NORDIC PULP & PAPER RESEARCH JOURNAL
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2022
·Vol. 37
·期 1
·205-211
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IF 1.595
Hanhan Yang,Jinjie Zhang,Yingping Qi,Yongfeng Shen,Hua Li
To enhance the strength of paper cultural relics and prolong the life of paper cultural relics, it is an urgent need to prepare new material for preservation and protection of paper. In this paper, chitosan quaternary ammonium salt/HEC-acrylate was synthesized with O-hydroxypropyl trimethyl quaternary ammonium salt chitosan (O-HACC) and Hydroxyethyl Cellulose (HEC)-acrylate emulsion, the synthesized materials has multiple functions, such as deacidification, reinforcement, anti-mildew and antibacterial etc. The synthesized new materials were applied on paper, and their protective effect was evaluated by testing the mechanical and optical properties and antibacterial properties of the paper. The results showed that when the mass concentration of O-HACC was 0.6 %, the tensile strength, folding times and tearing strength of the paper coated with protective solution were improved to a certain extent, while the optical properties and appearance of the paper remained basically unchanged. Meanwhile, the paper also had certain anti-mildew and bacterial resistance.
研究领域:
材料科学
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文物保护
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2016
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IF 3.902
Lu Chen,Jun Lin,Juan Li,Xiaozhao Wang,Junjun Zhuang,Huiming Wang,Kui Cheng,Wenjian Weng
In this study, mineralized collagen (COL) coatings with controlled loading and release of bone morphogenetic protein (rhBMP-2) as well as enhanced osteogenic differentiation were successfully achieved via the spatially-control of hydroxypropyltrimethyl ammonium chloride chitosan (HACC) within the coatings. The distribution of HACC in the inner part (HACC-IN) or the outer part (HACC-OUT) of the coatings were adjusted by different potential values and negative/positive alternations during alternating potentials assisted electrochemical deposition (AP-ECD). It was found that rhBMP-2 loading capacity was remarkably enhanced with the increased incorporation of HACC due to their strong interaction, and the release behavior was also tuned by HACC location. In general, HACC-IN coatings showed a prominent improvement in cytocompatibility and osteogenic differentiation. The main reason is considered that the inner location of HACC can eliminate the negative effect of HACC to initial cellular adhesion and bring to a sustained rhBMP-2 release behavior due to kinetic modification. An optimized coating in this work could load as high as 4644 ng/cm 2 rhBMP-2 and release only 25% for 14 days, which consequently leads to a better osteogenic differentiation. This study has thus inspired another promising protocol for designing growth factor incorporated bioactive coatings for bone implants with improved osteointegration.
研究领域:
生物材料学
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骨组织工程
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药物释放系统
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DOI
PubMed
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 4
·669
·
IF 5.1
Jiarui Liu,Jiachang Feng,Zhefeng Xu,Jinsong Zhang,He Wang
Natural antibacterial food packaging materials endowed with environmental responsiveness are garnering substantial research interest in sustainable food preservation. This study reports the development of a pH-responsive antimicrobial composite film through encapsulation of eugenol—a natural phenolic compound—within zeolitic imidazolate framework-8 (ZIF-8). The engineered eugenol@ZIF-8 system demonstrated pH-dependent release characteristics, with cumulative release reaching 32.2% at pH 6 versus merely 0.61% at pH 7 over 4 h. Subsequent integration of this nanocarrier into a polyvinyl alcohol (PVA)/hydroxypropyltrimethyl ammonium chloride chitosan (HACC) matrix yielded a multifunctional composite film for active food packaging applications. The characterization of film revealed that while eugenol@ZIF-8 incorporation slightly compromised mechanical strength (tensile resistance decreased by 18.7%) and flexibility (elongation at break reduced to 54.3% of control), it significantly enhanced hydrophobicity (water contact angle increased to 92.5°) and thermal stability (decomposition temperature elevated by 34 °C). The composite film demonstrated synergistic antibacterial efficacy through the combined action of Zn2+ions, ZIF-8 nanostructures, and eugenol, achieving 88% inhibition againstE. coli.Practical validation through fresh noodle preservation trials confirmed the material’s effectiveness, with the optimized formulation (PVA-HACC-2% eugenol@ZIF-8, PHEZ2) extending shelf life by >5 days compared to conventional packaging. This work establishes a novel strategy for engineering intelligent ZIF-based packaging systems that respond to food spoilage microenvironments, offering significant potential for reducing food loss.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Haiping Yu,Brian Chen,Lin Wen,Dongying Hu
The majority of hydrophobic coatings in protective fabrics use expensive and environmentally harmful fluorine-based chemicals, which makes sustainable substitutes desperately needed. In this study, hydroxypropyltrimethyl ammonium chloride chitosan (HACC) and octadecyltrichlorosilane (OTS) are combined via vacuum impregnation and straightforward spray-assisted assembly to create long-lasting hydrophobic and antibacterial fabrics without the use of fluorine. Both polyester (PET) and cotton fabrics coated with 6 %HACC@OTS exhibit strong resistance to common pollutants (milk, coffee, vinegar, tea, and cola) and synthetic blood without compromising gas permeability. They also achieve good hydrophobicity, with the WCA of 150.05 ± 0.91° and 146.96 ± 1.21°, respectively. The quaternary ammonium groups in HACC impair the permeability of bacteria's cell membranes, resulting in a powerful antibacterial activity against E. coli and S. aureus . Additionally, the alkyl chains obtained from OTS combine to efficiently preserve hydrophobic durability and antibacterial stability even after the coating has been repeatedly treated in harsh environments (abrasion, washing, ultraviolet light, acid and alkali solution, and ultrasonic treatment). Furthermore, 6 %HACC@OTS coating can be applied to a variety of rigid (glass, aluminum, wood, stone) and flexible (plastic, filter paper) surfaces due to its broad range of substrate compatibility. This scalable, environmentally friendly approach is in line with green manufacturing principles and presents a viable option for multipurpose textiles in protective gear, functional clothing, and healthcare.
研究领域:
材料科学
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纺织工程
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抗菌涂层
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绿色化学
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功能纺织品
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表面改性
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2019
·Vol. 54
·期 22
·14218-14232
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IF 3.442
Xu Bo,Zhang Xiong,Gan Shuchun,Zhao Jianhao,Rong Jianhua
Excellent mechanical and self-healing features could make hydrogels an ideal candidate for the application of load-bearing soft tissue replacements such as cartilage. In this study, a dual ionically cross-linked 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC)/poly(acrylic acid) (PAAc)-Fe 3+ hydrogel was constructed using a one-pot method (in situ polymerization of AAc in the presence of HACC and Fe 3+ ). Both macromolecular positively charged HACC and Fe 3+ metal ions acted as cross-linkers to form ionic bonds with negatively charged PAAc. The HACC/PAAc-Fe 3+ hydrogels demonstrated ultra-high mechanical strengths (tensile strength of ca. 9.86 MPa and compressive stresses greater than 95 MPa at 99% strain), excellent self-recoverability (ca. over 90% toughness recovery within 5 h without any external stimuli), outstanding self-healing properties (ca. 74% self-healing efficiency at 70 °C for 48 h), transparency, and high stabilities in aqueous environments. The mechanical properties of the hydrogels could be adjusted by varying the concentration of HACC and Fe 3+ . This work provides a new approach for the construction of novel tough and transparent hydrogels with a fully ionically cross-linked network.
研究领域:
材料科学
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生物医学工程
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化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Shuchun Gan,Bo Xu,Xiong Zhang,Jianhao Zhao,Jianhua Rong
Physically cross-linked double-network (DN) hydrogels are capturing more and more attention due to their good mechanical properties and self-recovery ability. However, they usually suffer from complicated preparation process and fussy performance regulation, which severely limit their applications in many fields. Herein, we fabricated a physically cross-linked poly(vinyl alcohol)-(2-hydroxypropyltrimethyl ammonium chloride chitosan) (PVA-HACC) DN hydrogels without organic solvents or toxic cross-linking agents via a simple two-step method of freezing/thawing and immersion processing. The effects of immersion time and concentration of Na 3 Cit solution on the structures and mechanical properties of the hydrogels were investigated. The obtained hydrogels exhibited excellent mechanical properties including high elastic modulus (1.44 MPa), high strength (a maximal tensile fracture stresses of 4.14 MPa and a maximal compressive stresses of over 70 MPa at 98% strain), and superior fracture toughness (17.09 MJ/m 3 ). In addition, good self-recovered property and anti-fatigue performance were realized for the hydrogels owing to the reversible HACC ionic networks. The preparation of PVA-HACC DN hydrogels offers a new guidance for the design and synthesis of environmentally friendly DN hydrogels with outstanding mechanical properties and broad application prospects.
研究领域:
材料科学
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高分子化学
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机械工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Xiangtao Liu,Sisi Zhang,Haiyan Zheng,Mengyao Bian,Linna Qian,Weijia Zhao,Ying Shi,Zhifang Wu
Dental caries, primarily induced by plaque biofilm, is a significant challenge in oral health due to the disruption of the equilibrium between mineralization and demineralization processes. The primary objective in caries management is to preserve biofilm homeostasis while promoting the repair and regeneration of dental hard tissues, thereby restoring the structural integrity and functionality of the affected teeth. This study aimed to develop a multifunctional film with mineralizing and antibacterial abilities by incorporating ultrasmall amorphous calcium phosphate (ACP) nanoclusters (~1 nm) into hydroxypropyl trimethyl ammonium chloride chitosan (HACC) matrix. The ACP nanoclusters were synthesized using polyacrylic acid and polyaspartic acid as stabilizers and were homogeneously dispersed into the HACC matrix to form ACP@HACC film. The capacity for Ca and P ions release from ACP@HACC film was evaluated by inductively coupled plasma-mass spectrometry, demonstrating a sustained ion release over a period of 7 days. The ACP@HACC film induced the mineralization of type I collagen fibrils within 4 days. In vivo studies further confirmed the occurrence of dentin remineralization after 4 days. The remineralization process mediated by the ACP@HACC film significantly restored the elastic modulus and microhardness of demineralized dentin. Additionally, cytotoxicity assessments confirmed the excellent biocompatibility of the ACP@HACC film. Dentin treated with the ACP@HACC film demonstrated antibacterial ability against Streptococcus mutans in vitro. The ACP@HACC film integrates the dual functionalities of mineralization and antibacterial activity while maintaining excellent biocompatibility. This innovative approach shows potential for the treatment of early carious lesions, offering a clinically viable supplement to conventional restorative strategies.
研究领域:
牙科
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生物材料
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纳米技术
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口腔生物学
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抗菌材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2023
·
IF 5
Chen Zhang,Zheng Jin,Yuhong Lin,Yiyu Wang,Kai Zhao
Doxorubicin (DOX) is considered one of the most effective chemotherapy drugs and is used as a first-line drug for many cancers. However, it has shown serious side effects such as cardiotoxicity and colonic ulcers , which limit its clinical use. Targeted delivery to tumor cells by nanocarriers or decreasing DOX dosage is considered to be an effective way to reduce the toxic and side effects of DOX on normal human tissues. In this paper, the mannose-functionalized N-2-HACC nanoparticles (MN NPs) loaded with DOX and Indocyanine Green (ICG) (DOX/ICG@MN NPs) were synthesized by the ion-crosslinking method, which were used for the in vitro targeted photothermal and chemical therapy. The results of FT-IR, particle size analysis, and SEM showed that ICG and DOX were successfully loaded, and DOX/ICG@MN NPs had great dispersibility and size. The results of the cell safety test showed that MN NPs had good safety. The photothermal stability tests revealed that the ICG in DOX/ICG@MN NPs had excellent thermal stability and photothermal conversion efficiency than the free ICG. The DOX release of DOX/ICG@MN NPs is pH-responsive, which promoted the effective release in slightly acidic environments at the tumor site. Owing to the specific targeting ability of mannose , DOX/ICG@MN NPs could be effectively uptake into HCT116 cells. In the presence of Near-Infrared irradiation (NIR), DOX/ICG@MN NPs exhibited synergistic treatment effects against tumor cells, which could significantly reduce the dosage of DOX and reduce the toxic side-effects on normal tissues. Therefore, this co-delivery system is considered to have significant potential for targeting tumors and chemo-photothermal therapy.
研究领域:
药学
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纳米技术
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癌症治疗
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Natural Gas Science and Engineering
·
2021
·
IF 4.965
Xuejian Liu,Quan Cao,Dongyan Xu,Shengjun Luo,Rongbo Guo
The maximum methane storage capacity (MSC) is of critical importance of methane hydrate to store methane. This paper reports the effects of vesicle solutions, formed through combination of carboxylate surfactants with cationic quaternary ammonium salt including hydroxypropyl trimethyl ammonium chloride chitosan (HACC) or dodecyl trimethyl ammonium chloride (DTAC), on the formation of methane hydrate. It was found that vesicles could raise the maximum MSC of hydrate by about 10 (V/V, the volume of methane stored by one volume of hydrate) at appropriate anion and cation concentrations. For example, at 800 ppm (parts per million) of sodium laurate (SL) and 600 ppm of HACC concentrations, the formed vesicles could elevate the maximum capacity to 151 V/V, 5.3% higher than that of sodium laurate alone. The vesicles formed could increase the maximum MSC, from 136 V/V to 147 V/V by sodium oleate (SO) and HACC, 145 V/V to 153 V/V by sodium decanoate (SD) and HACC and 137 V/V to 149 V/V by SO and DTAC. The reason for the enhancement is that the large hydrophobic space of the vesicles could solubilize methane molecules and facilitate them to contact with water molecules.
研究领域:
化学
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材料科学
·
能源存储
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Chen Zhou,Hai-Yong Ao,Xiao Han,Wen-Wen Jiang,Zhi-Fei Yang,Le Ma,Xiao-Yan Deng,Yi-Zao Wan
As a mild cationic antibacterial agent, hydroxypropyltrimethyl ammonium chloride chitosan (HACC) could kill gram-positive bacteria and gram-positive drug-resistant bacteria without cytotoxicity. Nevertheless, it was not effective against gram-negative bacteria. Herein, protocatechuic acid (PA) with broad-spectrum antibacterial properties and pharmacological activities was grafted on HACC. PA-g-HACC showed favourable antioxidant capacity and anti-inflammatory properties. Most importantly, the results of antibacterial assay indicated that the antibacterial rates of all PA-g-HACC groups against Staphylococcus aureus ( S. aureus ) and methicillin-resistant Staphylococcus aureus ( MRSA ) were above 92 %, and the antibacterial rate of PA-g-HACC against E. coli was increased with the amount of grafted PA. Furthermore, the cytocompatibility of PA-g-HACC was improved by appropriate grafting ratio of PA, while excessive grafted PA can lead to toxicity. We believe that PA-g-HACC in optimum grafting ratio of PA with favorable antibacterial properties, pharmacological activities and cytocompatibility will be potential antibacterial agent for treating infections.
研究领域:
材料科学
·
药学
·
生物医学工程
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微生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Wei Xiong,Ling Li,Fen Qiao,Junwu Chen,Zhi Chen,Xuedong Zhou,Kaiwen Hu,Xiujian Zhao,Yi Xie
Due to the inherent differences in surface tension between water and oil, it is a challenge to fabricate air superhydrophilic-superoleophobic materials despite their promising potential in the field of oil/water separation. Herein, a facile approach is developed to fabricate air superhydrophilic-superoleophobic SiO 2 coating by combination of controllable modifying SiO 2 nanoparticle surface by both hydrophilic groups (i.e., –OH groups) and oleophobic groups (i.e., fluorinated groups) with constructing porous and hierarchical structures. Hydroxyl-modified SiO 2 nanoparticles (NPs) are synthesized using a base-catalysed procedure in the presence of ammonia or NaOH. Chitosan quaternary ammonium salt (HACC) is introduced to bind SiO 2 by forming a unique hydrogen bond between HACC and –OH, followed by adding pentadecafluorooctanoic acid (PFOA) to complex with HACC to form fluorinated groups. The SiO 2 coatings are fabricated on various substrates (e.g., glass, foam and Cu mesh) by spraying procedure and characterized using SEM, FTIR, XPS, etc. The contact angles of oils (e.g., pump oil, castor oil , corn oil, hexadecane and bean oil) and water on the coatings are over 150° and close to 0°, respectively. By optimization, the representative SiO 2 -coated Cu mesh displayed high - efficiency of 99.2% in separating water from mixture of water/pump oil, and high penetration flux of 1.41 × 10 4 L·m −2 ·h −1 . Besides, the coating maintains its superhydrophilic-superoleophobic properties even after 110 cycles of sandpaper abrasion or after being immersed in water for 3 h. After 20 cycles of oil/water separation, the coating retains separation efficiency up to 97.93%. This study provides a new and universal protocol to fabricate unique superwetting surfaces with effective oil/water separation performance, long-term durability and outstanding reusability.
研究领域:
材料科学
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表面化学
·
环境工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）