO x may be the primary catalyst for Mn(II) oxidation, but its long-term activity is dependent on MnOB, which can maintain the catalytic activity by 1) producing new BioMnO x and 2) sustaining the high valence state of MnO x .
研究领域:
环境科学
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水处理
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微生物学
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催化
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Rourou Zhang,Zijing Wang,Guibai Li,Heng Liang,Bingsheng Liu,Geoffroy Lesage,Marc Heran,An Ding,Huu Hao Ngo
Gravity-driven membrane (GDM) filtration technology offers a low-energy, low-maintenance solution for water purification due to its powerful bio-cake, but faces predicament in contaminant removal under low temperatures. Quorum sensing (QS), a microbial communication process mediated by signal molecules such as C6-HSL (N-Hexanoyl-L-homoserine lactone), has been shown to influence microbial behavior and enhance biofilm formation, with promising potential for consolidation of GDM operation at low temperature. This study investigates the application of C6-HSL to enhance ammonia nitrogen and organics removal in low-temperature GDM systems. C6-HSL was administered at varying dosages (0/50/250/500 nM/d) at 5 °C, with further experiments conducted at 25 °C to assess the impact of QS regulation on GDM performance under room temperature. The results demonstrated that the optimized presence of C6-HSL (500 nM/d) improved the removal efficiency of dissolved organic carbon, ammonia nitrogen, and raised the stable flux (increase ratios at low vs. room temperature: ∼19 % vs. ∼7 %, ∼38 % vs. ∼9 %, and ∼7.9 % vs. 0.4 %, respectively). Analysis of the biofouling layer’s structural characteristics, composition, and biological activity indicated that the increased C6-HSL effectively promoted microbial growth and migration/movement, increased the production of extracellular polymeric substances (EPS) and soluble microbial products (SMP), and accelerated biofilm formation. The resulting thicker (∼172.98 vs. ∼119.21 μm), rougher (∼62.1 vs. ∼55.0 nm) cake layer, equipped with abundant channels for water penetration, contributed to increased contaminant degradation, but also stabilized the flux with slight growth (∼3.26 vs. ∼3.02 LMH) under low temperature. Notably, the enhancement effect of QS regulation was more pronounced at low temperature than at room temperature, attributing to the optimized release and diffusion of signal molecules and the more substantial stimulation of metabolic and enzymatic activity in nitrifying bacteria. This study provides valuable insights and technical support for decentralized water treatment in winter via reliable GDM process operation in challenging temperature conditions.
研究领域:
环境工程
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微生物学
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产品关联
DOI
高影响因子
WATER RESEARCH
·
2021
·
IF 11.236
Peng Du,Xing Li,Yanling Yang,Zhiwei Zhou,Xiaoyan Fan,Haiqing Chang,Heng Liang
It is a critical challenge for drinking water production when treating algae-contaminated surface water. In this study, the impact of in situ coagulation (C), activated alumina filtration (AA) and their combination (CAA) on the performance of gravity-driven membrane (GDM) was systematically assessed during 105-day operation. The results indicated that pretreatments in particular CAA could effectively enhance GDM flux, and the stable fluxes were increased to 3.1, 4.9 and 8.3 L/(m 2 ·h) (LMH) for CGDM, AA/GDM and CAA/GDM, respectively when compared to the control GDM (2.0 LMH). Coagulation was beneficial to formation of thick but loose biofouling layer, while AA filtration was effective to retain foulants including extracellular polymeric substances (EPS), organics, total nitrogen and total phosphorus. The CAA/GDM could mostly remove these foulants, and facilitate the proliferation of bacterial genera that could consume EPS, further alleviating membrane fouling. The difference in loosely bound EPS and tightly bound EPS of biofouling layer attributed to the difference of reversible fouling and irreversible fouling, respectively. Morphological observations, variation in functional groups or elements further confirmed the difference in biological layers in different GDM systems. The occurrence of specific bacterial genera involving the potential to degrade protein, chitin and other high molecular weight organics was responsible for contaminant removals.
研究领域:
环境科学
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水处理技术
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2023
·
IF 2.9
Jianhua Yan,Jiayu Wang,Hongjie Liu,Liwei Wang,Kefu Yu,Li Deng,Junyou Su,Hongfei Chen
Gestational diabetes mellitus (GDM) is a severe perinatal condition with serious consequences for the growth and development of the mother and baby. MicroRNA-29b (miR-29b) is essential to the pathogenesis of GDM and can be used as a molecular biomarker for diagnosis. Given the limitations of current GDM screening technologies, there is a pressing need for a sensitive detection approach to evaluate serum miR-29b in GDM patients, thus aiding in disease treatment. In this study, an electrochemical biosensor Co 7 Fe 3 –CN nanoparticles (NPs) was developed. Using a duplex-specific nuclease (DSN) signal amplification strategy with a linear range of 1–10 4 pM and a low detection limit of 0.79 pM, the ultra-sensitive detection and quantification of miR-29b were accomplished. The dependability and applicability of the developed biosensor were validated by the standard method of qRT-PCR, and the content of serum miR-29b in GDM patients was shown to be significantly lower than that in the control group ( P = 0.03). Specifically, miR-29b concentrations could be detected from 2.0 to 7.5 and 2.4 to 7.3 pM using qRT-PCR and the biosensor, respectively. These similar results indicated that a biosensor based on miR-29b detection has the potential to be used in the point-of-care testing of GDM patients in clinical practice.
研究领域:
生物传感器
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糖尿病
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分子生物学
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纳米技术
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临床诊断
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产品关联
DOI
PubMed
高影响因子
Nutrition & Metabolism
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2020
·Vol. 17
·期 1
·1-11
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IF 3.211
Sun Bingmei,Yan Hua,Li Chao,Yin Linlin,Li Fei,Zhou Lianxiang,Han Xiuqing
Background Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus.Methods The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde content, an increase of superoxide dismutase, catalase and gutathione peroxidase activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1, stearoyl-CoA desaturase-1, fatty acid synthase, and acetyl-coenzyme A carboxylase, was suppressed by PUFA in pregnant diabetic rats.Conclusion sThese results suggested that PUFA supplementation during pregnancy is beneficial in preventing diabetic complications in pregnant rats.
研究领域:
营养学
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药理学
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内分泌学
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妇产科学
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
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