SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Honglin Zhang,Ting Liu,Qiuhe Li,Xiyu Zhang,Hua Zhao,Yangdong Zheng,Feng Qin,Zhiguo Zhang,Tianqi Sheng,Ye Tian
The oxygen sensing enhancement based on room temperature phosphorescence (RTP) of Gd-HMME adjusted by imidazole was studied. The phosphorescence intensity I P0 and the Stern-Volmer equations under different imidazole concentration were obtained, and the physical mechanism of imidazole regulating the oxygen quenching constant K SV was analyzed. It was found that the K SV value increased by ∼46 folds in the range of 12.4(1)–576.1(5) kPa −1 , and the large-scale variation of K SV is conducive to the realization of high precision oxygen concentration measurement in a wide range. In addition, the standard deviation σ of continuous measurement results was given, and the limit of detection (LOD) was determined to be 6.6 ppm.
研究领域:
分析化学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Jia Zhang,Chunyu Lai,Bin Li,Hui Wang,Haimeng Yan,Xuanwen Bao,Xuqi Sun,Haibo Zhang,Zhou Tong,Tao Wang,Weijia Fang,Xiaomeng Dai,Peng Zhao,Dong Chen
Immune checkpoint blockade (ICB) therapies, such as targeting programmed death-1 (PD-1) and programmed cell death protein ligand-1 (PD-L1), are often ineffective in low-immunogenic tumors, limiting their widespread use. In this study, an emulsion hydrogel is developed to encapsulate the sonosensitizer hematoporphyrin monomethyl ether (HMME), aimed at enhancing sonodynamic immunotherapy for low-immunogenic cancers. The water-in-oil emulsion hydrogel, characterized by its shear-thinning rheological properties, demonstrates excellent ultrasound (US)-triggered and lipase-triggered release, followed by sustained release. The emulsion hydrogel loaded with HMME (Gel@HMME), when combined with US, induces an immune response by promoting dendritic cell (DC) maturation and M1-tumor-associated macrophage (M1-TAM) polarization. This, in turn, enhances the infiltration of helper T lymphocyte 1 (Th1) cells and cytotoxic T lymphocytes (CTLs), thereby amplifying the antitumor immune response. Furthermore, Gel@HMME + US enhances the expression of PD-L1 in tumor cells. The combination of ICB (anti-PD-1, αPD-1) with Gel@HMME + US exerts a significant therapeutic effect on pancreatic cancer by upregulating the expression of calreticulin. Thus, this study presents a promising strategy for treating low-immunogenic cancers using an injectable HMME-loaded emulsion hydrogel, which enhances sonodynamic immunotherapy.
研究领域:
生物材料
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癌症免疫治疗
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药物递送
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声动力治疗
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
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2017
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IF 2.686
Huimin Zhao,Lixin Zang,Qinyu Liu,Bingjie Ma,Meng Kou,Jinhua Lv,Chengshan Guo
The enhancement of the room-temperature phosphorescence (RTP) emissions of phosphorescent metalloporphyrins is critical toward extending their applications in many fields. Imidazole is widely used as a molten solvent in the synthesis of metalloporphyrins and can influence their RTP emissions. Here, the effects of imidazole on the RTP emissions of a series of metalloporphyrins (hematoporphyrin monomethyl ether coordinated to gadolinium (Gd-HMME), lutetium (Lu-HMME), and palladium (Pd-HMME) ions) were studied. It was found that imidazole effectively enhanced the RTP emissions of these metalloporphyrins both on a solid matrix and in solution. For metalloporphyrins on a solid matrix (filter paper), the RTP intensities of samples immersed in an imidazole solution were much higher than those immersed in methanol. Imidazole enhanced the phosphorescence quantum yields ( Φ P ) of Gd-, Lu- and Pd-HMME on filter paper by 23-, 5.0-, and 3.5-fold, respectively. For metalloporphyrins in solution (methanol), the RTP intensities increased gradually with the concentration of imidazole. These results indicate that imidazole has potential as an RTP enhancer by protecting the triplet states of phosphorescent metalloporphyrins.
研究领域:
化学
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材料科学
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光学
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DOI
高影响因子
SENSORS
·
2025
·Vol. 25
·期 6
·1670
·
IF 3.5
Yujie Niu,Jinxin Wang,Zhongxing Zhang,Ting Liu
Gaseous oxygen detection is essential in numerous production and manufacturing sectors. To meet the varying oxygen detection requirements across different fields, techniques that offer a wide oxygen detection range should be developed. In this study, a wood-based oxygen sensing material was designed using balsa wood as the supporting matrix and gadolinium hemoporphyrin monomethyl ether (Gd-HMME) as the oxygen-sensitive indicator. The wood-based Gd-HMME exhibits a cellular porous structure, which not only facilitates the loading of a substantial number of indicator molecules but also enables the rapid interaction between indicators and oxygen molecules.OPis defined as the ratio of the phosphorescence intensity of the oxygen-sensing material in the anaerobic and aerobic environment. A linear relationship betweenOPand oxygen partial pressure ([O2]) was obtained within the whole range of [O2] (0–100 kPa). The wood-based Gd-HMME exhibited excellent resistance to photobleaching, along with a rapid response time (3.9 s) and recovery time (4.4 s). It was demonstrated that the measurement results obtained using wood-based Gd-HMME were not influenced by other gaseous components present in the air. An automatic oxygen detection system was developed using LabVIEW for practical use, and the limit of detection was determined to be 0.01 kPa.
研究领域:
材料科学
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光学传感
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2016
·Vol. 45
·期 42
·16889-16895
·
IF 4.177
Lixin Zang,Huimin Zhao,Jianyu Hua,Feng Qin,Yangdong Zheng,Zhiguo Zhang,Wenwu Cao
A mechanism for the enhanced room-temperature phosphorescence (RTP) of gadolinium-coordinated hematoporphyrin monomethyl ether (Gd-HMME) in the presence of imidazole and free gadolinium ions (Gd3+) is revealed. Imidazole, the molten solvent used in the synthesis of Gd-HMME, was effective in enhancing the Gd-HMME RTP. In the presence of imidazole, further enhancement of the Gd-HMME RTP was observed upon adding Gd3+. Overall, a 40-fold enhancement of Gd-HMME RTP intensity was achieved by adding both imidazole and Gd3+. In addition, there was an increase in the RTP lifetime. Through spectroscopic analysis, we deduced that a protective medium is formed by the imidazole and the degree of this protection is further increased by Gd3+. The protective medium enhances the Gd-HMME RTP by partially inhibiting energy transfer from the lowest triplet state of Gd-HMME to oxygen. This was demonstrated by the presence of lower levels of singlet oxygen in the Gd-HMME solution after the addition of imidazole. These results indicate that imidazole could have potential application as an RTP enhancer or triplet state protector.
研究领域:
化学
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材料科学
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光化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Meiting Li,Zhuoyin Liu,Junjie Tang,LiLi Cheng,Yifan Xue,Yadong Liu,Jie Liu
Sonodynamic therapy (SDT), which involves the activation of sonosensitizers to generate cytotoxic reactive oxygen species under ultrasound irradiation, is a promising noninvasive modality for cancer treatment. However, the clinical translational application of SDT is impeded by the lack of efficient sonosensitizers, the inefficient accumulation of sonosensitizers at tumor sites, and the complicated immunosuppressive tumor microenvironment. Herein, we developed a facilely synthesized multifunctional porous organic polymer nanosonosensitizer (mHM@HMME) for enhanced SDT. Specifically, mHM@HMME nanosonosensitizers were prepared by incorporating chemotherapeutic mitoxantrone into the one-step synthesis process of disulfide bond containing porous organic polymers, followed by loading with organic sonosensitizer (HMME) and camouflaging with a cancer cell membrane. Due to the cancer cell membrane camouflage, this multifunctional mHM@HMME nanosonosensitizer showed prolonged blood circulation and tumor targeting aggregation. Under ultrasound irradiation, the mHM@HMME nanosonosensitizer exhibited a satisfactory SDT performance both in vitro and in vivo. Moreover, the potent SDT combined with glutathione-responsive drug release in tumor cells induced robust immunogenic cell death to enhance the antitumor effect of SDT in turn. Overall, this facilely synthesized multifunctional mHM@HMME nanosonosensitizer shows great potential application in enhanced SDT.
研究领域:
癌症研究
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纳米技术
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治疗学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2026
·Vol. 45
·期 4
·e70192
·
IF 12.1
Liang Zhou,Ning Wang,Zumeng Wang,Pingping Zhang,Yuqin Chu,Yingguang Liu,Wen Liu,Chengwu Zhang,Lili Yan
en This link goes to a English section zh This link goes to a Chinese section Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance. It is imperative to develop non-antibiotic-dependent strategies to efficiently eradicate biofilm infections in diabetic wounds. In this work, an innovative nanospray (CDs-HM) was successfully prepared by linking one acoustic sensitizer (hematoporphyrin monomethyl ether, HMME) to CDs fabricated with hemin, nickel(II) chloride, and polymer ethylene imine. CDs-HM exhibited catalase-enhanced sonodynamic properties and photothermal-enhanced chemodynamic properties. In vitro experiments and transcriptomic analysis demonstrated that CDs-HM successfully killed the bacteria and destroyed bacterial biofilm by disrupting bacterial cell membrane integrity, inducing oxidative stress, and inhibiting ATP production through synergistic photothermal therapy/chemodynamic therapy/sonodynamic therapy (PTT/CDT/SDT) effects. In the diabetic wound infection mouse model, CDs-HM remarkably eradicated MRSA biofilm, reduced inflammation levels, and promoted angiogenesis/collagen deposition so as to accelerate wound healing. It is noteworthy that CDs-HM displayed superior bacteria killing and wound healing effects compared with conventional vancomycin and nanosilver dressing interventions. The practicality and efficiency of CDs-HM endowed it with broad clinical translation prospects. It paved the way for developing novel strategies for combating diabetic wound infections. 摘要 en This link goes to a English section zh This link goes to a Chinese section 糖尿病伤口感染是糖尿病的常见并发症,严重影响患者的生活质量。由于细菌生物膜的形成和抗生素耐药性问题,糖尿病伤口感染的有效治疗仍是临床面临的一大挑战。因此,亟待开发非抗生素依赖的新策略以高效清除糖尿病伤口的生物膜感染。本研究通过将声敏剂(血卟啉单甲醚,HMME)与由氯化血红素、氯化镍和聚乙烯亚胺制备的碳点相偶联,成功构建了一种新型纳米喷雾(CDs-HM)。CDs-HM表现出过氧化氢酶增强的声动力学性能与光热增强的化学动力学性能。体外实验及转录组学分析表明,通过协同的光热/化学动力学/声动力学治疗,CDs-HM可破坏细菌细胞膜的完整性、诱导氧化应激并抑制ATP的生成,从而有效杀灭细菌并破坏其生物膜。在糖尿病伤口感染小鼠模型中,CDs-HM能显著清除耐甲氧西林金黄色葡萄球菌生物膜、降低炎症水平并促进血管生成和胶原沉积,进而加速伤口愈合。值得注意的是,与临床上常用的万古霉素和纳米银敷料联合治疗措施相比,CDs-HM展现出更优异的杀菌及促伤口愈合效果。CDs-HM展示出较强的实用性,使其具备了广阔的临床转化前景,也为开发糖尿病伤口感染治疗的新型策略奠定了基础。
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DOI
高影响因子
Advanced Healthcare Materials
·
2023
·Vol. 12
·期 15
·2202943
·
IF 10
Mixiao Tan,Xuemei Li,Hua Zhang,Min Zheng,Jie Xiong,Yang Cao,Guoliang Cao,Zhigang Wang,Haitao Ran
Synergistic photodynamic and photothermal therapy (PDT-PTT) has emerged as an appealing effective antitumor approach. However, clinical utilization of PDT-PTT is plagued by aggregation-caused photobleaching, sequential double irradiations, unsatisfying balance between single oxygen ( 1 O 2 ) quantum yield and photothermal conversion efficiency. Here, an anchored tumor-homing cell-penetrating peptide (PEGA- p VEC) and PANI-ES/HMME loaded FRET nanobullet (AHP-P) are reported. Within nanobullet, HMME (donor) and PANI-ES (acceptor) spontaneously form a förster resonance energy transfer (FRET) pair. Upon 660 nm laser irradiation, HMME convert near-infrared fluorescence (NIRF) to PANI, thus produce FRET-amplified photoacoustic imaging guided PTT. In addition, AHP-P with pH-sensitivity can gradually release HMME within acidic tumor environment, boosts the 1 O 2 regeneration alongside with highly efficient photothermal conversion for photoinduced cancer PTT-PDT. Furthermore, the AHP-P nanobullet can home in on the tumor site and penetrate into cytoplasm through PEGA- p VEC, inducing remarkable tumor regression with an ≈80% tumor volume reduction and decreased skin phototoxicity in vivo during FRET-amplified PTT-PDT.
研究领域:
生物医学工程
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癌症研究
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诊疗学
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纳米技术
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光声成像
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光疗
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2023
·
IF 15.1
Jiayin Yu,Zhihao Guo,Jiachang Yan,Changxin Bu,Chang Peng,Cuie Li,Rui Mao,Jian Zhang,Zhi Wang,Shi Chen,Meicun Yao,Zhiyong Xie,Chuan Yang,Yi Yan Yang,Peiyan Yuan,Xin Ding
Helicobacter pylori ( H. pylori ) has infected more than half of the world's population, and is the major cause of gastric cancer. The efficacy of standard antibiotic-based triple therapy is declining due to drug resistance development. Herein, a pH-responsive reactive oxygen species (ROS) nanogenerator (Fe-HMME@DHA@MPN) composed of acid-responsive metal polyphenol network (MPN) shell and mesoporous metal-organic nanostructure core [Fe-HMME (hematoporphyrin monomethyl ether, sonosensitizer)] loaded with dihydroartemisinin (DHA) is reported. These nanoparticles generate more ROS singlet oxygen than sonosensitizer HMME under ultrasonication, and this sonodynamic process is fueled by oxygen generated through Fenton/Fenton-like reactions of the degraded product in gastric acid Fe (II) and hydrogen peroxide (H 2 O 2 ) in the infection microenvironment. The encapsulated DHA, as a hydroperoxide source, is found to enhance the peroxidase-like activity of the Fe-HMME@DHA@MPN to generate ROS hydroxyl radical, beneficial for the microenvironment without sufficient H 2 O 2 . In vitro experiments demonstrate that the ROS nanogenerators are capable of killing multidrug-resistant H. pylori and removing biofilm, and ROS nanogenerators show high therapeutic efficacy in a H. pylori infection mouse model. Unlike the triple therapy, the nanogenerators display negligible side effects toward the normal gut microbiota. Taken together, these self-enhanced ROS nanogenerators have a great potential for treatment of H. pylori infection.
研究领域:
生物医学工程
·
纳米技术
·
微生物学
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药学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）