JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·Vol. 107
·期 11
·7352-7363
·
IF 3.5
Shengtai Zhang,Zhen Teng,Linzhen Wu,Yongqiang Tan,Chen Chen,Xiaosong Zhou
Designing waste forms using the cocktail effect of high-entropy ceramics can improve the efficiency of ceramic waste forms. In this work, traditional garnet (Y 1.2 Nd 1.8 Fe 5 O 12 , YIG) and high-entropy (HE) garnet (Y 0.6 Gd 0.6 Sm 0.6 Eu 0.6 Dy 0 . 6 Fe 5 O 12 , HEG) are synthesized through ignition and plasma sintering to form dense ceramic waste forms. The chemical stability of YIG and HEG was studied by using static leaching tests at pH = 3, 5, 7, 9, 11. The results indicate that acidic environments can increase the leaching rate of ceramics. Leaching behavior leads to a decrease in lattice volume, but the elements remain uniformly distributed. The leaching mechanism indicates that YIG and HEG are controlled by dissolution and surface effect in the early stage (1–7 days) of leaching. The leaching mechanism in the later stage (14–42 days) is characterized by diffusion control. The diffusion coefficient of long-term leaching indicates that HEG is more suitable as the immobilization substrate for high-level radioactive waste (HLW) than YIG.
研究领域:
材料科学
·
核废物管理
✓ 已验证
DOI
高影响因子
Cellular and Molecular Gastroenterology and Hepatology
·
2022
·
IF 8.797
Shichao Zhu,Xiyun Rao,Yude Qian,Jinbiao Chen,Renhua Song,Huili Yan,Xi Yang,Junhao Hu,Xiaohong Wang,Zhiming Han,Yi Zhu,Renjing Liu,Justin Jong-Leong Wong,Geoffrey W. McCaughan,Xiangjian Zheng
Background & Aims The liver has complex interconnecting blood vessel and biliary networks; however, how the vascular and biliary network form and regulate each other and liver function are not well-understood. We aimed to examine the role of Heg in mammalian liver development and functional maintenance. Methods Global ( Heg -/- ) or liver endothelial cell (EC)-specific deletion of Heg ( Lyve1-Cre;Heg fl/fl ) mice were used to study the in vivo function of Heg in the liver. Carbon-ink anterograde and retrograde injection were used to visualize the 3-dimensional patterning of liver portal and biliary networks, respectively. RNA sequencing, histology, and molecular and biochemical assays were used to assess liver gene expression, protein distribution, liver injury response, and function. Results Heg deficiency in liver ECs led to a sparse liver vascular and biliary network. This network paucity does not compromise liver function under baseline conditions but did alter liver zonation. Molecular analysis revealed that endothelial Heg deficiency decreased expression of Wnt ligands/agonists including Wnt2, Wnt9b, and Rspo3 in ECs, which limits Axin2 mediated canonical Wnt signaling and the expression of cytochrome P450 enzymes in hepatocytes. Under chemical-induced stressed conditions, Heg -deficiency in liver ECs protected mice from drug-induced liver injuries. Conclusion Our study found that endothelial Heg is essential for the 3-D patterning of the liver vascular and indirectly regulates biliary networks and proper liver zonation via its regulation of Wnt ligand production in liver endothelial cells. The endothelial Heg-initiated changes of the liver metabolic zonation and metabolic enzyme expression in hepatocytes was functionally relevant to xenobiotic metabolism and drug induced liver toxicity.
研究领域:
发育生物学
·
分子生物学
·
肝病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 5.6
Shengtai Zhang,Zhuangzhuang Ma,Linyuan Lu,Yunhao Wang,Tianhao Rui,Yulin Lan,Yang Yu,Mingxuan Deng,Xintao Zhang,Tao Duan,Haibin Zhang
High-entropy garnet (HEG) ceramics are emerging as promising matrices for nuclear waste immobilization, owing to their excellent chemical durability and structural stability. In this work, three HEG compositions with the formula A 3 Fe 5 O 12 -where A represents different combinations of rare-earth cations (A = (Y, Gd, Eu, Sm, Dy, Ho, Er, Tm), (Y, Gd, Eu, Sm, Nd, La, Dy, Ho, Er, Tm) and (Y, Gd, Eu, Sm, Nd, La, Dy, Ho, Er, Tm, Yb, Lu)) were synthesized via SPS. Their chemical durability was systematically evaluated through static and semi-dynamic leaching tests in deionized water at 90 °C. Among the three compositions, (Y, Gd, Eu, Sm, Dy, Ho, Er, Tm) 3 Fe 5 O 12 exhibited the lowest normalized elemental leaching rate, ranging from 10 -7 g∙m -2 ∙d -1 to 10 -8 g∙m -2 ∙d -1 , and the lowest long-term average cation release rate of 0.003 mg/(m 2 d). A key mechanistic insight was revealed through correlation analysis: the release rate of A-site cations shows a strong positive correlation with the degree of ionic size disorder. Furthermore, regression modeling indicates that the long-term elemental release behavior of HEGs can be effectively predicted by two structural descriptors:ionic size disorder and structural symmetry rather than by configurational entropy alone. These findings provide a concrete, property-driven design principle for developing highly durable HEG waste forms with tailorable leaching resistance.
✓ 已验证
产品关联
DOI
高影响因子
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