LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Lanqing Yang,Qiuya Li,Baoqing Bai,Tao Bo,Ligang Yu,Xu Jing,Shu Qin,Huilin Liu,Ying Zhang,Yukun Yang
Aflatoxin B1 (AFB1), a highly toxic mycotoxin prevalent in agricultural products, poses severe health threats. Addressing the critical need to mitigate AFB1-induced food safety risks, the primary objective of this study was to develop an accurate and ultrasensitive colorimetric/electrochemical (CL/EC) dual-mode aptasensor for AFB1 detection. To achieve this aim, we employed 3,3′,5,5′-tetramethylbenzidine (TMB) as a dual-function indicator. The catalytic oxidation of TMB generated oxidized oxTMB, concurrently producing colorimetric and electrochemical signal. Central to realizing the sensor's dual functionality, BSA@HOF-101 nano-enzymes were generated by in situ encapsulation of bovine serum albumin (BSA) in hydrogen-bonded organic frameworks (HOFs), which were indispensable enzyme mediators for the dual function of TMB. To specifically detect AFB1, BSA@HOF-101 was coupled with aptamer (Apt). The CL/EC dual-mode aptamer sensor offered detection of AFB1 across a concentration range from 10 −11 to 10 −7 g/mL. In addition, the sensor was successfully applied to the detection of AFB1 in corn and peanut samples with recoveries as high as 97.4 %–104.0 %. Collectively, this work established a robust analytical strategy with a dual-mode readout, providing a promising solution for the rapid and precise on-site monitoring of AFB1 contamination.
研究领域:
分析化学
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纳米技术
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食品安全
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生物传感器
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环境监测
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2025
·
IF 9
Menghao Lin,Juan Liu,Wenyu Zhou,Can Deng,Yaohan Du,Lichun Dong,Cailong Zhou
Hydrogen-bonded organic frameworks (HOFs), as a novel type of porous material formed by intermolecular hydrogen bonds, possess outstanding characteristics such as excellent solution processability and mild synthesis conditions, and exhibit great potential in the field of molecular separation. In this study, we synthesized one-dimensional needle-like HOF–F particles at low temperature through a simple method. These particles as fillers and cellulose acetate as polymer matrix were used to prepare HOF–F/CA mixed matrix membranes (MMMs). The MMMs were further applied in the field of molecular separation. A maximum interception rate of 99.1 % for dyes like Congo red was achieved, and a long-term separation of nearly 130 h could be maintained. Regarding per- and polyfluoroalkyl substances (PFAS) pollutants, the maximum interception rate could also reach 98.3 %. This research achievement has opened a new path for the practical application of HOFs in molecular separation and is expected to promote the further development of related fields.
研究领域:
材料科学
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化学工程
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分离技术
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Bai-Chuan Zhao,Yao-Yu Pan,Si-Jie Liao,Zhi-Ke He,Wei Xie,Ai-Guo Shen
The development of efficient trace sensing and green photodegradation synergetic system for antibiotics has become increasingly significant in ecological environmental risk prevention. Herein, a recyclable self-cleaning surface-enhanced Raman scattering (SERS) hybrid system was developed by in-situ deposition of gold nanoparticles (Au NPs) on hydrogen-bonded organic framework (HOF) nanorods. The hybrid system possessed excellent trace SERS detection performance (10 −13 M for rhodamine 6G), attributed to the considerable molecular enrichment capacity of HOFs and the intense local surface plasmon resonance (LSPR) effect of Au NPs. The hot-electron transfer pathway activated by the deposition of Au NPs extremely inhibited the hot carrier recombination and therefore induced a self-cleaning capacity of the hybrid system. Notably, the Au NPs decorated HOFs accomplished trace SERS sensing (10 −10 M) for ciprofloxacin with good self-cleaning and reusable capabilities. This work provides a new material construction strategy for the reusable trace monitoring and green removal of antibiotics, possessed with an enormous application potential in ecological environmental risk prevention.
研究领域:
环境科学
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纳米技术
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分析化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
·
IF 19
Ke Zhang,Xiaotong Lu,Yuhong Zhuo,Ya Li,Ting Yao,Yusi Li,Wei Yao,Dongqin Yu,Chao Qi,Kaiyong Cai
Disulfidptosis, a novel programmed cell death mechanism triggered by glucose deprivation in solute carrier family 7 member 11 (SLC7A11)-overexpressing tumors, facilitates the release of tumor-associated antigens (TAAs) and activates immune responses, providing a new strategy to enhance immunotherapy by converting redox vulnerabilities into immunogenic opportunities. Herein, a hydrogen-bonded organic frameworks (HOFs)-based cascade biocatalyst is constructed to boost disulfidptosis-mediated antitumor immunotherapy. Engineered via charge-mediated assembly, peroxidase-mimetic iron-porphyrin HOFs are integrated with glucose oxidase (GOx) to establish a microenvironmental self-optimizing catalytic network. The HOFs architecture not only enhances GOx stability but also converts enzymatically generated H 2 O 2 into cytotoxic hydroxyl radicals. Simultaneously, GOx-mediated glucose depletion acidifies the catalytic cavity microenvironment within HOFs, thereby amplifying catalytic efficiency. This biocatalysis system disrupts redox homeostasis, induces glucose deprivation, and activates disulfidptosis. By coupling immunogenic antigen release with oxidative damage, the platform transforms redox vulnerabilities into immune-activating signals, effectively converting “cold” tumors into immunologically active states. This molecularly engineered approach pioneers the construction strategy of cavity self-acidized HOFs-based biocatalysts that harmonize divergent catalytic conditions, enabling cross-scale biocatalysis, and offers a paradigm shift in cancer immunotherapy by integrating metabolic intervention, immunogenic cell death, and microenvironment remodeling into a unified therapeutic strategy.
研究领域:
癌症生物学
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免疫治疗
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纳米技术
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生物化学
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材料科学
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生物催化
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氧化还原生物学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
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2026
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IF 5.2
Wang Libin,Li Minghao,Chen Yao,Zhang Xiaomei,Hu Lupeng,Jiang Jinhua,Zhang Peihua,Fu Shaoju
Piezoelectric fabrics are urgently required by flexible
wearable
electronics applications for their advantages, such as high sensitivity,
wearer comfort, and environmental compatibility. However, existing
piezoelectric materials are often limited by poor comfort and a lack
of multifunctionality, making it difficult to reconcile sweat management
on the skin-contacting side with efficient mechanical energy harvesting.
Herein, a biodegradable poly( l -lactic acid) (PLLA) matrix
integrated with MXene and hydrogen-bonded organic frameworks (HOFs)
was employed to fabricate a PLLA/Mxene/HOFs self-powered nanofiber
membrane, serving as the basis for a flexible piezoelectric fabric
(PHMF) sensor with unidirectional moisture-guiding functionality.
The integration of HOFs and MXene into electrospun PLLA nanofibers
through hydrogen-bonding interactions elevated the glass transition
and melting temperatures. The PHMF sensor exhibited a tensile strength
of 5.61 MPa, and it consisted of Coolmax yarn and a hydrophobic layer
and allowed sweat to move from the inner layer near the skin to the
outer layer in 0.06 s. When sweat was applied to the inner layer,
the moisture content of the inner layer quickly increased to 650%
within 10 s before gradually decreasing to around 264%, while the
moisture content of the outer layer accumulated to 470%. The PHMF
sensor exhibited strong piezoelectric performance, with an open-circuit
voltage of 26 V measured at 3 Hz under dry conditions, response and
recovery times of 122.25 and 80.15 ms, respectively, and favorable
stability after 5000 cycles. This work demonstrates the potential
of eco-friendly and multifunctional PHMF sensors for flexible, wearable
electronics.
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yao Liu,Runzi Zhang,Xiaoyu Yang,Li Tang,Bing Shao,Yi He,Xiao Yang
With the growing public concern over environment and food safety, the detection of trace amounts of bisphenols S (BPS) becomes crucial. In this work, an ultrasensitive surface-enhanced Raman scattering (SERS) biosensor was developed based on hydrogen-bonded organic frameworks@horseradish peroxidase (HOFs@HRP) and hollow bowl-shaped SERS substrates (AFRNBs@AuNPs) for the detection of BPS. Due to the excellent biocompatibility and mild synthesis conditions, HOFs had been utilized as protective matrices for HRP, effectively preserving its enzymatic activity. Furthermore, hollow bowl-like morphology AFRNBs@AuNPs were successfully prepared as efficient SERS substrate. When BPS was present, the stronger affinity between BPS and its aptamer triggered a displacement reaction, allowing HOFs@HRP to bind with AFRNBs@AuNPs, thereby enabling the catalytic conversion of TMB into oxTMB and generating a detectable Raman signal. Accordingly, the biosensor exhibited a detection limit of 1.28 × 10 −12 M. This method pioneers a new approach for trace BPS detection, demonstrating broad application prospects.
研究领域:
分析化学
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环境科学
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食品安全
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生物传感
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纳米材料
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分子生物学
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转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Lijun Yang,Tiantian Zhou,Zhiyi Zhang,Wei Qi,Mengfan Wang
The enzymatic oxidation of amino acids using amino acid oxidases (AAOs) as biocatalysts for α-keto acid synthesis has garnered increasing attention due to its environmental friendliness and exceptional reaction efficiency. However, the by-product H 2 O 2 inevitably causes the decarboxylation of α-keto acids and subsequently deactivates the enzyme. Herein, we used a simple in-situ biomineralization method to immobilize Pt NPs with catalase-like activity and L-amino acid oxidase (LAAO) in to a hydrogen-bonded organic framework ( TW HOF) under a mild condition, and the synthesized LAAO-Pt@ TW HOF cascade catalytic system was applied to synthesis of α-keto acid. Compared with free LAAO, the LAAO-Pt@ TW HOF exhibited a 3.3-fold activity, well reusability and complete conversion (100 %) of L-tryptophan to indole-3-pyruvic acid was achieved. This work offers a potential application of HOF materials in constructing high-efficiency enzyme-metal coupled catalyst for cascade reactions.
研究领域:
生物化学
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材料科学
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催化反应
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Yao Liu,Runzi Zhang,Xiaoyu Yang,Yi He,Xiao Yang
With the increasing concern for ecological environmental and food safety, the development of synergistic systems integrating efficient bisphenol trace sensing and green photocatalytic degradation has emerged as a current research focus. In this study, a novel surface-enhanced Raman scattering (SERS) sensing-degradation integrated platform was successfully developed for the detection and degradation of bisphenol through the uniform modification of hydrogen-bonded organic framework nanorods loaded with gold nanoparticles (HOFs@Au). Based on the remarkable molecular enrichment effect of the porous structure of HOFs and the strong localized surface plasmon resonance (LSPR) effect from the AuNPs, the composite system exhibited excellent trace detection performance. Experimental results revealed that the HOFs@Au not only enabled trace SERS detection of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF), but also demonstrated excellent photocatalytic degradation performance. Based on the advantages of HOFs@Au, the SERS sensor demonstrated a detection limit as low as 10 −8 M, a high enhancement factor (EF) of 2.3 × 10 5 and photodegradation removal efficiency as high as 80 %, providing a novel solution for precise monitoring and green remediation of bisphenol contaminants. The system shows great potential for applications in ecological environmental risk early warning and food safety monitoring.
研究领域:
分析化学
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纳米技术
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环境科学
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材料科学
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食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYHEDRON
·
2025
·
IF 2.6
Chaochao Fan,Huanhuan Duan,Yue Wang,Wei Zuo,Wei Sun,Chuandong Jia
The assembly of hydrogen-bonded organic frameworks (HOFs) has been one of the focuses of supramolecular chemistry, while the HOFs based on organophosphate anion and neutral tecton have rarely been reported. Herein we utilized the emerging anion coordination-driven assembly (ACDA) strategy to successfully construct one novel two dimensional (2D) porous hydrogen-bonded organic framework ( 1 ) formed by the anion coordination of neutral and commercially available 2-benzimidazolone as hydrogen bonding donor, namely ligand L 1 , with organophosphate anion (PhOPO 3 2− ) as hydrogen bonding acceptor in a single-step crystallization. The assembly of organophosphate-directed 2D HOF was elucidated by single crystal X-ray diffraction analysis, in which the bridged water molecule played a significant role in respect of the formation of the O H⋯O hydrogen bonds and N H⋯O hydrogen bonding. Interestingly, TEA + cations were encapsulated within the aromatic cavities of the grid-like HOF mainly through C H⋯π interactions. This study is looking forward to furnishing new insights into the construction of hydrogen-bonded molecular frameworks with porosity utilizing anion coordination chemistry.
研究领域:
超分子化学
·
材料科学
·
晶体工程
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阴离子配位化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yukun Yang,Xiaoyi Zhang,Xiaomin Wang,Xu Jing,Ligang Yu,Baoqing Bai,Tao Bo,Jinhua Zhang,Hailong Qian,Ying Gu
As an emerging porous material, hydrogen-bonded organic framework materials (HOFs) still pose application challenges. In this work, the designed type “I + II” heterojunction extracted hot electrons from HOFs using quantum dots (QDs) and polypyrrole (Ppy), improving the stability and photoelectrochemical performance of materials. In addition to serving as a potential well, electropolymerized Ppy was used as a recognition element for bisphenol A (BPA), and a novel self-powered molecularly imprinted photoelectrochemical (MIP–PEC) sensor was designed. The sensing platform showed a linear relationship from 1 × 10 −10 to 1 × 10 −7 mol∙L −1 and from 1 × 10 −7 to 1 mol∙L −1 with an acceptable detection limit of 4.2 × 10 −11 mol∙L −1 . This is the first application of HOFs in constructing MIP–PEC sensors and a new attempt to improve the stability of HOFs for the application of porous crystal materials in the sensing field.
研究领域:
分析化学
·
材料科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）