RSC Advances
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2019
·Vol. 9
·期 48
·28248-28252
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IF 3.049
Yumin Leng,Fang Hu,Chunhua Ma,Chenxi Du,Linfeng Ma,Jiao Xu,Qiyuan Lin,Zhipei Sang,Zhiwen Lu
A simple, rapid, sensitive, selective and label-free method is presented for the colorimetric determination of lincomycin (Lin) by using HAuCl4 and NaOH. Upon the addition of Lin, the mixture of HAuCl4 and NaOH shows a color change from colorless to blue (or dark blue). The limit of colorimetric detection is as low as 1 μM, observed both in Milli-Q water and real samples. The selectivity of Lin detection is excellent compared with 9 other common antibiotics. On the basis of the “three-color” principle of Thomas Young, we extracted the red, green and blue (RGB) alterations of the sensor in the absence and presence of different concentrations of Lin. The color changes are quantitatively illustrated by the total Euclidean distances (EDs = [ΔR2 + ΔG2 + ΔB2]1/2). The good linear relationship between the EDs and Lin concentration is used for the quantitative assay of Lin. The developed method demonstrates great potential for the detection of Lin in environmental water and milk.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Pan Yalong,Han Lijun,Shen Junxue,Li Jing,Sun Taolei,Yu Yao
Pesticide contamination is a global challenge, threatening agricultural production and environmental safety. To address the urgent need for efficient and reliable pesticide detection methods, we developed a novel multi-channel colorimetric sensor array based on HAuCl 4 -mediated oxidation reactions. This innovative system incorporates six distinct colorimetric channels coupled with advanced multivariate statistical analysis, enabling simultaneous detection and discrimination of multiple pesticide residues. Through systematic optimization of key reaction parameters, the developed sensor improved selectivity and classification accuracy, particularly for structurally similar pesticides. The platform successfully identifies 11 different classes of pesticides and distinguishes five specific pesticides across various concentration levels. This approach overcomes the limitations of traditional single-target detection methods by employing multi-parameter analysis for accurate pesticide identification. Notably, the proposed method offers several practical advantages, including simple operation, rapid detection (within 30 min), high sensitivity (detection limits of 6 μg/mL), and cost-effectiveness by eliminating the need for expensive instrumentation. These features make the developed sensor array particularly suitable for on-site pesticide screening and food safety monitoring applications. Graphical
研究领域:
分析化学
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环境科学
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食品安全
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传感器技术
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2016
·
IF 4.712
Ru-Jia Yu,Wei Ma,Mao-Pan Peng,Zhi-Shan Bai,Yi-Tao Long
A novel redox-mediated chromogenic reaction was demonstrated based on the reaction between HAuCl 4 and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), which generate various color responses from red to green in the resulting solutions. Various redox substance could be used to mediate the reaction and trigger a distinct color response. We established a sensitive hydrogen peroxide colorimetric sensor based on the redox-mediated chromogenic reaction and depicted the application both in detection of enzyme and in an immunoassay . Combining the traditional chromogenic reagent with gold nanoparticles , our assay has the advantage in short response time (within three minutes), high sensitivity (10 −12 g mL −1 for HBsAg) and stability.
研究领域:
生物化学
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医学检测
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纳米技术
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DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 11
·期 3
·1245-1252
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IF 7.233
Kaixi Bi,Yiqin Chen,Qiang Wan,Tuo Ye,Quan Xiang,Mengjie Zheng,Xuejiao Wang,Qing Liu,Guanhua Zhang,Yongtao Li,Yupeng Liu,Huigao Duan
Reliable fabrication of gold nanoparticles with desirable size, geometry and spatial arrangement is essential for plasmonic applications. A common fabrication flow usually involves electron-beam lithography and a vacuum-evaporation-based lift-off process or etching. In this work, we evaluate an alternative approach to directly fabricate a plasmonic gold nanoparticle array without involving the vacuum evaporation process by using a chloroauric acid/poly(vinyl pyrrolidone) (HAuCl4/PVP) hybrid as a functional electron-beam resist. Systematic experiments were conducted to investigate the patterning behaviors in the fabrication process. With the optimized fabrication parameters, we show that the HAuCl4/PVP composite resist has a high patterning resolution and pure gold nanoparticles with tens of nanometers can be obtained after an annealing-based pyrolysis process. More particularly, compared to the patterned plasmonic gold nanoparticles obtained by conventional methods, the gold nanoparticles fabricated by our method can be transferred to soft substrates due to the absence of an adhesion layer, enabling various potential applications in flexible and stretchable optics. As an example, we demonstrated that the transferred gold nanoparticle array can be conformably assembled onto a flat gold surface to form a particle-on-film structure for surface-enhanced Raman scattering (SERS) applications.
研究领域:
纳米技术
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材料科学
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光学工程
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产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2016
·Vol. 18
·期 13
·8993-9004
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IF 4.449
Guanghua Fan,Yanhua Han,Suilian Luo,Yutong Li,Shiliang Qu,Qiang Wang,Renxi Gao,Minrui Chen,Min Han
Both fabrication of Au nano-objects and the nonlinear optical properties of Au nano-objects are the focus of research. In the present work, Au nanoparticles with different mean sizes (18, 32, 42, and 70 nm) are controllably fabricated in ethanol by changing the concentration of poly(vinylpyrrolidone) (PVP) and HAuCl4, as well as the power of continuous wave UV light at 365 nm. PVP acts as both reducing and protective agent. The mechanism of photoreduction of PVP to HAuCl4 is proposed. PVP undergoes a series of chemical reactions which include the attack of the hydrogen atom on the tertiary carbon atom at the α-position of the nitrogen atom, production of a hydroxyl radical, and chain scission. The hydroxyl radical combines with the hydrogen atom produced through the dissociation of HAuCl4, which facilitates the decomposition of HAuCl4. The fabrication mechanism of Au nanoparticles is discussed. The nonlinear absorption of these Au nanoparticles is investigated; all of them exhibit saturable absorption, and the saturable absorption dominates the nonlinear absorption with the increase of laser energy. The dominance of saturable absorption in the nonlinear absorption is due to the stronger single-photon absorbed intraband absorption from the ground state to the first excited state in the conduction band, the weaker excited state absorption in the conduction band, and the weaker two-photon absorption from the d band to the conduction band.
研究领域:
材料科学
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光学
·
化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
·
IF 5.401
Long Wu,Wenmin Yin,Xuecai Tan,Pan Wang,Fan Ding,Huan Zhang,Biru Wang,Weiyun Zhang,Heyou Han
It is attractive but remains challenging to develop nanomaterials-based methods to realize the colorimetric detection of ultratrace biological analytes. In this work, an HAuCl 4 -H 2 O 2 system was developed for the visual detection of intracellular hydrogen peroxide (H 2 O 2 ) based on the Au-Pt/SiO 2 sensing platform. Owing to their excellent intrinsic peroxidase-like activity, Au-Pt/SiO 2 nanospheres were introduced to catalyze the decomposition of H 2 O 2 and then directly reduce HAuCl 4 into gold nanoparticles (Au NPs) for the naked-eye detection. The produced Au NPs behaved color variations from light purple to wine red as H 2 O 2 concentration increased. Under the optimal conditions, this strategy showed excellent sensitivity for H 2 O 2 with a detection limit of 0.1 nM by naked-eye readout and 0.1 pM by UV–vis spectrometer (S/N = 3), as well as acceptable selectivity for H 2 O 2 , which could meet the demand for the detection of H 2 O 2 in biological systems. The method was further validated by the determination of H 2 O 2 in HeLa cells with low cellular cytotoxicity. Thus, this strategy would provide simple and sensitive detection of H 2 O 2 in biological systems, revealing the potential application in clinical, biological and environmental researches.
研究领域:
生物分析化学
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纳米生物学
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医学检测
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
·
IF 4.758
Yuan Zhou,Zhanfang Ma
Gold nanoclusters (AuNCs), due to their enzyme-like activity, can catalyze the decomposition of hydrogen peroxide (H 2 O 2 ), which can be used to reduce HAuCl 4 into gold nanoparticles (AuNPs). Hg 2+ effectively decreases the catalytic ability of AuNCs to decompose H 2 O 2 by the interactions between Au + on surface of AuNCs and Hg 2+ . In a system containing AuNCs, H 2 O 2 , and HAuCl 4 , increasing the Hg 2+ concentration prompts a color change from purple to red of the solution of as-synthesized AuNPs, which results from the increase in residual H 2 O 2 after decomposition by AuNCs. Based on this principle, a novel colorimetric method for ultrasensitive detection of mercury ions was developed in this work. AuNPs synthesized by a one-step method without modification were used to directly detect mercury ions in lake and river water samples. The detection limit of the present method was determined to be 8:9 pM with a linear response range of 0.1 nM–10 μM, which is much lower than the standard value defined by the Environmental Protection Agency (EPA). The method not only possesses advantages of convenience and simplicity, but also is promising for application in real samples.
研究领域:
分析化学
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环境科学
·
纳米技术
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DOI
高影响因子
ANALYTICAL SCIENCES
·
2022
·Vol. 38
·期 9
·1181-1188
·
IF 1.967
Wang Cheng-Yan,Ge Qingmei,Jiang Nan,Cong Hang,Tao Zhu,Liu Mao,Fan Ying
Metal–organic frameworks (MOFs) including cucurbit[7]uril block (Q[7]·HAuCl 4 ) were employed to develop a diphenylamine (DPA) sensor in electrochemical method, the presence of HAuCl 4 improved the conductivity of the macrocyclic compound. To further enhance of the sensitivity, Au nanoparticles were inserted between the surface of glassy carbon electrode and Q[7]·HAuCl 4 MOFs (GCE-AuNPs-Q[7]·HAuCl 4 ). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) were applied for evaluation on the electrochemical behavior. For the electrochemical inertness of DPA, a label-free electrochemical sensor in 5 mM K 3 [Fe(CN) 6 ] solution was achieved, to produce a limit of detection as low as 4.6 µM in a linear range of 5–1000 µM with good reproducibility, high stability and acceptable anti-interference ability. Application of the proposed electrode for the quantitative determination of DPA in tap water and apple juice confirms its real value. Graphical abstract
研究领域:
分析化学
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材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
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2022
·
IF 5.76
Yun Ni,Hezhong Ouyang,Lulu Yu,Chen Ling,Ziye Zhu,Aolin He,Ruijiang Liu
A label-free electrochemical aptasensor based on magnetic α-Fe 2 O 3 /Fe 3 O 4 heterogeneous hollow nanorods was developed for the detection of cancer antigen 125 (CA125). Magnetic α-Fe 2 O 3 /Fe 3 O 4 heterogeneous hollow nanorods were successfully prepared by the hydrolysis-calcination method, functionalized with polyethyleneimine (PEI), and modified with HAuCl 4 to form magnetic α-Fe 2 O 3 /Fe 3 O 4 -Au nanocomposites with a layer of 5 nm gold nanoparticles (Au NPs) on the surface. The magnetic α-Fe 2 O 3 /Fe 3 O 4 -Au nanocomposites were used to fix the DNA-aptamer probe to amplify the current signal. The intensity of the current signal was proportional to the concentration of CA125, indicating that the sensor was a turn-on sensor. The linear range of the electrochemical aptasensor was 5–125 U/mL ( R 2 = 0.9975), and the limit of detection (LOD) was 2.99 U/mL. The electrochemical aptasensor exhibited favorable specificity, reproducibility, and stability. The analytical performance of the aptasensor in real serum samples was also investigated.
研究领域:
生物化学
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纳米技术
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分析化学
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生物传感器
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癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）