Curcumin (CUR) has a bright future in the treatment of cancer as a natural active ingredient with great potential. However, curcumin has a low solubility, which limits its clinical application. In this study, IRMOF-10 was created by the direct addition of triethylamine, CUR was loaded into IRMOF-10 using the solvent adsorption method, and the two were characterized using a scanning electron microscope (SEM), X-ray diffraction (XRD), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG) methods, and Brunauer–Emmett–Teller (BET) analysis. We also used the MTT method, 4′,6-diamidino-2-phenylindole (DAPI) staining, the annexin V/PI method, cellular uptake, reactive oxygen species (ROS), and the mitochondrial membrane potential (MMP) to perform a safety analysis and anticancer activity study of IRMOF-10 and[email protected]on HepG2 cells. Our results showed that[email protected]had a CUR load of 63.96%, with an obvious slow-release phenomenon. The CUR levels released under different conditions at 60 h were 33.58% (pH 7.4) and 31.86% (pH 5.5). Cell experiments proved that IRMOF-10 was biologically safe and could promote curcumin entering the nucleus, causing a series of reactions, such as an increase in reactive oxygen species and a decrease in the mitochondrial membrane potential, thereby leading to cell apoptosis. In summary, IRMOF-10 is an excellent drug carrier and[email protected]is an effective anti-liver cancer sustained-release preparation.Keywords:MOFs;IRMOF-10;curcumin;HepG2 cells
A dual emission metal–organic framework (IRMOF-10-Eu) was prepared and used as a ratiometric fluorescent sensor for CO32− detection. IRMOF-10-Eu had good stability and excellent luminescence in aqueous solution. IRMOF-10-Eu showed dual fluorescence emission from the ligand and Eu3+ with single excitation. Upon treatment with CO32−, the fluorescence ratio (I624/I358) of the probe displayed significant change. The relative fluorescence intensity ratio (I624/I358) and CO32− concentration had a linear relationship in 50–300 μM range with a low detection limit of 9.58 μM. And the luminescence probe of CO32− showed a fast detection time. The possible mechanism was investigated. CO32− changed the structure of IRMOF-10-Eu and interrupted the energy transfer process. Thus, the fluorescence emission intensity of the ligand was increased and Eu3+ was decreased with the addition of CO32−. IRMOF-10-Eu was used to detect CO32− in seawater, which showed good prospect in practical application. Subsequently, a highly selective and sensitive probe, IRMOF-10-Eu, may pave an efficient way for CO32− detection in seawater.
Yifei Chen,Yongru You,Chen Xin,Xiuqin Dong,Hao Gong
The diverse pore structures and excellent tunable proprieties of IRMOFs materials made the possibility to explore the effect of the mode of ligand-immobilization on its catalytic performance for 1-butene hydroformylation. In this work, we report a successful case of theory-guided rational design of a highly active ligand-immobilized Rh/IRMOF catalyst based on previous work. Density functional theory calculations of elementary reaction barriers for 1-butene hydroformylation over 1Rh/IRMOFs-PPh 3 models (IRMOF-1, -8, -10, -14, and -16) were performed. The calculation results and topographic steric maps analysis predicted that 1Rh/IRMOF-10-PPh 3 have superior catalytic performance. This can be attributed to the “shape-selective” effect of phosphine ligands grafted in the backbone on the reactive transition state. In addition, the anchoring positions of the phenyl phosphine ligand grafting on the skeleton of 1Rh/IRMOF-10-PPh 3 was identified in details. The 1Rh/IRMOF-10-PPh 3 [3‐3] was predicted to have the highest n/i ratio. In order to verify the theoretical prediction, 1Rh/IRMOF-10–32PPh 3 catalyst was prepared by post-synthesis strategy and the n/i ratio was experimentally confirmed to be 3.49, which outperform the previous 1Rh/MOF-5-PPh 3 catalyst. This work suggests that the 1Rh/IRMOF-10-PPh 3 catalyst can be a promising catalyst for hydroformylation reactions.
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