JOURNAL OF CHEMICAL PHYSICS
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2024
·Vol. 160
·期 17
·
IF 3.1
Liu Yaqi,Liu Zhuo,Chen Yijing,He Jing,Niu Yuqing,He Yuwei,Wang Yanjie,Ju Yun,Jiang Jie,Zhang Hong,Qiao Lina
Fatty acids from cooking fumes and hypochlorous acid (HOCl) released from indoor cleaning adversely affect respiratory health, but the molecular-level mechanism remains unclear. Here, the effect of cooking oil fumes [palmitic acid (PA), oleic acid (OA), and linoleic acid (LA)] on lung model phospholipid (POPG) hydrochlorination mediated by HOCl at the air–water interface of the hanged droplets was investigated. Interfacial hydrochlorination of POPG was impeded by OA and LA, while that of POPG was facilitated by PA. The effect on POPG hydrochlorination increased with the decrease in oil fume concentration. A potential mechanism with respect to the chain length of these oil fumes, regardless of their saturation, was proposed. PA with a short carbon chain looses the POPG packing and leads to the exposure of the C=C double bonds of POPG, whereas OA and LA with a long carbon chain hinder HOCl from reaching the C=C bonds of POPG. These results for short chain and low concentration dependence suggest that the decay of oil fumes or the conversion of short-chain species by indoor interfacial chemistry might be adverse to lung health. These results provide insights into the relationship between indoor multicomponent pollutants and the respiratory system.
研究领域:
生物学
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医学
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环境科学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Jing Xu,Hanqing Liu,Le Ding,Tao Wang,Haifeng Zhou,Guangjun Zhou
Oxidizing Hypochlorous acid (HOCl),which widely exists in environment, is closely related to the health of organisms. Herein, the low-cost up-conversion (UCNPs)-Carmine system, without noble metal nanoparticle, was designed to detect HOCl based on inner filter effect (IFE) using UCNPs as energy donors and dye molecules carmine as energy receptors. Specifically, the green UCL (up-conversion luminescence) of UCNPs can be effectively quenched by the HOCl-sensitive carmine and red UCL retained unchanged, owing to the spectral overlap between the absorption of Carmine and emission of UCNPs in the green region. Once exposed to HOCl, the Carmine dye molecule is degraded, and thus the green UCL of UCNPs restores, the variation of which can accurately reflect the content of HOCl. This nanosensor has a low detection limit of only 0.30 μM, which is much lower than that of colorimetric detection, and is successfully applied to detect HOCl spiked in spring water with good recoveries. Notably, by means of 3D printing technology, we have created a portable hydrogel sensing platform that can quickly and efficiently detect HOCl in samples. The detection limit of G/R of this sensing platform is only 12.87 μM, and satisfactory recovery values in real sample detection. This innovation not only improves the sensitivity of the sensor, but also provides a more convenient solution for environmental monitoring and safety testing, demonstrating the potential of hydrogels for a wide range of applications in sensing.
研究领域:
分析化学
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环境科学
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生物医学工程
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产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Tingting Yang,Junyong Sun,Wu Yao,Feng Gao
To understand the relationship between endoplasmic reticulum (ER) stress and the level of hypochlorous acid (HOCl), it is highly desired to develop an ER-targetable HOCl probe to monitoring the HOCl level. In this study, a new turn-on type of two-photon ER-targetable fluorescent probe (ER-NPA) is designed for fluorescent sensing and imaging HOCl in ER using 4-hydroxy-1,8-naphthalimide as the fluorophore , p-aminophenyl ether as the recognition receptor, and methyl sulfonamide as ER-targetable group. The probe ER-NPA exhibits some intrinsic features such as excellent water solubility, good biocompatibility , significantly fast and enhanced fluorescence response to HOCl within 60 s, and detection limit as low as 6.2 nM for HOCl determination. The probe ER-NPA is successfully applied to real-time monitoring of exogenous and endogenous HOCl fluctuations in HeLa cells and zebrafish during ER stress. The developed probe ER-NPA may provide a new strategy to reveal the chemical biology roles of HOCl in ER stress-related diseases.
研究领域:
生物化学
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医学
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分子影像学
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产品关联
DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 32
·e04077
·
IF 2
Yu-Ning Ma,Fei-Fei Yu,Yan Ao,Yu-Feng Li,Yao Yuan,Shang-Wei Hou,Yi-Yi Cao,Jing Xi,Yang Luan,Xin-Yu Zhang
Graphical Bilirubin is rapidly degraded by HOCl into hematinic acid (HA), 2,5-diformyl-4-methyl-1 H -pyrrole-3-propanoic acid (BHP2), and 4-methyl-3-(1-hydroxy-2-chloroethyl) maleimide (MHCM), among other things. The concentrations of HA and BHP2 increased in murine whole blood and bone marrow suspensions on neutrophil activation, and that of BHP2 in the blood increased in mice dosed lipopolysaccharide (LPS). Bilirubin (BR) is the breakdown product of heme, and has antioxidative and anti-inflammatory activities. BR has been known to be degraded by H 2 O 2 ; however, its degradation by HOCl, an oxidant specific to activated neutrophils, has not been investigated. We herein reported that at pH = 7.4 and 37 °C, BR was rapidly degraded by HOCl into many products. Three major products were characterized: hematinic acid (HA), 2,5-diformyl-4-methyl-1 H -pyrrole-3-propanoic acid (BHP2), and 4-methyl-3-(1-hydroxy-2-chloroethyl) maleimide (MHCM), which is a novel compound. Acidic pH favored the MHCM formation, whereas neutral and alkaline pH and high HOCl:BR ratios favored production of HA and particularly BHP2. In murine whole blood and bone marrow suspensions, the levels of HA and BHP2 increased significantly after neutrophil activation with MHCM being undetected, and inhibition of HOCl generation abolished the increases. In the lipopolysaccharide (LPS)-induced murine inflammatory model, the BHP2 concentration in plasma, but not HA, increased significantly at 6 h and 24 h post-LPS administration, and returned to the pre-LPS stimulation level at 48 h. The results show that BR is readily degraded by HOCl, which can occur ex vivo and in vivo upon neutrophil activation, with BHP2 being a potential biomarker for HOCl production.
研究领域:
生物化学
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免疫学
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氧化应激研究
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炎症生物学
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代谢学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2025
·
IF 8.1
Lingyu He,Jiayu Luo,Haiyang Hu,Xin Zhang,Yang Lei
Using phosphorus-containing scale inhibitors (i.e., phosphonates) in cooling water poses a significant challenge to water pollution and eutrophication during discharge. Here we report an efficient electrochemical oxidation (EO) process based on a low-cost titanium suboxide (Ti 4 O 7 ) inert anode. We found that ubiquitous chloride ions (Cl − ) in cooling water significantly promoted the transformation of methylene phosphonic acid (NTMP, a representative phosphonate) into orthophosphate. In the Cl − -Ti 4 O 7 -AO system, hypochlorous acid (HOCl) is the primary reactive species responsible for the sequential cleavage of C–P and C–C bonds, converting organic phosphorus into inorganic phosphate. Furthermore, the presence of HCO 3 − or humic acid (HA) under realistic conditions showed negligible effects on the degradation of NTMP. In long-term operation, the Ti 4 O 7 -AO system sustained 100% conversion efficiency of NTMP over continuous-flow operation mode for more than 720 h, even though the cathode was almost entirely covered with CaCO 3 deposits. The results revealed that cathode scaling does not profoundly affect the conversion of organic phosphorus to phosphate in the Ti 4 O 7 -AO system. Overall, our study elucidates the mechanism and robust efficiency of the Cl − -Ti 4 O 7 -AO system in treating phosphonate-laden wastewater and offers a new solution for dealing with cooling water by coupling electrochemical oxidation with ubiquitous chloride ions.
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 38
·期 8
·3371-3374
·
IF 3.159
Jie Zhao,Hongjuan Li,Kui Yang,Shiguo Sun,Aiping Lu,Yongqian Xu
A fluorescent probe exhibiting specific and sensitive properties towards HOCl was successfully developed on the basis of the Baeyer–Villiger reaction. It worked well both in solution and on test papers, allowing the facile monitoring of hypochlorite. The probe was further used for imaging in living cells.
研究领域:
生物化学
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分析化学
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细胞生物学
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yin Li,Qian An,Xingcan Li,Chunya Li,gang Luo
Nonalcoholic fatty liver disease (NAFLD), a highly prevalent clinicopathological disorder characterized by excessive hepatic lipid accumulation, insulin resistance, and chronic inflammation, represents a growing global health challenge. Since inflammation plays a pivotal role in NAFLD progression, the sensitive and selective detection of inflammatory biomarkers is essential for early diagnosis. Herein, a ratiometric fluorescent probe (BDY-HOCl) based on boron dipyrromethene (BODIPY) was developed for in situ monitoring of hypochlorous acid (HOCl), a key factor for inflammatory responses. BDY-HOCl operates through HOCl-induced oxidative cleavage of an alkene linker between BODIPY and a Fischer aldehyde moiety, producing two distinct emission peaks with minimal spectral overlap and environmental interference, thereby ensuring accurate ratiometric fluorescence quantification. To further enhance stability and selectivity, BDY-HOCl was covalently anchored onto amine-functionalized SiO 2 @covalent organic frameworks (SiO 2 @COFs) via Schiff base condensation, yielding SiO 2 @COFs-BDY-HOCl . This nanocomposite can effectively reduce solvent-induced fluorescence quenching and improved HOCl detection with a low limit of detection (LOD) of 3.8 nM. Importantly, SiO 2 @COFs-BDY-HOCl enabled real-time fluorescence imaging of HOCl fluctuations in palmitate-stimulated hepatocytes, thereby providing a powerful platform for the early diagnosis of NAFLD through ratiometric fluorescence imaging HOCl, an inflammation-related factor.
研究领域:
生物医学工程
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分析化学
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分子成像
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纳米材料
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肝脏病学
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炎症研究
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yabin Li,Jingyao Qi,Jimin Shen,Binyuan Wang,Jing Kang,Pengwei Yan,Yizhen Cheng,Li Li,Linlu Shen,Zhonglin Chen
Extensive studies revealed that Cl - could inhibit the removal of targeted pollutants under low Cl - conditions in the peroxymonosulfate (PMS) system. However, the enhanced effect of Cl - has always been overlooked under high Cl - conditions. Here, we find that high concentration of Cl - played a critical role in bisphenol S (BPS) degradation by activating PMS using 16%-CoFe 2 O 4 @PAL (16% [email protected] ). The removal of BPS was sharply enhanced after introducing 0.5 and 1.0 M Cl - , and the corresponding k obs increased to 0.922 min −1 and 1.103 min −1 , which was 6-fold and 7-fold higher than the control (0.144 min −1 ), respectively. HOCl was demonstrated as the dominant species for removing BPS in 16% [email protected] /PMS system under high Cl - circumstances. The typical chlorinated BPS intermediates were identified, which showed higher eco-toxicity than BPS. The chlorinated byproducts along with their toxicity could be effectively eliminated after 30 min. The possible formation mechanism of chlorinated products was further revealed by theoretical calculations. Toxicity assessment experiments showed that BPS significantly affected hormone levels of zebrafish and showed toxicity on the testis and liver of zebrafish, which could be reduced using 16% [email protected] /PMS system. This study attracts attention to the overlooked HOCl in PMS-based processes under high salinity conditions.
研究领域:
环境科学
·
化学工程
·
毒理学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2019
·
IF 7.149
Yan Zhang,Jinhua Li,Jing Bai,Linsen Li,Shuai Chen,Tingsheng Zhou,Jiachen Wang,Ligang Xia,Qunjie Xu,Baoxue Zhou
The conversion of excess ammonia N into harmless N2 is a primary challenge for wastewater treatment. We present here a method to generate ClO• directionally for quick and efficient decomposition of NH4+ N to N2. ClO• was produced and enhanced by a bifacial anode, a front WO3 photoanode and a rear Sb–SnO2 anode, in which HO• generated on WO3 reacts with HClO generated on Sb–SnO2 to form ClO•. Results show that the ammonia decomposition rate of Sb–SnO2/WO3 is 4.4 times than that of WO3 and 3.3 times than that of Sb–SnO2, with achievement of the removal of NH4+ N on Sb–SnO2/WO3 and WO3 being 99.2 and 58.3% in 90 min, respectively. This enhancement is attributed to the high rate constant of ClO• with NH4+ N, which is 2.8 and 34.8 times than those of Cl• and HO•, respectively. The steady-state concentration of ClO• (2.5 × 10–13 M) is 102 times those of HO• and Cl•, and this is further confirmed by kinetic simulations. In combination with the Pd–Cu/NF cathode to form a denitrification exhaustion system, Sb–SnO2/WO3 shows excellent total nitrogen removal (98.4%), which is more effective than WO3 (47.1%) in 90 min. This study provides new insight on the directed ClO• generation and its application on ammonia wastewater treatment.
研究领域:
环境科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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