ACS Food Science & Technology
·
2025
·
IF 2.8
Walaa Kobacy,Ahmed K. Rashwan,Ahmed I. Osman,Ashraf K. Abu-Zaid,Ahmed R. Mazeed,Reda M. Mohamed
This study investigates the physicochemical, antioxidant, and anticancer properties of four Egyptian honey types: clover, fennel, sidr, and multiflower. These honeys exhibited significant variability in color, pH, acidity, sugars, and enzymatic activity. The fennel honey demonstrated the highest content of total phenolic (TPC) of 238.76 mg GAE/100 g, and the total flavonoid (TFC) was 94.06 mg QE/100 g. In addition, the antioxidant activity as measured by DPPH radical scavenging correlated strongly with bioactive compound concentrations, with fennel honey showing the highest inhibition (60.14%). In vitro cytotoxicity assays against Hep-2 human laryngeal cancer cells revealed fennel honey to have the lowest IC50 value (70 μg/mL), followed by multiflower honey (IC50 = 87 μg/mL), confirming a significant relationship between the TPC, TFC, and the anticancer effects. This highlights the role of bioactive compounds in honey as potential natural anticancer agents. Clover honey exhibited the weakest cytotoxicity (IC50 = 130 μg/mL) with the lowest TPC and TFC. These findings underscore the potential of Egyptian honey varieties, particularly fennel and multiflower honeys, as promising natural sources of antioxidants and anticancer agents, suggesting a beneficial therapeutic role in cancer prevention. Further studies are needed to elucidate the detailed mechanisms by which honey compounds exert these anticancer effects.
研究领域:
食品科学
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肿瘤学
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生物化学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 12
·2074-2080
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IF 5.047
Yong Jian Jiang,Min Lin,Tong Yang,Rong Sheng Li,Cheng Zhi Huang,Jian Wang,Yuan Fang Li
Nitrite (NO2−) is one of the important pollutants in food and the environment, which can seriously endanger the health of human beings. Therefore, detecting nitrite in food, environmental and biological samples is very significant for health monitoring. Herein, polymer carbon dots (PCDs) doped with nitrogen and phosphorus were prepared by polymerization of ascorbic acid (AA) and polyethylenimine (PEI) with phosphoric acid, and exhibited excellent stability, adjustable fluorescence emissions and good biocompatibility. It was found that the PCDs presented a sensitive response to nitrite (NO2−), and they were successfully applied for NO2− analysis in water and milk samples, and the dynamic monitoring of nitrite entry into Hep-2 cells.
研究领域:
分析化学
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环境科学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 3
·期 1
·119-126
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IF 0
Yinan Zhao,Shubiao Zhang,Yuan Zhang,Shaohui Cui,Huiying Chen,Defu Zhi,Yuhong Zhen,Shufen Zhang,Leaf Huang
Several novel tri-peptide cationic lipids were designed and synthesized for delivering DNA and siRNA. They have tri-lysine and tri-ornithine as headgroups, a carbamate group as a linker and 12 and 14 carbon atom alkyl groups as tails. These tri-peptide cationic lipids were prepared into cationic liposomes for the study of the physicochemical properties and gene delivery. Their particle size, zeta potential and DNA-binding were characterized to show that they were suitable for gene transfection. Further results indicate that these lipids can transfer DNA and siRNA very efficiently into NCI-H460 and Hep-2 tumor cells. The selected lipid, CDO14, was able to deliver combined siRNAs against c-Myc and VEGF for silencing distinct oncogenic pathways in lung tumors of mice, with little in vitro and in vivo toxicity.
研究领域:
药学
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分子生物学
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癌症研究
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产品关联
DOI
PubMed
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2011
·
IF 2.089
Xuejun Huang,Yao Chen,Changwei Wang,Hui Wang
Mutual solubility data of water + pentan-1-ol and liquid−liquid equilibrium of water + pentan-1-ol +2,6,6-trimethylbicyclo[3.1.1]hep-2-ene (α-pinene) and water + pentan-1-ol + 6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane (β-pinene) have been measured experimentally at (293.15, 303.15, 313.15, and 323.15) K under atmospheric pressure. The estimated uncertainty of phase composition and temperature were about (0.0005 and 0.05) K, respectively. The experimental ternary liquid−liquid equilibrium data have been simultaneously predicted and correlated by the extended and modified UNIQUAC models.
研究领域:
化学工程
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热力学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）