JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Xiao-Han Wang,Bingyou Jiang,Chunshan Zheng,Gaochao Pan,Shiju Wang,Yi Zhang,Ben Ji
The pore and wetting characteristics of bituminous coal and anthracite treated with different proportions of tetrasodium iminodisuccinate (IDS) and sodium dodecyl sulfate (SDS) were measured. The pore structure characteristics of the coal were studied via low-temperature nitrogen adsorption analysis and the Frenkel-Halsey-Hill fractal theory. Zeta potential measurements were conducted to quantitatively analyze the degree of aggregation or dispersion of coal particles dissolved in solution. Changes in the coal surface morphology were observed and analyzed by scanning electron microscopy (SEM). The results show that when the ratio of IDS:SDS is 1:3, the specific surface area (SSA) values of bituminous coal and anthracite are the lowest. The composite reagent has a greater effect on improving the pore structure of anthracite than bituminous coal. Compared with bituminous coal, anthracite has better pore connectivity and a wider pore network. The absolute zeta potentials of bituminous coal and anthracite reach the maximum at an IDS:SDS ratio of 1:3, with values of 91.08 mV and 91.35 mV, respectively. The electrostatic potential distributions of the molecules show that the advantages of the electrostatic potential difference with water molecules enable IDS and SDS molecules to effectively attract water molecules and form hydrogen bonds, thus revealing the optimization mechanism of coal wettability .
研究领域:
矿物学
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表面化学
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产品关联
DOI
高影响因子
MINERALS ENGINEERING
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2021
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IF 4.765
Mengyuan Zeng,Bingqiao Yang,Hanquan Zhang,Feifei Jia
Phosphate concentrates are widely used as primary sources in the production of fertilizers worldwide, but the efficient removal of dolomite from apatite in flotation relies heavily on selective depressants. Conventional apatite depressants such as sulfuric and phosphoric acid inevitably cause serious environmental pollution . It is urgent to explore green and efficient depressants to substitute conventional ones for the clean production of phosphate concentrate. In this work, iminodisuccinic acid (IDS) was explored as an efficient and environmental-friendly dolomite depressant in the direct flotation of apatite from dolomite. The depression performances were evaluated by micro-flotation and the interaction mechanism was revealed through adsorption capacity, Microcalorimetry , Zeta potential , Fourier Transform Infrared (FTIR), X-ray Photoelectron Spectroscopy (XPS) and Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) measurements. Mico-flotation results showed that IDS selectively depressed dolomite but hardly affected apatite flotation, improving the separation efficiency and upgrading the quality of apatite concentrates successfully. Mechanism study demonstrated that IDS preferentially adsorbed on dolomite due to its higher affinity to Mg sites on dolomite. IDS was dominantly chelated with Mg sites to form octahedral complexing structure via the coordination of COO − with Mg sites. While IDS was weakly adsorbed on apatite thought weak hydrogen bond between F sits of apatite with carboxyl within IDS. The pre-adsorption of IDS impeded NaOL adsorption on dolomite, but didn’t influence the NaOL adsorption on apatite. The work proved that IDS could be used as a green and selective dolomite depressant for the clean flotation of apatite from dolomite, which is of great importance for the sustainable production of fertilizer.
研究领域:
矿物加工工程
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环境科学
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DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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2021
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IF 5.051
Heping Zhu,Shilong Ying,Bingluo Zhou,Xinyang Hu,Xiao Liang,Wangyu Li,Dungai Wang,Hongchuan Jin,Yuanjiang Pan
Colorectal cancer (CRC) is a common malignant tumour of human digestive tract. The high mortality rate of CRC is closely related to the limitations of existing treatments. Thus, there is an urgent need to search for new anti-CRC agents. In this work, twenty novel coumarin-dithiocarbamate derivatives (IDs) were designed, synthesized and evaluated in vitro. The results suggest that the most active compound ID-11 effectively inhibited the proliferation of CRC cell lines while shown little impact on normal colon epithelial cells. Mechanism studies revealed that ID-11 displayed bromodomain-containing protein 4 inhibitory activity, and induced G2/M phase arrest, apoptosis as well as decreased the expression levels of the key genes such as c-Myc and Bcl-2 in CRC cell lines. Moreover, the ADMET properties prediction results shown that ID-11 possess well metabolic characteristics without obvious toxicities. Our data demonstrated that compound ID-11 may be a promising anti-CRC agent and deserved for further development.
研究领域:
药物化学
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肿瘤学
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分子生物学
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药物发现
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Zhiwen Guan,Fen Jiao,Lin Zhang,Tao Wei
With the increasing of application fields and market demand of barite and fluorite, the research of flotation separation of barite and fluorite has attracted much attention. In this work, a novel biodegradable fluorite depressant, tetrasodium iminodisuccinate (IDS) was developed for the flotation separation of barite and fluorite in sodium dodecyl sulfonate (SDSN) system, and its interaction mechanism were revealed. The micro-flotation results proved IDS had a strong depressant on fluorite at pH 6–11. Under the best conditions (pH 8, IDS 30 mg/L, SDSN 1 × 10 -4 mol/L), the BaSO 4 grade and recovery in the concentrate reached 90.15 % and 92.00 %, and the CaF 2 grade and recovery in the tailing reached 89.77 % and 95.32 %, which indicated that IDS could achieve the separation of barite and fluorite. Zeta potential, contact angle, Fourier Transform Infrared Spectrometer (FTIR), X-ray Photoelectron Spectroscopy (XPS) and Density Functional Theory (DFT) calculation indicated that IDS was chemisorbed on the fluorite, forming a bidentate binuclear stable adsorption configuration through the coordination of O with Ca site of fluorite, while a weak physical adsorption occurred between IDS and barite. Furthermore, the pre-adsorption of IDS hindered the binding between SDSN and fluorite, while the effect on barite was negligible. Therefore, IDS as a biodegradable and high-selectivity depressant, has potential value in the separation of barite and fluorite.
研究领域:
矿物加工工程
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表面化学
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理论计算
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Zhou Wentao,Gao Yali,Cao Jianhang,Zhang Ziyuan,Kang Fenghua,Ran Ke,He Zhiyu,Zhou Shixuan,Li Yintao
To address the limitations of conventional strippable materials (prolonged curing, poor substrate adaptability), this study developed a novel decontamination composite by incorporating tetrasodium iminodisuccinate (IDS) modified sodium montmorillonite (Na-Mt) into two-component polyurethane (2KPU). The modified Na-Mt exhibited expanded interlayer spacing (1.26 → 1.51 nm) and enhanced adsorption capacities for Cs(I), Sr(II), and Cd(II) by 58.5, 66.8, and 45.2 mg/g, respectively. Optimized composites achieved 21.6% higher peel strength, 12°C increased thermal stability, and > 95% decontamination rates across substrates (99.6% for Cs). Notably, rough-surface decontamination efficiency surpassed pure 2KPU by 6%. This fast-curing (≤ 30 min), high-performance material demonstrates significant potential for radionuclide removal in nuclear facility applications.
研究领域:
环境科学
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材料科学
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核工程
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化学工程
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吸附技术
✓ 已验证
产品关联
DOI
高影响因子
Biomed Research International
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2021
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IF 3.411
Ling Kui,Min Li,Xiaonan Yang,Ling Yang,Qinghua Kong,Yunbing Pan,Zetan Xu,Shouling Wang,Dandan Mo,Yang Dong,Yao Liu,Jianhua Miao
Lung cancer is known as the leading cause which presents the highest fatality rate worldwide; non-small-cell lung cancer (NSCLC) is the most prevalent type of lung carcinoma with high severity and affects 80% of patients with lung malignancies. Up to now, the general treatment for NSCLC includes surgery, chemotherapy, and radiotherapy; however, some therapeutic drugs and approaches could cause side effects and weaken the immune system. The combination of conventional therapies and traditional Chinese medicine (TCM) significantly improves treatment efficacy in lung cancer. Therefore, it is necessary to investigate the chemical composition and underlying antitumor mechanisms of TCM, so as to get a better understanding of the potential natural ingredient for lung cancer treatment. In this study, we selected 78 TCM to treat NSCLC cell line (A549) and obtained 92 transcriptome data; differential expression and WGCNA were applied to screen the potential natural ingredient and target genes. The sample which was treated with A. pierreana generated the most significant DEG set, including 6130 DEGs, 2479 upregulated, and 3651 downregulated. KEGG pathway analyses found that four pathways (MAPK, NF-kappa B, p53, and TGF-beta signaling pathway) were significantly enriched; 16 genes were significantly regulated in these four pathways. Interestingly, some of them such as EGFR, DUSP4, IL1R1, IL1B, MDM2, CDKNIA, and IDs have been used as the target biomarkers for cancer diagnosis and therapy. In addition, classified samples into 14 groups based on their pharmaceutical effects, WGCNA was used to identify 27 modules. Among them, green and darkgrey were the most relevant modules. Eight genes in the green module and four in darkgrey were identified as hub genes. In conclusion, we screened out three new TCM (B. fruticose, A. pierreana, and S. scandens) that have the potential to develop natural anticancer drugs and obtained the therapeutic targets for NSCLC therapy. Our study provides unique insights to screen the natural components for NSCLC therapy using high-throughput transcriptome analysis.
研究领域:
癌症生物学
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药理学
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分子生物学
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生物信息学
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传统中药
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）