Materials Chemistry Frontiers
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2016
·Vol. 1
·期 2
·361-368
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IF 0
Yi Zhang,Wei He,Jiehua Li,Kunjie Wang,Jianshu Li,Hong Tan,Qiang Fu
In this study, a series of waterborne biodegradable polyurethanes with antibacterial and biocompatible properties were developed. To obtain these polyurethanes, lysine-derivative gemini quaternary ammonium salt (GQAS) chain extenders with different hydrophobic alkyl chain lengths (named EGn, where n = 8, 12, 16; the hydrophobic alkyl chain length of GQAS) were designed and synthesized. Then, waterborne biodegradable polyurethanes (PCLPUn) were prepared using isophorone diisocyanate (IPDI), poly(ε-caprolactone) (PCL), poly(ethylene glycol) (PEG), L-lysine and EGn. The antibacterial activities of these EGn and PCLPUn emulsions were evaluated by a minimal inhibitory concentration (MIC) method, and the antibacterial and antifouling functionalities of the PCLPUn film surfaces were confirmed by a contact-active antibacterial and culture-based method using both Gram-positive and Gram-negative bacteria. The in vitro degradation and cytotoxicity of these obtained polyurethanes were also systematically investigated. These results indicated that the PCLPUn films possessed good antibacterial and antifouling abilities, biodegradability, and good biocompatibility. Notably, PCLPU12 shows the best antibacterial activity and cytocompatibility. Such antibacterial materials could be degraded to non-toxic components, and potentially be widely used in medical and environmental applications, especially as biodegradable coatings of surgical equipment and medical implants.
研究领域:
材料科学
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生物医学工程
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微生物学
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DOI
JOURNAL OF SURFACTANTS AND DETERGENTS
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2014
·Vol. 17
·期 6
·1099-1106
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IF 1.352
Wang Liyan,Qin Honglei,Ding Limin,Huo Shichao,Deng Qigang,Zhao Bing,Meng Lingwei,Yan Tie
A class of novel cationic Gemini imidazolium surfactants containing amide groups as the spacer were synthesized from ethylenediamine and 1-bromoalkane(C 8 , C 10 , C 12 , C 14 , C 16 ) by N -alkylation to get N , N ′-dialkyl ethylenediamine ( 1a–e ), 1a–e was further reacted with chloroacetyl chloride by N -acylation to get N , N ′-(ethane-1,2-diyl)bis(2-chloro- N -alkylacetamide) ( 2a–e ), which was further reacted respectively with 1-methyl imidazole by quaternized to form the surfactant molecule, N , N ′-((ethane-1,2-diyl)bis(alkyl-azanediyl)bis(2-oxoethane-2,1-diyl)) bis(1-methyl-1 H -imidazol-3-ium) dichloride. The structures of intermediates ( 1a–e ) and ( 2a–e ) were characterized by IR and 1 H NMR. The structures of the surfactants ( 3a–e ) were characterized by IR, 1 H-NMR and 13 C-NMR and element analysis. The critical micelle concentrations (CMC) of 3a–e were determined by the conductivity method at 25 °C. The CMC values decreased with increasing the length of the hydrophobic chain. The surfactants ( 3a–e ) showed good foaming stability, emulsion ability and wetting ability. The surfactants ( 3a–e ) also have good antimicrobial activity against Staphylococcus aureus , Escherichia coli and Bacillus subtilis .
研究领域:
化学
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材料科学
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生物学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
·
IF 3.8
Hongbin Ju,Lizhi Zhang,Heqin Guo,Litao Jia,Bo Hou,Debao Li,Tao Geng
The catalytic epoxidation of α-olefin with long carbon chains has always been a challenge. Traditional homogeneous or heterogeneous catalysts showed poor performance toward the reaction. In this paper, layered organic–inorganic catalysts were prepared by the reaction of phosphotungstic acid and a Gemini quaternary ammonium salt, which could convert long α-olefin to epoxide with a selectivity of 85% in the absence of organic solvents. Combined with characterization results, it was confirmed that the catalyst was layered structure materials, which was supported by a quaternary ammonium salt chain, and the active molecules were distributed between the layered structures. The possible mechanism was also discussed preliminarily.
研究领域:
催化化学
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材料科学
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有机合成
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产品关联
DOI
高影响因子
RSC Advances
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2016
·Vol. 6
·期 21
·17336-17344
·
IF 3.289
Yuanqing Song,Yunlong Gao,Xinyuan Wan,Feng Luo,Jiehua Li,Hong Tan,Qiang Fu
Complications such as thromboembolism and bacterial infection, arising from the widespread use of implanted medical devices, are serious problems for current clinical treatment. In this work, dual-functional anticoagulant and antibacterial blend coatings were designed and fabricated from gemini quaternary ammonium salt waterborne polyurethane (GWPU) emulsion and heparin aqueous solution. The results demonstrate that the L-lysine-derivative gemini quaternary ammonium salt (GQAS) in GWPU endows the coating with excellent non-releasing antibacterial ability and simultaneously the release of heparin provides superior anticoagulant activity. Moreover, the controlled release of heparin is achieved by the ionic interaction between the positive charge in GQAS and the negative charge in heparin. On the basis of the dual-functional anticoagulant and antibacterial properties of GWPU/heparin blend coatings, this work proposes a facile strategy to achieve syncretic performances in biomaterials, and these coatings would have the potential to improve the application of implanted devices.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2017
·
IF 4.164
Yue Xu,Hang Gao,Yan Shen,Shigan Chai,Jinzhi Zhang,Qichao Zou
Novel Gemini quaternary ammonium salts (GQASs) with ester groups were synthesized. Cationic poly(styrene- co -butyl acrylate) (P(St- co -BA)) nanolatex was synthesized in the presence of GQASs as emulsifier. The structures of GQASs were characterized with Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy; the property of P(St- co -BA) nanolatex was characterized with dynamic light scattering. The results indicated that GQASs and P(St- co -BA) nanolatex with GQASs were successfully synthesized. GQASs, nanolatex, and the polymer films exhibited excellent antibacterial activities against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli . The GQASs performed even better than the corresponding single-stranded quaternary ammoniums. The antibacterial mechanism was also preliminarily studied, and longer, softer hydrophobic chains of GQAS had stronger antibacterial activity. The work provided a novel, simple approach for developing high-efficiency antibacterial polymer material with a low cost, which has broad biomaterial applications.
研究领域:
材料科学
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生物学
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医学
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产品关联
DOI
PubMed
高影响因子
DESIGNED MONOMERS AND POLYMERS
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2014
·
IF 2.21
Ting Qiu,Lu Zhang,Xiao-Dong Xing
In order to get durable antibacterial polymer materials, two series of novel polymerizable Gemini quaternary ammonium salts (QAS) were synthesized via a facile approach. The first series of monomers which have a completely symmetrical structure contain two unsaturated double bonds that allow it to polymerize as cross-linker. The second series of monomers are asymmetric Gemini QAS and contain only one polymerizable double bond. All the QAS monomers were characterized by 1H NMR and IR spectra. The six kinds of QAS monomers were bonded to dental restoration resin system. To evaluate the bactericidal activity of these compounds against Escherichia coli and Staphylococcus aureus (S. aureus), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration were tested by using broth dilution test. Among the six monomers, four compounds were found to have MIC values (for S. aureus) less than 10 μg/mL. The asymmetric Gemini QAS which have a long alkyl chain length of 12 carbons on the nitrogen showed stronger antibacterial activity than other monomers. The inhibitory effect of polymeric resins incorporated with QAS against the growth of S. aureus was determined by counting the number of viable cells. The result showed that the antibacterial activities of cured resins were increased as the concentration of QAS monomers increased.
研究领域:
材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
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