Ruixue Guo,Xinbo Guo,Xiaodan Hu,Arshad Mehmood Abbasi,Lin Zhou,Tong Li,Xiong Fu,Rui Hai Liu
The purpose of this work was to improve the oral bioavailability of a poorly soluble functional food ingredient, the total flavones of Hippophaë rhamnoides L. (TFH). A self-microemulsion drug delivery system (SMEDDS) was developed to overcome the problems of poor absorption of TFH in vivo . The optimal SMEDDS significantly enhanced the solubility of TFH up to 530 times compared to that in water. The mean droplet size was 61.76 nm with uniform distribution. And the loaded system was stable at 25 °C for 3 mo with transparent appearance. The in vitro release of TFH from SMEDDS was faster and more complete than that from suspension. After oral administration of TFH–SMEDDS in rats, the relative bioavailability of TFH was dramatically improved for 3.09 times compared with the unencapsulated form. The investigation indicated the potential application of SMEDDS as a vehicle to improve the oral bioavailability of TFH. Practical Application The lipid-based nanotechnology, namely self-microemulsion drug delivery system (SMEDDS) was used to improve the bioavailability and oral delivery of total flavones of Hippophaë rhamnoides L. (TFH). The relevant bioavailability of TFH could be remarkably 3-fold improved by the optimized SMEDDS. The SMEDDS produced via a simple one-step process for poorly soluble TFH to achieve a significant improvement in the bioavailability, may endorse the promising utilization of TFH in functional foods as well as pharmaceutical fields with an enhanced absorption in vivo .
Yaping Zheng,Kangmeng Sun,Xinyuan Sun,Yue Li,Peigen Xiao,Chunnian He
Sea buckthorn is rich in active ingredients, widespread, and has both medicinal and nutritional value. The present comparative study of wild and cultivated species remains insufficient, which is not conducive to their quality control. Therefore, this study aimed to compare the differences of 21 sea buckthorn samples in total phenolic content (TPC), total flavonoid content (TFC), phenolic components content, secondary metabolites, and antioxidant capacity and the fatty acid, to investigate the quality differences of different varieties. The TPC, TFC and antioxidant activity of wild varieties were higher than those of the cultivated. Multivariate statistical analysis revealed large differences in phenolic content, with higher levels of gallic acid and isorhamnetin-3- O -neohesperidin in the wild, whereas the cultivated were characterized by narcissin and kaempferol. These findings provided the scientific basis for the improvement of quality evaluation standards for different varieties and offered new insights for the further development of sea buckthorn resources.
Sea buckthorn ( Hippophaë rhamnoides L.) pulp oil (SPO) is enriched in natural bioactive components with high pharmacological activities. However, the presence of polysaccharides affects oil quality. Herein, the effects of different polysaccharide-adsorption treatments on the bioactive components and the in vitro antioxidant activities of SPO were investigated. The results demonstrated that the microwave-assisted activated clay (MAE-ACL) adsorption was more effective than the ultrasound-assisted activated clay adsorption for removing polysaccharides. Although the bioactive component levels and antioxidant activities of the SPO were reduced during the adsorption, the squalene content showed no significant difference. By performing principal component and correlation analyses that further evaluated the connection between the bioactive components and the free radical scavenging activities of SPO, MAE-ACL was determined to be the more suitable polysaccharide-adsorption treatment.
危险品化学品经营许可证（带存储）