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Electrochemical oxidation of allylic CH bond for α, β-unsaturated ketones without peroxide

Zhong-Lin Zang,Qi Wang,Zhi-Chao Dong,Sheng-Yao Huang,Hao-Zeng Wu,Cheng-He Zhou,Gui-Xin Cai

α,β -Unsaturated ketone is one of the important building blocks of the plenty of alkaloids, spices and pharmaceutical agents. Herein, we describe a peroxide-free electrochemical strategy to realize site-selective allylic C − H oxidation for the synthesis of α,β -unsaturated ketones. This electrochemically driven oxidation exhibits a broad substrate scope. Mechanistic investigations of this reaction uncovered HOAc and H 2 O as the oxygen source to achieve peroxide-free electrochemical allylic C − H oxidation.