Advanced Science
·
2025
·
IF 14.1
Xingdie Zhou,Zhendong Lv,Zehao Chen,Yiming Xu,Chao Lin,Li Liu,Hao Chen,Bing Niu,Wenguo Cui,Yuhui Zhang
Disruption of low oxygen tension homeostasis during intervertebral disc degeneration inhibits endogenous stem cell viability and function, posing a challenge for endogenous regeneration. Here, to achieve sustained hypoxia manipulation, constructed hypoxia-inducible interpenetrating polymer network (IPN) hydrogel microspheres (HIMS) are constructed by microfluidics to integrate the hypoxic system with a stabilizing network. The IPN is synthesized through a two-step polymerization process, consisting of rapid photo-crosslinked gelatin methacrylate anhydride (GM) polymer I and slow enzyme-crosslinked vanillin-grafted gelatin (GV) polymer II. The enzymatic reaction between GV and laccase is able to create a hypoxic microenvironment to modulate oxygen tension in situ within the injured region. HIMS can reduce microenvironmental oxygen tension by 1/3 and maintain a hypoxic microenvironment for up to 5 days, thereby activating the PI3K/AKT/HIF-1α signaling pathway in endogenous stem cells to promote differentiation into nucleus pulposus-like cells. Additionally, NSC-Exos are loaded onto HIMS to trigger endogenous progenitor/stem cell recruitment and migration. Both in vitro and in vivo assays demonstrate that NSC-Exos@HIMS facilitates stem cell recruitment, targets differentiation, and stimulates extracellular matrix synthesis. Overall, the microspheres established herein provide a novel strategy for manipulating oxygen tension and enhancing endogenous tissue regeneration in injured regions during intervertebral disc degeneration.
研究领域:
组织工程
·
再生医学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2023
·Vol. 13
·期 2
·268
·
IF 5.3
La Shi,Xiaolong Fu,Yang Li,Shuxin Wu,Saiqin Meng,Jiangning Wang
The mechanical properties of HTPE/PEG interpenetrating polymer network (IPN) binders were systemically studied with molecular dynamics (MDs) simulations and experiments. In this study, an algorithm was used to construct the crosslinking interpenetrating polymer network models and then the mechanical behaviors of Hydroxyl-terminated polyethylene glycol-tetrahydrofuran co-polyether/poly ethylene glycol (HTPE/PEG) IPN models were analyzed at a molecular scale. Firstly, glass transition temperatures (Tg), mean square displacement (MSD) and mechanical properties of IPN crosslinked model simulations showed that better thermomechanical parameters appeared at low temperatures, which were in good agreement with the experimental methods, including dynamic mechanical analysis and uniaxial tensile. Then bond-length distribution was performed to verify the crosslinked structures between prepolymers and curing agents. FTIR-ATR spectra analysis of four IPN binder specimens also gave a convictive result to the special interpenetrating polymer network of polyether polyurethane binders. Cohesive energy density and friction-free volume explained how the micro-structures of IPN crosslinked models and the force of inter-molecule chains affected the mechanical behaviors of the HTPE/PEG polyurethane matrix. Lastly, the morphology of IPN binder specimen tensile fracture indicated the mechanism at different temperatures. These studies were helpful in understanding the mechanical properties of HTPE/PEG interpenetrating polymer network binders and provide molecular insight into mechanisms of mechanical behaviors, which would guide the property improvement of HTPE propellant.Keywords:HTPE/PEG;IPN;mechanical properties;molecular dynamic simulation;crosslinking structures
研究领域:
高分子科学
·
材料科学
·
机械工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 5
·1-11
·
IF 2.426
Pan Zheng,Lv Yukai,Chen Yulong,Qian Xin
Waterproofing layers play a pivotal role in tunnel engineering and building basements. Magnesium acrylate (CA-Mg 2 ) shot-membrane waterproofing materials- commonly used as a waterproof layer- is a type of hydrogel. Poly(vinyl alcohol) (PVA) solution subjected to freezing/thawing treatment has been added to a CA-Mg 2 monomer, resulting in the formation of a CA-Mg 2 /PVA interpenetrating polymer network (IPN) hydrogel which can produced by a redox initiation system. This new IPN hydrogel contains not only a CA-Mg 2 network formed with Mg 2+ coordination bonds, but also a PVA network created by hydrogen bonding between hydroxyl groups. In comparison to CA-Mg 2 hydrogels, the fracture stress of the CA-Mg 2 /PVA hydrogel increased from 0.45 MPa to 0.72 MPa, elongation from 602% to 854%, and the self-healing efficiency of the IPN hydrogel reached 99.9% over 3 h. A new shot-membrane waterproofing materials based on the CA-Mg 2 /PVA hydrogel was prepared and its fracture stress was 1.44 MPa, and self-healing efficiency 80%, at 3 h. In addition, damage to the hydrogel could be repaired repeatedly.
研究领域:
材料科学
·
土木工程
·
化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Neng Hu,Li Lin,Jun Tan,Weijia Wang,Lin Lei,Huiqing Fan,Jiping Wang,Peter Müller-Buschbaum,Qi Zhong
The risk of extensive exposure of the human epidermis to solar ultraviolet radiation is significantly increased nowadays. It not only induces skin aging and solar erythema but also increases the possibility of skin cancer. Therefore, a simply prepared, highly sensitive, and optically readable device for monitoring the solar ultraviolet radiation is highly desired for the skin health management. Because of the photoinitiated polymerization triggered by graphene-carbon nitride (g-C3N4) under ultraviolet radiation, g-C3N4 is homogeneously distributed in the hybrid hydrogels containing N-isopropylacrymide (NIPAM), poly(ethylene glycol) methyl ether methacrylate (OEGMA300), and sodium alginate (SA). By further immersing the hybrid hydrogels into calcium chloride solution, hybrid alginate-Ca2+/P(NIPAM-co-OEGMA300)/g-C3N4 interpenetrating polymeric network (IPN) hydrogels are obtained. Due to the homogeneous distribution of g-C3N4 and the existence of thermoresponsive polymers, the hybrid IPN hydrogels present good adsorption capability and high degradation efficiency for methylene blue (MB) especially at high temperature under ultraviolet radiation. Based on this unique property, the bracelet monitoring skin health is prepared by simply immersing the hybrid IPN hydrogels into the MB solution and then wrapping it with PET foil. Because the immersion time for the top, middle, and bottom parts of the hybrid IPN hydrogels is gradually increased, their colors vary from light to dark blue. A longer time is required for the discoloration of the darker part under solar ultraviolet radiation. Thus, the bracelet can be used to conveniently monitor the dose of solar ultraviolet radiation by simply checking the discoloration in the bracelet under sunshine. Due to the facile preparation and low cost of the bracelet, it is a promising candidate for wearable devices for skin health management.
研究领域:
材料科学
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生物医学工程
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皮肤健康管理
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可穿戴设备
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2019
·
IF 3.42
Panpan Hao,Ting Zhao,Lili Wang,Shaojie Liu,Erjun Tang,Xiaodong Xu
In this paper, a linear isocyanate terminated urethane oligomer, polyethylene glycol modified isophorone diisocyanate oligomer (PEG-IPDI), was prepared by the reaction of polyethylene glycol and isophorone diisocyanate. It is mixed as a cross-linking agent with an acrylic copolymer composed of 2-ethylhexyl acrylate, butyl acrylate, methyl methacrylate, hydroxyethyl acrylate and acrylic acid to form a network pressure sensitive adhesive (PSA) through the reaction of isocyanate groups in PEG-IPDI with hydroxyl and carboxyl groups in acrylic copolymer chains. By blending this network PSA with a photo-initiator and a trifunctional acrylic monomer in a certain ratio, the UV-curable PSA was obtained. After uniformly coating it on the treated polyethylene terephthalate film, a UV-induced peelable PSA tape for a silicon wafer dicing process was prepared. The PSA network formed before UV irradiation was held together with another network produced by UV irradiation of the trifunctional acrylate monomer to give an interpenetrating network (IPN) structure. The results showed that this novel UV-curable PSA tape with IPN structure had strong peel strength before UV irradiation, and could meet the fixed requirements of silicon wafer cutting process. After UV curing, the peel strength was remarkably lowered due to the formation of IPN structure. Compared to those semi-IPN structured PSA tapes prepared with traditional multi-functional urethane acrylate oligomers, the adhesion performances of IPN structured UV peelable PSA tape prepared in this work were similar, but the remaining adhesive on the wafer after the release of the UV cured tape was greatly reduced.
研究领域:
材料科学
·
粘合剂
·
聚合物化学
·
半导体制造
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产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2021
·
IF 5.03
Chao Ma,Kang Zhang,Feng Zhou,Yapeng Zheng,Wenru Zeng,Bibo Wang,Weiyi Xing,Weizhao Hu,Yuan Hu
Even though organophosphorus additives can improve flame retardancy and compress strength of flexible polyurethane foam (FPUF), but thermal stability and resilience are deteriorated. In this work, phosphorus-containing monoacrylate and triacrylate, (dimethoxyphosphoryl)methyl acrylate (DMPMA) and tris(acryloyloxymethyl)phosphine oxide (TAMPO), were synthesized. The liquid DMPMA and/or TAMPO were added into FPUF ingredients with radical initiator and polymerized in the heating process after foaming to form FPUF/polyacrylate composites. The neat and modified foams were controlled to have similar densities. Gel content of more than 96% was obtained for FPUF incorporated with TAMPO. And structure of interpenetrating polymer network (IPN) of FPUF3-5 loaded 20 wt% DMPMA and TAMPO of polyol (ratio of 3:1, 1:1 and 1:3 respectively) was further confirmed by their bicontinuous phase morphology with nanoscale domain uniformly distributed. All modified foams attain improved flame retardancy. Simultaneously increased thermal stability, compression force deflection (CFD) value and resilience were achieved by FPUF4-5. Especially, FPUF4 exhibits satisfied flame retardancy (limited oxygen index of 22.1%, pass of TB117-2000 vertical burning test, prolonged time to ignition, 49% decrement of peak heat release rate and 33% reduction of total heat release), elevated thermal stability and improved compressive (15% improvement of CFD) and resilient (5.2% raise of resilience) properties, concurrently. Therefore, DMPMA and TAMPO have great potential as liquid additive-type flame retardants for manufacturing flame retardant , supportive and comfort FPUF in seating and cushioning applications.
研究领域:
材料科学
·
高分子化学
·
消防安全工程
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DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 7
·1-13
·
IF 3.097
Yao Qi,Lan Hai,Li Xin,Chen Youyi
Organic–inorganic interpenetrating network poly (acrylic acid- co -acrylamide) IPN-P(AA-co-AM) polymer sphere with core–shell structure has been synthesized by modified suspension polymerization, which the core is high cross-linked and shell is light cross-linked, respectively. The dispersed phase (water phase) and continuous phase (oil phase), as well as core and shell crosslinking agent are screened based on the water absorption capacity of the polymer spheres. In addition, SiO 2 is applied to endow polymer spheres with excellent thermal and water absorption properties. FTIR, TG, SEM, and XPS analyze the chemical structure, thermal properties, morphology and surface element of polymer spheres, respectively. Particularly, the forming mechanism of polymer spheres and water absorption dynamic model are discussed in detail. The results show that the Organic–inorganic IPN-P(AA-co-AM) polymer spheres are successfully synthesized. The polymer spheres could be wrapped effectively when the SiO 2 content up to 2%. Compared to polymer spheres without SiO 2 , the thermal stability is greatly improved. The optimum core and shell crosslinking agent are pentaerythritol triacrylate (PETA) and sodium alginate, respectively. The maximum absorption capacity of polymer spheres for distilled water and 0.9wt% sodium chloride can up to 922.22 g/g and 93.87 g/g, respectively. Finally, the water absorption of IPN-P(AA-co-AM) polymer spheres dynamic model is closed to second-order.
研究领域:
高分子科学
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材料科学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 134
·期 8
·
IF 1.866
Zhe Yu,Ying Zhang,Zi Jian Gao,Xiu Yan Ren,Guang Hui Gao
In this investigation, polyacrylamide (PAAm) as the flexible network is introduced to enhance the mechanical strength of hyaluronic acid–gelatin (HA–Gel) hydrogels by interpenetrating polymer network (IPN). The structure, mechanical property, and rheology property of the IPN hydrogels are investigated. It is found that the compressive strength of the HA–Gel/PAAm IPN hydrogels has increased five times higher than that of HA–Gel hydrogels. Rheological test demonstrates that elastic moduli (G′) and viscous moduli (G″) of HA–Gel/PAAm IPN hydrogels increase 100 times higher than those of HA–Gel hydrogels. Moreover, the HA–Gel hydrogels are fractured under the low compressive stress, whereas HA–Gel/PAAm IPN hydrogels are not broken under the high compressive stress. It is envisioned that the IPN hydrogels will be an effective approach to enhance the mechanical strength and broaden the range of hydrogels' applications. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44503.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2019
·Vol. 304
·期 11
·1900309
·
IF 3.038
Changzhuang Bai,Qiuhua Huang,Xiao Zhang,Xiaopeng Xiong
Tough hydrogels receive continuous attention because of their promising applications in many fields. Herein, tough hydrogels of poly ( N , N -dimethylacrylamide) (PDMAA)/alginate (SA) are prepared, with interpenetrating network (IPN) and of PDMAA/chitosan (CS) with semi-IPN microstructure, respectively. The toughening of the hydrogel by incorporating natural polymers is studied by compressing tests and dynamic mechanical analyses. Moreover, cyclic load–unload compressing of the two types of hydrogels are performed at low strains and under relatively high strains, in order to compare their strength and anti-fatigue properties. The results indicate that the mechanical strength can be markedly improved upon addition of the natural polymers, and the IPN hydrogel of PDMAA/SA reveals much higher mechanical performances but is less stable. However, the semi-IPN hydrogel of PDMAA/CS displays excellent anti-fatigue stability, but with relatively low strength. Swelling tests, scanning electron microscopy, and Fourier transform infrared spectroscopy are carried out to study the microstructures of the hydrogels, which are carefully analyzed to understand the difference in mechanical performances of those hydrogels. The results suggest that the presence of sacrificial unit and higher chain density in the IPN are helpful for toughening hydrogels, while the semi-IPN network is beneficial to improve the energy dissipation efficiency.
研究领域:
材料科学
·
高分子科学
·
生物医学工程
·
软材料
·
聚合物力学性能
✓ 已验证
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 3
·524
·
IF 3.164
Yi Chen,Yueyun Zhou,Wenyong Liu,Hejie Pi,Guangsheng Zeng
In order to improve the performance of traditional sodium alginate (SA) hydrogels cross-linked by Ca2+ions to meet greater application demand, a strategy was designed to structure novel SA-based gels (named OP-PN gels) to achieve both stimulus responsiveness and improved mechanical strength. In this strategy, the SA chains are co-cross-linked by CaCl2and cationic octa-ammonium polyhedral oligomeric silsesquioxane (Oa-POSS) particles as the first network, and an organically cross-linked poly(N-isopropyl acrylamide) (PNIPA) network is introduced into the gels as the second network. Several main results are obtained from the synthesis and characterization of the gels. For OP-PN gels, their properties depend on the content of both uniformly dispersed Oa-POSS and PNIPA network directly. The increased Oa-POSS and PNIPA network content significantly improves both the strength and resilience of gels. Relatively, the increased Oa-POSS is greatly beneficial to the modulus of gels, and the increased PNIPA network is more favorable to advancing the tensile deformation of gels. The gels with hydrophilic PNIPA network exhibit better swelling ability and remarkable temperature responsiveness, and their volume phase transition temperature can be adjusted by altering the content of Oa-POSS. The deswelling rate of gels increases gradually with the increase of POSS content due to the hydrophobic Si–O skeleton of POSS. Moreover, the enhanced drug loading and sustained release ability of the target drug bovine serum albumin displays great potential for this hybrid gel in the biomedical field.Keywords:octa-ammonium POSS;sodium alginate;hydrogels;temperature responsiveness
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Shu Tian,Daoyi Jiang,Jibin Pu,Xiaofeng Sun,Zhanming Li,Bin Wu,Wenru Zheng,Wenqing Liu,Zhixiong Liu
A series of hybrid antifouling coatings consisting of silicone elastomer and nanocomposite hydrogel were successfully prepared. The morphology of the hybrid coatings and the silver nanoparticles (AgNPs) embedded into the coatings were studied by SEM and TEM. The pure silicone coating showed a relatively flat morphology. Smooth spheroidal aggregates self-assembled by hydrophilic polymer with a diameter of 4–14 μm appeared when the polymer chains were introduced. However, with increasing of AgNPs the spheroidal aggregates were gradually covered with a thin silicone film and were firmly embedded into the coatings. The glass transition temperature of the hybrid coatings measured by DSC technique showed that the silicone elastomer and the hydrogel matrix formed interpenetrating polymer networks (IPN). The static water contact angle of the hybrid coatings with different amount of the hydrophilic polymer chains before and after being immersed into water was also measured. Furthermore, these hybrid coatings showed good antimicrobial performance for Escherichia coli and anti-algae property. The result showed that the SH-0.25-1.5 sample could almost kill 100% E. coli. Compared with the control sample, the settlement of the Phaeodactylum tricornutum, Navicula torguatum and Chlorella on the surface of SH-0.25-1.5 sample decreased approximately 37%, 37% and 52%, respectively. The antifouling performances of the hybrid coatings were examined by field tests in South China Sea and the result showed the hybrid coatings with nanocomposite hydrogel exhibited good antifouling property. These hybrid coatings have promising applications in marine antifouling coating and interfaces of biomaterials.
研究领域:
材料科学
·
海洋生物学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Xiaoliang Qi,Wei Wei,Junjian Li,Ting Su,Xihao Pan,Gancheng Zuo,Jianfa Zhang,Wei Dong
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly( N -(3-dimethylaminopropyl)acrylamide- co -acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.
研究领域:
药学
·
生物医学工程
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）