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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY · 2022 · IF 4.831

A novel dual-function probe for fluorescent turn-on recognition and differentiation of Al3+ and Ga3+ and its application

Qi Liu,Yatong Liu,Zhiyong Xing,Yuntong Huang,Li Ling,Xinglin Mo

In this study, a novel dual-function probe BMP based on benzothiazole was easily synthesized and characterized through common optical technique. In the system consisting of DMF/H 2 O (v/v, 2/3), probe BMP showed azure and blue-green to Al 3+ and Ga 3+ , respectively. Besides, the binding ratios of BMP to Al 3+ and Ga 3+ were determined as 1:1, which confirmed by Job’s plot. Furthermore, for Al 3+ and Ga 3+ , the limit of detection (LOD) was determined to be 1.51 × 10 -6 M and 4.28 × 10 -6 M, respectively. Moreover, it was worth noting that BMP showed good performances in paper colorimetry, cell phone colorimetric identification and cell imaging.

CAS / MDL: 10034-81-8 7784-27-2 13465-95-7 13477-34-4 10026-22-9 7789-02-8 207398-97-8 7758-94-3 10099-74-8 10034-96-5 10025-64-6 13478-00-7 7778-74-7 7601-89-0 7761-88-8 13494-90-1

研究领域: 分析化学 · 材料科学 · 生物化学

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RSC Advances · 2016 ·Vol. 6 ·期 70 ·66215-66223 · IF 3.289

A facile, fast responsive and highly selective mercury(II) probe characterized by the fluorescence quenching of 2,9-dimethyl-1,10-phenanthroline and two new metal–organic frameworks

Fa-Shuo Shan,Jia-Ping Lai,Hui Sun,Ping Zhang,Chong Luo,Yan-Hui He,Huan-Ran Feng

A fast responsive and highly selective mercury(II) sensor was developed using the fluorescence quenching mechanism of 2,9-dimethyl-1,10-phenanthroline (2,9-DMP) towards mercury(II). Furthermore, two kinds of metal–organic frameworks (MOFs) of 2,9-DMP–Hg(II) have been synthesized and characterized by X-ray diffraction. The probe 2,9-DMP exhibited a fast and highly selective response to mercury(II) ions in aqueous solution, showing a good linear relationship over the concentration range of 0.050–2.0 μM for Hg(II) with R2 = 0.9994. The established procedure was used to monitor the concentration of mercury(II) in drinking water and Zhujiang River water samples with satisfactory recoveries of 85.42–101.5% and 81.72–96.09%, respectively. Furthermore, the fluorescence quenching mechanism of 2,9-DMP by mercury(II) was investigated and clarified by the data of single crystal X-ray diffraction of MOFs and the Job's plot analyses of 2,9-DMP towards Hg(II).

研究领域: 分析化学 · 环境科学 · 材料科学

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY · 2016 · IF 2.653

Several hemicyanine dyes as fluorescence chemosensors for cyanide anions

Muhan Liang,Kangnan Wang,Ruifang Guan,Zhiqiang Liu,Duxia Cao,Qianqian Wu,Yanyan Shan,Yongxiao Xu

Four hemicyanine dyes as chemosensors for cyanide anions were synthesized easily. Their photophysical properties and recognition properties for cyanide anions were investigated. The results indicate that all the dyes can recognize cyanide anions with obvious color, absorption and fluorescence change. The recognition mechanism analysis basing on in situ 1 H NMR and Job plot data indicates that to the compounds with hydroxyl group , the recognition mechanism is intramolecular hydrogen bonding interaction. However, to the compounds without hydroxyl group, cyanide anion is bonded to carbon–carbon double bond in conjugated bridge and induces N + CH 3 to neutral NCH 3 . Fluorescence of the compounds is almost quenched upon the addition of cyanide anions.

CAS / MDL: 1761-61-1 17754-90-4 7570-45-8 109-06-8 555-16-8 108-89-4

研究领域: 分析化学 · 光谱学 · 分子化学

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JOURNAL OF MOLECULAR STRUCTURE · 2018 · IF 2.011

A highly selective and sensitive fluorescence probe with A-π-D-π-A structure for detection of Ag+

Yi-bao Jiang,Chao Gao,Xian Zhang,Jin-shui Yao,Qin-ze Liu,Xiao-xia Cai

A novel triphenylamine derivative, 4,4′ -bis-([1,10]phenanthrolin-2-yl) imidazo -triphenylamine (IPTPA) with an A-π-D-π-A structure, has been synthesized and characterized. The UV absorption , single and two-photon fluorescence spectra showed that IPTPA was highly sensitive to Ag + with a lower detection limit of 3.97 nmoL/L and a moderate binding constant of 2.16 × 10 5 /M at room temperature . The two-photon active cross-section of IPTPA was calculated with a value of 94.68 GM at 800 nm in the tris-HCl buffer solution. The binding mechanism between IPTPA and Ag + were explored by the Job plot, ESI-MS and 1 H NMR. The A-π-D-π-A structure of IPTPA was substituted by the A-π-D-π-D structure of IPTPA-Ag to improve the fluorescence. Furthermore, the fluorescence microscopy images indicated that IPTPA could detect Ag + in living cells.

CAS / MDL: 66-71-7

研究领域: 分析化学 · 材料科学 · 生物医学工程 · 光学

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SENSORS AND ACTUATORS B-CHEMICAL · 2024 · IF 8

A novel near-infrared-II fluorescence probe for serum albumin biosensing and site-binding mechanism study

Jixiang Song,Pengfei Chen,Longsheng Zhang,Junbo Hu,Ruining Yang,Pengfei Sun,Yanqin Huang,Xingfen Liu,Xiaomei Lu,Quli Fan

Abnormal albumin levels are predictors of nephropathy, liver cirrhosis, coronary heart disease, and diabetes. Sensitive and rapid detection of endogenous albumin is of great significance to disease diagnosis and new drug discovery. Here, the first near-infrared-II fluorescence probe for albumin was developed. Based on the remarkable fluorescence enhancement induced by albumin, both human serum albumin (HSA) and bovine serum albumin (BSA) were quantified in several minutes. The limit of detection for albumin in urine samples is as low as 50 nM, which meets the requirement well for clinical analysis. The fluorescence imaging of drug-induced albumin in living cells verified strong capability for the probe to monitor the endogenous albumin. The site-binding mechanism between the probe and albumin was investigated via Job's plots analysis, drug substitution assays, and molecular docking. The NIR-II probe exhibits a specific and high-affinity binding (K b =5.26×10 11 M −1 ) with albumin, which enabled a further determination of trypsin and a protease inhibitor. This novel versatile biosensor provides a promising strategy for on-site evaluating of endogenous albumin for clinical diagnostics and drug screening.

CAS / MDL: 79902-63-9

研究领域: 生物医学工程 · 分析化学 · 分子生物学 · 临床诊断 · 新药发现

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JOURNAL OF MOLECULAR STRUCTURE · 2016 · IF 1.78

Host-guest inclusion systems of daidzein with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD): Preparation, binding behaviors and water solubility

Yinghui Deng,Yanhua Pang,Yafei Guo,Yufeng Ren,Fen Wang,Xiali Liao,Bo Yang

Daidzein is an isoflavone of naturally abundance existing in plants and foods which has attracted much attention for its significant benefits on human health. However, its application was severely limited by its poor solubilities, instability and low bioavailability. To overcome these drawbacks, inclusion complexes of daidzein with two cyclodextrin (CD) derivatives, i.e., 2-hydropropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) were prepared and characterized both in solution and solid state by 1D and 2D NMR , XRD, SEM and elemental analyses. Fluorescence spectroscopy and the Job plot were used to demonstrate a mainly 1:1 inclusion mode between daidzein and CDs. Their thermal stabilities were evaluated with TG and DSC experiments. Moreover, water solubility of daidzein was significantly improved by inclusion complexation with CDs. These results might suggest valuable approaches to developments of new pharmaceutical formulations of daidzein.

CAS / MDL: 486-66-8

研究领域: 药学 · 化学 · 材料科学

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JOURNAL OF COORDINATION CHEMISTRY · 2019 · IF 1.685

A hydroxyquinoline-appended ruthenium(II)-polypyridyl complex that induces and stabilizes G-quadruplex DNA

Xuexue Xu,Shuang Wang,Yaxuan Mi,Huaqian Zhao,Zebao Zheng,Xiaolong Zhao

A polypyridyl ruthenium(II) complex with hydroxyquinoline-derived ligand has been synthesized and characterized. The ability to act as telomeric quadruplex inducer and stabilizer, and quadruplex-binding properties of the complex have been evaluated by absorption and emission analyses, fluorescent intercalator displacement (FID) titrations, circular dichroism (CD) spectroscopy, polymerase chain reaction (PCR) stop assay, color reaction studies, fluorescence resonance energy transfer (FRET) melting assay, Job plot, and molecular modeling. Observations revealed that the complex could well induce and stabilize the formation of antiparallel G-quadruplex of telomeric DNA in the presence or absence of metal cations, and showed superior G-quadruplex selectivity over duplex DNA with remarkable ΔTm value of 18.0 °C even at 50-fold excessive supplies of calf thymus (ct) DNA. The complex exhibited high interaction affinity of 2.56 × 106 M−1 with G-quadruplex DNA and evident luminescence enhancements of 3.1 and 4.2 times for quadruplex binding in Na+ and K+ buffer, respectively. In addition, the 1:1 [quadruplex]/[complex] binding mode ratio was determined. The results suggest that the complex can be developed as potential anticancer reagent through binding and stabilization of G-quadruplex DNA.

CAS / MDL: 366-18-7 168646-54-6 14510-06-6

研究领域: 化学 · 生物化学 · 分子生物学 · 癌症研究

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A novel dual-function probe for fluorescent turn-on recognition and differentiation of Al3+ and Ga3+ and its application

A facile, fast responsive and highly selective mercury(II) probe characterized by the fluorescence quenching of 2,9-dimethyl-1,10-phenanthroline and two new metal–organic frameworks

Several hemicyanine dyes as fluorescence chemosensors for cyanide anions

A highly selective and sensitive fluorescence probe with A-π-D-π-A structure for detection of Ag+

A novel near-infrared-II fluorescence probe for serum albumin biosensing and site-binding mechanism study

Host-guest inclusion systems of daidzein with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD): Preparation, binding behaviors and water solubility

A hydroxyquinoline-appended ruthenium(II)-polypyridyl complex that induces and stabilizes G-quadruplex DNA