Energies
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2021
·Vol. 14
·期 24
·8539
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IF 3.004
Lijian Wang,Kang Zhang,Yi Qiu,Huiyun Chen,Jie Wang,Zhihua Wang
The sulfur-iodine (SI) cycle holds great promise as an alternative large-scale process for converting water into hydrogen without CO2emissions. A major issue regarding the long-term stability and activity of the catalysts is their poor sulfur deactivation resistance in the HI feeding process. In this work, the effect of Ru addition for enhancing the activity and sulfur resistance of SiO2-supported Ni catalysts in the HI decomposition reaction has been investigated. The presence of H2SO4molecules in the HI results in severe sulfur deactivation of the Ru-free Ni/SiO2catalysts by blocking the active sites. However, Ni–Ru/SiO2catalysts show higher catalytic activity without sulfur-poisoning by 25% and exhibit more superior catalytic performance than the Ru-free catalyst. The addition of Ru to the Ni/SiO2catalyst promotes the stability and activity of the catalysts. The experimental trends in activity and sulfur tolerance are consistent with the theoretical modeling, with the catalytic activities existing in the order Ni/SiO2< Ni–Ru/SiO2. The effect of Ru on the improvement in sulfur resistance over Ni-based catalysts is attributed to electronic factors, as evidenced by theory modeling analysis and detailed characterizations.Keywords:hydrogen production;SI cycle;HI decomposition;bimetallic catalysts;sulfur-tolerant
研究领域:
化学工程
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催化科学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2023
·
IF 4.6
Ning Fan,Qian Li,Yuan Liu,Bohua Ma,Meng Li,Dongfeng Yin
Purpose Organophosphorus compounds (OPs) is a serious threat to human health and life safety, but because of the existence of blood-brain barrier, most of the therapeutic drugs cannot enter the center, reactivate centrally located toxic acetylcholinesterase (AChE), it is urgent to find an efficient treatment method. Methods The c(RGDyK) cyclic peptide modified HI-6-loaded brain targeting liposomes [c(RGDyK)-PEG 2000 HI-6-lipo] were prepared by ammonium sulfate gradient method. The in vitro blood-brain barrier (BBB) model was established, and the function of the liposomes was evaluated. The animal model of DDVP poisoning was established, and the central toxic enzyme reactivation ability of c(RGDyK)-PEG 2000 HI-6-lipo by both the intravenous and nasal administration route was verified. Results The HI-6-loaded liposomes with brain targeting function were successfully synthesized and prepared with high encapsulation efficiency (70.23 ± 2.18%), drug loading (2.86 ± 0.07)%, average particle size 242.9 nm (polydispersion index 0.149), and ζ potential -16.2 mV. Combined with the in vitro and in vivo studies, the c(RGDyK)-PEG 2000 HI-6-lipo has better ability to cross the BBB. In addition, compared with intravenous injection, nasal administration was proved to be more effective against organophosphorus poisoning, and the reactivation rate of brain acetylcholinesterase reached (26.19 ± 7.70)%. Conclusion The prepared c(RGDyK)-PEG 2000 HI-6-lipo has a better ability to cross BBB. Nasal administration, as a way to bypass the BBB and directly deliver drugs into the brain, effectively improves the bioavailability of HI-6 in the brain. This study holds promise by providing a non-invasive approach to deliver water-soluble oxime antidote into the brain and reactivate central acetylcholinesterase via the naso-brain route.
研究领域:
药剂学
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毒理学
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神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2020
·
IF 6.984
Yaxin Deng,Shuxian Li,Xin Li,Rui Wang
Effective electron transport layers (ETLs) provide enhanced charge separation and transport, therefore as a vital part in improving the efficiency of planar perovskite solar cells (PSCs). Herein, we report a new synergistic strategy using HI to passivate TiO 2 film and surface while incorporating tin element into TiO 2 ETL. HI is first used to control the hydrolysis of TiO 2 precursors and eliminate oxygen vacancies related trap states. Then, tin element is incorporated into HI-passivated TiO 2 precursor solution to construct composite TiO 2 /SnO 2 film, affording increased electron mobility and suitable energy level. Moreover, the entire preparation process is performed under uncontrolled environmental conditions at 150 °C temperatures. Benefiting from the improved quality of the ETLs, the unencapsulated PSCs achieve optimized power conversion efficiency (PCE) of 17.77% with greatly improved stability. After storage in ambient for 1450 h, the device still maintains 92% of its initial efficiency, while hold 79% PCE after 7 h of 1 sun exposure and 86% PCE after heating at 100 °C for 21 h.
研究领域:
材料科学
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太阳能
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纳米技术
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电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2017
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IF 3.648
Yong Zhou,Yinyan Gong,Yongli Huang,Zengsheng Ma,Xi Zhang,Chang Q. Sun
Solvation of acid, base, and salt is ubiquitously important to all subject areas in chemistry , health care and life science. However, fine resolution of the solvation dynamics, solute-solvent molecular interactions , and solute capability of transforming the hydrogen bond (O:H O, or HB) and surface stress remain great challenge. Incorporating the notion of O:H O bond cooperativity with a strategy of differential phonon spectroscopy (DPS) has enabled resolution on the fraction and stiffness of the solvent HB from the mode of water to the hydration shells upon NaOH, NaI and HI solvation. Results show that Na + and I + ionic polarization shortens the H O bond and stiffens its phonon from 3200 to 3500 cm − 1 in the hydration shells. The H + in the HI solution forms a H ↔ H anti-HB that disrupts the solution network and surface stress. The excessive electron lone pairs of OH – form the O : ⇔ : O super-HB that compresses the network, sharing the same effect of mechanical compression shifting the H O phonon from above 3100 cm − 1 to its below; the solute H O bond performs the same to the H O dangling bond at surface featured at 3610 cm − 1 . The fraction coefficients or phonon abundance transition, f H = 0, f HO ∝ C, and f x ∝ 1-exp(− C/C 0 ) (x = Na + and I − and C the solute concentration) towards saturation, feature the solute capability of HB transformation. Practice not only confirms the essentiality of the H ↔ H anti-HB point fragilization, the O : ⇔ : O super-HB point compression, and the ionic polarization to the performance of the respective HI, NaOH, and NaI solutions, but also demonstrate the power of the DPS that enables fine-resolution of solvation dynamics and solute capabilities.
研究领域:
化学
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医疗保健
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生命科学
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物理化学
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光谱学
✓ 已验证
DOI
高影响因子
Frontiers in Physiology
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2023
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IF 4
Jiqiang Song,Yanping Yu,Zhichao Yan,Shan Xiao,Xianxin Zhao,Fang Wang,Qi Fang,Gongyin Ye
Chloride intracellular channel (CLIC) is a member of the chloride channel protein family for which growing evidence supports a pivotal role in fundamental cellular events. However, the physiological function of CLIC in insects is still rarely uncovered. The ovary-derived High Five (Hi-5) cell line isolated from the cabbage looper ( Trichoplusia ni ) is widely used in laboratories. Here, we studied both characteristics and functions of CLIC in Hi-5 cells ( Tn CLIC). We identified the TnCLIC gene in Hi-5 cells and annotated highly conserved CLIC proteins in most insect species. After RNA interference of TnCLIC , the phenomenon of significantly increased cell death suggests that the Tn CLIC protein is essential for the survival of Hi-5 cells. The same lethal effect was also observed in Spodoptera frugiperda 9 and Drosophila melanogaster Schneider 2 cells after CLIC knockdown. Furthermore, we found that this kind of cell death was accompanied by increases in intracellular calcium ions after TnCLIC knockdown with the transcriptomic analyses and the detection of calcium levels. Our results provide insights into insect CLIC as a key factor for cell survival and lay the foundation for the cell death mechanism.
研究领域:
分子生物学
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细胞生物学
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昆虫学
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遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 38
·15035-15046
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IF 4.5
Wang Xiongwei,Ma Rui-Juan,Guo Tingyu,Zhang Xuewei,Wang Hui,Zhao Xu
Abstract The hydrogen iodide decomposition reaction of the sulfur-iodine (SI) cycle is realized by electrolysis at room temperature to achieve efficient hydrogen production, while iodine is recycled throughout the SI reaction. In this work, we report a facile hydrothermal method for the synthesis of sulfur-doped titanium dioxide (S- \(\hbox {TiO}_2\) ) nanosheets with evenly distributed on the Ti foil (S- \(\hbox {TiO}_2\) /Ti). The noble metal-free S- \(\hbox {TiO}_2\) /Ti electrode demonstrates excellent electrochemical catalytic performance for iodine evolution reaction. It can deliver a high current density of 100 mA/ \(\hbox {cm}^2\) with a potential of 1.05 V, which is close to 90% of that of precious metal platinum and 5.6 times of bare Ti foil. Furthermore, the S- \(\hbox {TiO}_2\) /Ti electrode is stable in a mixed acid solution of HI and \(\hbox {H}_2\hbox {SO}_4\) . Compared to \(\hbox {TiO}_2\) /Ti, diffuse reflectance spectroscopy and ultraviolet photoelectron spectroscopy analysis evidence a reduction in the band gap and work function of S- \(\hbox {TiO}_2\) /Ti due to the doping of sulfur. Correspondingly, the current efficiency approaches to 100% under the electrolysis constant voltage 1.30 V. Eventually, the detailed mechanism to describe the improvement of the electrocatalytic performance was suggested. Graphical abstract
研究领域:
材料科学
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可再生能源
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电化学
✓ 已验证
产品关联
DOI
高影响因子
Processes
·
2024
·Vol. 12
·期 8
·1768
·
IF 2.8
Jinxu Zhang,Bo Ling,Yong He,Yanqun Zhu,Zhihua Wang
Hydrogen energy, as a clean, renewable, and high-calorific energy carrier, has garnered significant attention globally. Among various hydrogen production methods, the thermochemical iodine–sulfur (I-S) cycle is considered the most promising due to its high efficiency and adaptability for large-scale industrial applications. This study focuses on the distillation characteristics of the HIx(HI–I2–H2O) solution within the I-S cycle, which is crucial for achieving the high-concentration HI necessary for efficient hydrogen production. Previous methods, including phosphoric acid extraction–distillation and reactive distillation, have addressed azeotrope issues but introduced complexities and equipment demands. This research constructs a hypo-azeotropic HIxsolution distillation experimental system and uses the Aspen Plus v14 software to optimize distillation parameters. By analyzing the effects of feed stage, reflux ratio, and feed temperature, the study provides essential data for improving distillation efficiency and supports the scale-up of I-S cycle technology. The findings indicate that optimal distillation is achieved with a feed position at 1/3 column height, a reflux ratio of 1.4, and a feed temperature near the boiling point, enhancing the feasibility of industrial hydrogen production via the I-S cycle.
研究领域:
化学工程
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能源科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2018
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IF 4.229
Ke Zhang,Xu Zhao,Sihan Chen,Liping Chang,Jiancheng Wang,Weiren Bao,Hui Wang
In chemical cycles to produce hydrogen , the H 2 S splitting cycle and the sulfur-iodine (S I) water splitting cycle both share the Bunsen reaction and HI decomposition. Therefore, they have to overcome the same challenges in the technology development, one of them being the complex and difficult separations of the mixed hydroiodic acid and sulfuric acid solution after the Bunsen reaction. To avoid the separations, this paper studies the electrolysis of the HI/H 2 SO 4 /H 2 O/toluene mixture, focusing on the electrochemical characterization of the Pt electrode by using linear sweep voltammetry (LSV) and cyclic voltammetry (CV). The results show that hydrogen is identified from the gas generated from the cathode in electrolysis. Iodide oxidation is the main reaction in the anode chamber and no significant side reactions are observed. Iodine deposition on the anode surface increases the resistance to iodide diffusion to the anode. However, it can be mitigated by adding toluene in or applying stirring to the anolyte HI/H 2 SO 4 solution. The Pt cathode and sulfuric acid catholyte also work stably.
研究领域:
化学工程
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电化学
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可再生能源
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2019
·
IF 4.084
Lijian Wang,Yanqun Zhu,Guangshi Fu,Yong He,Yanwei Zhang,Zhihua Wang
The sulfur–iodine (SI) cycle is deemed to be one of the most promising alternative methods for large-scale hydrogen production by water splitting, free of CO 2 emissions. Decomposition of hydrogen iodide is a pivotal reaction that produces hydrogen . The homogeneous conversion of hydrogen iodide is only 2.2% even at 773 K [1]. A suitable catalyst should be selected to reduce the decomposition temperature of HI and attain reaction yields approaching to the thermodynamic equilibrium conversion. However, residual H 2 SO 4 could not be avoided in the SI cycle because of incomplete purification. The H 2 SO 4 present in the HI feeding stream may lead to the poisoning of HI decomposition catalysts. In this study, the activity and sulfur poisoning of Ru and Ni catalysts loaded on carbon and alumina , respectively, were investigated at 773 K. HI conversion efficiency markedly decreased from 21% to 10% with H 2 SO 4 (3000 ppm) present, which was reversible when H 2 SO 4 was withdrawn in the case of Ru/C. In the case of Ru/C and Ni/Al 2 O 3 , catalyst deactivation depends on the concentration of H 2 SO 4 ; the higher the concentration of H 2 SO 4, the greater the severity of deactivation. Catalysts before and after sulfur poisoning were characterized by transmission electron microscopy (TEM), energy-dispersive X-Ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). Experimental results and characterization of poisoned and fresh catalysts indicate that the catalyst deactivation could be ascribed to the competitive adsorption of sulfur species and change in its surface properties.
✓ 已验证
产品关联
DOI
高影响因子
ACS Chemical Neuroscience
·
2022
·
IF 5.78
Qianlei Zhao,Tingting Chen,Chao Ni,Yingying Hu,Yan Nan,Wei Lin,Yanli Liu,Feixia Zheng,Xulai Shi,Zhongdong Lin,Jianghu Zhu,Zhenlang Lin
The blood–brain barrier (BBB) is an important physiological barrier of the human body contributing to maintaining brain homeostasis and normal function. Hypoxic-ischemic (HI)-related brain injury is one of the main causes of neonatal acute morbidity and chronic disability. The previous research of our group confirmed that there was serious BBB destruction during HI brain injury. However, at present, the protection strategy of BBB is very limited, and further research on the protection mechanism is warranted. Indole-3-propionic acid (IPA) is a bacterial metabolism with anti-inflammatory and antioxidant properties, having neuroprotective effects and protective effects on the mucosal barrier. However, the role of IPA in BBB is not clear. In this research, we demonstrated the protective effect of IPA on BBB disruption from HI brain injury and hypothesized that it involves the amelioration of inflammation, oxidative stress, and MMP activation, thereby inhibiting apoptosis of rat brain microvascular endothelial cells (rBMECs). We demonstrated that expression levels of several inflammatory markers, including iNOS, TNF-α, IL-6, and IL-1β, were significantly increased from HI damage or OGD injury. However, IPA treatment inhibited the increase significantly. Moreover, we demonstrated that IPA reduced intracellular ROS levels and MMP activation in rBMECs from OGD injury. Further research on the underlying detailed molecular mechanisms suggested that IPA attenuates inflammation by inhibiting NF-κB signaling. Finally, we investigated the mechanism of the relationship between PXR activation and NF-κB inhibition. The results suggested overexpression of PXR in rBMECs could significantly counteract the decrease of junction proteins and downregulate the increased p-IκB-α and p-NF-κB from OGD injury. However, the protective effects of IPA were reversed by antagonists of the PXR. Taken together, IPA might mitigate HI-induced damage of the BBB and the protective effect may be exerted through modulating the PXR signaling pathway.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Junya Zhang,Tiedong Lu,Yunwei Cui,Qihe Tang,Yuansong Wei,Hans Hermann Richnow
Methanogenesis is a critical driver of global carbon cycling and bioenergy recovery, yet how bacteriophages modulate methane production remains poorly understood. Here, we integrated high-throughput chromosome conformation capture (Hi-C) with multi-omics to map in situ phage–host interactions through an over 440 day anaerobic digestion experiment. We captured 6100 active physical linkages, revealing that 16.3 ± 2.1% of interactions involved auxiliary metabolic genes (AMGs). Notably, we observed a dynamic community-level compositional shift in viral life strategies driven by operational stress. Under mesophilic conditions, lysogenic piggyback-the-winner dynamics prevailed, with AMGs enhancing host competitiveness. Conversely, thermophilic conditions with high total solids stress triggered lytic kill-the-winner strategies. During this phase, AMGs supported rapid phage replication targeting overproliferating bacteria to restore the disrupted balance between acidogenesis and methanogenesis. Furthermore, we identified 529 DNA viral operational taxonomic units (vOTUs) directly infecting methanogens, alongside broad-host-range phages spanning bacterial and archaeal domains. Importantly, we detected four RNA vOTUs exclusively under thermophilic conditions, providing the first omics-based evidence of RNA phages actively infecting methanogenic archaea. These findings highlight phages as important modulators of methane production, offering a foundational framework for developing targeted phage-engineering strategies to optimize bioenergy systems and mitigate methane emissions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Yaxin Deng,Shuxian Li,Xuandong Li,Rui Wang,Xin Li
Planar structures for halide perovskite solar cells with the high efficiencies typically use high-temperature processed TiO 2 as the electron transporting layers (ETLs). Here, we demonstrate that an in-situ passivation strategy for TiO 2 film through the introduction of HI during low-temperature preparation process. HI not only controls hydrolysis of TiO 2 precursor but also eliminates defects and suppresses trap states in TiO 2 film. Meanwhile, the double-layer architecture is constructed by coating TiO 2 with SnO 2 layer, the double ETLs can improve the photovoltaic performance of methylamine lead iodide (MAPbI 3 ) perovskite solar cells. The TiO 2 (HI)/SnO 2 ETL can effectively reduce the interfacial charge recombination and facilitate electron transfer. More importantly, the preparation of TiO 2 and SnO 2 are totally performed at low-temperature (150 °C) and the devices are fabricated in uncontrolled ambient conditions. Our best-performing planar perovskite cell using such a TiO 2 (HI)/SnO 2 ETL has achieved a maximum power conversion efficiency (PCE) of 16.74%, and the devices exhibit good stability which maintaining 85% and 83% of their initial efficiency after heating at 100 °C for 22 h and under illuminating upon 1 sun irradiation for 6 h, respectively. Our results suggest a new approach for further improving the stability of PSCs fabricated in the air condition.
研究领域:
材料科学
·
光伏技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）